| Budget Amount *help |
¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2017: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2016: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000)
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| Outline of Final Research Achievements |
We focused on a role of dopaminergic transmission in modulation of stress-coping behaviors responsive to the environmental challenge. Our achievement is summarized as follows. 1. We identified a small brain area called habenula, which modulated central dopaminergic activity, directed mouse stress-coping behaviors to the passive behaviors. 2. We developed a novel method to knock out the dopaminergic receptors in a specific brain regions. With it, it turned out that dopaminergic transmission in the ventral striatum modulate the coping behaviors under the acute stress.
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