| Budget Amount *help |
¥237,250,000 (Direct Cost: ¥182,500,000、Indirect Cost: ¥54,750,000)
Fiscal Year 2018: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2017: ¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2016: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2015: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2014: ¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
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| Outline of Final Research Achievements |
We succeeded in expanding the large-scale imaging genomic DNA omics cohort for healthy aging to 1400 cases. Using this unique database, we will clarify the dynamic changes of the human brain networks to maintain cognitive function against healthy aging. We also developed novel imaging biomarker based on brain network findings for the early diagnosis and treatment of neurodegenerative dementia. Besides, using iPSCs and animals, a new dementia model has been successfully created to show that protein dysfunction is one of the earliest phenomena of the dementia process. We clarified that loss of function of a specific protein is vital for the onset of pathological conditions. Furthermore, we have obtained results that will lead to the development of future disease-modifying therapy of neurodegenerative dementia.
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