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Functional dynamics of the cortical network regulating emotion and attention

Planned Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 26112009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

TSUTSUI Ken-Ichiro  東北大学, 生命科学研究科, 教授 (90396466)

Co-Investigator(Kenkyū-buntansha) 臼井 信男  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40752118)
泰羅 雅登  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50179397)
Research Collaborator HOSOKAWA Takayuki  
NAKAMURA Shinya  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥71,890,000 (Direct Cost: ¥55,300,000、Indirect Cost: ¥16,590,000)
Fiscal Year 2018: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2015: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2014: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Keywords神経科学 / 経頭蓋磁気刺激 / ニホンザル / 皮質表面電位 / 遅延反応課題 / サル / 注意 / 情動
Outline of Final Research Achievements

To elucidate the dynamics of cortical network for attention and emotion control, we conducted the manipulation of local brain activity by repetitive transcranial stimulation (rTMS), and the wide-range simultaneous electrophysiological recordings. Concerning the attention control and working memory, we dissociated the function of the dorsolateral prefrontal and dorsal premotor cortices, each being involved in the sensory and motor aspect of attention and working memory. Concerning the emotion and mood regulations, we found the critical role of the ventromedial frontal cortex. And it was suggested that the malfunction of the ventromedial frontal cortex may lead to emotion and mood disorders, such as major depression. And especially for the control of attention and working memory, it was suggested that the top-down information flow from the frontal to posterior cortices may be playing a critical role.

Academic Significance and Societal Importance of the Research Achievements

情動や注意の制御は、高次機能の中心的な要素である。また、その機能の破綻は、うつ病や統合失調症など、さまざまな精神疾患につながると考えられている。本研究によって、前頭葉の異なる領域が、情動や注意の制御に特異的な役割を果たしていること、また、特に注意や作業記憶の機能に関しては、それを実現するための神経回路の動態が明らかになった。これらの成果によって、高次脳機能の理解が深まるとともに、精神疾患の病態の理解と、治療戦略の改善、あるいは、新たな治療法の開発につながるものと期待される。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (91 results)

All 2019 2018 2017 2016 2015 2014

All Journal Article (16 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 16 results,  Open Access: 7 results) Presentation (75 results) (of which Int'l Joint Research: 25 results,  Invited: 19 results)

  • [Journal Article] Behavioral evidence for the use of functional categories during group reversal task performance in monkeys.2018

    • Author(s)
      Hosokawa T, Honda Y, Yamada M, Romero MDC, Iijima T, Tsutsui KI* (*correspondence author)
    • Journal Title

      Scientific Reports

      Volume: 26;8(1) Issue: 1 Pages: 15878-15878

    • DOI

      10.1038/s41598-018-33349-3

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat2018

    • Author(s)
      Ohara Shinya、Onodera Mariko、Simonsen ?yvind W.、Yoshino Rintaro、Hioki Hiroyuki、Iijima Toshio、Tsutsui Ken-Ichiro、Witter Menno P.
    • Journal Title

      Cell Reports

      Volume: 24 Issue: 1 Pages: 107-116

    • DOI

      10.1016/j.celrep.2018.06.014

    • NAID

      120006491716

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex Differences in Risk Preference and c-Fos Expression in Paraventricular Thalamic Nucleus of Rats During Gambling Task2018

    • Author(s)
      Ishii H, Onodera M, Ohara S, Tsutsui KI, Iijima T
    • Journal Title

      Front. Behav. Neurosci.

      Volume: - Pages: 68-68

    • DOI

      10.3389/fnbeh.2018.00068

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] rTMSを用いたサル内側前頭皮質における気分・情動制御メカニズムの探索2018

    • Author(s)
      中村晋也、筒井健一郎
    • Journal Title

      臨床精神医学

      Volume: 47(8) Pages: 883-887

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ventrolateral Prefrontal Cortex Updates Chosen Value According to Choice Set Size2018

    • Author(s)
      Fujiwara J, Usui N, Eifuku S, Iijima T, Taira M, Tsutsui KI, Tobler PN
    • Journal Title

      J Cogn Neurosci.

      Volume: 30 Issue: 3 Pages: 307-318

    • DOI

      10.1162/jocn_a_01207

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Robust, highly customizable, and economical multi-channel electrode for chronic multi-unit recording in behaving animals2017

    • Author(s)
      Tateyama Yukina、Oyama Kei、Shiraishi Masaru、Iijima Toshio、Tsutsui Ken-Ichiro
    • Journal Title

      Neuroscience Research

      Volume: 125 Pages: 54-59

    • DOI

      10.1016/j.neures.2017.07.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased transgene expression level of rabies virus vector for transsynaptic tracing.2017

    • Author(s)
      Ohara S, Sota Y, Sato S, Tsutsui KI, Iijima T
    • Journal Title

      PLOS ONE

      Volume: 12(7) Issue: 7 Pages: e0180960-e0180960

    • DOI

      10.1371/journal.pone.0180960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey2017

    • Author(s)
      Kodama T, Kojima T, Honda Y, Hosokawa T, Tsutsui KI, Watanabe M
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Issue: 9 Pages: 2387-2394

    • DOI

      10.1523/jneurosci.2155-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A dynamic code for economic object valuation in prefrontal cortex neurons2016

    • Author(s)
      Tsutsui KI, Grabenhorst F, Kobayashi S, Schultz W
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 12554-12554

    • DOI

      10.1038/ncomms12554

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neck collar for restraining head and body movements in rats for behavioral task performance and simultaneous neural activity recording.2016

    • Author(s)
      Tateyama Y, Oyama K, Lo CW, Iijima T, Tsutsui KI
    • Journal Title

      Journal of Neruoscience Methods

      Volume: 263 Pages: 68-74

    • DOI

      10.1016/j.jneumeth.2016.02.005

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative Overview of Visuospatial Working Memory in Monkeys and Rats2016

    • Author(s)
      Tsutsui KI, Oyama K, Nakamura S, Iijima T
    • Journal Title

      Frontiers of Systems Neuroscience

      Volume: 10 Pages: 99-99

    • DOI

      10.3389/fnsys.2016.00099

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Similarity in neuronal firing regimes across mammalian species2016

    • Author(s)
      Yasuhiro Mochizuki, ..., Ichiro Fujita, et al.
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 21 Pages: 5736-5747

    • DOI

      10.1523/jneurosci.0230-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection.2016

    • Author(s)
      Tsutsui KI, Hosokawa T, Yamada M, Iijima T
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 10 Pages: 3038-3048

    • DOI

      10.1523/jneurosci.2063-15.2016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum.2015

    • Author(s)
      Oyama K, Tateyama Y, Hernadi I, Tobler PN, Iijima T, Tsutsui KI
    • Journal Title

      Journal of Neurophysiology

      Volume: 114 Issue: 5 Pages: 2600-2615

    • DOI

      10.1152/jn.00097.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of G-gene Deletion and Replacement on Rabies Virus Vector Gene Expression.2015

    • Author(s)
      Sato S, Ohara S, Tsutsui KI, Iijima T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0128020-e0128020

    • DOI

      10.1371/journal.pone.0128020

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dopaminergic and serotonergic modulation of anterior insular and orbitofrontal cortex function in risky decision making.2015

    • Author(s)
      Ishii H, Ohara S, Tobler PN, Tsutsui KI, Iijima T.
    • Journal Title

      Neurosci Res

      Volume: 92 Pages: 53-61

    • DOI

      10.1016/j.neures.2014.11.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Trans-cranial magnetic stimulation (TMS): a powerful tool for neuromodulation and functional mapping of the cerebral cortex2019

    • Author(s)
      Tsutsui KI
    • Organizer
      東北大学未来型医療創造卓越大学院プログラムキックオフシンポジウム
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Repetitive transcranial magnetic stimulation (rTMS): a powerful neural intervention tool to explore the brain2019

    • Author(s)
      Tsutsui KI
    • Organizer
      AMED-DFG workshop in Tuebingen "New directions in systems neuroscience exploring the basis for future translation"
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Low-frequency rTMS to ventral medial frontal cortex induces depression-like behavioral and physiological state in monkeys2019

    • Author(s)
      Nakamura S, Tsutsui KI
    • Organizer
      International Brain Stimulation Conference
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Function of the primate medial frontal cortex in the control of mood and affect: an rTMS study2019

    • Author(s)
      Nakamura S, Tsutsui KI
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repetitive transcranial magnetic stimulation (rTMS): a powerful neural intervention tool to explore the brain2019

    • Author(s)
      Tsutsui KI
    • Organizer
      AMED-DFG workshop in Tuebingen
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生物学的精神医学・精神化学学会 学会内シンポジウム2018

    • Author(s)
      Tsutsui KI
    • Organizer
      Pioneering a new field of translational primate research by TMS
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Role of Primate Medial Frontal Cortex in Control of Mood and Affective State: An rTMS Study2018

    • Author(s)
      Tsutsui KI
    • Organizer
      生理学研究所-チュービンゲン大学合同シンポジウム
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Looking into mindthrough the structure and functionof neural circuits in the brain2018

    • Author(s)
      Tsutsui KI
    • Organizer
      東北大学-ユニバーシティ・カレッジ・ロンドン合同シンポジウム
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] 経頭蓋磁気刺激によるサル精神疾患モデル2018

    • Author(s)
      Tsutsui KI
    • Organizer
      新学術領域「適応回路シフト」成果報告シンポジウム 「脳の機能、病態、回復を発現する神経回路ネットワーク」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Dynamics of large-scale brain network for visuospatial working memory in rats studied by multi-channel simultaneous recording2018

    • Author(s)
      Ohi M, Oyama K, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Changes of electrocorticogram (ECoG) signals induced by repetitive transcranial magnetic stimulation (rTMS) in monkeys2018

    • Author(s)
      Ogawa K, Nakamura S, Hosokawa T, Iijima T, Nishimura Y, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Effects of rTMS to medial frontal cortex on competitive food-picking behavior in monkeys2018

    • Author(s)
      Hosokawa T, Lu X, Saita A, Nakamura S, Iijima T, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Positive and negative emotion reflected in monkey EEG2018

    • Author(s)
      Honda Y, Hosokawa T, Nakamura S, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Distinct inputs to the entorhinal layer Va and Vb of the rat2018

    • Author(s)
      Onodera M, Ohara S, Simonsen OW, Hioki H, Iijima T, Witter MP, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Ketamine ameliorates depression-like symptoms induced by low-frequency repetitive transcranial magnetic stimulation to the medial frontal cortex in monkeys2018

    • Author(s)
      Nakamura S, Hosokawa T, Iijima T, Tsutsui KI
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Presentation] Neural mechanisms underlying anti-conformity in social behavior2018

    • Author(s)
      Fujiwara J, Tobler PN, Tsutsui KI, Taira M, Ugawa Y, Eifuku S
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Do rodents have prefrontal cortex?2018

    • Author(s)
      Tsutsui KI
    • Organizer
      山梨大学脳科学国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pioneering a new field of translational primate research by TMS2018

    • Author(s)
      Tsutsui KI
    • Organizer
      生物学的精神医学・精神化学学会 学会内シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 経頭蓋磁気刺激によるサル精神疾患モデル2018

    • Author(s)
      sutsui KI
    • Organizer
      新学術領域「適応回路シフト」成果報告シンポジウム 「脳の機能、病態、回復を発現する神経回路ネットワーク」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] TMS approach to study cortical network2017

    • Author(s)
      Tsutsui KI
    • Organizer
      新学術領域「適応回路シフト」国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 内側前頭皮質腹側部の気分・情動調節機能 - 低頻度経頭蓋磁気刺激(TMS)による機能阻害による検討2017

    • Author(s)
      Tsutsui KI
    • Organizer
      第39回 生物学的精神医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Critical role of the monkey dorsolateral and ventrolateral frontal cortex in the top-down control of behavior:inactivation study using low-frequency repetitive trans-cranial magnetic stimulation (lf-rTMS)2017

    • Author(s)
      Tsutsui KI
    • Organizer
      第40回 日本神経科学大会サテライトシンポジウム(東北大・生理研合同企画)「洞察・予測・意思決定:高次脳機能研究の最先端(Insight,foresight,and decision making: Frontiers of higher brain function research)」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Use of trans-cranial magnetic stimulation (TMS) as a tool for basic neuroscience research: The role of medial frontal cortex tested by inhibitory repetitive TMS2017

    • Author(s)
      Tsutsui KI
    • Organizer
      MyNeuro 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of monkey prefrontal cortex in category-based top-down behavioral adaptation2017

    • Author(s)
      Hosokawa T, Nakamura S, Yamada M, Iijima T, Tsutsui KI
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Neural mechanisms underlying self-consistency in social behavior2017

    • Author(s)
      Fujiwara J, Philippe T, Tsutsui KI, Taira M, Ugawa Y, Eifuku S
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Decrease in motivation induced by low-frequency repetitive transcranial magnetic stimulation (rTMS) to the medial frontal cortex in monkeys.2017

    • Author(s)
      Nakamura S, Iijima T, Tsutsui KI
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Impact of repetitive transcranial magnetic stimulation (rTMS) on local neural activity evaluated by electrocorticogram (ECoG) recordings in monkeys.2017

    • Author(s)
      Ogawa K, Nakamura S, Hosokawa T, Iijima T, Nishimura Y, Tsutsui KI
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Viral tracing with rabies virus vector identifies different disynaptic inputs to the hippocampal subfields along the dorsoventral axis in the rat2017

    • Author(s)
      Ohara S, Ishii H, Hioki H, Tsutsui KI, Menno P Witter, Iijima T
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rule-dependent activity in the rat medial prefrontal and posterior parietal cortex and its relevance in task performance2017

    • Author(s)
      Oyama K, Tateyama Y, Iijima T, Tsutsui KI
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Local projection of layer Vb neurons in lateral and medial entorhinal cortex of the rat2017

    • Author(s)
      Onodera M, Ohara S, Yoshino R, Iijima T, Menno P. Witter, Tsutsui KI
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Changes in neural activity of the primary motor cortex induced by repetitive transcranial magnetic stimulation (rTMS) in monkeys - An ECoG study2017

    • Author(s)
      Ogawa K, Nakamura S, Hosokawa T, Iijima T, Nishimura Y, Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Robust, highly customizable, and economical multi-channel electrode for chronic multi-unit recording in behaving animals2017

    • Author(s)
      Shiraishi M, Tateyama Y, Oyama K, Ohi M, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of low-frequency repetitive transcranial magnetic stimulation (rTMS) to the lower part of the medial frontal cortex on behavioral activity, sociability and motivation in monkeys2017

    • Author(s)
      Nakamura S, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intrinsic projection of entorhinal layer Vb neurons of the rat2017

    • Author(s)
      Onodera M, Ohara S, Iijima T, Witter M,Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms underlying self-consistency in social behavior2017

    • Author(s)
      Fujiwara J, Tobler PN, Tsutsui KI, Taira M, Ugawa Y, Eifuku S
    • Organizer
      Society for Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decision related activities of anterior insular and orbitofrontal cortex in a gambling behavior of rats.2016

    • Author(s)
      Ishii H, Kaizu Y, Takahashi S, Ohara S, Tobler PN, Tsutsui KI,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efferent projections of the calbindinpositive entorhinal neurons in the rat: Connectional differences between the medial and lateral entorhinal cortex.2016

    • Author(s)
      Ohara S, Itou K, Shiraishi M, Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] rTMSの作用機序解明および臨床利用における刺激条件最適化に向けて2016

    • Author(s)
      筒井健一郎
    • Organizer
      脳科学研究戦略推進プログラム「BMI技術」報告会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Using transcranial magnetic stimulation (TMS) as a tool for primate neuroscience research2016

    • Author(s)
      Tsutsui KI
    • Organizer
      31st International Congress of Psychology (ICP2016)
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Connectional differences between calbindin positive neurons in the medial and lateral entorhinal cortex of the rat.2016

    • Author(s)
      Ohara S,Itou K,Shiraishi M,Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Connectional differences between layer Va and Vb neurons in the lateral entorhinal cortex of the rat.2016

    • Author(s)
      Onodera M, Ohara S,Shiraishi M, Itou K,Tsutsui KI, Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inactivation of rat dorsomedial prefrontal cortex or posterior parietal cortex, but not ventromedial prefrontal cortex, impairs the performance of the visuospatial delayed response task.2016

    • Author(s)
      Oyama K,Lo CW,Tateyama Y,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neural correlates of abstract thought process in monkey prefrontal cortex.2016

    • Author(s)
      Hosokawa T,Nakamura S,Yamada M,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Reduction of spontaneous physical activity and sociability induced by low-frequency repetitive transcranial stimulation (rTMS) to the lower part of the medial frontal cortex in monkeys.2016

    • Author(s)
      Nakamura S,Ogawa K,Goto Y,Hosokawa T,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sustained delay activity in mPFC and PPC of head-fixed rats performing delayed pro-/anti-response task.2016

    • Author(s)
      Tateyama Y,Oyama K,Lo CW,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 反復経頭蓋磁気刺激(rTMS)によるサル内側前頭葉の情動・気分調節機能の検証2016

    • Author(s)
      筒井健一郎
    • Organizer
      第57回日本心身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 経頭蓋時期刺激(TMS)で拓く霊長類研究の新展開2015

    • Author(s)
      筒井健一郎
    • Organizer
      ナショナルバイオリソース第12回公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Cortical and subcortical projections of the entorhinal layer III neurons of the rat.2015

    • Author(s)
      Ohara S., Ito, K., Sota, Y., Tsutsui, K-I., Witter, P. M., Iijima, T.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rabies virus vector with improved transgene expression level for transsynaptic tracing.2015

    • Author(s)
      Sota, Y., Ohara, S., Sato, S., Ito, K., Tsutsui, K-I., Iijima, T.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of neural representations between rat anterior insular and orbitofrontal cortex in risky decision making.2015

    • Author(s)
      Ishii, H., Kaizu, Y., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural responses observed only in a gambling task in the rat anterior insular cortex.2015

    • Author(s)
      Kaizu, Y., Ishii, H., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytoarchitectonic information of rat medial prefrontal “delay” neurons revealed by single-neuron electroporation.2015

    • Author(s)
      Oyama, K., Tateyama, Y., Lo, CW., Ohara, S., Karube, F., Fujiyama, F., Iijima, T., Tsutsui, K-I.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of bimodal value representation on goal directed behavior and reflective choice in behaving macaque.2015

    • Author(s)
      Yasuda M, Nakamura S, Okada KI, Kobayashi Y, Tsutsui KI, Nakamura K.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparing the impact of online and low-frequency offline rTMS over the unilateral dorsolateral prefrontal cortex on the delayed response task performance.2015

    • Author(s)
      Ogawa K, Nakamura S, Hosokawa T, Iijima T, Tsutsui KI.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inactivation of rat dorsomedial prefrontal cortex impairs delayed response performance under head fixation2015

    • Author(s)
      Lo C, Tateyama Y, Oyama K, T. Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neck collar: A novel non-invasive system for restricting head and body movements in rats for behavioral task performance and simultaneous neuron activity recording2015

    • Author(s)
      Tateyama Y, Oyama K, Lo C, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] entrolateral prefrontal activity reflects increases in object value induced by larger choice sets.2015

    • Author(s)
      Fujiwara J, Usui N, Eifuku S, Iijima T, Taira M, Tsutsui KI, Tobler PN.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      米国・シカゴ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Afferents and Efferents of the Commissural Projection Neurons in Enthorinal Cortex Layer 3 of the Rat.2015

    • Author(s)
      Ohara, S., Itou, K., Sota, Y., Sato, S., Tsutsui, K-I., Iijima, T.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Morphological identification of rat medial prefrontal neurons showing sustained activity during a delay period of a delayed response task by single-neuron electroporation.2015

    • Author(s)
      Oyama, K., Tateyama, Y., Lo, CW., Ohara, S., Karube, F., Fujiyama, F., Iijima, T., Tsutsui, K-I.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Risky choice selective neuron in rat anterior insular cortex.2015

    • Author(s)
      Ishii, H., Kaizu, Y., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ventrolateral prefrontal activity reflects increases in object value induced by larger choice sets.2015

    • Author(s)
      Fujiwara J, Usui N, Eifuku S, Iijima T, Taira M, Tsutsui KI, Tobler PN.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] An integrated system for the quantitative measure of motivation and emotion in monkeys.2015

    • Author(s)
      Yasuda M, Nakamura S, Okada KI, Kobayashi Y, Tsutsui KI, Nakamura K.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Different contributions of monkey frontal, premotor, and parietal corticies in spatial working memory task revealed by on-line rTMS.2015

    • Author(s)
      Tsutsui KI
    • Organizer
      International Symposimu on Magnetic Stimulation: Past, Present and Future
    • Place of Presentation
      東京
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The effect of inactivation of prefrontal cortex on immediate behavioral adaptation in group reversal2015

    • Author(s)
      Hosokawa T, Nakamura S, Matsui Y, Yamada M, Iijima T, Tsutsui KI
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2015-03-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Different roles of the monkey dorsolateral prefrontal, premotor and posterior parietal cortices in a2015

    • Author(s)
      Nakamura S, Hosokawa T, Iijima T, Tsutsui KI
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2015-03-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional segregation of prefrontal and premotor cortices in a delayed response task: An rTMS study2014

    • Author(s)
      Nakamura S, Hosokawa T, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of dorsolateral and ventrolateral prefrontal cortex in behavioral adaptation to group2014

    • Author(s)
      Hosokawa T, Nakamura S, Matsui Y, Yamada M, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sustained activity in mPFC of head-fixed rats performing delayed response task2014

    • Author(s)
      Tateyama Y, Oyama K, Omori K, Iijima T, Tsutsui KI
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Deleting G protein of rabies virus vector enhances transgene expression level via decreased cell2014

    • Author(s)
      Sato S, Ohara S, Tsutsui KI, Iijima T
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dopaminergic and serotonergic modulation of anterior insular and orbitofrontal cortex in risky2014

    • Author(s)
      Ishii H, Ohara S, Kaizu Y, Tobler PN, Tsutsui KI, Iijima T
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Topographical organization of multisynaptic inputs to the hippocampus: Dual transsynaptic tracing2014

    • Author(s)
      Ohara S, Sato S, Tsutsui KI, Witter MP, Iijima T
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遅延反応課題遂行中のラット頭頂連合野における感覚情報と運動情報2014

    • Author(s)
      舘山 幸菜 小山 佳 大森 和音 飯島 敏夫 筒井 健一郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] rTMSを用いた機能阻害によって明らかになった遅延反応課題における大脳皮質諸領野の役割分担2014

    • Author(s)
      中村 晋也 細川 貴之 飯島 敏夫 筒井 健一郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] グループ逆転課題遂行中のサル前頭連合野におけるカテゴリ情報の表現2014

    • Author(s)
      細川 貴之 中村 晋也 山田 宗和 飯島 敏夫 筒井 健一郎
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 狂犬病ウイルスベクターを用いたラット海馬歯状回への投射経路の解析2014

    • Author(s)
      大原 慎也 佐藤 翔 筒井 健一郎 Witter Menno P 飯島 敏夫
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report

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Published: 2014-11-20   Modified: 2020-03-30  

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