Exploring stress-responsive molecules involved in cell competition

• Project Area: Cell competition: a mechanism for survival of the fittest in the multi-cellular community
• Project/Area Number: 26114009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: Ichijo Hidenori 東京大学, 大学院薬学系研究科(薬学部), 教授 (00242206)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥95,940,000 (Direct Cost: ¥73,800,000、Indirect Cost: ¥22,140,000); Fiscal Year 2018: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2017: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2016: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2015: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
• Keywords: 細胞競合 / Scribble / トランスクリプトーム解析 / 液性因子 / ASK1 / ストレス / シグナル伝達 / ゲノムワイドsiRNAスクリーニング / ライブイメージング

Outline of Final Research Achievements

In this study, using Scribble knock down model, we scrutinized the molecular mechanism of cell competition, which is considered to be involved in early cancer elimination and ontogenesis. First, we established a high-throughput quantitation system of cell competition, using high content image analyzer. Then, we performed a transcriptome analysis focusing on the difference between normal and transformed cells and a candidate approach focusing on MAP kinase pathway. From these results, we found that a humoral factor that is expressed through ASK1-p38 pathway is required for cell competition induced by Scribble depletion.

Academic Significance and Societal Importance of the Research Achievements

本研究では、全自動ハイコンテントイメージアナライザーを用いて、精密な細胞競合の測定系を構築した。またそれを利用してこれまで分子メカニズムが不明であった哺乳類細胞における細胞競合において、ASK1-p38経路というシグナル伝達経路が形質転換細胞であるScribble欠損細胞内で活性化し、特定の液性因子の発現を誘導すること、またその液性因子が正常細胞に感知されて細胞競合が引き起こされることを明らかにした。これらの知見は、細胞競合現象の理解を深めるとともに、細胞競合の関わる初期のがんの排除などを制御する薬剤の具体的なターゲットを提示した点で意義があると考えられる。

Research Products

• [Journal Article] β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress (2018)
  • Author(s): Cheng Ran、Takeda Kohsuke、Naguro Isao、Hatta Tomohisa、Iemura Shun-ichiro、Natsume Tohru、Ichijo Hidenori、Hattori Kazuki
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1862 Issue: 10 Pages: 2271-2280
  • DOI: 10.1016/j.bbagen.2018.07.015
  • Peer Reviewed
• [Journal Article] A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model (2018)
  • Author(s): Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T., and Ichijo, H.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2668-2668
  • DOI: 10.1038/s41467-018-05127-2
  • NAID: 120006546002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cryo-EM structure of the volume-regulated anion channel LRRC8 (2018)
  • Author(s): Kasuya Go、Nakane Takanori、Yokoyama Takeshi、Jia Yanyan、Inoue Masato、Watanabe Kengo、Nakamura Ryoki、Nishizawa Tomohiro、Kusakizako Tsukasa、Tsutsumi Akihisa、Yanagisawa Haruaki、Dohmae Naoshi、Hattori Motoyuki、Ichijo Hidenori、Yan Zhiqiang、Kikkawa Masahide、Shirouzu Mikako、Ishitani Ryuichiro、Nureki Osamu
  • Journal Title: Nat. Struct. Mol. Biol. Volume: 25 Pages: 797-804
  • DOI: 10.1101/331207
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ASK family kinases mediate cellular stress and redox signaling to circadian clock (2018)
  • Author(s): Imamura Kiyomichi、Yoshitane Hikari、Hattori Kazuki、Yamaguchi Mitsuo、Yoshida Kento、Okubo Takenori、Naguro Isao、Ichijo Hidenori、Fukada Yoshitaka
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 14 Pages: 3646-3651
  • DOI: 10.1073/pnas.1719298115
  • Peer Reviewed / Open Access
• [Journal Article] A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress (2018)
  • Author(s): Watanabe Kengo、Umeda Tsuyoshi、Niwa Kuniyoshi、Naguro Isao、Ichijo Hidenori
  • Journal Title: Cell Reports Volume: 22 Issue: 11 Pages: 2809-2817
  • DOI: 10.1016/j.celrep.2018.02.045
  • Peer Reviewed / Open Access
• [Journal Article] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. (2018)
  • Author(s): Galluzzi, L. et al.
  • Journal Title: Cell Death Differ. Volume: 25 Issue: 3 Pages: 486-541
  • DOI: 10.1038/s41418-017-0012-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] mASKing cancer cells in a tumor microenvironment (2018)
  • Author(s): Kamiyama Miki、Naguro, Isao、Ichijo Hidenori
  • Journal Title: Cell Cycle Volume: 17 Issue: 2 Pages: 139-140
  • DOI: 10.1080/15384101.2017.1407402
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis signal-regulating kinase 1 in regulated necrosis (2018)
  • Author(s): Hattori Kazuki、Ichijo Hidenori
  • Journal Title: Cell Cycle Volume: 17 Issue: 1 Pages: 5-6
  • DOI: 10.1080/15384101.2017.1397330
  • Peer Reviewed / Open Access
• [Journal Article] Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging (2017)
  • Author(s): Hasegawa Yu、Toyama Kensuke、Uekawa Ken、Ichijo Hidenori、Kim-Mitsuyama Shokei
  • Journal Title: Journal of Alzheimer's Disease Volume: 61 Issue: 1 Pages: 259-263
  • DOI: 10.3233/jad-170645
  • Peer Reviewed / Open Access
• [Journal Article] TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1 negative regulator PRMT1. (2017)
  • Author(s): Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H., Matsuzawa, A.
  • Journal Title: Cell Rep. Volume: 21 Issue: 9 Pages: 2447-2457
  • DOI: 10.1016/j.celrep.2017.11.007
  • Peer Reviewed / Open Access
• [Journal Article] Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway (2017)
  • Author(s): Hattori Kazuki、Ishikawa Hiroyuki、Sakauchi Chihiro、Takayanagi Saki、Naguro Isao、Ichijo Hidenori
  • Journal Title: EMBO reports Volume: 18 Issue: 11 Pages: 2067-2078
  • DOI: 10.15252/embr.201744228
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of apoptosis signal-regulating kinase-1 in house dust miteinduced allergic asthma in mice (2017)
  • Author(s): Maruoka, S., Gon, Y., Mizumura, K., Okamoto, S., Tsuya, K., Shikano, S., Soda, K., Naguro, I., Ichijo, H. and Hashimoto, S.
  • Journal Title: Allergology International Volume: 66 Issue: Supplement.1 Pages: S50-S52
  • DOI: 10.1016/j.alit.2017.05.007
  • NAID: 130006182289
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. (2017)
  • Author(s): Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., Ichijo, H.
  • Journal Title: Cell Death and Differentiation Volume: 24 Issue: 12 Pages: 2066-2076
  • DOI: 10.1038/cdd.2017.114
  • Peer Reviewed
• [Journal Article] Structures of PGAM5 provide insight into active site plasticity and multimeric assembly. (2017)
  • Author(s): Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Schroder, M., Sekine, S., Ichij, H., Engen, J. R., Takeda, K., Knapp, S.
  • Journal Title: Structure 25, 1089-1099 (2017) Volume: 25 Issue: 7 Pages: 1089-1099
  • DOI: 10.1016/j.str.2017.05.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Apoptosis signal-regulating kinase 1 regulates platelet granule secretion, thromboxane A2 generation, and thrombus formation in mice. (2017)
  • Author(s): Naik, M.-U. Patel, P., Derstine, R., Turaga, R., Chen, X., Golla, K., Neeves, K.-B., Ichijo, H. and Naik, U.-K.
  • Journal Title: Blood Volume: 29 Issue: 9 Pages: 1197-1209
  • DOI: 10.1182/blood-2016-07-729780
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons (2017)
  • Author(s): Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
  • Journal Title: Science Translational Medicine Volume: 9 Issue: 391 Pages: 391-391
  • DOI: 10.1126/scitranslmed.aaf3962
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pleiotropic properties of ASK1. (2017)
  • Author(s): Sakauchi C, Wakatsuki H, Ichijo H, Hattori K.
  • Journal Title: Biochim Biophys Acta. Volume: 1861 Issue: 1 Pages: 3030-3038
  • DOI: 10.1016/j.bbagen.2016.09.028
  • Peer Reviewed
• [Journal Article] KLHDC10 deficiency protects mice against TNFα-induced systemic inflammation. (2016)
  • Author(s): Yamaguchi, N., Sekine, S., Naguro, I., Sekine, Y. and Ichijo, H.
  • Journal Title: PLOS one Volume: 11 Issue: 9 Pages: e0163118-e0163118
  • DOI: 10.1371/journal.pone.0163118
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. (2016)
  • Author(s): Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S.
  • Journal Title: Elife Volume: 18357 Pages: 18357-18357
  • DOI: 10.7554/elife.18357
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitogen-activated protein kinases as key players in osmotic stress signaling. (2016)
  • Author(s): Zhou, X., Naguro, I., Ichijo, H. and Watanabe, K.
  • Journal Title: Biochem. Biophys. Acta Volume: 1860 Issue: 9 Pages: 2037-2052
  • DOI: 10.1016/j.bbagen.2016.05.032
  • Peer Reviewed
• [Journal Article] Mislocalization, aggregation formation and defect in proteolysis in ALS (2016)
  • Author(s): Tsubota, A., Ichijo, H. and Homma, K.
  • Journal Title: AIMS Molecular Science Volume: 3 Issue: 2 Pages: 246-268
  • DOI: 10.3934/molsci.2016.2.246
  • Peer Reviewed
• [Journal Article] ASK1 signaling regulates brown and beige adipocyte maturation (2016)
  • Author(s): Kazuki H, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, and Ichijo H
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 11158-11158
  • DOI: 10.1038/ncomms11158
  • Peer Reviewed / Open Access
• [Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress (2016)
  • Author(s): Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
  • Journal Title: EBioMedicine Volume: 6 Pages: 82-92
  • DOI: 10.1016/j.ebiom.2016.01.031
  • Peer Reviewed / Open Access
• [Journal Article] Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway. (2016)
  • Author(s): Maruyama J, Kobayashi Y, Umeda T, Vandewalle A, Takeda K, Ichijo H, Naguro I.
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 18710-18710
  • DOI: 10.1038/srep18710
  • NAID: 120006987229
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS. (2016)
  • Author(s): Hayashi, Y., Homma, K. and Ichijo, H.
  • Journal Title: Adv. Biol. Regul. Volume: 60 Pages: 95-104
  • DOI: 10.1016/j.jbior.2015.10.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants. (2015)
  • Author(s): Fujisawa, T., Yamaguchi, N., Kadowaki, H., Tsukamoto, Y., Tsuburaya, N., Tsubota, A., Takahashi, H., Naguro, I., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Homma, K. and Ichijo, H.
  • Journal Title: Neurobiol. Dis. Volume: 82 Issue: 2 Pages: 478-486
  • DOI: 10.1093/hmg/ddv467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regulation of Cellular Signalling by Thioredoxin. (2015)
  • Author(s): Machida, T., Ichijo, H. and Naguro, I.
  • Journal Title: Redox Proteins in Supercomplexes and Signalosomes Volume: CRC Press Pages: 255-274
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP. (2015)
  • Author(s): Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H
  • Journal Title: Cell reports Volume: 13 Issue: 5 Pages: 944-956
  • DOI: 10.1016/j.celrep.2015.09.047
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants. (2015)
  • Author(s): Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto T, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H
  • Journal Title: Neurobiology of Disease Volume: 82 Pages: 478-486
  • DOI: 10.1016/j.nbd.2015.08.010
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Apoptosis Signal-regulating Kinase 1(ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis (2015)
  • Author(s): Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.
  • Journal Title: J Biol Chem Volume: in press Issue: 17 Pages: 10791-10803
  • DOI: 10.1074/jbc.m114.623280
  • NAID: 120007150218
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression (2015)
  • Author(s): Kamiyama, M., Naguro, I. and Ichijo, H.
  • Journal Title: Cancer Sci. Volume: 106 Issue: 7 Pages: 785-796
  • DOI: 10.1111/cas.12676
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. (2015)
  • Author(s): Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
  • Journal Title: Science Signaling Volume: 8 Issue: 388 Pages: 1-12
  • DOI: 10.1126/scisignal.aab1883
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses (2014)
  • Author(s): Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A. and Ichijo, H.
  • Journal Title: Sci. Signal. Volume: 7 Issue: 309
  • DOI: 10.1126/scisignal.2004822
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis Signal-Regulating Kinase 1 (ASK1) as a therapeutic target (2014)
  • Author(s): Kawarazaki, Y., Ichijo, H. and Naguro, I.
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: 18 Issue: 6 Pages: 651-664
  • DOI: 10.1517/14728222.2014.896903
  • Peer Reviewed
• [Journal Article] ASK1 promotes the contact hypersensitivity response through IL-17 production (2014)
  • Author(s): Mizukami, J. Sato, T., Camps, M., Ji, H., Rueckle, T., Swinnen, D., Tsuboi, R., Takeda, K. and Ichijo, H
  • Journal Title: Sci. Rep. Volume: 4 Issue: 1 Pages: 4714-4714
  • DOI: 10.1038/srep04714
  • NAID: 120006986607
  • Peer Reviewed / Open Access
• [Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses (2014)
  • Author(s): Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
  • Journal Title: Sci. Signal. Volume: 7 Issue: 323
  • DOI: 10.1126/scisignal.2004841
  • Peer Reviewed
• [Journal Article] Lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. (2014)
  • Author(s): Okada, M., Matsuzawa, A., Yoshimura, A. and Ichijo, H.
  • Journal Title: J. Biol. Chem. Volume: 289 Issue: 47 Pages: 32926-32936
  • DOI: 10.1074/jbc.m114.579961
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] FGF21 secreted from Scribble-deficient cells induces cell competition (2019)
  • Author(s): Motoyuki Ogawa, Toshitaka Nakamura, Isao Naguro, Hidenori Ichijo,
  • Organizer: Keystone Symposia-ell Competition in Development and Disease (B6)-
  • Int'l Joint Research
• [Presentation] FGF21 によるScribble 欠損細胞の排除機構の解析 (2018)
  • Author(s): 小川基行, 中村俊崇, 名黒功, 一條秀憲
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] Scribble KDによるSARM1の発現上昇が細胞脆弱性を誘導する (2018)
  • Author(s): 河原崎陽介, 小川基行, 中村俊崇, 名黒功, 一條秀憲
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] FGF1およびFGF21によるScribble欠損細胞の排除機構の解析 (2018)
  • Author(s): 小川基行, 河原崎陽介, 名黒功, 一條秀憲
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] Scribble欠損細胞の細胞死に関わるp38 MAPK下流因子の探索 (2018)
  • Author(s): 中村俊崇, 小川基行, 河原崎陽介, 名黒功, 一條秀憲
  • Organizer: 第7回細胞競合コロキウム
• [Presentation] Scribble KDによるSARM1の発現上昇が細胞脆弱性を誘導する (2018)
  • Author(s): 河原崎陽介, 小川基行, 中村俊崇, 名黒功, 一條秀憲
  • Organizer: 第3回メカノバイオロジー学会
• [Presentation] 細胞競合におけるFGF1及びFGF21によるScribble欠損細胞の排除機構の解析 (2018)
  • Author(s): 小川基行, 河原崎陽介, 中村俊崇, 名黒功, 一條秀憲
  • Organizer: 第3回メカノバイオロジー学会
• [Presentation] ScribbleのKDによる細胞の脆弱性獲得にSARMは必要である (2017)
  • Author(s): 河原崎陽介、小川基行、名黒功、一條秀憲
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2017-03-16
• [Presentation] Scribble欠損により分泌される細胞遊走因子の解析 (2017)
  • Author(s): 小川基行、河原崎陽介、名黒功、一條秀憲
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2017-03-16
• [Presentation] 血管内皮細胞におけるASK1が肺へのがん転移を制御する (2017)
  • Author(s): 古川夏輝、神山美樹、名黒功、一條秀憲
  • Organizer: 第6回 細胞競合コロキウム
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2017-03-16
• [Presentation] Scribble欠損による細胞競合モデルで働くストレス応答シグナルの解析 (2017)
  • Author(s): 河原崎陽介, 小川基行, 名黒功, 一條秀憲
  • Organizer: 第9回シグナルネットワーク研究会
• [Presentation] Roles of SARM1-ASK1-p38 pathway in the cell competition induced by Scribble deficiency (2017)
  • Author(s): 河原崎陽介, 名黒功, 一條秀憲
  • Organizer: 第3回国際シンポジウム 新学術領域研究 細胞競合ー細胞社会を支える適者生存システム
• [Presentation] Roles of chemoattractants in cell competition induced by Scribble deficiency (2017)
  • Author(s): 小川基行, 河原崎陽介, 名黒功, 一條秀憲
  • Organizer: 第3回国際シンポジウム 新学術領域研究 細胞競合ー細胞社会を支える適者生存システム
• [Presentation] 細胞競合に関与するストレス応答分子の探索 (2017)
  • Author(s): 一條秀憲
  • Organizer: 新学術領域研究ー細胞競合ー細胞社会を支える適者生存システム
• [Presentation] Scribble欠損誘導性細胞競合モデルにおける細胞遊走因子の関与 (2017)
  • Author(s): 小川基行, 河原崎陽介, 名黒功, 一條秀憲
  • Organizer: ConBio2017
• [Presentation] ストレスシグナルのメカニズム解明から創薬へ (2017)
  • Author(s): 一條秀憲
  • Organizer: 日本薬学会第137年会
  • Invited
• [Presentation] Physiological and pathophysiological roles of SOD1 under Zinc deficiency (2017)
  • Author(s): Hidenori Ichijo
  • Organizer: ISZB 5th meeting, in collaboration with Zinc-Net
  • Int'l Joint Research / Invited
• [Presentation] ASK family kinases in Stress Signaling and Disease (2017)
  • Author(s): Hidenori Ichijo
  • Organizer: 58th International Symposium on "Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues"
  • Invited
• [Presentation] ストレスシグナルの分子細胞生物学-その破綻と疾患と創薬- (2017)
  • Author(s): 一條秀憲
  • Organizer: 第6回山梨医学フォーラム
  • Invited
• [Presentation] 哺乳類培養細胞を用いた細胞競合制御因子の網羅的探索 (2017)
  • Author(s): 小川基行、河原崎陽介、名黒功、一條秀憲
  • Organizer: 新学術領域 細胞競合・ダイイングコード
  • Place of Presentation: ホテルコスモスクエア国際交流センター（大阪府大阪市）
• [Presentation] NFAT5の浸透圧依存的な核内移行制御因子としてのHES1の同定 (2017)
  • Author(s): 立野浩輝、名黒功、一條秀憲
  • Organizer: 新学術領域 細胞競合・ダイイングコード
  • Place of Presentation: ホテルコスモスクエア国際交流センター（大阪府大阪市）
• [Presentation] 細胞競合時に起きる細胞自立的な変化を担う分子群の網羅的解析 (2016)
  • Author(s): 河原崎陽介、小川基行、名黒功、一條秀憲
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] 哺乳類培養細胞を用いた新たな細胞競合モデル系の構築 (2016)
  • Author(s): 小川基行、河原崎陽介、名黒功、一條秀憲
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] 細胞競合時に起きる細胞自律的な変化を担う分子群の網羅的解析 (2016)
  • Author(s): 河原崎陽介、小川基行、名黒功、一條秀憲
  • Organizer: 新学術領域研究-細胞競合-
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2016-08-30
• [Presentation] 酸化ストレス、小胞体ストレス、浸透圧ストレス、熱産生 (2016)
  • Author(s): 一條秀憲
  • Organizer: 第5回徳島文理大学薬学部学術講演会
  • Place of Presentation: 徳島文理大学(徳島県徳島市）
  • Year and Date: 2016-01-23
  • Invited
• [Presentation] ストレスシグナルと疾患～酸化ストレス、小胞体ストレス、浸透圧ストレス、熱産生～ (2016)
  • Author(s): 一條秀憲
  • Organizer: 第4回AAA（Academy of Aging and Cardiovascular-Diabetes Research)
  • Place of Presentation: ロイヤルパークホテル（東京都中央区）
  • Year and Date: 2016-01-09
  • Int'l Joint Research
• [Presentation] ASK family kinases in Stress Signaling and Cancer (2016)
  • Author(s): Hidenori Ichijo
  • Organizer: The 15th KICancer Retreat
  • Invited
• [Presentation] C.elegansを用いたgenome-wide RNAi screenによるASK1シグナルの新規活性化因子の同定 (2015)
  • Author(s): 河原崎陽介、名黒功、一條秀憲
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-11-25
• [Presentation] Regulation of stress signaling in cell death and disease (2015)
  • Author(s): 一條秀憲
  • Organizer: Fifty-sixth International Symposium on "Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues"
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2015-10-05
  • Int'l Joint Research / Invited
• [Presentation] ER stress-dependent motoneuron toxicity and PPI-targeted drug screening in ALS. (2015)
  • Author(s): 一條秀憲
  • Organizer: 6th Cisbio htrf symposium
  • Place of Presentation: Brewster, MA, USA
  • Year and Date: 2015-09-14
  • Int'l Joint Research / Invited
• [Presentation] Establishment of image-based high-throughput evaluation system for cell competition (2015)
  • Author(s): Kawarazaki, Y., Naguro, I. and Ichijo, H.
  • Organizer: 1st Internatinoal Symposium on Cell Competition -Cell Competition in Development and Cancer-
  • Place of Presentation: 京都大学 芝蘭会館（京都府京都市）
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] 細胞がストレスを感じる仕組みと疾患 (2015)
  • Author(s): 一條秀憲
  • Organizer: 第22回日本免疫毒性学会
  • Place of Presentation: 京都大学百周年時計台記念館国際交流ホール（京都府京都市）
  • Year and Date: 2015-09-10
• [Presentation] 小胞体ストレスと神経細胞死 (2015)
  • Author(s): 一條秀憲
  • Organizer: 第67回日本細胞生物学会大会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-06-30
  • Invited
• [Presentation] ストレスシグナルのリン酸化シグナル伝達系の解明 (2015)
  • Author(s): 一條秀憲
  • Organizer: 第15回日本蛋白質科学会年会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] Ubiquitin-dependent deguradation of ASK1 signaling pathway (2015)
  • Author(s): Hidenori Ichijo
  • Organizer: International Symposium on Ubiquitin and Diseases
  • Place of Presentation: Hunan, China
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] ASK1はADPシグナルへの作用を介して血小板の機能を制御する (2015)
  • Author(s): 一條秀憲
  • Organizer: 日本薬学会九州支部特別講演会
  • Place of Presentation: 長崎大学薬学部（長崎県長崎市）
  • Year and Date: 2015-05-22
  • Invited
• [Presentation] 細胞競合で機能するストレス応答経路の探索 (2015)
  • Author(s): 河原崎陽介、名黒功、一條秀憲
  • Organizer: 第4回細胞競合コロキウム
  • Place of Presentation: 北海道大学（北海道札幌市）
  • Year and Date: 2015-03-12
• [Presentation] C.elegansを用いたgenome-wide RNAi screenによってASK1ファミリー抑制因子としてMahjongが同定された (2015)
  • Author(s): 河原崎陽介、名黒功、一條秀憲
  • Organizer: 第2回新学術「細胞競合」領域研究会議
  • Place of Presentation: 門司港ホテル（福岡県北九州市）
  • Year and Date: 2015-01-13
• [Presentation] 細胞競合に関与するストレス応答分子の探索 (2015)
  • Author(s): 一條秀憲
  • Organizer: 第2回新学術「細胞競合」領域研究会議
  • Place of Presentation: 門司港ホテル（福岡県北九州市）
  • Year and Date: 2015-01-13
• [Book] Advances in BIOLOGICAL REGULATIOＮ (2017)
  • Author(s): Guest Editors: Hidenori Ichijo and Isao Naguro
  • Total Pages: 90
  • Publisher: ELSEVIER