| Budget Amount *help |
¥93,470,000 (Direct Cost: ¥71,900,000、Indirect Cost: ¥21,570,000)
Fiscal Year 2018: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2016: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
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| Outline of Final Research Achievements |
Intestinal epithelium is the highest proliferative tissue in our body, and its self-renewal is fueled by intestinal stem cells resided at crypt bottoms. Cell proliferation ensues inevitable genomic mutations, however, it remains unknown to what extent intestinal stem cells accumulate genomic mutations along with aging. In this study, using human intestinal organoid culture, Sato et al. determined the dynamics of genomic mutations in healthy and diseased epithelium in association with aging and its relationship with disease phenotype. As a result, the mutation rate was projected to be 40 mutations/year in single intestinal stem cell. Moreover, we demonstrated that mucosal inflammation of ulcerative colitis accelerated the mutation rate of intestinal stem cells and acquired genetic mutations related to the resistance against inflammation.
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