| Budget Amount *help |
¥103,220,000 (Direct Cost: ¥79,400,000、Indirect Cost: ¥23,820,000)
Fiscal Year 2018: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2017: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2016: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2015: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2014: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
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| Outline of Final Research Achievements |
In this research, we attempted to identify cell adhesion molecules involved in epithelial cell competition and to elucidate their roles and modes of action. In an in vitro analysis, we established and analyzed the cultured epithelial cells in which afadin, a binding protein of cell adhesion molecule nectin, was genetically ablated. By using this cell line, we partly elucidated the function of afadin in epithelial cell competition. In in vivo analyses, we found the involvement of the membrane receptor CXCR4 as a molecule that regulates the dormancy-wakefulness competition in cancer cells. Furthermore, we analyzed the functions of nectin-1 and nectin-4 in the mammary gland development and elucidated the regulatory mechanism of nectin-4 for the activation of the prolactin receptor. Through those studies, we partly revealed roles and modes of action of cell adhesion molecules in epithelial cell competition.
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