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Elucidation of mechanisms underlying disulfide bond formation in nascent chains

Planned

Project AreaNascent-chain Biology
Project/Area Number 26116005
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

Kenji Inaba  東北大学, 多元物質科学研究所, 教授 (10423039)

Co-Investigator(Kenkyū-buntansha) 門倉 広  東北大学, 多元物質科学研究所, 准教授 (70224558)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥115,700,000 (Direct Cost: ¥89,000,000、Indirect Cost: ¥26,700,000)
Fiscal Year 2018: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2017: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2016: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2015: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2014: ¥34,580,000 (Direct Cost: ¥26,600,000、Indirect Cost: ¥7,980,000)
Keywordsタンパク質品質管理 / ジスルフィド結合 / X線結晶構造解析 / 高速原子間力顕微鏡 / X線結晶構造解析
Outline of Final Research Achievements

Disulfide bond formation is a crucial step in the folding of numerous cell-surface proteins. Here, we developed a system to study the cotranslational folding of a cell-surface multidomain protein, LDL receptor. Using the system, we found that isomerization of nonnative disulfides to native ones, a key step in the folding of many cell-surface proteins, takes place at a specific timing during synthesis in a manner dependent of a downstream region of the polypeptide. Thus, folding of multidomain proteins in the ER may be more coordinated and elaborated than thought. We also succeeded in single-molecule observation of PDI engaged in the catalysis of oxidative protein folding using high-speed atomic force microscopy. Consequently, we discovered that PDI dimerizes in a substrate-dependent manner and catalyzes its oxidative folding in the central cavity of the dimer. These findings provide a number of new insights into the disulfide bond formation system of mammalian cells.

Academic Significance and Societal Importance of the Research Achievements

本研究では、リボソーム上で翻訳合成されつつ小胞体に送り込まれてくるLDL受容体の新生鎖にジスルフィド結合が導入される過程の詳細を解明することに初めて成功した。さらに、50年以上もの研究の歴史があるPDI酵素が基質依存的に二量体を形成し、酸化的フォールディングを促進するという、同酵素の全く新しい触媒機構を解明した。ジスルフィド結合形成の仕組みの破綻は糖尿病や高脂血症などの疾患の原因になることから、以上の知見は基礎的に重要であるばかりでなく、ジスルフィド結合の形成不全が引き起こす疾患の発症の機序の解明に役立つと期待される。

Report

(6 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(132 results)

All 2020 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights) Funded Workshop

  • [Int'l Joint Research] San Raffaele Scientific Institute(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Utah(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Uniiversity of Copenhagen(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] San Raffaele Scientific Institute(イタリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Basel(Switzerland)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Glasgow(United Kingdom)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Glasgow(United Kingdom)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] San Raffaele Scientific Institute(Italy)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells2020

    • Author(s)
      Kadokura, H.*, Dazai, Y., Fukuda, Y., Hirai, N., Nakamura, O., Inaba, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA(印刷中)

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methods to identify the substrates of thiol-disulfide oxidoreductases.2019

    • Author(s)
      Fujimoto Takushi、Inaba Kenji、Kadokura Hiroshi
    • Journal Title

      Protein Sci.

      Volume: 28 Pages: 30-40

    • DOI

      10.1002/pro.3530

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding.2019

    • Author(s)
      Shunsuke Okada, Motonori Matsusaki, Kenta AraiK , Yuji Hidaka, Kenji Inaba, Masaki Okumura, Takahiro Muraoka
    • Journal Title

      Chem Commun

      Volume: 55(6) Pages: 759-762

    • DOI

      10.1039/c8cc08657e

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic assembly of protein disulfide isomerase in catalysis of oxidative protein folding2019

    • Author(s)
      Okumura Masaki、Noi Kentaro、Kanemura Shingo、Kinoshita Misaki、Saio Tomohide、Inoue Yuichi、Hikima Takaaki、Akiyama Shuji、Ogura Teru、Inaba Kenji
    • Journal Title

      Nat. Chem. Biol.

      Volume: 15 Pages: 499-509

    • DOI

      10.1038/s41589-019-0268-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.2019

    • Author(s)
      Watanabe Satoshi、Amagai Yuta、Sannino Sara、Tempio Tiziana、Anelli Tiziana、Harayama Manami、Masui Shoji、Sorrentino Ilaria、Yamada Momo、Sitia Roberto、Inaba Kenji
    • Journal Title

      Nat. Commun.

      Volume: 10 Pages: 1-16

    • DOI

      10.1038/s41467-019-08429-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of the physiological substrates of PDIp, a pancreas-specific protein disulfide isomerase family member.2018

    • Author(s)
      Fujimoto Takushi、Nakamura Orie、Saito Michiko、Tsuru Akio、Matsumoto Masaki、Kohno Kenji、Inaba Kenji、Kadokura Hiroshi
    • Journal Title

      J Biol Chem

      Volume: 293 Pages: 18421-18433

    • DOI

      10.1074/jbc.ra118.003694

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ero1-mediated reoxidation of PDI accelerates the folding of cone-snail toxins.2018

    • Author(s)
      O'Brien H., Kanemura S., Okumura M., Baskin P., Bandyopadhyay P., Ellgaard L., Inaba K., and Safavi-Hemami H.*
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 11 Pages: 3418-3418

    • DOI

      10.3390/ijms19113418

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells2018

    • Author(s)
      Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Pages: 1287-1301

    • DOI

      10.1083/jcb.201707143

    • NAID

      120006457754

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The highly dynamic nature of ERdj5 is key to efficient elimination of aberrant protein oligomers through ER-associated degradation2017

    • Author(s)
      Maegawa KI, Watanabe S#, Noi K#, Okumura M#, Amagai Y#, Inoue M, Ushioda R, Nagata K, Ogura T, Inaba K.(#equal contribution)
    • Journal Title

      Structure.

      Volume: 25 Pages: 846-857

    • DOI

      10.1016/j.str.2017.04.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface2017

    • Author(s)
      Watanabe, S., Harayama, M., Kanemura, S., Sitia, R. and Inaba, K.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: in press Pages: 3224-3232

    • DOI

      10.1073/pnas.1621426114

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preparation of selenoinsulin as a long-lasting insulin analog2017

    • Author(s)
      Kenta Arai+, Toshiki Takei+, Masaki Okumura+, Satoshi Watanabe+, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, and Michio Iwaoka
    • Journal Title

      Angewandte Chemie Int. Ed.

      Volume: 印刷中 Pages: 5522-5526

    • DOI

      10.1002/anie.201701654

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Commun

      Volume: 8 Pages: 1-10

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120006365562

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] X線小角散乱解析が明らかにしたPDIファミリータンパク質ERp46及びPDI酸化酵素Ero1αの構造ダイナミクスと機能2017

    • Author(s)
      金村 進吾、奥村 正樹、稲葉 謙次
    • Journal Title

      分子研レターズ

      Volume: 76 Pages: 34-36

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The highly dynamic nature of ERdj5 is key to efficient elimination of aberrant protein oligomers through ER-associated degradation2017

    • Author(s)
      Maegawa, K., Watanabe, S., Noi, K., Okumura, M., Amagai, Y., Inoue, M., Ushioda, R., Nagata, K., Ogura, T. and Inaba, K.*
    • Journal Title

      Structure

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.2016

    • Author(s)
      Ushioda R, Miyamoto A, Inoue M, Watanabe S, Okumura M, Maegawa KI, Uegaki K, Fujii S, Fukuda Y, Umitsu M, Takagi J, Inaba K., Mikoshiba K, Nagata K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Pages: 6055-6063

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Human ER oxidoreductin-1a undergoes dual regulation through complementary redox interactions with protein-disulfide isomerase2016

    • Author(s)
      Kanemura, S., Okumura, M., Yutani, K., Ramming, T., Hikima, T., Appenzeller-Herzog, C. , Akiyama, S. and Inaba, K.*
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Pages: 23952-23964

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The membrane topology of Vitamin K Epoxide Reductase is conserved between human isoforms and the bacterial enzyme2016

    • Author(s)
      Cao, Z, van Lith, M., Mitchell, L. J., Pringle, M. A., Inaba, K. and Bulleid, N. J.
    • Journal Title

      Biochemical Journal

      Volume: 473 Pages: 851-858

    • DOI

      10.1042/bj20151223

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover2016

    • Author(s)
      T. Ramming, S. Kanemura, M. Okumura, K. Inaba and C. Appenzeller-Herzog.
    • Journal Title

      Redox Biology

      Volume: 7 Pages: 14-20

    • DOI

      10.1016/j.redox.2015.11.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] One-dimensional sliding of p53 along DNA is accelerated in the presence of Ca2+ or Mg2+ at millimolar concentrations.2015

    • Author(s)
      Murata A, Ito Y, Kashima R, Kanbayashi S, Nanatani K, Igarashi C, Okumura M, Inaba K, Tokino T, Takahashi S, Kamagata K
    • Journal Title

      J. Mol. Biol.

      Volume: 427 Pages: 2663-2678

    • DOI

      10.1016/j.jmb.2015.06.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural Basis of a Ni Acquisition Cycle for [NiFe]-Hydrogenase by HypA and Its Enhancer2015

    • Author(s)
      Watanabe, S., Kawashima, T., Nishitani, Y., Kanai, T., Wada, T., Inaba, K., Atomi, H., Imanaka, T. and Miki, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Pages: 7701-7706

    • DOI

      10.1073/pnas.1503102112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A PDI-catalyzed thiol/disulfide switch regulates the production of hydrogen peroxide by human Ero1.2015

    • Author(s)
      T. Ramming, M. Okumura, S. Kanemura, S. Baday, J. Birk, S. Moes, P. Jenö, S. Bernèche, K. Inaba and C. Appenzeller-Herzog.
    • Journal Title

      Free Radic. Biol. Med.

      Volume: 83 Pages: 361-372

    • DOI

      10.1016/j.freeradbiomed.2015.02.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum.2015

    • Author(s)
      Okumura M, Kadokura H, Inaba K.
    • Journal Title

      Free Rad. Biol. Med

      Volume: 83 Pages: 314-322

    • DOI

      10.1016/j.freeradbiomed.2015.02.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 新規PDIファミリータンパク質ERp46の構造と機能2015

    • Author(s)
      奥村 正樹、金村 進吾、稲葉 謙次
    • Journal Title

      日本生物物理学会会報誌

      Volume: 55 Pages: 34-36

    • NAID

      130004794735

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the functional interplay between ER oxidoreduclin-1α (Ero1α) and protein disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.2014

    • Author(s)
      Okumura M, Kadokura H, Hashimoto S, Yutani K, Kanemura S, Hikima T, Hidaka Y, Ito L, Shiba K, Masui S, Imai D, Imaoka S, Yamaguchi H, Inaba K
    • Journal Title

      J. Biol Chem.

      Volume: 26 Pages: 27004-27018

    • DOI

      10.1074/jbc.m114.564104

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Progressive quality control of secretory proteins in the early secretory compartment by ERp44.2014

    • Author(s)
      Sannino S, Anelli T, Cortini M, Masui S, Degano M, Fagioli C, Inaba K, Sitia R
    • Journal Title

      J. Cell. Sci.

      Volume: 127 Pages: 4260-4269

    • DOI

      10.1242/jcs.153239

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radically Different Thioredoxin Domain Arrangement of ERp46, an Efficient Disulfide Bond Introducer of the Mammalian PDI Family.2014

    • Author(s)
      Kojima, R., Okumura, M., Masui. S., et al.
    • Journal Title

      Structure

      Volume: 22 Pages: 431-443

    • DOI

      10.1016/j.str.2013.12.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 哺乳動物細胞の小胞体におけるジスルフィド結合形成ネットワークの構造基盤2014

    • Author(s)
      奥村正樹、稲葉謙次
    • Journal Title

      実験医学(羊土社)

      Volume: 32 Pages: 208-215

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト細胞小胞体機能の低下を鋭敏に検出するレポーターの開発と応用2019

    • Author(s)
      八巻聡、河野憲二、稲葉謙次、門倉広
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanistic basis and physiological functions of GPx7 and GPx8, newly identified PDI oxidases, in the mammalian endoplasmic reticulum2019

    • Author(s)
      Elza Firdiani Sofia, Shingo Kanemura, Hiroshi Kadokura, Masaki Okumura, Kenji Inaba
    • Organizer
      第19回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Observing co-translational oxidative folding of a cell surface protein in the ER of mammalian cell2018

    • Author(s)
      Hiroshi Kadokura
    • Organizer
      International Symposium on“Proteins; from the Cradle to the Grave”, Shiga, Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Physiological substrates of PDIp, a pancreas-specific protein disulfide isomerase family member protein2018

    • Author(s)
      Takushi Fujimoto, Orie Nakamura, Michiko Saito, Akio Tsuru, Masaki Matsumoto, Kenji Kohno, Kenji Inaba, Hiroshi Kadokura
    • Organizer
      FASEB conference, Protein Folding in the Cell
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological function of PDIp, a pancreas-specific protein disulfide isomerase family member protein2018

    • Author(s)
      Takushi Fujimoto, Orie Nakamura, Michiko Saito, Akio Tsuru, Masaki Matsumoto, Kenji Kohno, Kenji Inaba, Hiroshi Kadokura
    • Organizer
      5th CWRU-Tohoku Joint Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observing co-translational oxidative folding of a cell surface protein in the ER of mammalian cells2018

    • Author(s)
      Yo Fukuda, Yui Dazai, Naoya Hirai, Orie Nakamura, Kenji Inaba, and Hiroshi Kadokura
    • Organizer
      International Symposium on“Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of physiological function of PDIp, a pancreas-specific protein disulfide isomerase family member protein2018

    • Author(s)
      Takushi Fujimoto, Orie Nakamura, Michiko Saito, Akio Tsuru, Masaki Matsumoto, Kenji Kohno, Kenji Inaba, and Hiroshi Kadokura
    • Organizer
      International Symposium on“Proteins; from the Cradle to the Grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanistic basis of hydrogen peroxide-dependent PDI family oxidation catalyzed by GPx7 and GPx82018

    • Author(s)
      Elza Firdiani Sofia, Shingo Kanemura, Hiroshi Kadokura, Masaki Okumura, Kenji Inaba
    • Organizer
      International Symposium on New Horizon in Advanced Materials Tohoku University-Taipei Tech Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zinc ions regulate ERp44-mediated protein quality control in the early secretory pathway2018

    • Author(s)
      Kenji Inaba
    • Organizer
      International Meeting “Proteins: from the cradle to the grave
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Zinc ions regulate ERp44-dependent protein quality control in the early secretory pathway2018

    • Author(s)
      Kenji Inaba
    • Organizer
      International Symposium on New Horizon in Advanced Materials Tohoku University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Zinc ions have a new physiological role in protein quality control in the early secretory pathway2018

    • Author(s)
      Kenji Inaba
    • Organizer
      CWRU-Tohoku joint symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural basis of zinc-dependent ERp44 regulation for protein quality control in the early secretory pathway2018

    • Author(s)
      Satoshi Watanabe, Yuta Amagai, Sara Sannino, Manami Harayama, Shoji Masui, Momo Yamada, Roberto Sitia, and Kenji Inaba
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zn2+ controls the function of ERp44 in the early secretory pathway2018

    • Author(s)
      Yuta Amagai, Satoshi Watanabe, Sara Sannino, Momo Yamada, Tiziana Tempio, Manami Harayama, Roberto Sitia and Kenji Inaba
    • Organizer
      International Symposium on “Proteins; from the Cradle to the Grave
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural and mechanistic insights into substrate recognition by P5, a member of PDI family2018

    • Author(s)
      M. Okumura, S. Kanemura, M. Matsusaki, M. Kinoshita, K. Arai, S. Akiyama, and K. Inaba
    • Organizer
      International Symposium on “Proteins ; from the cradle to the grave
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of molecular mechanisms of PDI family enzymes acting on nascent chains in early-stage of translation2018

    • Author(s)
      Chihiro Hirayama, Masaki Okumura, Kodai Machida, Kentro Noi, Teru Ogura, Hiroaki Imataka, Kenji Inaba
    • Organizer
      International Meeting “Proteins: from the cradle to the grave”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the Zinc Transporter critical for regulation of ERp44, a key protein quality controller in the early secretory pathway2018

    • Author(s)
      Momo Yamada, Yuta Amagai, Satoshi Watanabe, Roberto Sitia, Kenji Inaba
    • Organizer
      International Symposium on New Horizon in Advanced Materials Tohoku University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanistic basis of hydrogen peroxide-dependent PDI family oxidation catalyzed by GPx7 and GPx82018

    • Author(s)
      Elza Firdiani Sofia, Shingo Kanemura, Hiroshi Kadokura, Masaki Okumura, Kenji Inaba
    • Organizer
      International Symposium on Proteins: From the Cradle to the Grave
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular basis of the ERp44-Zn2+ cooperation for protein quality control in the early secretory pathway2018

    • Author(s)
      Kenji Inaba
    • Organizer
      第91回日本生化学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ERp44の機能制御に関わる亜鉛トランスポーターの同定2018

    • Author(s)
      山田 桃、天貝佑太、渡部 聡、Roberto Sitia、稲葉 謙次
    • Organizer
      第41回分子日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Structural basis of pH- and zinc-dependent multiple client recognition by ERp442018

    • Author(s)
      Watanabe S., Amagai Y. Sitia R. Inaba K
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 筋小胞体カルシウムATPアーゼSERCA2bの膜貫通ヘリックス相互作用による制御機構の構造基盤2018

    • Author(s)
      井上 道雄、作田 菜奈美、渡部 聡、田中 良樹、潮田 亮、加藤 幸成、高木 淳一、塚崎 智也、永田 和宏、稲葉 謙次
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 初期分泌経路内のタンパク質品質管理におけるERp44の新たな生理的機能の探索2018

    • Author(s)
      天貝佑太、稲葉謙次
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小胞体内腔における新生のジスルフィド結合形成反応の解析2018

    • Author(s)
      金村進吾、奥村正樹、Neil Bulleid、稲葉謙次
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] P5による基質認識の分子構造基盤2018

    • Author(s)
      奥村正樹、金村進吾、松崎元紀、荒井堅太、秋山修志、稲葉謙次
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Newly identified insight into mechanism by which PDI/ERp46 catalyze oxidative protein folding of nascent chain2018

    • Author(s)
      平山千尋、奥村正樹、町田幸大、野井健太郎、小椋光、今高寛晃、稲葉謙次
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Structure and mechanisms of substrate recognition of P5, a member of the PDI family2018

    • Author(s)
      奥村正樹、金村進吾、松崎元紀、木下岬、荒井堅太、秋山修志、稲葉謙次
    • Organizer
      第41回日本分子生物学学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Observing co-translational oxidative folding of a cell surface protein in the ER of mammalian cells2018

    • Author(s)
      Yo Fukuda, Yui Dazai, Naoya Hirai, Orie Nakamura, Kenji Inaba, Hiroshi Kadokura
    • Organizer
      CLS, Tokyo Tech. International Forum 2018 “Redox regulation of protein functions, transcription, translation and folding、東京工業大学キャンパス・イノベーションセンター
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The highly dynamic nature of ERdj5 plays a key role in efficient ER-associated degradation of aberrant protein oligomers2018

    • Author(s)
      Inaba, K.
    • Organizer
      CLS Tokyo Inst Tech, International Forum
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 哺乳動物細胞小胞体内におけるLDL受容体新生ポリペプチド鎖の酸化的フォールディング機構の解析2017

    • Author(s)
      太宰 結、中村織江、稲葉謙次、門倉 広
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] LDL受容体の新生ポリペプチド鎖におけるジスルフィド結合形成機構の解析2017

    • Author(s)
      福田 洋,太宰 結,中村織江,稲葉謙次,門倉 広
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cotranslational oxidative folding of a cell surface membrane protein in mammalian cells2017

    • Author(s)
      Yui Dazai, Orie Nakamura, Yo Fukuda, Kenji Inaba, Hiroshi Kadokura
    • Organizer
      International Symposium on Protein Quality Control
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Observing cotranslational oxidative folding of a cell surface membrane protein2017

    • Author(s)
      Hiroshi Kadokura
    • Organizer
      Microbial Genetics and Genomics VI
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural basis of redox-dependent regulation of Sarco/Endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b)2017

    • Author(s)
      Inaba, K.
    • Organizer
      The 55th Annual Meeting of Japan Biophysical Society
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] How do PDI family members act on nascent chains to catalyze their oxidative folding?2017

    • Author(s)
      Okumura, M., Hirayama, C., Noi, K., Machida, K., Imataka, H., Ogura, T. and Inaba, K.
    • Organizer
      The 17th Annual Meeting of Japan Protein Science Society
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Zn-dependent regulation of the protein quality control by ERp44 in the early secretory pathway2016

    • Author(s)
      Harayama, M., Watanabe, S., Amagai, Y., Sannino, S., Sitia, R., Inaba, K
    • Organizer
      第39回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] PDIとのレドックス相互作用を介したEro1aの二重の酸化活性制御機構2016

    • Author(s)
      金村 進吾, 奥村 正樹, 油谷 克英, Thomas Ramming, 引間 孝明, Christian Appenzeller-Herzog, 秋山 修志, 稲葉 謙次
    • Organizer
      第39回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸化的フォールディングの触媒過程にみられるPDIの動的な結合・解離2016

    • Author(s)
      奥村 正樹, 野井 健太郎, 金村 進吾, 引間 孝明, 秋山 修志, 小椋 光, 稲葉 謙次
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小胞体カルシウムポンプSERCA2bの活性制御機構の解析2016

    • Author(s)
      柳澤孝俊, 井上道雄, 作田菜奈美, 潮田亮, 永田和宏, 稲葉謙次
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ERdj5とBiPの共役による酸化的フォールディング触媒機構の解明2016

    • Author(s)
      大村 圭一, 奥村 正樹, 前川 憲一, 金村 進吾, 井上 道雄, 潮田 亮, 永田 和宏, 稲葉 謙次
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 哺乳動物細胞小胞体におけるLDLレセプター新生ポリペプチド鎖の酸化的フォールディング機構2016

    • Author(s)
      太宰 結、稲葉謙次、門倉 広
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分泌タンパク質の品質管理に関与する ERp44 の pH と亜鉛イオンによる機能制御の構造基盤2016

    • Author(s)
      渡部 聡,原山麻奈美,天貝佑太,増井翔史,金村進吾,SaraSannino, Roberto Sitia, 稲葉謙次
    • Organizer
      平成28年度 日本結晶学会年会
    • Place of Presentation
      茨城県立県民文化センター(茨城県水戸市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dynamic assembly/disassembly of Protein Disulfide Isomerase during the catalysis of oxidative protein folding.2016

    • Author(s)
      Okumura, M., Noi, K., Kanemura, S., Hikima, T., Akiyama, S., Ogura, T., Inaba, K
    • Organizer
      EMBO Meeting 2016
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual regulation of human Ero1 via redox interplays with PDI2016

    • Author(s)
      Kanemura, S., Okumura, M., Yutani, K., Ramming, T., Appenzeller-Herzog, C. Akiyama, S., Inaba, K
    • Organizer
      EMBO Meeting 2016
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小胞体タンパク質品質管理に関与するERp44のpHと亜鉛イオンによる機能制御2016

    • Author(s)
      渡部 聡, 原山麻奈美, 天貝佑太, 増井翔史, Sara Sannino, Roberto Sitia, 稲葉謙次
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター 東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵特異的に発現しているPDIファミリータンパク質(PDIp)の生理的な機能の解析2016

    • Author(s)
      藤本拓志、斎藤美知子、都留秋雄、松本雅記、河野憲二、稲葉謙次、門倉 広
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター 東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] How do PDI family member proteins act on unfolded/misfolded proteins to ensure protein quality control in the early secretory pathway?2016

    • Author(s)
      Inaba, K
    • Organizer
      Nascent chain biology meeting 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Observing disulfide bond formation in a cell surface protein as the polypeptide chain elongates from the ribosome in mammalian cells2016

    • Author(s)
      Kadokura, H
    • Organizer
      Nascent chain biology meeting 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic assembly/disassembly of Protein Disulfide Isomerase during the catalysis of oxidative protein folding2016

    • Author(s)
      Okumura, M., Noi, K., Kanemura, S., Hikima, T., Akiyama, S., Ogura, T., Inaba, K
    • Organizer
      Nascent chain biology meeting 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human Ero1 undergoes dual regulation via redox interplays with PDI2016

    • Author(s)
      Kanemura, S., Okumura, M., Yutani, K., Ramming, T., Appenzeller-Herzog, C. Akiyama, S., Inaba, K
    • Organizer
      Nascent chain biology meeting 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural basis of pH- and zinc-dependent protein quality control by ERp442016

    • Author(s)
      Watanabe, S., Harayama, M., Amagai, Y., Sannino, S. Masui, S., Sitia, R. and Inaba, K.
    • Organizer
      Nascent Chain Biology 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological function of pancreas-specific PDI family protein (PDIp)2016

    • Author(s)
      Fujimoto, T., Saito, M., Tsuru, A., Matsumoto, M., Kohno, K., Inaba, K. and Kadokura, H.
    • Organizer
      Nascent Chain Biology 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of oxidative folding of newly-synthesized LDL receptor in the ER of mammalian cells2016

    • Author(s)
      Dazai, Y., Inaba, K. and Kadokura, H.
    • Organizer
      Nascent Chain Biology 2016
    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸化的フォールディングを支えるPDIファミリー酵素の新規触媒機構の解明2016

    • Author(s)
      奥村正樹, 野井健太郎, 金村進吾, 引間孝明, 秋山修志, 小椋光, 稲葉謙次
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 哺乳動物分泌蛋白質の新生鎖上にジスルフィド結合を形成する仕組み2016

    • Author(s)
      門倉 広、稲葉謙次
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 膵特異的に発現しているPDIファミリータンパク質(PDIp)の生理的な基質の同定2016

    • Author(s)
      藤本拓志、斎藤美知子、都留秋雄、松本雅記、河野憲二、稲葉謙次、門倉広
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 亜鉛イオンによるERp44を介した小胞体タンパク質品質管理機構の分子基盤2016

    • Author(s)
      渡部 聡, 原山麻奈美, 天貝佑太, 増井翔史, Sara Sannino, Roberto Sitia, 稲葉謙次
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膵臓特異的に発現しているPDIファミリータンパク質(PDIp)の生理的な機能の解析2015

    • Author(s)
      藤本拓志、斎藤美知子、都留秋雄、松本雅記、河野憲二、稲葉謙次、門倉広
    • Organizer
      第38回 日本分子生物学会年会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高速AFMが明らかにしたPDIによる基質の酸化的フォールディング触媒機構の解明2015

    • Author(s)
      奥村 正樹、野井 健太郎、金村 進吾、秋山 修志、小椋 光、稲葉 謙次
    • Organizer
      第38回 日本分子生物学会年会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] PDI酸化酵素Ero1αのCys208-Cys241ジスルフィド結合の開裂を介した新規活性化機構2015

    • Author(s)
      金村 進吾、奥村 正樹、油谷 克英、Thomas Ramming、引間 孝明、Sefer Baday、 Simon Bernèche、秋山 修志、Christian Appenzeller-Herzog、稲葉 謙次
    • Organizer
      第38回 日本分子生物学会年会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dynamic natures of PDI family members in catalysis of oxidative protein folding and ER associated degradation2015

    • Author(s)
      Inaba, K
    • Organizer
      Symposium: From cytosol to ER; Translation, translocation and modification
    • Place of Presentation
      東北大学片平キャンパス(宮城県仙台市)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms of disulfide bond formation in nascent polypeptide chains in the ER of mammalian cells2015

    • Author(s)
      Kadokura, H
    • Organizer
      Symposium: From cytosol to ER; Translation, translocation and modification
    • Place of Presentation
      東北大学片平キャンパス(宮城県仙台市)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preparations and Crystallizations of ER calcium storage protein Calsequestrin, its anchor protein Junctin and their complex2015

    • Author(s)
      Watanabe, A., Watanabe, S., Kanemura, S., Okumura, M., Inaba, K
    • Organizer
      Campus Asia Symposium 2015
    • Place of Presentation
      上海、中国
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic natures of PDI family member proteins that act on nascent chains in the endoplasmic reticulum2015

    • Author(s)
      Inaba, K
    • Organizer
      Nascent chain biology meeting 2015
    • Place of Presentation
      東京大学弥生講堂一条ホール(東京都文京区)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Real-time monitoring of PDI-catalyzed oxidative protein folding by high-speed atomic force microscopy2015

    • Author(s)
      奥村正樹、野井健太郎,金村進吾、増井翔史、引間孝明、秋山修志、小椋光、稲葉謙次
    • Organizer
      第53回 生物物理学会年会
    • Place of Presentation
      金沢大学角間キャンパス自然科学本館(石川県金沢市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Dynamic natures of PDI family members in catalysis of oxidative protein folding and ER associated degradation2015

    • Author(s)
      Inaba, K
    • Organizer
      EMBO meeting 2015
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic natures of PDI family members in catalysis of oxidative protein folding and ER associated degradation2015

    • Author(s)
      Inaba, K
    • Organizer
      Case Western Reserve University-Tohoku University joint symposium
    • Place of Presentation
      Cleaveland, USA
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] インスリンと相互作用するPDIファミリータンパク質の同定2015

    • Author(s)
      金谷健太郎、土屋雄一、河野憲二、稲葉謙次、門倉広
    • Organizer
      第67回 日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵特異的に発現するPDIファミリータンパク質(PDIp)の生理的機能の解析2015

    • Author(s)
      藤本拓志、斎藤美知子、都留秋雄、河野憲二、稲葉謙次、門倉広
    • Organizer
      第67回 日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小胞体タンパク質品質管理に関わるERp44のpH依存的な構造ダイナミクス2015

    • Author(s)
      渡部 聡、増井翔史、稲葉謙次
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高速AFM が明らかにするPDI による酸化的フォールディングの触媒機構2015

    • Author(s)
      奥村正樹、野井健太郎、金村進吾、増井翔史、引間孝明、秋山修志、小椋光、稲葉謙次
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト由来ジスルフィド結合形成酵素Ero1 αの新たな活性制御機構2015

    • Author(s)
      金村進吾、奥村正樹、油谷克英、Ramming, T.、引間孝明、Baday, S.、Berneche, S.、秋山修志、Appenzeller-Herzog, C.、稲葉謙次
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小胞体内のカルシウム貯蔵に関わる Calsequestrin とそのアンカータンハク質 Junctin の複合体の結晶化を目指した相互作用解析2015

    • Author(s)
      渡邊 あゆ美・渡部 聡・稲葉 謙次
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dual conformations of ERdj5 play a significant role in acceleration of the ER associated degradation.2015

    • Author(s)
      Inaba, K.
    • Organizer
      ER & Redox club meeting
    • Place of Presentation
      Venice, Italy
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time monitoring of PDI-catalyzed oxidative protein folding by high-speed atomic force microscopy2015

    • Author(s)
      Okumura, M., Noi, K., Kanemura, S., Masui, S., Hikima, T., Akiyama, S., Ogura, T. and Inaba, K.
    • Organizer
      ER & Redox club meeting
    • Place of Presentation
      Venice, Italy
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A newly identified disulfide bond in regulation of human Ero1α2015

    • Author(s)
      Kanemura, S., Okumura, M., Ramming, T., Baday, S., Bernèche, S., Appenzeller-Herzog, C. and Inaba, K.
    • Organizer
      ER & Redox club meeting
    • Place of Presentation
      Venice, Italy
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural and mechanistic basis of the protein disulfide bond formation system in mammalian cells2014

    • Author(s)
      Kenji Inaba
    • Organizer
      The 15th RIES-Hokudai International Symposium
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ、札幌
    • Year and Date
      2014-12-16
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural and mechanistic basis of the protein disulfide bond formation system in mammalian cells2014

    • Author(s)
      Kenji Inaba
    • Organizer
      The 7th Korea-Japan Seminars on Biomolecular Sciences
    • Place of Presentation
      Korea Institute for Advanced Study、大韓民国ソウル
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 構造が解き明かす細胞のタンパク質品質管理の仕組み2014

    • Author(s)
      稲葉 謙次
    • Organizer
      第19回東北大学学際ライフサイエンスシンポジウム
    • Place of Presentation
      東北大学 片平キャンパス、仙台
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 分泌タンパク質新生ポリペプチド鎖にジスルフィド結合を形成する仕組み2014

    • Author(s)
      門倉 広、稲葉謙次
    • Organizer
      日本生化学会年会
    • Place of Presentation
      京都国際会館、京都
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structural and mechanistic basis of the protein disulfide bond formation system in mammalian cells2014

    • Author(s)
      Kenji Inaba
    • Organizer
      日本生化学会年会
    • Place of Presentation
      京都国際会館、京都
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Structural and mechanistic basis of the protein disulfide bond formation system in mammalian cells2014

    • Author(s)
      Kenji Inaba
    • Organizer
      Tohoku University Chemistry Summer School
    • Place of Presentation
      東北大学 青葉山キャンパス、仙台
    • Year and Date
      2014-08-24
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞のタンパク質品質管理の仕組み―構造生物学と細胞生物学の融合を目指して2014

    • Author(s)
      稲葉 謙次
    • Organizer
      生体関連化学サマースクール
    • Place of Presentation
      ラフォーレ蔵王、蔵王
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Oxidative folding of proteins 2nd Edition2018

    • Author(s)
      Okumura, M., Watanabe, S. and Inaba, K.
    • Total Pages
      25
    • Publisher
      Royal Chemical Society
    • ISBN
      9781782629900
    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学多元物質科学研究所生体分子構造研究分野 稲葉研究室

    • URL

      http://www2.tagen.tohoku.ac.jp/lab/inaba/html/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科|稲葉謙次

    • URL

      https://www.lifesci.tohoku.ac.jp/research/teacher/detail---id-16689.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科|門倉 広

    • URL

      https://www.lifesci.tohoku.ac.jp/research/teacher/detail---id-19734.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学多元物質科学研究所 稲葉研究室

    • URL

      http://www.tagen.tohoku.ac.jp/labo/inaba/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科 | 稲葉謙次

    • URL

      https://www.lifesci.tohoku.ac.jp/research/teacher/detail.html?id=16689

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科 | 門倉 広

    • URL

      https://www.lifesci.tohoku.ac.jp/research/teacher/detail.html?id=19734

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科 | 稲葉謙次

    • URL

      http://www.lifesci.tohoku.ac.jp/teacher/t_inaba/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科 | 門倉 広

    • URL

      http://www.lifesci.tohoku.ac.jp/teacher/h_kadokura/

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 新規人工インスリン「セレノインスリン」の化学合成と機能解明に成功

    • URL

      http://www2.tagen.tohoku.ac.jp/lab/news_press/20170411/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学 多元物質科学研究所 稲葉研究室

    • URL

      http://www.tagen.tohoku.ac.jp/labo/inaba/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院 生命科学研究科 分子生命科学専攻 : (協力講座)生体機能分子科学講座 稲葉謙次

    • URL

      http://www.lifesci.tohoku.ac.jp/teacher/t_inaba/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院 生命科学研究科 分子生命科学専攻 : (協力講座)生体機能分子科学講座 門倉 広

    • URL

      http://www.lifesci.tohoku.ac.jp/teacher/h_kadokura/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] タンパク質のリフォールディング剤、タンパク質のリフォールディング方法及びタンパク質の再生方法2018

    • Inventor(s)
      村岡 貴博、岡田 隼輔、奥村 正樹、稲葉 謙次、松﨑 元紀
    • Industrial Property Rights Holder
      村岡 貴博、岡田 隼輔、奥村 正樹、稲葉 謙次、松﨑 元紀
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] Nascent Chain Biology Meeting 20162016

    • Place of Presentation
      富士レークホテル(山梨県富士河口湖町)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report

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Published: 2014-11-20   Modified: 2021-02-19  

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