| Budget Amount *help |
¥200,330,000 (Direct Cost: ¥154,100,000、Indirect Cost: ¥46,230,000)
Fiscal Year 2018: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2017: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2016: ¥39,390,000 (Direct Cost: ¥30,300,000、Indirect Cost: ¥9,090,000)
Fiscal Year 2015: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2014: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
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| Outline of Final Research Achievements |
The Siomi group has investigated to elucidate the molecular mechanisms of (1) piRNA precursor selection, (2) Yb body formation, and (3) nuclear localization of the Piwi-piRNA complex. For this, the Siomi group has used cultured ovarian somatic cells in which the Piwi-piRNA complex is fully functional in transposon silencing. The Siomi group published several papers in this 5-year project. The Ohno group has investigated to understand the mechanism underlying the nuclear retention of nuclearly located lncRNAs, particularly of Neat1 RNA, and came to the point to propose the model for the event. Currently, the Ohno group is preparing the manuscript.
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