| Budget Amount *help |
¥168,740,000 (Direct Cost: ¥129,800,000、Indirect Cost: ¥38,940,000)
Fiscal Year 2018: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2017: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2016: ¥30,420,000 (Direct Cost: ¥23,400,000、Indirect Cost: ¥7,020,000)
Fiscal Year 2015: ¥30,290,000 (Direct Cost: ¥23,300,000、Indirect Cost: ¥6,990,000)
Fiscal Year 2014: ¥47,190,000 (Direct Cost: ¥36,300,000、Indirect Cost: ¥10,890,000)
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| Outline of Final Research Achievements |
Translation of mRNA is a fundamental biological process in living organisms. We developed a simultaneous mRNA/tRNA ribosome profiling technique that allowed us to capture both mRNA and tRNA inside ribosomes and analyze mRNA translation in details. Using this technology, we found a novel translation inhibitory mechanism in which altered tRNA is involved. In addition, we have developed mouse models of FTLD (frontotemporal lobar degeneration) and autism and found that dysregulated mRNA translation in neurons is responsible for mental disorders including impaired anxiety and social behaviors. In particular, we found that altered ocal translation in dendrites is closely involved in mental disorders.
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