| Budget Amount *help |
¥102,050,000 (Direct Cost: ¥78,500,000、Indirect Cost: ¥23,550,000)
Fiscal Year 2018: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2017: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2016: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2015: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2014: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Outline of Final Research Achievements |
Transcriptome studies in eukaryotes have uncovered a large number of long noncoding RNAs (lncRNAs) in their genomes. Physiological and biochemical roles of these lncRNAs are enigmatic, and thereby comprehensive understandings of lncRNA function is far away from the goal. In current study, we chose Drosophila Lobe-less (LOL) RNA as a model, which is specifically expressed in proliferating neuroblasts during embryogenesis. Using various nerve cell specific cell markers, we found that the lol gene is essential for axon guidance of mushroom body neurons. Transcriptome analysis with a high-throughput sequencer showed that lol regulates many genes including neurogenesis- and axon-guidance specific genes in. We also found lol genetically interacts with Polycomb Group (Pc-G) genes, suggesting that lol functions as chromatin modifiers, consistent with its nuclear localization.
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