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Neural mechanisms of adaptive circuit shift in operant learning of behaviors

Planned Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 26112005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTamagawa University

Principal Investigator

ISOMURA Yoshikazu  玉川大学, 脳科学研究所, 教授 (00415077)

Co-Investigator(Kenkyū-buntansha) 酒井 裕  玉川大学, 脳科学研究所, 教授 (70323376)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2017: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
Keywords大脳皮質 / 大脳基底核 / 行動制御 / 光遺伝学 / ラット / 運動野 / 線条体 / 運動発現 / 行動選択 / 神経科学 / 生理学 / 行動抑制 / 脳・神経
Outline of Final Research Achievements

We aimed to elucidate neural mechanism(s) of adaptive circuit shift in the cerebral cortex-basal ganglia loops for animal’s adaptive behaviors. Combining our original behavioral experiments using head-fixed rats with multi-neuronal recordings and optogenetics, we revealed functional mechanisms underlying proactive inhibition and limb-control laterality by the cerebral cortex (primary and secondary motor cortices, orbitofrontal cortex, and posterior parietal cortex) and underlying outcome-based action selection by the basal ganglia (direct and indirect pathways from the dorsomedial striatum).

Academic Significance and Societal Importance of the Research Achievements

げっ歯類の大脳皮質の行動抑制や両側支配性の機能的活動情報の解析により、特に二次運動野と後頭頂連合野の神経回路が行動制御に重要であることが推察された。また、過去の行動の結果から次の行動の選択を決定することに背内側線条体の直接路と間接路が異なって関与することは、その上流情報である大脳皮質からのグルタミン酸入力信号と黒質緻密部からのドーパミン入力信号の統合機構が今後の研究のカギとして浮かび上がるであろう。これらの成果は、私たちが最適な行動を選択し実行する脳の仕組みの理解を一歩進めるものである。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (46 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 9 results) Book (1 results) Remarks (7 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] チュービンゲン大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] アルベルト・アインシュタイン医科大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] アルベルト・アインシュタイン医科大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.2019

    • Author(s)
      1.Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y.
    • Journal Title

      J Neurosci.

      Volume: 39 Issue: 3 Pages: 485-502

    • DOI

      10.1523/jneurosci.1584-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Area-specific Modulation of Functional Cortical Activity During Block-based and Trial-based Proactive Inhibition2018

    • Author(s)
      Yoshida Junichi、Saiki Akiko、Soma Shogo、Yamanaka Ko、Nonomura Satoshi、Rios Alain、Kawabata Masanori、Kimura Minoru、Sakai Yutaka、Isomura Yoshikazu
    • Journal Title

      Neuroscience

      Volume: 388 Pages: 297-316

    • DOI

      10.1016/j.neuroscience.2018.07.039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Laterality in Forelimb-Movement Representations of Rat Primary and Secondary Motor Cortical Neurons with Intratelencephalic and Pyramidal Tract Projections2017

    • Author(s)
      Soma Shogo、Saiki Akiko、Yoshida Junichi、Rios Alain、Kawabata Masanori、Sakai Yutaka、Isomura Yoshikazu
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Issue: 45 Pages: 10904-10916

    • DOI

      10.1523/jneurosci.1188-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses.2017

    • Author(s)
      Nonomura S, Fujiwara-Tsukamoto Y, Kajihara T, Fujiyama F, Isomura Y
    • Journal Title

      Neurosci Res

      Volume: - Pages: 53-59

    • DOI

      10.1016/j.neures.2017.03.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioural functions2017

    • Author(s)
      Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
    • Journal Title

      Journal of Physiology

      Volume: 595 Issue: 1 Pages: 385-413

    • DOI

      10.1113/jp272794

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.2017

    • Author(s)
      Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y.
    • Journal Title

      Cereb Cortex.

      Volume: 印刷中 Issue: 3 Pages: 1-15

    • DOI

      10.1093/cercor/bhx012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 記憶ふたたび 9.オペラント条件づけで脳を探る2016

    • Author(s)
      相馬 祥吾,川端 政則,礒村 宜和
    • Journal Title

      生体の科学

      Volume: 67 Issue: 1 Pages: 42-46

    • DOI

      10.11477/mf.2425200396

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Spatiotemporal Organization and Cross-Frequency Coupling of Sleep Spindles in Primate Cerebral Cortex.2016

    • Author(s)
      Takeuchi, S., R. Murai, H. Shimazu, Y. Isomura, T. Mima and T. Tsujimoto
    • Journal Title

      Sleep

      Volume: 39(9) Issue: 9 Pages: 1719-1735

    • DOI

      10.5665/sleep.6100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarity in neuronal firing regimes across mammalian species2016

    • Author(s)
      Yasuhiro Mochizuki, ..., Ichiro Fujita, et al.
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 21 Pages: 5736-5747

    • DOI

      10.1523/jneurosci.0230-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Balanced motor primitive can explain generalization of motor learning effects between unimanual and bimanual movements.2016

    • Author(s)
      Takiyama K & Sakai Y
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 23331-23331

    • DOI

      10.1038/srep23331

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gamma Oscillations and Their Cross-frequency Coupling in the Primate Hippocampus During Sleep2015

    • Author(s)
      Takeuchi, S., Mima, T., Murai, R., Shimazu, H., Isomura, Y., & *Tsujimoto
    • Journal Title

      Sleep

      Volume: 38 Issue: 7 Pages: 1085-91

    • DOI

      10.5665/sleep.4818

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anomalous Neuronal Responses to Fluctuated Inputs2015

    • Author(s)
      Ryosuke Hosaka and Yutaka Sakai
    • Journal Title

      Physical Review E

      Volume: 92 Issue: 4 Pages: 042705-042705

    • DOI

      10.1103/physreve.92.042705

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 習慣の神経メカニズム.2015

    • Author(s)
      吉田 純一,礒村 宜和
    • Journal Title

      生体の科学

      Volume: 66 Pages: 14-18

    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural representation for right and left limb movements in rodent cerebral cortex.2018

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      The 8th CIN-NIPS Joint Symposium (Centre for Integrative Neuroscience, University of Tubingen, Tubingen, Germany)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Reactive inhibition correlates with only trial-based but not block-based proactive inhibition2018

    • Author(s)
      Yoshida J, Soma S, Sakai Y, Isomura Y
    • Organizer
      Neuroscience 2018 (San Diego Convention Center, San Diego, USA)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of indirect pathway neurons and dopaminergic innervation in the rat dorsomedial striatum.2018

    • Author(s)
      Nonomura S, Kato S, Iguchi Y, Nishizawa K, Sakai Y, Kawaguchi Y, Nambu A, Watanabe M, Kobayashi K, Isomura Y, Kimura M
    • Organizer
      Neuroscience 2018 (Kobe International Conference Center, Kobe, Hyogo)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Laterality for forelimb-movements in motor cortex in a hemiparkinsonian rat model.2018

    • Author(s)
      Rios A, Soma S, Yoshida J, Kawabata M, Sakai Y, Isomura Y
    • Organizer
      Neuroscience 2018 (Kobe International Conference Center, Kobe, Hyogo)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lateralized limb representation of posterior parietal cortex neurons during forelimb movements of the rat.2018

    • Author(s)
      Soma S, Yoshida J, Nonomura S, Sakai Y, Isomura Y
    • Organizer
      Neuroscience 2018 (Kobe International Conference Center, Kobe, Hyogo)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳活動計測に適したラットの行動学習システム.2017

    • Author(s)
      礒村宜和
    • Organizer
      第10回ラットリソースリサーチ研究会
    • Place of Presentation
      京都大学医学部(京都市左京区)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cortical and striatal mechanism to control forelimb movements in rodents.2017

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      The 7th NIPS-CIN Joint Symposium (National Institute for Physiological Sciences, Okazaki, Aichi)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 行動発現を制御する大脳皮質回路2017

    • Author(s)
      礒村 宜和
    • Organizer
      平成29年度生理学研究所研究会(生理学研究所, 愛知県岡崎市)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Plenary Lecture: Cortical, hippocampal and striatal activations during reward-seeking behaviors.2017

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      The 6th International Conference on Cognitive Neurodynamics (ICCN-2017) (Hotel Alcázar de la Reina, Carmona, Spain)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cortical, striatal and hippocampal activations during reward-seeking behaviors.2016

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      Computational Basal Ganglia
    • Place of Presentation
      National Institute for Physiological Sciences, Okazaki, Aichi
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大脳皮質の多領域間スパイク・コミュニケーションの解明を目指して.2016

    • Author(s)
      礒村宜和
    • Organizer
      平成28年度生理学研究所研究会「大脳皮質の機能原理を探る」
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Distinct roles of orbitofrontal cortex in response execution and inhibition during a stop-signal task.2016

    • Author(s)
      Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, R-Davila AA, Kawabata M, Kimura M, Sakai Y, Isomura Y
    • Organizer
      The Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cortical, striatal and hippocampal circuits for reward-based behaviors.2016

    • Author(s)
      Yoshikazu Isomura
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Functional neural activity in orbitofrontal cortex during proactive inhibition with a novel stop-signal task.2016

    • Author(s)
      Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Kawabata M, Sakai Y, Isomura Y
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Functional activity for goal-oriented behaviors in motor cortex, striatum and hippocampus.2016

    • Author(s)
      Isomura Y
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016.
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional activity in orbitofrontal cortex during proactive inhibition.2016

    • Author(s)
      Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Kawabata M, Sakai Y & Isomura Y
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016.
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Behavioral evaluation of impairment of response inhibition by habit formation.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      The 75th Annual Meeting of the Japanese Society for Animal Psychology
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel operant learning task to evaluate rat behavioral inhibition during habit formation.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      Neuroscience 2015, The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] A new stop-signal task to explore inhibitory function in operant learning to habituation process.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      The 92nd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel stop-signal task to explore inhibitory function in operant learning to habituation process.2015

    • Author(s)
      Yoshida J, Saiki A, Yamanaka K, Sakai Y & Isomura Y
    • Organizer
      Winter workshop on mechanism of brain and mind 2015
    • Place of Presentation
      ルスツリゾート(北海道留寿都)
    • Year and Date
      2015-01-07
    • Related Report
      2014 Annual Research Report
  • [Book] 心理学辞典(下山晴彦編)2014

    • Author(s)
      礒村 宜和(分担執筆)
    • Total Pages
      1088
    • Publisher
      誠信書房
    • Related Report
      2014 Annual Research Report
  • [Remarks] https://researchmap.jp/yoshikazuisomura/

    • Related Report
      2018 Annual Research Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/yoshikazuisomura/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 礒村研究室ホームページ

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 研究室HP

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Researchmap礒村宜和

    • URL

      http://researchmap.jp/yoshikazuisomura/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 玉川大学脳科学研究所礒村研究室

    • URL

      http://www.tamagawa.ac.jp/teachers/isomura/index.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 投射先同定装置、投射先同定方法及びプログラム2017

    • Inventor(s)
      酒井裕、礒村宜和
    • Industrial Property Rights Holder
      学校法人玉川学園
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2014-11-20   Modified: 2022-02-28  

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