Genetic dissection of cell competition in Drosophila

• Project Area: Cell competition: a mechanism for survival of the fittest in the multi-cellular community
• Project/Area Number: 26114002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: IGAKI TATSUSHI 京都大学, 生命科学研究科, 教授 (00467648)
• Co-Investigator(Kenkyū-buntansha): 高松 敦子 早稲田大学, 理工学術院, 教授 (20322670)
• Research Collaborator: OHSAWA Shizue
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥166,920,000 (Direct Cost: ¥128,400,000、Indirect Cost: ¥38,520,000); Fiscal Year 2018: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2017: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2016: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2015: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000); Fiscal Year 2014: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
• Keywords: 細胞競合 / がん / 細胞間コミュニケーション / 細胞死 / 細胞内シグナル伝達 / ショウジョウバエ / 遺伝学 / 細胞間相互作用 / 数理解析 / 細胞極性

Outline of Final Research Achievements

Oncogenic polarity-deficient cells emerged in the epithelial tissue are actively eliminated from the tissue by ‘cell competition’ when surrounded by wild-type cells. We used fruit fly Drosophila as a model organism and identified the molecular mechanisms of how wild-type cells recognize neighboring mutant cells and how mutant cells are eliminated from the tissue by nearby wild-type cells.

Academic Significance and Societal Importance of the Research Achievements

本研究により、細胞間の適者生存を司る新たな細胞間相互作用と考えられる細胞競合の分子機構の理解が大きく進んだ。また、本研究により明らかになった分子機構を基に、がん細胞と正常細胞の細胞間相互作用に着目したこれまでにない新たながん治療戦略の基盤を構築できる可能性がある。

Research Products

• [Int'l Joint Research] Hong Kong Univ of Science and Technology(その他の国・地域（香港）)
• [Journal Article] Cell competition: Emerging mechanisms to eliminate neighbors (2018)
  • Author(s): Nagata R and Igaki T.
  • Journal Title: Dev Growth Differ Volume: 60 Issue: 9 Pages: 522-530
  • DOI: 10.1111/dgd.12575
  • Peer Reviewed / Open Access
• [Journal Article] Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology (2018)
  • Author(s): Tsuboi Alice、Ohsawa Shizue、Umetsu Daiki、Sando Yukari、Kuranaga Erina、Igaki Tatsushi、Fujimoto Koichi
  • Journal Title: Current Biology Volume: 28 Issue: 13 Pages: 2115-2128
  • DOI: 10.1016/j.cub.2018.05.029
  • NAID: 120006491713
  • Peer Reviewed / Open Access
• [Journal Article] Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila (2018)
  • Author(s): Katsukawa M, Ohsawa S, Zhang L, Yan Y, Igaki T
  • Journal Title: Current Biology Volume: 28 Issue: 11 Pages: 1756-1767
  • DOI: 10.1016/j.cub.2018.04.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila (2018)
  • Author(s): Cong Bojie、Ohsawa Shizue、Igaki Tatsushi
  • Journal Title: Oncogene Volume: 0 Issue: 23 Pages: 0-0
  • DOI: 10.1038/s41388-018-0201-8
  • Peer Reviewed
• [Journal Article] Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis (2018)
  • Author(s): Ohsawa Shizue、Vaughen John、Igaki Tatsushi
  • Journal Title: Developmental Cell Volume: 44 Issue: 3 Pages: 284-296
  • DOI: 10.1016/j.devcel.2018.01.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Breaking Down Neighbors to Fuel Tumorigenesis (2017)
  • Author(s): Vaughen J and Igaki T
  • Journal Title: Developmental Cell Volume: 40 Issue: 3 Pages: 219-220
  • DOI: 10.1016/j.devcel.2017.01.011
• [Journal Article] The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition. (2017)
  • Author(s): Masatoshi Yamamoto (#), Shizue Ohsawa (#), Kei Kunimasa, Tatsushi Igaki (#equal contribution)
  • Journal Title: Nature Volume: 542 Issue: 7640 Pages: 246-250
  • DOI: 10.1038/nature21033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Tumor growth regulation by cell competition and cooperation (2016)
  • Author(s): 井垣達吏
  • Journal Title: 生化学 Volume: 88 Issue: 6 Pages: 723-732
  • DOI: 10.14952/SEIKAGAKU.2016.880723
  • NAID: 40021054305
  • ISSN: 0037-1017
  • Year and Date: 2016-12-25
• [Journal Article] Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia (2016)
  • Author(s): Vaughen J and Igaki T
  • Journal Title: Developmental Cell Volume: 39 Issue: 6 Pages: 683-695
  • DOI: 10.1016/j.devcel.2016.11.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Predator-prey interactions at the interface between two groups of cells in monolayer tissue. (2016)
  • Author(s): Seiya Nishikawa,Atsuko Takamatsu, Shizue Ohsawa, Tatsushi Igaki
  • Journal Title: J. Theor. Biol. Volume: 404 Pages: 40-50
  • DOI: 10.1016/j.jtbi.2016.05.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 細胞競合の基本原理とその破綻 はじめに (2016)
  • Author(s): 井垣達吏
  • Journal Title: 医学のあゆみ Volume: 257 Pages: 263-263
• [Journal Article] 細胞競合の基本原理とその破綻 極性崩壊による細胞競合とがん制御 (2016)
  • Author(s): 柴田翔子、井垣達吏
  • Journal Title: 医学のあゆみ Volume: 257 Pages: 265-269
• [Journal Article] 上皮の恒常性維持と細胞競合における機械的な力の役割 (2016)
  • Author(s): 山本真寿、井垣達吏
  • Journal Title: 医学のあゆみ Volume: 257 Pages: 992-998
• [Journal Article] JNK signaling is coverted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity (2015)
  • Author(s): Masato Enomoto, Daisuke Kizawa, Shizue Ohsawa, Tatsushi Igaki
  • Journal Title: Developmental Biology Volume: 403 Issue: 2 Pages: 162-171
  • DOI: 10.1016/j.ydbio.2015.05.001
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Non-autonomous overgrowth by oncogenic niche cells: cellular cooperatrion and competition in tumorigenesis (2015)
  • Author(s): Enomoto M, Vaughen J, Igaki T
  • Journal Title: Cancer Science Volume: 106 Issue: 12 Pages: 1651-8
  • DOI: 10.1111/cas.12816
  • Peer Reviewed / Open Access
• [Journal Article] Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki (2015)
  • Author(s): Igaki T
  • Journal Title: Disease Models and Mechanisms Volume: 8 Issue: 12 Pages: 1491-4
  • DOI: 10.1242/dmm.024059
  • NAID: 120005980860
  • Open Access
• [Journal Article] Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila (2014)
  • Author(s): Nakamura M, Ohsawa S, Igaki T
  • Journal Title: Nature Communications Volume: 5 Issue: 1 Pages: 5264-5264
  • DOI: 10.1038/ncomms6264
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila (2014)
  • Author(s): Takino K, Ohsawa S, Igaki T
  • Journal Title: Developmental Biology Volume: 395 Issue: 1 Pages: 19-28
  • DOI: 10.1016/j.ydbio.2014.09.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic coorperation (2014)
  • Author(s): Ohsawa S,Takemoto D, Igaki T
  • Journal Title: J. Biochem Volume: 156 Issue: 3 Pages: 129-36
  • DOI: 10.1093/jb/mvu045
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 細胞の協調と競合におけるHippo経路の役割 (2014)
  • Author(s): 榎本将人、井垣達吏
  • Journal Title: 医学のあゆみ Volume: 251 Pages: 389-396
• [Journal Article] がんの発生・進展を促すニッチ細胞 (2014)
  • Author(s): 榎本将人、井垣達吏
  • Journal Title: 実験医学「幹細胞ニッチが見えてきた！」 Volume: 32 Pages: 2574-2581
• [Presentation] Mechanism of tumor-suppressive cell competition (2019)
  • Author(s): Igaki, T
  • Organizer: Keystone Symposia Cell Competition in Development and Disease
  • Int'l Joint Research / Invited
• [Presentation] Cell competition is triggered by autophagy (2019)
  • Author(s): Nagata R, Nakamura M, Sanaki Y, Igaki T
  • Organizer: Keystone Symposia Cell Competition in Development and Disease
  • Int'l Joint Research
• [Presentation] Exploring a universal mechanism of cell competition (2019)
  • Author(s): Nagata R, Nakamura M, Sanaki Y, Igaki T
  • Organizer: 17th International Student Seminar
  • Int'l Joint Research
• [Presentation] Genetic screening for cooperative factors driving malognant tumorigenesis with RasV12 (2019)
  • Author(s): Li Jiaqi
  • Organizer: 第８回細胞競合コロキウム
• [Presentation] 細胞競合はオートファジーを介した細胞死遺伝子誘導により駆動される (2019)
  • Author(s): 永田理奈, 中村麻衣、佐奈喜祐哉、井垣達吏
  • Organizer: 第８回細胞競合コロキウム
• [Presentation] Dissecting the mechanism of cell competition by a genetic screen in Drosophila (2019)
  • Author(s): Hui Liang
  • Organizer: 第８回細胞競合コロキウム
• [Presentation] Hyperinsulinemia promotes tumorigenesis by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 59th Annual drosophila research conference
  • Int'l Joint Research
• [Presentation] Dissecting JNK-mediated cell elimination in Drosophila (2018)
  • Author(s): Nakamura M Igaki T
  • Organizer: 59th Annual drosophila research conference
  • Int'l Joint Research
• [Presentation] Tumor Suppression and Epithelial Maintenance by Polarity-Mediated Cell Competition (2018)
  • Author(s): Igaki, T
  • Organizer: Gordon Research Conference on Cell Polarity Signaling
  • Int'l Joint Research / Invited
• [Presentation] Polarity-mediated cell competition shapes germ-line stem cell niche in Drosophila (2018)
  • Author(s): Taniguchi, K., Igaki Tatsushi
  • Organizer: Gordon Research Conference on Cell Polarity Signaling
  • Int'l Joint Research
• [Presentation] Tumor progression driven by polyploid giant cells in Drosophila (2018)
  • Author(s): Bojie Cong, Shizue Ohsawa, Tatsushi Igaki
  • Organizer: 第70回日本細胞生物学会大会・第51回日本発生生物学会合同大会
• [Presentation] Hyperinsulinemia promotes tumorigenesis by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 第70回日本細胞生物学会大会・第51回日本発生生物学会合同大会
• [Presentation] 遺伝学的スクリーニングによる細胞競合の共通原理の解析 (2018)
  • Author(s): 中村麻衣、永田理奈、齋藤都暁、近藤周、井垣達吏
  • Organizer: 第6回新学術領域「細胞競合」班会議
• [Presentation] 細胞競合の共通メカニズムの遺伝学的解明 (2018)
  • Author(s): 永田理奈、中村麻衣、井垣達吏
  • Organizer: 第6回新学術領域「細胞競合」班会議
• [Presentation] 細胞競合の勝敗を規定する組織環境条件の遺伝学および数理学的解析 (2018)
  • Author(s): 片山宰、西川星也、大澤志津江、高松敦子、井垣達吏
  • Organizer: 第6回新学術領域「細胞競合」班会議
• [Presentation] Hyperinsulinemia promotes tumorigenesis by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: EMBO workshop size and shape
  • Int'l Joint Research
• [Presentation] Hyperinsulinemia promotes tumorigenesis by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: The 13th Japanese Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] Role of cell competition in shaping germ-line stem cell niche (2018)
  • Author(s): Taniguchi, K., Igaki Tatsushi
  • Organizer: The 13th Japanese Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] Exploring a universal mechanism of cell competition (2018)
  • Author(s): 永田理奈、中村麻衣、井垣達吏
  • Organizer: The 13th Japanese Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] Genetic and theoretical analysis of cell competition: dissecting the initial cellular environment that determines win or lose (2018)
  • Author(s): Sai Katayama, Seiya Nishikawa, Shizue Ohsawa, Atsuko Takamatsu and Tatsushi Igaki
  • Organizer: The 13th Japanese Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] Dissecting the role of cell competition in wound healing (2018)
  • Author(s): Iida C, Ohsawa S, Yamamoto M, Igaki T
  • Organizer: The 13th Japanese Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] 1. Yorkie/YAP drives tumor progression by antagonizing Pointed/ETS- mediated cellular senescence (2018)
  • Author(s): Igaki, T
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association
  • Invited
• [Presentation] 高インスリン血症は細胞競合を破綻させ発がんを亢進させる (2018)
  • Author(s): 佐奈喜祐哉，木沢大輔，井垣達吏
  • Organizer: 第二回淡路ショウジョウバエ研究会
• [Presentation] Hyperinsulinemia promotes tumorigenesis by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 分子生物学会ワークショップ疾患克服バイオロジー：「若さ」と「老い」から探る疾患の発症原理
• [Presentation] Exploring the universal feedback mechanism of gene expression regulation. (2018)
  • Author(s): Daiki Kitamura, Mai Nakamura ,Tatsushi Igaki
  • Organizer: 16th International Student seminar
• [Presentation] Mechanisms and roles of tumor-suppressive cell competition (2018)
  • Author(s): Tatsushi Igaki
  • Organizer: Symposium "Cell Competition in Development and Cancer"
• [Presentation] Intrinsic tumor supprression and epithelial maintenance by cell competition (2018)
  • Author(s): Tatsushi Igaki
  • Organizer: CDB symposium2018 Dynamic Homeostasis from Development to Aging
• [Presentation] Hyperinsulinemia promotes tumorigenesi by abrogating cell competition (2018)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 16th International Student Seminar
• [Presentation] Exploring the universal feedback mechanism of gene expression regulation. (2018)
  • Author(s): Daiki Kitamura, Mai Nakamura ,Tatsushi Igaki
  • Organizer: 16th International Student Seminar
• [Presentation] 細胞競合の普遍的メカニズムの遺伝学的探索 (2018)
  • Author(s): 越智直孝、永田理奈、中村麻衣、井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] 創傷治癒における細胞競合機構の役割 (2018)
  • Author(s): 飯田 千晶、大澤志津江, 山本真寿, 井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] Yorkie drives tumorigenesis by antagonizing Pointed/ETS-mediated cellular senescence in Drosophila (2017)
  • Author(s): Ito T, Enomoto M, Igaki T
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2017-03-16
• [Presentation] エンドサイトーシス破綻が引き起こす細胞核の肥大化メカニズムとその腫瘍悪性化における役割 (2017)
  • Author(s): 叢 博杰、大澤 志津江、井垣 達吏
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2017-03-16
• [Presentation] 細胞競合の普遍的メカニズムの遺伝学的解明 (2017)
  • Author(s): 永田理奈、中村麻衣、井垣達吏
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2017-03-16
• [Presentation] 細胞競合の勝敗を規定する組織環境・初期条件の遺伝学的および数理学的解析 (2017)
  • Author(s): 片山宰、西川星也、大澤志津江、高松敦子、 井垣達吏
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2017-03-16
• [Presentation] Exploring a common mechanism of cell competition (2017)
  • Author(s): Tatsushi Igaki
  • Organizer: 3st International Symposium on Cell Competition "Cell Competition in Development and Cancer"
• [Presentation] Epithelial tumor suppression by cell competition (2017)
  • Author(s): Tatsushi Igaki
  • Organizer: 33rd International Symposium of Radiation Biology Center "Cutting Edge of Radiation and Cancer Biology
• [Presentation] Hyperinsulinemia promotes tumorigenesi by abrogating cell competition (2017)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 16th International Student seminar
• [Presentation] 細胞競合と創傷治癒の共通原理の解明 (2017)
  • Author(s): 飯田 千晶 、大澤志津江, 山本真寿, 井垣達吏
  • Organizer: 第69回日本細胞生物学会大会
• [Presentation] 死細胞が発信する細胞間シグナルネット ワークによる創傷治癒制御 (2017)
  • Author(s): 榎本将人, 井垣達吏
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] 生体内インスリンレベルによる細胞競合の制御 (2017)
  • Author(s): 佐奈喜祐哉、木澤大輔，井垣達吏
  • Organizer: がんと代謝若手の会
• [Presentation] 生体内インスリンレベルによる細胞競合の制御 (2017)
  • Author(s): 佐奈喜祐哉、木澤大輔，井垣達吏
  • Organizer: 細胞競合ステムセルエイジング若手の会
• [Presentation] JNK シグナルの細胞間伝播による創傷治癒制御 (2017)
  • Author(s): 井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] 細胞競合の共通メカニズムの遺伝学的探索 (2017)
  • Author(s): 永田理奈、中村麻衣、井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] 細胞間の競合と協調によるがん制御を駆動する因子の遺伝学的スクリーニング (2017)
  • Author(s): 新井聡太、KimSeulki、榎本将人、井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] JNKとYorkieの協調は多倍体肥大化細胞を誘導することで 腫瘍悪性化を促進する (2017)
  • Author(s): 叢 博杰、大澤 志津江、井垣 達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] 細胞競合の勝敗を規定する組織環境条件の遺伝学および数理学的解析 (2017)
  • Author(s): 片山宰、西川星也、大澤志津江、高松敦子、井垣達吏
  • Organizer: 生命科学系学会合同年次大会 Conbio2017
• [Presentation] JNKとYorkieの協調は多倍体肥大化細胞を誘導することで 腫瘍悪性化を促進する (2017)
  • Author(s): 叢 博杰、大澤 志津江、井垣 達吏
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] 遺伝子発現フィードバック制御に普遍的な機構は存在するのか (2017)
  • Author(s): 北村大樹、中村麻衣、井垣達吏
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] ショウジョウバエを用いた生理的細胞競合の解析 (2017)
  • Author(s): 丸山博之、叢博傑、大澤志津江、井垣達吏
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] ショウジョウバエを用いたがん研究：細胞競合の遺伝学的解析 (2017)
  • Author(s): 井垣達吏
  • Organizer: 日本薬学会 第１３８年会
• [Presentation] JNK and Yorkie cooperate to drive tumor progression by generating polyploid giant cells in Drosophila (2017)
  • Author(s): Bojie Cong, Shizue Ohsawa, Tatsushi Igaki
  • Organizer: 4th Asia-Pacific Drosophila Research Conference(APDRC4)
• [Presentation] Dissecting the role of cell competition in wound healing (2017)
  • Author(s): Chiaki Iida, Shizue Ohsawa, Masato Yamamoto, Tatsushi Igaki
  • Organizer: 4th Asia-Pacific Drosophila Research Conference(APDRC4)
• [Presentation] The role of systemic organ interaction in scrib-induced cell competition (2017)
  • Author(s): Yuya Sanaki, Daisuke Kizawa, Tatsushi Igaki
  • Organizer: 3st International Symposium on Cell Competition Cell Competition in Development and Cancer
• [Presentation] Dissecting the role of cell competition in wound healing (2017)
  • Author(s): Chiaki Iida, Shizue Ohsawa, Masato Yamamoto, Tatsushi Igaki
  • Organizer: 3st International Symposium on Cell Competition Cell Competition in Development and Cancer
• [Presentation] A genetic screen identifies RNA helicase mutations that trigger cell competition in Drosophila (2017)
  • Author(s): Rina Nagata, Mai Nakamura ,Tatsushi Igaki
  • Organizer: 3st International Symposium on Cell Competition Cell Competition in Development and Cancer
• [Presentation] Genetic and theoretical analysis analyses of cell competition: dissecting the initial cellular environmental condition that determines cells to become winner or loser (2017)
  • Author(s): Katayama Sai Seiya Nishikawa, Shizue Ohsawa, Atsuko Takamatsu, Tatsushi Igaki
  • Organizer: 3st International Symposium on Cell Competition Cell Competition in Development and Cancer
• [Presentation] 細胞競合と創傷治癒の共通原理の解明 (2017)
  • Author(s): 飯田 千晶、大澤志津江, 山本真寿, 井垣達吏
  • Organizer: 第69回日本細胞生物学会大会
• [Presentation] JNKとYorkieの協調的な活性化は細胞の多倍体肥大化を誘導して腫瘍悪性化を引き起こす (2017)
  • Author(s): 叢 博杰、大澤 志津江、井垣 達吏
  • Organizer: 第69回日本細胞生物学会大会
• [Presentation] シグナル強度の制御を介した細胞排除の遺伝学的解析 (2017)
  • Author(s): 中村麻衣、井垣 達吏
  • Organizer: 第26回日本Cell Death学会学術集会
• [Presentation] Ligand-receptor systems that drive tumor-suppressive cell competition (2016)
  • Author(s): 井垣達吏
  • Organizer: 第３９回日本分子生物学会 年会
  • Place of Presentation: パシィフィコ横浜（横浜）
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Epithelial cell-turnover in Minute animals: a possible role of cell competition in morphogenetic robustness (2016)
  • Author(s): Igaki T
  • Organizer: Cell competition meeting 2016
  • Place of Presentation: ラモンアレセス財団集会室（マドリッド）
  • Year and Date: 2016-10-25
  • Int'l Joint Research / Invited
• [Presentation] Dissecting the mechanism of nuclear hypertrophy and tumor progression caused by endocytic dysregulation (2016)
  • Author(s): Cong B.J, Ohsawa S, Takino K, Igaki T
  • Organizer: 第12回 日本ショウジョウバエ研究会（JDRC12）
  • Place of Presentation: 立教大学 (東京)
  • Year and Date: 2016-09-09
• [Presentation] 細胞競合を引き起こす新規ショウジョウバエ変異体の網羅的探索 (2016)
  • Author(s): 若狭直樹、佐奈喜 祐哉、井垣 達吏
  • Organizer: 平成28年度 第4回新学術領域研究会議
  • Place of Presentation: 東京大学 薬学講堂 (東京)
  • Year and Date: 2016-08-30
• [Presentation] 細胞競合の分子メカニズムの遺伝学的解明 (2016)
  • Author(s): 永田理奈、中村麻衣 井垣達吏
  • Organizer: 平成28年度 第4回新学術領域研究会議
  • Place of Presentation: 東京大学 薬学講堂 (東京)
  • Year and Date: 2016-08-30
• [Presentation] 細胞競合機構の遺伝学および数理学的解析 (2016)
  • Author(s): 片山宰、西川星也、大澤志津江、高松敦子、 井垣達吏
  • Organizer: 平成28年度 第4回新学術領域研究会議
  • Place of Presentation: 東京大学 薬学講堂 (東京)
  • Year and Date: 2016-08-30
• [Presentation] Ligand-receptor systems that govern tumor-suppressive cell competition (2016)
  • Author(s): Igaki T
  • Organizer: The Allied Genetics Conference 2016
  • Place of Presentation: Orlando World Center Marriott (オーランド)
  • Year and Date: 2016-07-13
  • Int'l Joint Research / Invited
• [Presentation] The ligand Sas and its receptor PTP10D drive tumor-suppressive cell competition. (2016)
  • Author(s): Yamamoto M, Ohsawa S, Kunimasa K, Igaki T
  • Organizer: The Allied Genetics Conference 2016
  • Place of Presentation: Orlando World Center Marriott (オーランド)
  • Year and Date: 2016-07-13
  • Int'l Joint Research
• [Presentation] Dissecting a common principle underlying cell competition and wound healing (2016)
  • Author(s): Iida C, Ohsawa S, Yamamoto M, Igaki T
  • Organizer: The Allied Genetics Conference 2016
  • Place of Presentation: Orlando World Center Marriott (オーランド)
  • Year and Date: 2016-07-13
  • Int'l Joint Research
• [Presentation] 細胞競合を駆動する細胞表面リガンド－受容体の同定とそのがん制御における役割 (2016)
  • Author(s): 山本真寿、大澤志津江、國政啓、井垣 達吏
  • Organizer: 第68回日本細胞生物学会・ 第11回日本ケミカルバイオロジ ー学会 合同大会
  • Place of Presentation: 京都テルサ （京都）
  • Year and Date: 2016-06-15
• [Presentation] エンドサイトーシス破綻が引き起こす細胞核の肥大化メカニズムとその腫瘍悪性化における役割 (2016)
  • Author(s): 叢 博杰、大澤 志津江、瀧野 恭子、井垣 達吏
  • Organizer: 第68回日本細胞生物学会・ 第11回日本ケミカルバイオロジ ー学会 合同大会
  • Place of Presentation: 京都テルサ （京都）
  • Year and Date: 2016-06-15
• [Presentation] 細胞競合と創傷治癒の共通原理の解明 (2016)
  • Author(s): 飯田千晶、大澤志津江, 山本真寿, 井垣達吏
  • Organizer: 第68回日本細胞生物学会・ 第11回日本ケミカルバイオロジ ー学会 合同大会
  • Place of Presentation: 京都テルサ （京都）
  • Year and Date: 2016-06-15
• [Presentation] Ensuring robust control of organ size by "cell-turnover" in Drosophila (2016)
  • Author(s): Ohsawa S, Akai N, Igaki T
  • Organizer: the CDB Symposium 2016 - Size in Development: Growth, Shape and Allometry
  • Place of Presentation: 理研CDB (神戸)
  • Year and Date: 2016-03-28
• [Presentation] Epithelial Slit-Robo regulates tumor-suppressive cell competition (2016)
  • Author(s): Vaughen, J, Igaki T
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-18
• [Presentation] Genetic identification of Pointed/ETS transcriptional factor as a regulator of senescence-mediated tumor progression in *Drosophila* (2016)
  • Author(s): Ito T, Enomoto M, Igaki T
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-18
• [Presentation] 細胞競合における勝者—敗者を決定する機構の遺伝学的解析 (2016)
  • Author(s): 佐奈喜 祐哉，柴田翔子，井垣達吏
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-18
• [Presentation] 細胞競合と創傷治癒の共通原理の解明 (2016)
  • Author(s): 飯田 千晶, 大澤 志津江, 山本 真寿, 井垣 達吏
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-18
• [Presentation] エンドサイトーシス破綻が引き起こす細胞核の肥大化メカニズム (2016)
  • Author(s): 叢 博杰、大澤 志津江、瀧野 恭子、井垣 達吏
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-18
• [Presentation] 細胞競合を駆動するリガンド－受容体の同定とがん制御における役割 (2016)
  • Author(s): 山本 真寿、大澤 志津江、國政 啓、井垣 達吏
  • Organizer: 第5回細胞競合コロキウム
  • Place of Presentation: 北海道大学 (札幌)
  • Year and Date: 2016-03-17
• [Presentation] 細胞競合によるがん制御の分子基盤 (2016)
  • Author(s): 井垣 達吏
  • Organizer: 第1回 生活習慣病とがんの代謝栄養メカニズム研究会
  • Place of Presentation: アステラス製薬株式会社（東京）
  • Year and Date: 2016-02-27
  • Invited
• [Presentation] 細胞老化を介した細胞非自律的ながん制御の分子基盤 (2016)
  • Author(s): 中村 麻衣、吉本 将成、大澤 志津江、井垣 達吏
  • Organizer: 第1回 生活習慣病とがんの代謝栄養メカニズム研究会
  • Place of Presentation: アステラス製薬株式会社（東京）
  • Year and Date: 2016-02-27
• [Presentation] 細胞競合によるがん制御の分子基盤 (2015)
  • Author(s): 井垣 達吏
  • Organizer: Advans 研究会2015
  • Place of Presentation: ホテルグランドパレス (東京)
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] 細胞競合の共通メカニズムの遺伝学的解析 (2015)
  • Author(s): 柴田 翔子、許 悦鳴、井垣達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-03
• [Presentation] ショウジョウバエを用いたプログラム細胞老化の遺伝学的解析 (2015)
  • Author(s): 吉本将成、中村麻衣、大澤志津江、井垣 達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-03
• [Presentation] 細胞競合を介した発生ロバストネスの遺伝的基盤 (2015)
  • Author(s): 大澤志津江、赤井菜々美、井垣達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-02
  • Invited
• [Presentation] Genetic analysis of super-competition triggered by lgl mutation (2015)
  • Author(s): Ahm K Alam, Igaki T
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-02
• [Presentation] 細胞競合を介したがん抑制機構を駆動するリガンド－受容体分 子の同定 (2015)
  • Author(s): 山本 真寿、大澤 志津江、國政 啓、井垣 達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-02
• [Presentation] Genetic analysis of tumor progression triggered by intratumor heterogeneity (2015)
  • Author(s): Ito T, Enomoto M, Igaki T
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-02
• [Presentation] 細胞競合と創傷治癒の共通原理とその分子基盤（A common principle underlying cell competition and wound healing） (2015)
  • Author(s): 飯田 千晶, 大澤 志津江, 山本 真寿, 井垣 達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-01
• [Presentation] Genetic and theoretical approaches for understanding cellular fitness in cell competition (2015)
  • Author(s): Baba S, Ohsawa S, Nishikawa S, Takamatsu A, Igaki T
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-01
• [Presentation] 新規ホモ接合Minuteモデルを用いた細胞競合の遺伝学的解析 (2015)
  • Author(s): 佐奈喜 祐哉、柴田翔子、井垣達吏
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸 ポートアイランド (神戸)
  • Year and Date: 2015-12-01
• [Presentation] Identification of the ligand-receptor system that governs tumor-suppressive cell competition (2015)
  • Author(s): Igaki T
  • Organizer: 第１回 細胞競合国際シンポジウム
  • Place of Presentation: 芝欄会館 (京都)
  • Year and Date: 2015-09-10
  • Int'l Joint Research / Invited
• [Presentation] Identification of the ligand-receptor system that drives tumor-suppressive cell competition (2015)
  • Author(s): Yamamoto M, Ohsawa S, Kunimasa K, Igaki T
  • Organizer: 第１回 細胞競合国際シンポジウム
  • Place of Presentation: 芝欄会館 (京都)
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] Slit-robo signaling removes tumorigenic cells via cell competition (2015)
  • Author(s): Vaughen J, Kizawa D, Yamamoto M, Igaki T
  • Organizer: 第１回 細胞競合国際シンポジウム
  • Place of Presentation: 芝欄会館 (京都)
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] Genetic and theoretical approaches for understanding cellular fitness in cell competition (2015)
  • Author(s): Baba S, Ohsawa S, Igaki T
  • Organizer: 第１回 細胞競合国際シンポジウム
  • Place of Presentation: 芝欄会館 (京都)
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] Genetic analysis of Cell competition using homozygous *Minute* cell competition model (2015)
  • Author(s): Sanaki Y, Shibata S, Igaki T
  • Organizer: 第１回 細胞競合国際シンポジウム
  • Place of Presentation: 芝欄会館 (京都)
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] 細胞の競合と協調によるがん制御 (2015)
  • Author(s): 井垣達吏
  • Organizer: Basic Urology Research Seminar
  • Place of Presentation: 東京
  • Year and Date: 2015-08-29
  • Invited
• [Presentation] 細胞老化を介したがん制御 (2015)
  • Author(s): 井垣達吏
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 虎ノ門 ヒルズフォーラム （東京）
  • Year and Date: 2015-07-21
  • Invited
• [Presentation] 上皮細胞競合を駆動するリガンド-受容体システム Identification of the ligand-receptor system that governs tumor-suppressive cell competition (2015)
  • Author(s): 井垣達吏
  • Organizer: 第67回 日本細胞生物学会大会
  • Place of Presentation: タワーホール船堀 (東京)
  • Year and Date: 2015-07-01
  • Invited
• [Presentation] Identification of the ligand-receptor system that governs tumor-suppressive cell competition (2015)
  • Author(s): Igaki T
  • Organizer: Barcelona BioMEd Conference “Drosophila as a model in cancer"
  • Place of Presentation: Insitute for Research in Biomedicine （Barcelona）
  • Year and Date: 2015-06-15
  • Int'l Joint Research / Invited
• [Presentation] Non-autonomous tumor progression by cellular senescence in Drosophila (2015)
  • Author(s): Ohsawa S, Nakamura M, Igaki T
  • Organizer: Barcelona BioMEd Conference “Drosophila as a model in cancer"
  • Place of Presentation: Insitute for Research in Biomedicine （Barcelona）
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] Tumor progression by a genetic heterogeneity of clones with distinct oncogenic activities (2015)
  • Author(s): Enomoto M, Takemoto D, Igaki T
  • Organizer: Barcelona BioMEd Conference “Drosophila as a model in cancer"
  • Place of Presentation: Insitute for Research in Biomedicine （Barcelona）
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] Slit-robo signaling removes tumorigenic cells via cell competition (2015)
  • Author(s): Vaughen J, Kizawa D, Ohsawa S, Igaki T
  • Organizer: Barcelona BioMEd Conference “Drosophila as a model in cancer"
  • Place of Presentation: Insitute for Research in Biomedicine （Barcelona）
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] Identification of the ligand-receptor system that governs tumor-suppressive cell competition (2015)
  • Author(s): Igaki T
  • Organizer: 3ｒｄ Asia-Pacific Drosophila Research Conference, Beijing
  • Place of Presentation: Beijing Concerence Center （北京）
  • Year and Date: 2015-05-12
  • Int'l Joint Research / Invited
• [Presentation] Identification of the ligand-receptor system that drives tumor-suppressive cell competition (2015)
  • Author(s): Yamamoto M, Ohsawa S, Kunimasa K, Igaki T
  • Organizer: 3ｒｄ Asia-Pacific Drosophila Research Conference, Beijing
  • Place of Presentation: Beijing Concerence Center （北京）
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] Slit-robo signaling removes tumorigenic cells via cell competition (2015)
  • Author(s): Vaughen J, Kizawa D, Yamamoto M, Igaki T
  • Organizer: 3ｒｄ Asia-Pacific Drosophila Research Conference, Beijing
  • Place of Presentation: Beijing Concerence Center （北京）
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] 細胞競合による上皮の恒常性維持機構 (2015)
  • Author(s): 井垣達吏
  • Organizer: 第84回日本寄生虫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2015-03-21
  • Invited
• [Presentation] Non-cell autonomous tumor progression driven by cellular senescecne (2015)
  • Author(s): Nakamura M, Ohsawa S, Igaki T
  • Organizer: 56th Drosophila Research Conference
  • Place of Presentation: シカゴ（イリノイ、アメリカ）
  • Year and Date: 2015-03-06 – 2015-03-08
• [Presentation] Identification of the ligand-receptor system that governs tumor-suppressive cell competition (2015)
  • Author(s): Igaki T, Yamamoto M, Kunimasa K, Ohsawa S
  • Organizer: 56th Drosophila Research Conference
  • Place of Presentation: シカゴ（イリノイ、アメリカ）
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] umor progression by a genetic heterogeneity of cell clones with distinct oncogenic activities (2015)
  • Author(s): Enomoto M, Takemoto D, Igaki T
  • Organizer: 56th Drosophila Research Conference
  • Place of Presentation: シカゴ（イリノイ、アメリカ）
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] 上皮細胞競合を駆動する細胞認識機構の遺伝学的解析 (2014)
  • Author(s): 井垣達吏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-27
  • Invited
• [Presentation] 細胞老化が駆動する非自律的腫瘍悪性化の遺伝学的解析 (2014)
  • Author(s): 中村麻衣、大澤志津江、井垣達吏
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25
• [Presentation] 細胞競合における敗者の認識と細胞死誘導機構 (2014)
  • Author(s): 井垣達吏
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-18
  • Invited
• [Book] 細胞表面リガンド-受容体Sas-PTP10Dはがん抑制にはたらく細胞競合を駆動する (2017)
  • Author(s): 飯田千晶、井垣達吏
  • Total Pages: 4
  • Publisher: 科学評論社
• [Book] BIO Clinica (2015)
  • Author(s): 中村麻衣、井垣達吏
  • Total Pages: 6
  • Publisher: 北隆館
• [Book] 細胞工学 (2015)
  • Author(s): 吉本将成、井垣達吏
  • Total Pages: 5
  • Publisher: 秀潤社
• [Remarks] 京都大学大学院生命科学研究科システム機能学分野井垣研究室HP
  • URL: http://www.lif.kyoto-u.ac.jp/genetics/
• [Remarks] 井垣研究室ホームページ
  • URL: http://www.lif.kyoto-u.ac.jp/genetics/
• [Remarks] 井垣研究室
  • URL: http://www.lif.kyoto-u.ac.jp/genetics/
• [Remarks] 京都大学大学院生命科学研究科システム機能学分野ホームページ
  • URL: https://www.lif.kyoto-u.ac.jp/genetics/