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Understanding of stem cell aging as the onset basis of hematopoietic tumors in elderly patients

Planned Research

Project AreaEstablishing a new paradigm of the pathogenesis of diseases through the understanding of stem cell aging
Project/Area Number 26115009
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Hospital Organization Nagoya Medical Center (2015-2018)
Kyoto University (2014)

Principal Investigator

Sanada Masashi  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 高度診断研究部長 (20529044)

Co-Investigator(Kenkyū-buntansha) 横手 幸太郎  千葉大学, 大学院医学研究院, 教授 (20312944)
宮本 敏浩  九州大学, 医学研究院, 准教授 (70343324)
Research Collaborator Kikushige Yoshikane  
Kataoka Keisuke  
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥186,550,000 (Direct Cost: ¥143,500,000、Indirect Cost: ¥43,050,000)
Fiscal Year 2018: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2017: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2016: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Fiscal Year 2015: ¥36,010,000 (Direct Cost: ¥27,700,000、Indirect Cost: ¥8,310,000)
Fiscal Year 2014: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Keywords老化 / クローン造血 / 白血病幹細胞 / 早老症 / 骨髄異形成症候群 / 慢性リンパ性白血病 / マウスモデル / 変異 / MDS / CLL / 造血器腫瘍 / ゲノム異常 / ゲノム変異 / 幹細胞 / クローン / 造血幹細胞 / がん / ゲノム / モデルマウス
Outline of Final Research Achievements

It has been clarified that age-related clonal hematopoiesis (ARCH) is closely involved in the development process of MDS and AA. Furthermore, we elucidated the molecular pathogenesis of RNA spliceosome mutations that are frequently observed in MDS and ARCH. ARCH was not found in Werner syndrome (WS) patients as well as in MDS that developed from WS, suggesting the existence of different aging and tumor development mechanisms. We found that gene mutations identical to CLL cells were acquired at the hematopoietic stem cell level in most of CLL cases, and identified IRAK-3 molecules ectopically expressed in CLL cells as a tumorigenic mechanism from CLL stem cells. It was shown that tumor cells secrete galectin-9, which is a ligand of TML-3, a stem cell-specific molecule of AML, into autocrine. Using the CRISPR / Cas9 system, mice with deletion alleles of Wrn and senescence related gene and double deletion mice were generated.

Academic Significance and Societal Importance of the Research Achievements

多くの腫瘍性疾患において加齢は最大のリスク因子であり、細胞老化が腫瘍化と密接に関わることをゲノム解析により明らかとした。RNAスプライシング分子変異の分子病態の解明は、強力な抗がん剤治療が困難な高齢者MDSにおける治療開発に寄与することが期待される。早老症研究は老化研究において重要であるが、早老症との差異につながる知見を得た意義は大きい。本研究で作成したマウスモデルやWerner症候群の疾患レジストリは、今後の同症候群並びに老化研究の重要な基盤になると考える。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (111 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (52 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 51 results,  Open Access: 38 results,  Acknowledgement Compliant: 13 results) Presentation (47 results) (of which Int'l Joint Research: 15 results,  Invited: 10 results) Book (8 results) Remarks (1 results)

  • [Int'l Joint Research] University of Washington/Cleaveland Clinic/University of Nebraska(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] MLL(Germany)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Cancer Science Institute(Singapore)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas2019

    • Author(s)
      Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
    • Journal Title

      Leukemia

      Volume: Epub ahead of print Issue: 7 Pages: 1687-1699

    • DOI

      10.1038/s41375-019-0380-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and transcriptional landscape of plasma cells in POEMS syndrome2019

    • Author(s)
      Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, Aoyama K, Nishijima D, Isshiki Y, Kayamori K, Kawajiri-Manako C, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Miyano S, Ohara O, Yokote K, Sakaida E, Kuwabara S, Sanada M, Iwama A, Ogawa S, Nakaseko C.
    • Journal Title

      Leukemia

      Volume: - Issue: 7 Pages: 1723-1735

    • DOI

      10.1038/s41375-018-0348-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related remodelling of oesophageal epithelia by mutated cancer drivers.2019

    • Author(s)
      Yokoyama A, Ogawa S., et al.
    • Journal Title

      Nature

      Volume: 565 Issue: 7739 Pages: 312-317

    • DOI

      10.1038/s41586-018-0811-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.2018

    • Author(s)
      Shiozawa Y, Malcovati L, Gall A, Sato-Otsubo A, Kataoka K, Sato Y, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Makishima H, Shiraishi Y, Chiba K, Hellstrom-Lindberg E, Miyano S, Ogawa S, Cazzola M
    • Journal Title

      Nat. Commun.

      Volume: 9 Issue: 1 Pages: 3649-3649

    • DOI

      10.1038/s41467-018-06063-x

    • NAID

      120006537149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion2018

    • Author(s)
      Madan Vikas、Han Lin、Hattori Norimichi、Teoh Weoi Woon、Doan Ngan B.、Sanada Masashi、Sato-Otsubo Aiko、Meggendorfer Manja、Yang Henry、Said Jonathan W.、Ogawa Seishi、Haferlach Torsten、Liang Der-Cherng、Shih Lee-Yung、Nakamaki Tsuyoshi、Wang Q. Tian、Koeffler H. Phillip
    • Journal Title

      Haematologica

      Volume: 103 Issue: 12 Pages: 1980-1990

    • DOI

      10.3324/haematol.2018.189928

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia2018

    • Author(s)
      Sakai H, Hosono N, Nakazawa H, Przychodzen B, Polprasert C, Carraway HE, Sekeres MA, Radivoyevitch T, Yoshida K, Sanada M, Yoshizato T, Kataoka K, Nakagawa MM, Ueno H, Nannya Y, Kon A, Shiozawa Y, Takeda J, Shiraishi Y, Chiba K, Miyano S, Singh J, Padgett RA, Ogawa S, Maciejewski JP, Makishima H
    • Journal Title

      Leukemia

      Volume: 32(3) Issue: 3 Pages: 839-843

    • DOI

      10.1038/leu.2017.319

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PhysiologicalSrsf2P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice2017

    • Author(s)
      Kon Ayana、Yamazaki Satoshi、Nannya Yasuhito、Kataoka Keisuke、Ota Yasunori、Nakagawa Masahiro Marshall、Yoshida Kenichi、Shiozawa Yusuke、Morita Maiko、Yoshizato Tetsuichi、Sanada Masashi、Nakayama Manabu、Koseki Haruhiko、Nakauchi Hiromitsu、Ogawa Seishi
    • Journal Title

      Blood

      Volume: 131 Issue: 6 Pages: 621-635

    • DOI

      10.1182/blood-2017-01-762393

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of genetic alterations in stem-cell transplantation for myelodysplasia and secondary acute myeloid leukemia.2017

    • Author(s)
      Yoshizato T, et. al., Sanada M, et. al., Ogawa S.
    • Journal Title

      Blood

      Volume: 129 Issue: 17 Pages: 2347-2358

    • DOI

      10.1182/blood-2016-12-754796

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia2017

    • Author(s)
      Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H.
    • Journal Title

      Blood

      Volume: 129 Issue: 15 Pages: 2148-2160

    • DOI

      10.1182/blood-2016-06-724658

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Werner syndrome: a model for sarcopenia due to accelerated aging2017

    • Author(s)
      Yamaga Masaya、Takemoto Minoru、Shoji Mayumi、Sakamoto Kenichi、Yamamoto Masashi、Ishikawa Takahiro、Koshizaka Masaya、Maezawa Yoshiro、Kobayashi Kazuki、Yokote Koutaro
    • Journal Title

      Aging

      Volume: 9 Issue: 7 Pages: 1738-1744

    • DOI

      10.18632/aging.101265

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent trends in WRN gene mutation patterns in individuals with Werner syndrome.2017

    • Author(s)
      Yamaga M, Takemoto M, Takada-Watanabe A, Koizumi N, Kitamoto T, Sakamoto K, Ishikawa T, Koshizaka M, Maezawa Y, Yokote K
    • Journal Title

      J Am Geriatr Soc

      Volume: 印刷中 Issue: 8 Pages: 1853-1856

    • DOI

      10.1111/jgs.14906

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progress in the leukemic stem cell study and a novel therapeutic approach targeting leukemic stem cells2017

    • Author(s)
      菊繁 吉謙、宮本 敏浩、赤司 浩一
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 10 Pages: 1838-1843

    • DOI

      10.11406/rinketsu.58.1838

    • NAID

      130006132650

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.2017

    • Author(s)
      Nadeau SA, An W, Mohapatra BC, Mushtaq I, Bielecki TA, Luan H, Zutshi N, Ahmad G, Storck MD, Sanada M, Ogawa S, Band V, Band H.
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 9 Pages: 3666-3682

    • DOI

      10.1074/jbc.m116.772723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recurrent genetic defects on chromosome 5q in myeloid neoplasms.2017

    • Author(s)
      Hosono N, Makishima H, Mahfouz R, Przychodzen B, Yoshida K, Jerez A, LaFramboise T, Polprasert C, Clemente MJ, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Cui E, Verma AK, McDevitt MA, List AF, Saunthararajah Y, Sekeres MA, Boultwood J, Ogawa S, Maciejewski JP.
    • Journal Title

      Oncotarget.

      Volume: 8 Issue: 4 Pages: 6483-6495

    • DOI

      10.18632/oncotarget.14130

    • NAID

      120006355735

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ynamics of clonal evolution in myelodysplastic syndromes.2017

    • Author(s)
      Makishima H, et al.
    • Journal Title

      Nat Genet.

      Volume: 49 Issue: 2 Pages: 204-212

    • DOI

      10.1038/ng.3742

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction.2017

    • Author(s)
      Ide K, Baba Y, Takemoto M, Koide H, Ide S, Yamaga M, Kobayashi K, Yokote K.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 17 Issue: 2 Pages: 346-347

    • DOI

      10.1111/ggi.12809

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.2017

    • Author(s)
      Yokote K, Chanprasert S, Lee L, Eirich K, Takemoto M, Watanabe A, Koizumi N, Lessel D, Mori T, Hisama FM, Ladd PD, Angle B, Baris H, Cefle K, Palanduz S, Ozturk S, Chateau A, Deguchi K, Easwar TK, Federico A, Fox A, Grebe TA, Hay B, Nampoothiri S, Seiter K, Streeten E, Poke G, Poot M, Posmyk R, Oshima J
    • Journal Title

      Hum Mutat

      Volume: 38 Issue: 1 Pages: 7-15

    • DOI

      10.1002/humu.23128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The obesity-related pathology and Th17 cells.2017

    • Author(s)
      Endo, Y., Yokote, K., and Nakayama, T.
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 74 Issue: 7 Pages: 1231-1245

    • DOI

      10.1007/s00018-016-2399-3

    • NAID

      40021094104

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of unipotent megakaryocyte progenitors in human hematopoiesis.2017

    • Author(s)
      K. Miyawaki. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi
    • Journal Title

      Blood

      Volume: 印刷中 Issue: 25 Pages: 3332-3343

    • DOI

      10.1182/blood-2016-09-741611

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Graft-versus-host disease targets ovary and causes female infertility in mice.2017

    • Author(s)
      S. Shimoji, D. Hashimoto, H. Tsujigiwa, K. Miyawaki, K. Kato, S. Takahashi, R. Ogasawara, T. Jiromaru, H. Iwasaki, T. Miyamoto, K. Akashi, *T. Teshima
    • Journal Title

      Blood

      Volume: 129 Issue: 9 Pages: 1216-1225

    • DOI

      10.1182/blood-2016-07-728337

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donor Lymphocyte Infusion for Relapsed Hematological Malignancies after Unrelated Allogeneic Bone Marrow Transplantation Facilitated by the Japan Marrow Donor Program.2017

    • Author(s)
      T. Miyamoto, T. Fukuda, M. Nakashima, T. Henzan, S. Kusakabe, N. Kobayashi, J. Sugita, T. Mori, M. Kurokawa, S. I. Mori
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 23 Issue: 6 Pages: 938-944

    • DOI

      10.1016/j.bbmt.2017.02.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs.2017

    • Author(s)
      T. Tochigi, T. Aoki, *Y. Kikushige, T. Kamimura, Y. Ito, T. Shima, T. Yamauchi, Y. Mori, G. Yoshimoto, K. Kamezaki, K. Kato, K. Takenaka, H. Iwasaki, K. Akashi, T. Miyamoto
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 4 Pages: 423-432

    • DOI

      10.1007/s12185-016-2148-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparative analysis of pulmonary hypertension in patients treated with imatinib, nilotinib and dasatinib.2017

    • Author(s)
      M. Minami, T. Arita, H. Iwasaki, T. Muta, T. Aoki, K. Aoki, S. Yamasaki, T. Matsushima, K. Kato, K. Takenaka, K. Tanimoto, T. Kamimura, R. Ogawa, K. Akashi, *T. Miyamoto
    • Journal Title

      Br J Haematol

      Volume: 177 Issue: 4 Pages: 578-587

    • DOI

      10.1111/bjh.14608

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms.2016

    • Author(s)
      Mori T, Nagata Y, Makishima H, Sanada M, Shiozawa Y, Kon A, Yoshizato T, Sato-Otsubo A, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Ishiyama K, Miyawaki S, Mori H, Nakamaki T, Kihara R, Kiyoi H, Koeffler HP, Shih LY, Miyano S, Naoe T, Haferlach C, Kern W, Haferlach T, Ogawa S, Yoshida K.
    • Journal Title

      Leukemia.

      Volume: 30 Issue: 11 Pages: 2270-2273

    • DOI

      10.1038/leu.2016.212

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.2016

    • Author(s)
      Madan V, et al.
    • Journal Title

      Leukemia.

      Volume: 30 Issue: 12 Pages: 1672-1681

    • DOI

      10.1038/leu.2016.237

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.2016

    • Author(s)
      Angela, M.,* Endo, Y.,* Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 13683-13683

    • DOI

      10.1038/ncomms13683

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Case of sarcomatoid carcinoma occurring in a patient with Werner syndrome.2016

    • Author(s)
      Mitamura Y, Azuma S, Matsumoto D, Takada-Watanabe A, Takemoto M, Yokote K, Motoshita J, Oda Y, Furue M, Takeuchi S
    • Journal Title

      J Dermatol

      Volume: 43 Issue: 11 Pages: 1362-1364

    • DOI

      10.1111/1346-8138.13399

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-world evidence for the safety of ipragliflozin in elderly Japanese patients with type 2 diabetes mellitus (STELLA-ELDER): final results of a post-marketing surveillance study.2016

    • Author(s)
      Yokote K, Terauchi Y, Nakamura I, Sugamori H.
    • Journal Title

      Expert Opin Pharmacother

      Volume: 17 Issue: 15 Pages: 1995-2003

    • DOI

      10.1080/14656566.2016.1219341

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel podocyte gene, Semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.2016

    • Author(s)
      Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K
    • Journal Title

      Scientific Report

      Volume: 6 Issue: 1 Pages: 25955-25955

    • DOI

      10.1038/srep25955

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved Glycemic Control and Vascular Function and Reduction of Abdominal Fat Accumulation with Liraglutide in a Case of Werner Syndrome with Diabetes Mellitus.2016

    • Author(s)
      Ide S, Yamamoto M, Takemoto M, Fujimoto M, Ide K, Kobayashi K, Yokote K.
    • Journal Title

      J Am Geriatr Soc

      Volume: 64 Issue: 3 Pages: 687-688

    • DOI

      10.1111/jgs.13970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Matricellular protein CCN3 mitigates abdominal aortic aneurysm.2016

    • Author(s)
      Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z
    • Journal Title

      J Clin Invest

      Volume: 126 Issue: 4 Pages: 1282-1299

    • DOI

      10.1172/jci82337

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations.2016

    • Author(s)
      A. Yurino, K. Takenaka, T. Yamauchi, T. Nunomura, Y. Uehara, F. Jinnouchi, K. Miyawaki, Y. Kikushige, K. Kato, T. Miyamoto, H. Iwasaki, Y. Kunisaki, *K. Akashi
    • Journal Title

      Stem Cell Reports

      Volume: 7 Issue: 3 Pages: 425-438

    • DOI

      10.1016/j.stemcr.2016.07.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calreticulin mutation does not contribute to disease progression in essential thrombocythemia by inhibiting phagocytosis.2016

    • Author(s)
      S. Daitoku, K. Takenaka, T. Yamauchi, A. Yurino, F. Jinnouchi, T. Nunomura, T. Eto, T. Kamimura, M. Higuchi, N. Harada, N. Saito, T. Miyamoto, H. Iwasaki, *K. Akashi
    • Journal Title

      Exp Hematol

      Volume: 44 Issue: 9 Pages: 817-825

    • DOI

      10.1016/j.exphem.2016.05.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.2015

    • Author(s)
      Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 101(3) Issue: 3 Pages: 841-846

    • DOI

      10.1210/jc.2015-2855

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.2015

    • Author(s)
      Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K
    • Journal Title

      Cell Stem Cell.

      Volume: 17 Issue: 3 Pages: 341-352

    • DOI

      10.1016/j.stem.2015.07.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.2015

    • Author(s)
      Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.
    • Journal Title

      N Engl J Med.

      Volume: 373 Issue: 1 Pages: 35-47

    • DOI

      10.1056/nejmoa1414799

    • NAID

      120005623244

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.2015

    • Author(s)
      Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Satoru M, Thol F, Ganser A, Yang H, Haferlach T, Ogawa S, Koeffler HP
    • Journal Title

      Nature Commun.

      Volume: 6 Issue: 1 Pages: 6042-6042

    • DOI

      10.1038/ncomms7042

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健康人におけるクローナル造血2015

    • Author(s)
      真田 昌
    • Journal Title

      腫瘍内科

      Volume: 16 Pages: 573-573

    • Related Report
      2015 Annual Research Report
  • [Journal Article] CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.2015

    • Author(s)
      Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K.
    • Journal Title

      Stem Cells

      Volume: 33 Issue: 3 Pages: 976-87

    • DOI

      10.1002/stem.1906

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.2015

    • Author(s)
      Kobayashi K1, Nojiri H2, Saita Y2, Morikawa D1, Ozawa Y3, Watanabe K3, Koike M1, Asou Y4, Shirasawa T5, Yokote K6, Kaneko K2, Shimizu T3.
    • Journal Title

      Scientific Reports

      Volume: Mar 16;5 Issue: 1 Pages: 9148-9148

    • DOI

      10.1038/srep09148

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.2014

    • Author(s)
      Matsunawa M, Yoshida K
    • Journal Title

      Leukemia

      Volume: (Epub ahead of print) Issue: 9 Pages: 1-7

    • DOI

      10.1038/leu.2014.73

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.2014

    • Author(s)
      7.Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H, Shiozawa Y, Kataoka K, Kon A, Aoki K, Chiba K, Tanaka H, Kume H, Miyano S, Fukayama M, Nureki O, Homma Y, Ogawa S.
    • Journal Title

      Science

      Volume: 344 Issue: 6186 Pages: 917-920

    • DOI

      10.1126/science.1252328

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent genetic defects on chromosome 7q in myeloid neoplasms.2014

    • Author(s)
      10.Hosono N, Makishima H, Jerez A, Yoshida K, Przychodzen B, McMahon S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Gómez-Seguí I, Verma AK, McDevitt MA, Sekeres MA, Ogawa S, Maciejewski JP.
    • Journal Title

      Leukemia

      Volume: 28 Issue: 6 Pages: 1348-1351

    • DOI

      10.1038/leu.2014.25

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice.2014

    • Author(s)
      Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S
    • Journal Title

      Blood Cancer J.

      Volume: 12 Issue: 12 Pages: e264-e264

    • DOI

      10.1038/bcj.2014.83

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.2014

    • Author(s)
      Iwamoto C
    • Journal Title

      Exp Hematol

      Volume: 42 Issue: 3 Pages: 163-171

    • DOI

      10.1016/j.exphem.2013.11.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.2014

    • Author(s)
      Shima T, Miyamoto T, Kikushige Y, Yuda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.
    • Journal Title

      Exp. Hematol.

      Volume: 42 Issue: 11 Pages: 955-65

    • DOI

      10.1016/j.exphem.2014.07.267

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acquired initiating mutations in early hamatopoietic cells of CLL patients2014

    • Author(s)
      Damm, F., E. Mylonas, A. Cosson, K. Yoshida, V. Della Valle, E.
    • Journal Title

      Cancer Discov

      Volume: 4 Issue: 9 Pages: 1088-1101

    • DOI

      10.1158/2159-8290.cd-14-0104

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis.2014

    • Author(s)
      Kikushige Y, Miyamoto T
    • Journal Title

      Int J Hematol

      Volume: 100 Issue: 4 Pages: 335-340

    • DOI

      10.1007/s12185-014-1651-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas.2014

    • Author(s)
      Oshitari T, Kitahashi M, Mizuno S, Baba T, Kubota-Taniai M, Takemoto M, Yokote K, Yamamoto S, Roy S
    • Journal Title

      BMC Ophthalmol.

      Volume: - Issue: 1 Pages: 31-31

    • DOI

      10.1186/1471-2415-14-31

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocrine and metabolic abnormalities in a girl with childhood Werner syndrome: case report.2014

    • Author(s)
      Toda N, Ihara K, Takemoto M, Yokote K, Hara T.
    • Journal Title

      J Am Geriatr Soc

      Volume: 62 Issue: 7 Pages: 1404-1405

    • DOI

      10.1111/jgs.12897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice.2014

    • Author(s)
      Shibuya S, Ozawa Y, Watanabe K, Izuo N, Toda T, Yokote K, Shimizu T.
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 10 Pages: e109288-e109288

    • DOI

      10.1371/journal.pone.0109288

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture2014

    • Author(s)
      Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hmasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 11 Pages: 1-13

    • DOI

      10.1371/journal.pone.0112900

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] landscape of driver mutations and their clinical impacts in pediatric patients with B-progenitor acute lymphoblastic leukemia2018

    • Author(s)
      Hiroo Ueno, Kenichi Yoshida, Yasuhito Nannya, Yuka Iijima, Yusuke Shiozawa, Yuishi Shiraishi, Tomomi Ishida, Toshihiko Imamura, Satoru Miyano, Seishi Ogawa, Keizo Horibe, Masashi Sanada
    • Organizer
      29th Annual Meeting of the International BFM Study Group
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スプライシング因子変異による骨髄異形成症候群発祥の分子病態の解明2018

    • Author(s)
      昆彩奈、山崎聡、南谷泰仁、片岡圭亮、太田泰徳、中川正宏、吉田健一、吉里哲一、真田昌、中山学、古関明彦、中内啓光、小川誠司
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食道病理学的正常部の上皮には、食道癌ドライバー遺伝子によって年齢依存のリモデリングが生じる2018

    • Author(s)
      横山顕礼、吉里哲一、垣内伸之、南谷泰仁、鈴木啓道、塩澤裕介、竹内康英、牧島秀樹、角田茂、真田昌、宮野悟、武藤学、小川誠司
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DDX41アリルの造血器腫瘍発症リスクの検討2018

    • Author(s)
      武田淳恵、吉田健一、鎌谷洋一郎、桃沢幸秀、久保充明、長崎正朗、千葉滋、直江知樹、宮崎泰司、宮野悟、眞田昌、牧島秀樹、小川誠司
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 成人B細胞性急性リンパ性白血病のゲノム学的・臨床的な特徴2018

    • Author(s)
      安田貴彦, 西島大, 小島進也, 河津正人, 上野敏秀, 都築忍, 清井仁, 松村到, 宮崎泰司, 堀部敬三, 間野博行, 直江知樹, 真田昌, 早川文彦
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規診断多発性骨髄腫における網羅的ゲノム解析2018

    • Author(s)
      金森貴之, 真田昌, 李政樹, 上野浩生, 西島大, 安田貴彦, 青木奨, 吉田嵩, 木下史緒理, 成田朋, 伊藤旭, 楠本茂, 増田裕太, 小林宣彦, 塩澤裕介, 吉田健一, 中川正宏, 南谷泰仁, 白石友一, 千葉健一, 田中洋子, 小松弘和, 宮野悟, 半田寛, 小川誠司, 飯田 真介
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨髄異形成症候群におけるder(1;7)に伴う遺伝子異常の意義2018

    • Author(s)
      奥田瑠璃花, 牧島秀樹, 吉里哲一, 南谷泰仁, 永田安伸, 竹田淳恵, 吉田健一, 真田昌, 白石友一, 宮野悟, Wolfgang Kern, Constance R. Baer, Niroshan Nadarajah, Tamara Alpermann, Claudia Haferlach, 笠原千嗣, 半田寛, 千葉滋, Torsten Haferlach, 小川誠司
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨髄異形成症候群患者320例におけるDNAメチル化と遺伝子プロファイル2018

    • Author(s)
      森本俊, 牧島秀樹, 永田安伸, Constance Baer, Niroshan Nadarajah, Tamara Alpermann, 永江玄太, 南谷泰仁, 宮崎泰司, 吉田健一, 吉里哲一, 中川正宏, 稲垣良作, 竹田淳恵, 藤井陽一, 竹内康英, 白石友一, 千葉健一, 田中洋子, 真田昌, 宮野悟, Claudia Haferlach, Wolfgang Kern, 油谷浩幸, Torsten Haferlach, 小川 誠司
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] MDSに対するアザシチジンの有効性を予測するゲノム異常2018

    • Author(s)
      南谷泰仁, 竹田淳恵, 佐藤信也, 趙蘭英, 塩澤裕介, 白石友一, 千葉健一, 田中洋子, 真田昌, 中村信彦, 鶴見寿, 柴田悠平, 笠原千嗣, 上条玲奈, 田口正剛, 半田寛, 臼杵憲祐, 高折晃史, 千葉滋, 麻生範雄, 清井仁, 直江知樹, 牧島秀樹, 吉田健一, 宮野悟, 宮崎泰司, 小川誠司
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Novel and Significant Impact of Germline Variants Predisposed to Pathogenic Somatic Mutations and Loss of Heterozygosity (LOH) in Myelodysplastic Syndromes (MDS) and Clonal Hematopoiesis of Indeterminate Potential (CHIP)2018

    • Author(s)
      Hideki Makishima , Tetsuichi Yoshizato, Yasuhito Nannya, Yasuhide Momozawa, Yoshiko Atsuta, MD, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Keizo Horibe, Masashi Sanada, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano and Seishi Ogawa
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNA Methylation and Genetic Profiles in 320 Patients with Myelodysplastic Syndromes.2018

    • Author(s)
      Suguru Morimoto, Hideki Makishima, Yasunobu Nagata, Niroshan Nadarajah, Constance Baer, Tamara Alpermann, Masashi Sanada, Satoru Miyano, Claudia Haferlach, Wolfgang Kern, Hiroyuki Aburatani, Torsten Haferlach and Seishi Ogawa
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia.2018

    • Author(s)
      Takahiko Yasuda, Dai Nishijima, Shinya Kojima, Masahito Kawazu, Toshihide Ueno, Shinobu Tsuzuki, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Keizo Horibe, Hiroyuki Mano, Tomoki Naoe, Masashi Sanada and Fumihiko Hayakawa
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biological Characterization of the U2af1 S34F Mutation in the Pathogenesis of Myelodysplasia.2018

    • Author(s)
      Ayana Kon, Yasuhito Nannya, Masahiro Nakagawa, Keisuke Kataoka, Masashi Sanada, Manabu Nakayama, Haruhiko Koseki and Seishi Ogawa
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia2018

    • Author(s)
      Hiroo Ueno, Kenichi Yoshida, Yusuke Shiozawa, Yasuhito Nannya, Yuka Iijima-Yamashita, Nobutaka Kiyokawa, Yoshiyuki Kosaka, Koji Kato, Takeshi Inukai, Junko Takita, Toshihiko Imamura, Satoru Miyano, Atsushi Manabe, Keizo Horibe Seishi Ogawa and Masashi Sanada
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Genomic Predispositions to Sporadic Myeloid Neoplasms Mediated By DDX41 in Japan2018

    • Author(s)
      June Takeda, Kenichi Yoshida, Tetsuichi Yoshizato, Yuichi Shiraishi, Yusuke Okuno, Ayana Kon, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Yukihide Momozawa, Masao Nagasaki, Satoru Miyano, Michiaki Kubo, Hideki Makishima and Seishi Ogawa
    • Organizer
      ASH2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal evolution in MDS from clonal hematopoiesis to acute leukemia2018

    • Author(s)
      Masashi Sanada
    • Organizer
      The 2nd JSPS-NUS Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性リンパ球性白血病の病態形成において中心的役割を担う鍵分子IRAK-3の同定2017

    • Author(s)
      菊繁吉謙
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Autologous transplantation of gene-transfered adipocytes for treatment of intractable diseases.2017

    • Author(s)
      Yokote, K.
    • Organizer
      Joint symposium between Taipei Medical University and Chiba Universaity at Taipei Medical Universoty
    • Place of Presentation
      Taipei
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TIM-3/galectin-9 autocrine loop enhances self-renewal capacity of human leukemic stem cells through mimicking canonical Wnt signaling2017

    • Author(s)
      Y. Kikushige
    • Organizer
      2017 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologica Malignancies
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2017-02-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高齢者糖尿病の治療目標2017

    • Author(s)
      横手幸太郎
    • Organizer
      第54回日本糖尿病学会関東甲信越地方会
    • Place of Presentation
      横浜
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dynamics of Clonal Evolution in Acute Myeloid Leukemia2017

    • Author(s)
      Masashi Sanada
    • Organizer
      2017 Joint Annual Congress of The Hematology Society of Taiwan and Taiwan Society of Blood and Marrow Transplantation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biomarker researches in acute leukemia for precision medicine2017

    • Author(s)
      Masashi Sanada
    • Organizer
      76th Annual Meeting of Japanese Cancer Association
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 肥満症治療の現状と展望2016

    • Author(s)
      横手幸太郎
    • Organizer
      第150回日本医学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-12-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] IRAK-M is a key molecule in pathogenesis of chronic lymphocytic leukemia2016

    • Author(s)
      菊繁吉謙
    • Organizer
      日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] PCSK9の発見は、期待へ‐糖尿病合併症を見据えたLDL-C低下治療の新たな展開2016

    • Author(s)
      横手幸太郎
    • Organizer
      第31回日本糖尿病合併症学会・第22回日本糖尿病眼学会総会共催セミナー
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖尿病と肥満症:診療と研究の話題から2016

    • Author(s)
      横手幸太郎
    • Organizer
      第37回日本肥満学会 イブニングセミナー2
    • Place of Presentation
      東京
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肥満症の治療2016

    • Author(s)
      横手幸太郎
    • Organizer
      第37回日本肥満学会 シンポジウム4
    • Place of Presentation
      東京
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動脈硬化予防を目指す生活習慣病の管理2016

    • Author(s)
      横手幸太郎
    • Organizer
      平成28年度日本内科学会生涯教育講演会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] A TIM-3/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression2016

    • Author(s)
      Y. Kikushige
    • Organizer
      45th Annual Scientific Meeting of International Society of Experimental Hematology (ISEH)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diet therapy in prevention of atherosclerotic vascular diseases.2016

    • Author(s)
      Yokote, K.
    • Organizer
      10th APSAVD Congress APSAVD-IAS-JAS Joint Symposium-Novel therapeutic agents for dyslipidemia~Asian perspective~
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動脈硬化予防のための脂質管理の現状と展望2016

    • Author(s)
      横手幸太郎
    • Organizer
      第48回日本動脈硬化学会総会・学術集会スポンサードシンポジウムⅠ
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢糖尿病患者における薬物治療と包括的管理2016

    • Author(s)
      横手幸太郎
    • Organizer
      第58回日本老年医学会学術集会 ランチョンセミナー
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動脈硬化性疾患予防ガイドライン:主として脂質管理の観点から2016

    • Author(s)
      横手幸太郎
    • Organizer
      第58回日本老年医学会学術集会 シンポジウム6
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 加齢により発症が促進される疾患メカニズムの解明:ヒト早老モデルに立脚した解析から2016

    • Author(s)
      横手幸太郎
    • Organizer
      第58回日本老年医学会学術集会 ノバルティス老化および老年医学研究基金2014年度受賞者講演
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clinical and biological features of Werner syndrome.2016

    • Author(s)
      Yokote, K.
    • Organizer
      The 3rd International Meeting on RECQ Helicases in Biology and Medicine (RECQ2016)
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 動脈硬化予防を目指す生活習慣病の管理2016

    • Author(s)
      横手幸太郎
    • Organizer
      平成28年度日本内科学会生涯教育講演会Aセッション
    • Place of Presentation
      東京
    • Year and Date
      2016-05-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢者糖尿病の薬物治療-適切な薬剤選択と低血糖予防を目指した血糖コントロールの考え方-2016

    • Author(s)
      横手幸太郎
    • Organizer
      第59回日本糖尿病学会年次学術集会 会長特別企画Special Session 3
    • Place of Presentation
      京都
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] イプラグリフロジンの高齢者における安全性:特定使用成績調査(STELLA-ELDER)2016

    • Author(s)
      横手幸太郎
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢者造血器腫瘍の発症基盤としてのステムセルエイジング2016

    • Author(s)
      真田 昌
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] クローン解析に基づく造血器腫瘍の病態理解2015

    • Author(s)
      真田 昌
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Progeroid syndrome as a model of aging,metabolic diseases and cancer. (老化、がん、代謝疾患のモデルとしての早老症)2015

    • Author(s)
      横手幸太郎
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Werner syndrome in Japan: from the medical, molecular and social aspects.2015

    • Author(s)
      Yokote, K.
    • Organizer
      Nathan shock center of excellence in the Basic Biology of Aging
    • Place of Presentation
      Seatle, USA
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comprehensive Analysis of Alternative RNA Splicing in Myelodysplastic Syndrome2014

    • Author(s)
      Yusuke Shiozawa, Sato Sato-Otsubo, Anna Gallì, Kenichi Yoshida, Tetsuichi Yoshizato, Yusuke Sato, Keisuke Kataoka,Masashi Sanada,Yuichi Shiraishi, Kenichi Chiba, Satoru Miyano, Luca Malcovati, Mario Cazzola, and Seishi Ogawa
    • Organizer
      56th American Society of Hematology 2014 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-05 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS2014

    • Author(s)
      Vikas Madan, Deepika Kanojia, Li Jia, Ryoko Okamoto, Aiko Sato-Otsubo, Alexander Kohlmann, Masashi Sanada, Vera Grossmann, Janani Sundaresan, Yuichi Shiraishi, Satoru Miyano, Felicitas Thol, Arnold Ganser, Henry Yang, Torsten Haferlach, Seishi Ogawa, and H. Phillip Koeffler
    • Organizer
      56th American Society of Hematology 2014 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-05 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia2014

    • Author(s)
      Tetsuichi Yoshizato, Bogdan Dumitriu, Masashi Sanada, et al.
    • Organizer
      56th American Society of Hematology Annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-05 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Progeroid syndrome as a model of aging-related metabolic disorders.2014

    • Author(s)
      横手幸太郎
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Progeroid syndrome as a model of aging-related metabolic disorders.2014

    • Author(s)
      Yokote, K.
    • Organizer
      International Conference on Diabetes and Metabolism 2014
    • Place of Presentation
      Korea
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Book] EBM血液疾患の治療2019-20202018

    • Author(s)
      金倉譲、木崎昌弘、鈴木律朗、神田善伸、北中明、大島孝一、牧島秀樹、吉里哲一、山崎宏人、後藤明彦、町田真一郎、新谷直樹、原田浩徳、鈴木隆浩、前田嘉信、川口辰哉、上野志貴子、小原直、眞田昌、宮本敏浩 他
    • Total Pages
      567
    • Publisher
      中外医学社
    • ISBN
      9784498225145
    • Related Report
      2018 Annual Research Report
  • [Book] 最新版 計算いらず コレステロール・中性脂肪対策のおいしいレシピ2017

    • Author(s)
      横手幸太郎
    • Publisher
      学研
    • Related Report
      2016 Annual Research Report
  • [Book] 造血器腫瘍アトラス2016

    • Author(s)
      真田 昌
    • Total Pages
      863
    • Publisher
      日本医事新報社
    • Related Report
      2016 Annual Research Report
  • [Book] 白血病学(上)2016

    • Author(s)
      真田 昌
    • Total Pages
      539
    • Publisher
      日本臨床社
    • Related Report
      2016 Annual Research Report
  • [Book] ここが知りたい! 内分泌疾患診療ハンドブック2016

    • Author(s)
      横手幸太郎
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] やさしい 脂質異常症の管理2016

    • Author(s)
      横手幸太郎
    • Publisher
      医薬ジャーナル社
    • Related Report
      2016 Annual Research Report
  • [Book] 特集:内分泌代謝疾患のtrends & topics 20172016

    • Author(s)
      横手幸太郎
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Annual Research Report
  • [Book] 医学のあゆみVol.249 No.10特集 がんゲノム研究の進歩ー網羅的解析からの知見2014

    • Author(s)
      眞田 昌
    • Total Pages
      129
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Remarks] ステムセルエイジングから解明する疾患原理_研究活動

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/stemcellaging/research/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2022-01-28  

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