| Budget Amount *help |
¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
We constructed a mathematical model of a hierarchical tissue from a stem cell population to functional cell populations. By performing comprehensive stochastic simulations, the process of cancer initiation through the tissue collapse was thoroughly investigated. We also obtained experimental data about tissue kinetics of hematopoietic tissue and colon tissue, and incorporated them to the model. As a result, we found that when the number and the cell division rate of a stem cell population is small and low, respectively, the time until cancer initiation becomes long. Finally we revealed the relationship between the complexity of a tissue and the feasibility of cancer initiation.
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