• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

タウのタンパク質老化と毒性機序

Planned

Project AreaPrevention of brain protein aging and dementia
Project/Area Number 26117004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionGakushuin University (2016-2018)
National Center for Geriatrics and Gerontology (2014-2015)

Principal Investigator

高島 明彦  学習院大学, 理学部, 教授 (00154774)

Co-Investigator(Kenkyū-buntansha) 久永 眞市  首都大学東京, 理工学研究科, 教授 (20181092)
石垣 診祐  名古屋大学, 医学系研究科, 寄附講座助教 (40378170)
宮坂 知宏  同志社大学, 生命医科学部, 准教授 (90342857)
池川 雅哉  同志社大学, 生命医科学部, 教授 (60381943)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Granted (Fiscal Year 2018)
Budget Amount *help
¥237,250,000 (Direct Cost: ¥182,500,000、Indirect Cost: ¥54,750,000)
Fiscal Year 2018: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2017: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2016: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2015: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2014: ¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
Keywords神経科学 / 脳神経疾患 / 老化 / タウタンパク質 / Aβ / 認知症 / 脳機能 / 凝集 / リン酸化 / 神経細胞死 / タウ / 局在 / 過活動 / 樹状突起
Outline of Annual Research Achievements

計画研究班はアルツハイマー病研究の初期からタウタンパク質が認知症を引き起こす原因であると考えてこれまで研究を行い、タウを過剰にリン酸化する酵素の発見、タウ凝集機構を明らかにしてきた。認知症治療を考える上で加齢に伴う正常タンパクから病原タンパクへと転換するタンパク質老化機構を明らかにする目的で研究を行っている。
今年度、タウの軸索局在機構としてタウの軸索局在に関与するドメインとして PRR2 領域を同定した。生後1日目のマウス脳より微小管非結合画分を調製し、共免疫沈降法によりタウと結合しているタンパク質群の同定を行なった結果、タウ分子には複数のチューブリンおよび、タンパク質翻訳にかかわる多くの因子の結合が認められこれらがタウタンパク質の軸索局在に寄与することが示唆された。
タウタンパク質の新たな生理機能を探索する目的でタウ遺伝子ノックアウト(KO)マウスを調べたところ、タウKOマウスの摂食量増大が観察された。この原因をさらに検討した結果中脳腹側被蓋野における神経活動が亢進が観察され報酬系の異常に伴う摂食量の亢進に起因している可能性を示唆した。
脳発達期におけるタウのリン酸化とアイソフォームの変化についてマウス脳を用いて解析した。その結果、生後、高リン酸化されたタウは速やかに脱リン酸化され、0N3Rから0N4Rへ変化する。甲状腺ホルモン合成阻害剤(MMI)をマウスに与えたところ発達遅延に伴って脱リン酸化時期が遅延するが0N3Rから0N4Rへの変化時期は変わらなかったことから、タウのリン酸化とアイソフォーム変化は異なる制御を受けていることが示された。
タウ凝集について15種類の異なるFTDP-17変異を持つヒトリコンビナントタウの凝集を経時的に観察し、野生型タウと比較したところ顆粒状タウオリゴマーの増大が全ての変異体に共通する凝集体であることが明らかになった。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

これまで毎年、計画班内ミーティングを行い、互いの研究進捗、アイデアを共有し、タウタンパク質の生理機能、リン酸化から凝集に至る機構を明らかにするため共同研究を進めている。具体的には共通に必要な抗体作成、スクリーニングを行い、それらを共有して使用している。宮坂、石垣、高島、久永らはこれまでの成果を論文にまとめ報告し、残る新たなテーマに取り組んでいる。ここまでにタウの局在機構、異常局在機構について神経細胞の過興奮によってタウmRNAからタウ蛋白への翻訳促進が起こりタウのsomatodendriteへの異常局在が起こるという新たな知見を得ている。この異常局在からタウ過剰リン酸化、凝集について今年度検討を行ない、タウの局在変化から凝集に至る分子機構を解明するところまで漕ぎついている。さらに、タウの新たな生理機能が明らかになりつつあることから、当初目標に対して順調に進展していると考えている。

Strategy for Future Research Activity

・複合体の全容解明から生理的タウの存在様式を決定することにより、改めて毒性タウを定義する。さらに、タウオパチー神経の特徴である、タウの異常化と微小管の消失の関係について新たなモデルを構築し、解析する。
・ヒト脳及びアルツハイマー病患者脳を用いて、GSK3β活性とタウの異常リン酸化の関連を調べていく。アイソフォーム変化に関わるスプライシング機構を解析する。
・DREADDのシステムや電気生理学的な解析などを通じて、どのような報酬系の経路がタウの喪失に脆弱になって摂食異常に関与するのかを明らかにしていく。
・毒性タウ凝集体の決定、細胞死機構を決定し、樹状突起において観察されるタウの過剰発現から細胞死に至る過程を明らかにする。
・論文化を促進する

Report

(4 results)
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(165 results)

All 2018 2017 2016 2015 2014

All Journal Article Presentation Patent(Industrial Property Rights)

  • [Journal Article] Silencing of FUS in the common marmoset ( Callithrix jacchus ) brain via stereotaxic injection of an adeno-associated virus encoding shRNA2018

    • Author(s)
      Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G
    • Journal Title

      Neurosci Res.

      Volume: in press Pages: 30183-9

    • DOI
      10.1016/j.neures.2017.08.006
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018

    • Author(s)
      Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
    • Journal Title

      J Biol Chem

      Volume: 293 Pages: 1781-1793

    • DOI
      10.1074/jbc.m117.798918
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy.2018

    • Author(s)
      Kimura, T., Sharma, G., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Front Neurosci.

      Volume: 12 Pages: 44-44

    • DOI
      10.3389/fnins.2018.00044
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.2017

    • Author(s)
      Maekawa M、Watanabe A、Iwayama Y、Kimura T、Hamazaki K、Balan S、Ohba H、Hisano Y、Nozaki Y、Ohnishi T、Toyoshima M、Shimamoto C、Iwamoto K、Bundo M、Osumi N、Takahashi E、Takashima A、Yoshikawa T
    • Journal Title

      Transl Psychiatry

      Volume: 7

    • DOI
      10.1038/tp.2017.182
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice2017

    • Author(s)
      Umcda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
    • Journal Title

      Acta Neuropathol Commun

      Volume: 5 Pages: 59-59

    • DOI
      10.1186/s40478-017-0461-5
    • NAID
      120006371271
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local somatodendritic translation and hyperphosphorylation of tau protein triggered by AMPA and NMDA receptor stimulation.2017

    • Author(s)
      Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F. X. Almeida, Akihiko Takashima
    • Journal Title

      EBio Medicine

      Volume: 印刷中 Pages: 120-126

    • DOI
      10.1016/j.ebiom.2017.05.012
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease.2017

    • Author(s)
      Ano Y, Dohata A, Taniguchi Y, Hoshi A, Uchida K, Takashima A, Nakayama H.
    • Journal Title

      J Biol Chem.

      Volume: 292 Pages: 3720-3728

    • DOI
      10.1074/jbc.m116.763813
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered tau isoform ratio caused by loss of FUS and SFPQ function leads to FTLD-like phenotypes2017

    • Author(s)
      Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
    • Journal Title

      Cell Report

      Volume: 18 Pages: 1118-1131

    • DOI
      10.1016/j.celrep.2017.01.013
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging2017

    • Author(s)
      Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima A, Maruyama K, Hirasawa A, Awaji T.
    • Journal Title

      Mol Brain.

      Volume: 10 Pages: 2-2

    • DOI
      10.1186/s13041-016-0282-7
    • NAID
      120005971848
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43?kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis2017

    • Author(s)
      Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 76(9) Pages: 759-768

    • DOI
      10.1093/jnen/nlx055
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3′UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M.
    • Journal Title

      Cell Rep.

      Volume: 20(13) Pages: 3071-3084

    • DOI
      10.1016/j.celrep.2017.08.100
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered GluA1 ( Gria1 ) Function and Accumbal Synaptic Plasticity in the Clock Δ19 Model of Bipolar Mania2017

    • Author(s)
      Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y, McClung CA.
    • Journal Title

      Biol Psychiatry

      Volume: S0006 Pages: 31721-3

    • DOI
      10.1016/j.biopsych.2017.06.022
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry2017

    • Author(s)
      Kakuda N, Miyasaka T, Iwasaki N, Nirasawa T, Wada-Kakuda S, Takahashi-Fujigasaki J, Murayama S, Ihara Y, Ikegawa M.
    • Journal Title

      Acta Neuropathol Commun

      Volume: 5 Issue: 1 Pages: 73-73

    • DOI
      10.1186/s40478-017-0477-x
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy.2017

    • Author(s)
      Oka Mikiko、Fujisaki Naoki、Maruko-Otake Akiko、Ohtake Yosuke、Shimizu Sawako、Saito Taro、Hisanaga Shin-Ichi、Iijima Koichi M、Ando Kanae
    • Journal Title

      J Biochem.

      Volume: 162 Pages: 335-342

    • DOI
      10.1093/jb/mvx038
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains2017

    • Author(s)
      Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 8602-8602

    • DOI
      10.1038/s41598-017-09239-5
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga SI.
    • Journal Title

      J Neurosci.

      Volume: 37 Pages: 790-806

    • DOI
      10.1523/jneurosci.2197-16.2016
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production2017

    • Author(s)
      Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga S, Murayama S, Hashimoto Y, Manya H, Endo, T.
    • Journal Title

      J Biochem.

      Volume: 161 Issue: 1 Pages: 99-111

    • DOI
      10.1093/jb/mvw056
    • NAID
      40021091544
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析2017

    • Author(s)
      木村妙子、久永眞市
    • Journal Title

      電気泳動

      Volume: 61 Pages: 49-52

    • NAID
      130006207357
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdk5の多彩な機能-神経細胞から非神経系2017

    • Author(s)
      斎藤太郎、久永眞市
    • Journal Title

      生化学

      Volume: 89 Pages: 710-718

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of Tau by 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation2016

    • Author(s)
      Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Pages: 22714-22720

    • DOI
      10.1074/jbc.m116.734350
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mechanism of neurodegeneration through tau and therapy for Alzheimer disease.2016

    • Author(s)
      Takashima A
    • Journal Title

      Journal of Sport and Health Science

      Volume: 5 Pages: 391-392

    • DOI
      10.1016/j.jshs.2016.08.009
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated2016

    • Author(s)
      Ando K, Oka M, Ohtake M, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 478 (2) Pages: 929-34

    • DOI
      10.1016/j.bbrc.2016.08.053
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants2016

    • Author(s)
      Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 33479-33479

    • DOI
      10.1038/srep33479
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons2016

    • Author(s)
      Sharma S, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura T, Hisanaga S.
    • Journal Title

      Genes Cells.

      Volume: 21 Pages: 1080-1094

    • DOI
      10.1111/gtc.12404
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.2016

    • Author(s)
      Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 18675-18688

    • DOI
      10.1074/jbc.m116.734707
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Synuclein fibrils exhibit gain-of-toxic-function, promoting tau aggregation and inhibiting microtubule assembly.2016

    • Author(s)
      Oikawa T, Nonaka T, Hisanaga S, Hasegawa M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 15046-15056

    • DOI
      10.1074/jbc.m116.736355
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.2016

    • Author(s)
      Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 8896-907

    • DOI
      10.1074/jbc.m115.713552
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two degradation pathways of the p35 Cdk5 activation subunit, dependent and independent of ubiquitination.2016

    • Author(s)
      Takasugi et al.,
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Pages: 4649-4657

    • DOI
      10.1074/jbc.m115.692871
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.2016

    • Author(s)
      Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.
    • Journal Title

      Am J Pathol.

      Volume: 186 Pages: 398-409

    • DOI
      10.1016/j.ajpath.2015.10.009
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis2016

    • Author(s)
      Noda, T., Iijima, M., Noda, S., Maeshima, S., Nakanishi, H., Kimura, S., Koike, H., Ishigaki, S., Iguchi, Y., Katsuno, M., and Sobue, G.
    • Journal Title

      Intern. Med.

      Volume: 55 Issue: 18 Pages: 2571-2580

    • DOI
      10.2169/internalmedicine.55.6706
    • NAID
      130005414859
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.2016

    • Author(s)
      Masuda M, Senda J, Watanabe H, Epifanio B, Tanaka Y, Imai K, Riku Y, Li Y, Nakamura R, Ito M, Ishigaki S, Atsuta N, Koike H, Katsuno M, Hattori N, Naganawa S, and Sobue G.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener

      Volume: 17 Pages: 571-579

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis.2016

    • Author(s)
      Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S, Katsuno M, Sobue G.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular2016

    • Author(s)
      Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
    • Journal Title

      Sci Rep.

      Volume: 22 Pages: 28512-28512

    • DOI
      10.1038/srep28512
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low2016

    • Author(s)
      Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: in press Pages: 851-8

    • DOI
      10.1136/jnnp-2015-311541
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The role of the carboxyl-terminal sequence of tau and MAP2 in the pathogenesis of dementia.2016

    • Author(s)
      Xie C, Miyasaka T.
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 9 Pages: 158-158

    • DOI
      10.3389/fnmol.2016.00158
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug discovery focused on the pathological mechanisms of tauopathy.2016

    • Author(s)
      Miyasaka T.
    • Journal Title

      Proceeding of the Annual Meeting of the Japanese Research Group on Senile Dementia

      Volume: 21 Pages: 1-5

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] Imaging Mass Spectrometry for the Research of Alzheimer’s Disease2016

    • Author(s)
      Ikegawa M, Miyasaka T, Kakuda N, Ihara Y
    • Journal Title

      J. Mass Spectrom. Soc. Jpn.

      Volume: 64 Issue: 1 Pages: 17-20

    • DOI
      10.5702/massspec.S16-04
    • NAID
      130005125536
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning.2016

    • Author(s)
      Moreira PS, Sotiropoulos I, Silva J, Takashima A, Sousa N, Leite-Almeida H, Costa PS.
    • Journal Title

      Front Behav Neurosci.

      Volume: 10 Pages: 18-18

    • DOI
      10.3389/fnbeh.2016.00018
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.2015

    • Author(s)
      Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
    • Journal Title

      Hum Mol Genet.

      Volume: 24(17) Pages: 4879-4900

    • DOI
      10.1093/hmg/ddv212
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau.2015

    • Author(s)
      Xie C, Soeda Y, Shinzaki Y, In Y, Tomoo K, Ihara Y, Miyasaka T.
    • Journal Title

      J Neurochem

      Volume: 135 Pages: 19-26

    • DOI
      10.1111/jnc.13228
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glycogen Synthase Kinase-3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2.2015

    • Author(s)
      Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A
    • Journal Title

      J Biol Chem

      Volume: 290 Pages: 29438-48

    • DOI
      10.1074/jbc.m114.619668
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residue with 1,2-dihydroxybenzene groups2015

    • Author(s)
      Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
    • Journal Title

      Nature Commun.

      Volume: 6 Pages: 10216-10216

    • DOI
      10.1038/ncomms10216
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization.2015

    • Author(s)
      Udagawa, T., Fujioka, Y., Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki S*., and Sobue, G.
    • Journal Title

      Nat Commun.

      Volume: 6 Pages: 7098-7098

    • DOI
      10.1038/ncomms8098
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcriptional and post-transcriptional regulation of transmembrane protein 132A.2015

    • Author(s)
      Oh-Hashi, K., Sone, A., Hikiji, T., Hirata, Y., Vitiello, M., Fedele, M., Ishigaki S., Sobue, G., and Kiuchi, K.
    • Journal Title

      Mol Cell Biochem

      Volume: 405 Pages: 291-299

    • DOI
      10.1007/s11010-015-2419-x
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length2015

    • Author(s)
      Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
    • Journal Title

      Genes Dev

      Volume: 29(10) Pages: 10451057-10451057

    • DOI
      10.1101/gad.255737.114
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors.2015

    • Author(s)
      Hikiji, T., Norisada, J., Hirata, Y., Okuda, K., Nagasawa, H., Ishigaki S., Sobue, G., Kiuchi, K., and Oh-hashi, K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 463 Pages: 881-887

    • DOI
      10.1016/j.bbrc.2015.05.132
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis.2015

    • Author(s)
      Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.
    • Journal Title

      Am J Pathol.

      Volume: 185 Pages: 3053-3065

    • DOI
      10.1016/j.ajpath.2015.07.016
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of p35 mutations associated with mental retardation on the cellular function of p35-CDK52015

    • Author(s)
      Takada S, Mizuno K, Saito T, Asada A, Giese KP, Hisanaga S.
    • Journal Title

      PLOSONE

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau2015

    • Author(s)
      Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga SI, Hasegawa M.
    • Journal Title

      Acta Neuropathol

      Volume: 129 Pages: 893-907

    • DOI
      10.1007/s00401-015-1415-2
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Female Hippocampus Vulnerability to Environmental Stress as Precipitating Factor in Tau Aggregation Pathology.2015

    • Author(s)
      Sotiropoulos I, Silva J, Kimura T, Rodrigues AJ, Costa P, Almeida OF, Sousa N, Takashima A.
    • Journal Title

      J Alzheimers Dis.

      Volume: 43 Pages: 763-774

    • DOI
      10.3233/jad-140693
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.2015

    • Author(s)
      Takahashi, M., Miyata, H., Kametani, F., Nonaka, T., Akiyama, H., Hisanaga, S., Hasegawa, M.
    • Journal Title

      Acta Neuropathol.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How Does the Ca<sup>2+</sup>-paradox Injury Induce Contracture in the Heart?—A Combined Study of the Intracellular Ca<sup>2+</sup> Dynamics and Cell Structures in Perfused Rat Hearts—2015

    • Author(s)
      Mani H, Tanaka H, Adachi T, Ikegawa M, Dai P, Fujita N, Takamatsu T.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 48 Issue: 1 Pages: 1-8

    • DOI
      10.1267/ahc.14059
    • NAID
      130004902931
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcriptional and post-transcriptional regulation of transmembrane protein 132A.2015

    • Author(s)
      Oh-Hashi K, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, Ishigaki S, Sobue G, Kiuchi K.
    • Journal Title

      Mol Cell Biochem.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length.2015

    • Author(s)
      Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
    • Journal Title

      Gen. Dev.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization.2015

    • Author(s)
      Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S*, Sobue G*.
    • Journal Title

      Nat Commun.

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice2014

    • Author(s)
      Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
    • Journal Title

      Acta Neuropathol

      Volume: 127(5) Pages: 685-698

    • DOI
      10.1007/s00401-014-1259-1
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau.2014

    • Author(s)
      Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A.
    • Journal Title

      Front Neurol.

      Volume: 5 Pages: 26-26

    • DOI
      10.3389/fneur.2014.00026
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of disease modifying drugs for dementia—focusing on anti-tau drugs—2014

    • Author(s)
      添田義行, 高島明彦
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 54 Issue: 12 Pages: 1178-1180

    • DOI
      10.5692/clinicalneurol.54.1178
    • NAID
      130004921162
    • Related Report
      2014 Annual Research Report
  • [Journal Article] サイクリン依存性キナーゼ5の活性制御機構と神経細胞死における役割2014

    • Author(s)
      斎藤太郎、久永眞市
    • Journal Title

      生体の科学

      Volume: 65 Pages: 266-270

    • Related Report
      2014 Annual Research Report
  • [Journal Article] LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.2014

    • Author(s)
      Takano et al
    • Journal Title

      Mol Biol. Cell

      Volume: 25 Pages: 1755-1768

    • DOI
      10.1091/mbc.e14-01-0675
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Valproic acid downregulates Cdk5 activity via transcription of p35 mRNA.2014

    • Author(s)
      Takahashi, et al.
    • Journal Title

      Biochem. Biophysic Res Commun.

      Volume: 447 Pages: 678-682

    • DOI
      10.1016/j.bbrc.2014.04.072
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.2014

    • Author(s)
      Furusawa et al.,
    • Journal Title

      J. Neurochem.

      Volume: 130 Pages: 498-506

    • DOI
      10.1111/jnc.12746
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ,Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk52014

    • Author(s)
      Ito, Y., Asada, A., Kobayashi, H., Takano, T., Sharma, G., Saito, T., Ohta, Y., Amano, M., Kaibuchi, K., and Hisanaga, S.
    • Journal Title

      Mol Cell Neurosci.

      Volume: 61 Pages: 19627-19636

    • DOI
      10.1016/j.mcn.2014.05.006
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.2014

    • Author(s)
      Kobayashi, H., Saito, T., Sato, K., Furusawa, K., Hosokawa, T., Tsutsumi, K., Asada, A., Kamada, S., Ohshima, T., and Hisanaga, S.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Pages: 19627-19636

    • DOI
      10.1074/jbc.m113.501148
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological and pathological phosphorylation of tau by Cdk5.2014

    • Author(s)
      Kimura, T., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Frontiers Mol. Neurosci.

      Volume: 7 Pages: 65-65

    • DOI
      10.3389/fnmol.2014.00065
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Filamin acts as a key regulator in epithelial defence against transformed cells2014

    • Author(s)
      Kajita M., Sugimura, K., Ohoka, A., Burden, J., Suganuma, H., Ikegawa, M., Shimada, T., Kitamura, T., Shindoh, M., Ishikawa, S., Yamamoto, S., Saitoh, S., Yako, Y., Takahashi, R., Okajima, T., Kikuta, J., Maijima, Y., Ishii, M., Tada, M., and Fujita, Y.
    • Journal Title

      Nat Commun.

      Volume: 5 Pages: 4428-4428

    • DOI
      10.1038/ncomms5428
    • NAID
      120005537465
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] タウタンパク質老化機構2017

    • Author(s)
      高島明彦
    • Organizer
      第30回日本老年学会総会シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Local somatodendrititc translation of tau protein triggered by AMPA and NMDA receptor stimulation2017

    • Author(s)
      高島明彦
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] タンパク質の生理機能と認知症における役割2017

    • Author(s)
      高島明彦
    • Organizer
      CnBio(分子生物学会)ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] ALS/FTLDにおけるFUSの機能の重要性2017

    • Author(s)
      石垣診祐
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 3’UTR length-dependent control of SynGAP isoform α2 mRNA by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function. (ポスター)2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      WCN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Silencing of FUS in the brain of non-human primates via stereotaxic injection of an adeno-associated virus encoding shRNA.(ポスター)2017

    • Author(s)
      Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      WCN 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aberrant interaction between FUS and SFPQ in 4R-tau dominant tauopathy brains. (ポスター)2017

    • Author(s)
      Ishigaki S, Riku Y, Fujioka Y, Honda D, Yokoi S, Endo K, Kawai K, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Silencing of FUS in the non-human primate brain via stereotaxic injection of an adeno-associated virus encoding shRNA. (ポスター)2017

    • Author(s)
      Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FUS and ELAV-like proteins cooperatively control SynGAP isoform α2 in a 3'UTR length-dependent manner to promote dendritic spine maturation and cognitive function.2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      The 47th Society for Neuroscience annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a single cell analysis tool for neurological disorders on 2D-plate with positional information. (ポスター)2017

    • Author(s)
      Ishigaki S, Uno H, Wang Z-H, Ukita Y, Bhardwaj R, Tue PT, Yurino H, Hashimoto S, Oka T, Kawahara K, Urisu T, Takamura Y, and Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cooperative control of SynGAP isoform α2 mRNA stability by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function. (ポスター)2017

    • Author(s)
      Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of adeno-associated virus vector system for silencing FUS in common marmoset brain. (ポスター)2017

    • Author(s)
      Endo K, Ishigaki S, Masamizu Y, Hatanaka N, Fujioka Y, Watakabe A, Yamamori T, Katsuno M, Watanabe H, Matsuzaki M, Nambu A, Sobue G.
    • Organizer
      The 40th annual Meeting of the Japan Neuroscience Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ubiquitin-dependent and -independent degradation of p35 activation subunit of neuronal Cdk, Cdk5.2017

    • Author(s)
      Takasugi T, Minegishi S, Asada A, Saito T, Hiroyuki K, Hisanaga S.
    • Organizer
      Experimental Biology 2017 (Annual meeting of American Socity of Biochemistry and Molecullar Biology)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エンドソームのトラッフィキング制御と軸索形成及び維持2017

    • Author(s)
      久永眞市
    • Organizer
      SAM研究会シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cdk5 regulation of the GRAB-mediated Rab11-Rab8 cascade in axon outgrowth.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      第60回日本神経化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] LMTK1 is a novel membrane bound kinase involved in anxiety and depression.2017

    • Author(s)
      Takahashi M, Sugiyama A, Takahashi R, Fukuda K, Tomomura M, Ando K, Hisanaga S.
    • Organizer
      ISN-ESN Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dendritic spine formation is regulated by Lemur kinase 1A (LMTK1A) via Rab11A-positive endosome trafficking.2017

    • Author(s)
      Nishino H, Takano T, Tsutsumi K, Asada A, Saito T, Ando K, Hisanaga S.
    • Organizer
      ISN-ESN Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2017

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
    • Organizer
      The International Society of Neurochemistry (ISN) and the European Society for Neurochemistry (ESN)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phosphorylation of serotonin 1A receptor (5HT1AR) by Cdk5.2017

    • Author(s)
      Takahashi M, Kobayashi Y, Ando K, Saito Y, Hisanaga S.
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cyclin-dependent kinase 5, its role in neuronal differentiation, synaptic activity and neurodegeneration.2017

    • Author(s)
      Hisanaga S.
    • Organizer
      Royan International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析2017

    • Author(s)
      木村妙子、久永眞市
    • Organizer
      電気泳動学会シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2017

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
    • Organizer
      Cell symposium: Big question in Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates neuronal migration in the developing cerebral cortex.2017

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      ASCB/EMBO 2017 Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルツハイマー型認知症関連因子βセクレターゼ(BACE1)の細胞内輸送におけるLemur kinase1A(LMTK1A)の役割2017

    • Author(s)
      駒木圭介、池田識人、佐藤裕、淺田明子、斉藤太郎、久永眞市
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phospho-tau bar code-死後脳でのタウリン酸化解析はタウオパチーの診断に役立つか?2017

    • Author(s)
      久永眞市
    • Organizer
      新学術領域研究「コホート・生体試料支援プラットフォーム」研究者対象シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 認知症治療最前線2017

    • Author(s)
      高島明彦
    • Organizer
      学際生命科学東京コンソーシアム 第11回市民講演会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Unravelling Alzheimer’s Brain Pathology with MALDI Imaging mass spectrometry2017

    • Author(s)
      池川雅哉
    • Organizer
      第1回京都生体質量分析研究会シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Unraveling amyloid beta-pathology in Alzheimer's Disease with MALDI Imaging Mass Spectrometry2017

    • Author(s)
      池川雅哉
    • Organizer
      17th Korean Human Proteome Organization
    • Place of Presentation
      Seoul
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates axon outgrowth by directing Rab8A to Rab11A-positive endosomes.2016

    • Author(s)
      Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
    • Organizer
      American Society for Cell Biology
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] イメージング質量分析法を用いたアルツハイマー病脳タンパク質の解析2016

    • Author(s)
      池川雅哉
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] βセクレターゼ(BACE1)の細胞内輸送におけるLemur kinase1(LMTK1)の役割2016

    • Author(s)
      駒木圭介、池田識人、高野哲也、友村美根子、淺田明子、斎藤太郎、安藤香奈絵、久永眞市
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] DEVELOPMENT OF A MOLECULAR ANALYSIS CHIP FOR SINGLE CELLS ON 2D-PLANE WITH POSITIONAL INFORMATION2016

    • Author(s)
      Takamura Y, Uno H, Wang Z-H, Ishigaki S, Shimura R, Tue PT, Miyuki C, Shimoda T, Ukita Y, Urisu T, Kawahara K
    • Organizer
      International conference on single cell research 2016
    • Place of Presentation
      Tokyo(ポスター)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vivo regulation of GSK3b activity unveiled by the quantitative measurement of its phospho-isotypes.2016

    • Author(s)
      Krishnankutty K, Kimura T, Saito T, Aoyagi K, Asada A, Ando K, Ohara-Imaizumi M, Ishiguro K, Hisanaga S.
    • Organizer
      46th annual meeting of Society for Neuroscience
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Accumulation of phosphorylated tau in neurons in FUS-silenced mice2016

    • Author(s)
      Ishigaki S, Fujioka Y, Honda D, Yokoi S, Endo K., Okado H, Watanabe H, Katsuno M, Takashima A., Sobue G.
    • Organizer
      The 46th Society for Neuroscience annual meeting
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Loss of SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes2016

    • Author(s)
      Fujioka Y, Ishigaki S, Yokoi S, Honda D, Okado H, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 46th Society for Neuroscience annual meeting
    • Place of Presentation
      San Diego, CA(ポスター)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] プレーナパッチクランプによる単一細胞解析と外部汚染の検証2016

    • Author(s)
      宇野 秀隆, 王 志宏, 石垣 診祐, 浮田 昭, 高村 禅, 宇理須 恒雄
    • Organizer
      第77用物理学会秋季学術講演会
    • Place of Presentation
      新潟(ポスター)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phosphorylation and Isoform Expression of Microtubule-Associated Protein Tau are Regulated Independently during Brain Development.2016

    • Author(s)
      Tuerde D, Kimura T, Miyasaka T, Asada A, Saito1 T, Ando, K, Hisanaga S.
    • Organizer
      Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      クアラルンプール、マレーシア
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Loss of PSF/SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes2016

    • Author(s)
      Fujioka Y, Ishigaki S, Yokoi S, Honda D, Okado H, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 39th annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜(ポスター)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 樹状突起スパイン形成におけるLemur kinase1A(LMTK1A) の役割2016

    • Author(s)
      西野尋紀、堤弘次、浅田明子、斎藤太郎、久永眞市
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Loss of FUS causes phosphorylated tau accumulation in aged mice2016

    • Author(s)
      石垣 診祐、藤岡 祐介、本田 大祐、横井 聡、岡戸 晴生、渡辺 宏久、勝野 雅央、祖父江 元
    • Organizer
      第57回神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Loss of PSF/SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes2016

    • Author(s)
      藤岡 祐介、石垣 診祐、本田 大祐、横井 聡、岡戸 晴生、渡辺 宏久、勝野 雅央、祖父江 元
    • Organizer
      第57回神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 前頭側頭葉変性症と筋萎縮性側索硬化症の線条体ではstriosomeの障害が特徴である2016

    • Author(s)
      陸 雄一、渡辺 宏久、吉田 眞里、三室 マヤ、岩崎 靖、石垣 診祐、祖父江 元、勝野 雅央
    • Organizer
      第57回神経学会学術大会
    • Place of Presentation
      神戸(ポスター)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] A rapid functional decline type of sporadic ALS is linked to low expression of TTN2016

    • Author(s)
      Naoki Atsuta, Hazuki Watanabe, AkihiroHirakawa, Ryoichi Nakamura, Masahiro Nakatochi, Shinsuke Ishigaki, Aritoshi Iida, Shiro Ikegawa, Daichi Yokoi, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Ryuji Kaji, Gen Sobue,
    • Organizer
      第57回神経学会学術大会
    • Place of Presentation
      神戸(ポスター)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mechanism of Neurodegeneration through Tau and Therapy for AD.2016

    • Author(s)
      Takashima A
    • Organizer
      The 1st International Gachon Neuroscience Symposium,
    • Place of Presentation
      Korea
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of neurodegeneration and therapy for Alzheimer's disease2016

    • Author(s)
      高島明彦
    • Organizer
      AD International Conference in Hefei
    • Place of Presentation
      University of Science and Technology of China
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タウとアルツハイマー病2016

    • Author(s)
      高島明彦
    • Organizer
      埼玉医科大学 卒後教育委員会 後援 学術集会
    • Place of Presentation
      埼玉医科大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症治療最前線2016

    • Author(s)
      高島明彦
    • Organizer
      第88回学習院大学技術交流会
    • Place of Presentation
      学習院大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タウのタンパク質老化と毒性機序2016

    • Author(s)
      高島明彦
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム
    • Place of Presentation
      一橋大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Functional linkage between FUS and tau in ALS/FTLD2016

    • Author(s)
      Ishigaki S, Fujioka Y, Honda D, Yokoi S, Okado H, Watanabe H, Katsuno M, Sobue G.
    • Organizer
      The 39th annual Meeting of the Japan Neuroscience Society Symposium
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2016 Annual Research Report
  • [Presentation] Accumulation of phosphorylated tau in FUS-silenced mice2016

    • Author(s)
      Ishigaki S
    • Organizer
      Brain Protein Aging and Dementia Control International Workshop 2016
    • Place of Presentation
      Nagoya(ポスター)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経細胞におけるアルツハイマー病原因蛋白質タウの軸索局在の分子機序2016

    • Author(s)
      岩田美里、渡邊祥司、宮坂知宏、朴洪宣、御園生裕明
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳発生に伴うタウ関連タンパク質の発現変化2016

    • Author(s)
      上田翔洋、角田聡子、久保厚子、宮坂知宏
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経細胞におけるタウ蛋白質の軸索局在化機構の解明2016

    • Author(s)
      岩田美里、渡邊祥司、宮坂知宏、朴洪宣、御園生裕明
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Strategy of tau related therapy.2015

    • Author(s)
      高島明彦
    • Organizer
      第55回日本核医学会学術総会 シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] タウイメージングに期待されること2015

    • Author(s)
      高島明彦
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病治療に向けて:タウ研究からのアプローチ2015

    • Author(s)
      高島明彦
    • Organizer
      第10回青森神経科学談話会
    • Place of Presentation
      弘前
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] イメージング質量分析を用いたアルツハイマー病脳の解析2015

    • Author(s)
      池川雅哉
    • Organizer
      日本質量分析学会 第63回質量分析総合討論会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-06-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Proteomic Imaging of amyloids in Brains from Amyloid Precursor Protein (APP) Transgenic Mice in comparison with Human Alzheimer Disease.2015

    • Author(s)
      Masaya Ikegawa, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Hiroyuki Sumikura, Shigeo Murayama, Yasuo Ihara.
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics.
    • Place of Presentation
      St. Louis, USA
    • Year and Date
      2015-05-31 – 2015-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Proteomic Mass Imaging of Pancreas from Type 2 Diabetes (T2D) Rat Model2015

    • Author(s)
      Noriyuki Iwasaki, Kei Masuyama, Hiroshi Wakazono, Takashi Nirasawa, Hirofumi Fujigaya, Masumi Higashiyama, Daisuke Hibi, Mayu Shukutani, Yuki Kuzuhara, Hiroyuki Yanagi, Masaya Ikegawa
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics.
    • Place of Presentation
      St. Louis, USA
    • Year and Date
      2015-05-31 – 2015-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Therapy against toxic tau aggregation in AD2015

    • Author(s)
      高島明彦
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Distribution of endogenous and exogenous tau in the mouse brain2015

    • Author(s)
      Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akihiko Takashima, Yasuo Ihara, Tomohiro Miyasaka
    • Organizer
      The 12th International Conference on Alzheimer's and Parkinson's Diseases
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Aging and Tau2015

    • Author(s)
      Takashima A.
    • Organizer
      Asian Aging Core for Longevity (AACL) 10 years and Beyond Japan-Korea Joint Seminars
    • Place of Presentation
      Osaka, Japan.
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] タウの基礎研究から試みる認知症治療薬開発2015

    • Author(s)
      高島明彦
    • Organizer
      シンポジウム「アルツハイマー病先制治療薬の創出」
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-01-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳特異的キナーゼCdk5の活性制御と生理および病理2014

    • Author(s)
      久永眞市
    • Organizer
      第4回メトロポリタン脳の老化・認知症ファーラム 特別講演
    • Place of Presentation
      東京
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] tau-Tg マウス脳における内在性および外来性タウの神経細胞内局在2014

    • Author(s)
      久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-12-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] FUS/TLSからみたALS/FTLDのRNA病態2014

    • Author(s)
      石垣診祐、祖父江 元
    • Organizer
      第33回 日本認知症学会学術集会 シンポジウム
    • Place of Presentation
      横浜市
    • Year and Date
      2014-12-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 正常脳におけるタウの神経細胞内局在2014

    • Author(s)
      久保厚子、御園生裕明、松田響子、松山誠、河田光博、初田裕幸、村山繁雄、井原康夫、宮坂知宏
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] FUSとSFPQの複合体はMaptの選択的splicingを制御しALS/FTLDの高次機能障 害に関与する2014

    • Author(s)
      石垣 診祐、 藤岡 祐介、 宇田川 剛、本田 大祐、横井 聡、渡辺 宏 久、勝野 雅央、祖父江 元
    • Organizer
      第33回 日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] FUSはGluA1 mRNA安定性の調節を介してシナプス機能及びFTLD様行動を制御する2014

    • Author(s)
      渡辺宏久、宇田川剛、藤岡祐介、本田大祐、横井聡、石垣診祐、田中基樹、曽我 部正博、永井拓、山田清文、岡戸晴生、大野欽司、勝野雅央、祖父江元
    • Organizer
      第33回 日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rab結合タンパク質GRABのCdk5-p35によるリン酸化とその役割2014

    • Author(s)
      古澤孝太郎、浅田明子、斎藤太郎、福田光則、久永眞市
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規の神経セリン/スレオニンキナーゼ LMTK1 の新生ニューロンの移動や形態における役割2014

    • Author(s)
      漆原智己、高橋路佳、網本紫、高野哲也、土屋幸憲、斎藤太郎、友村美根子、久永眞市.
    • Organizer
      第37回日本分子生物学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] アミロイド前駆体タンパクAPPの細胞内輸送に対するCD2APおよびCIN85の役割2014

    • Author(s)
      金子秀一郎、浅田明子、斎藤太郎、久永真市
    • Organizer
      第37回日本分子生物学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathophysiology -FUS knock-down glial cells have a neuro-protective effect.2014

    • Author(s)
      Yusuke Fujioka, Shinsuke Ishigaki, Takashi Shiromizu, Tsuyoshi Udagawa,Satoshi Yokoi, Daiyu Honda, Kensuke Ikenaka, Masahisa Katsuno, Takeshi Tomonaga and Gen Sobue
    • Organizer
      The 43rd Society for Neuroscience annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] PP1-binding neuronal protein kinase LMTK1 suppresses neurite outgrowth through the regulation of Rab11-dependent endosomal trafficking.2014

    • Author(s)
      Takano, T., Tsutsumi, K., Fukuda, M., Tomomura, M., Hisanaga, S.
    • Organizer
      第11回国際フォスファターゼコンファレンス
    • Place of Presentation
      仙台市
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳神経疾患解析のための時間・空間プロテオミックイメージング2014

    • Author(s)
      池川雅哉、韮澤 崇、岩崎了教
    • Organizer
      日本質量分析学会関東談話会イメージングマスワークショップ
    • Place of Presentation
      東京都
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cdk5活性化因子p35のプロテアソーム分解について2014

    • Author(s)
      高杉俊之、嶺岸正治、小林弘侑、斎藤太郎、浅田明子、久永眞市.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] タウタンパク質老化と毒性機序2014

    • Author(s)
      高島明彦
    • Organizer
      脳タンパク質老化と認知症制御キックオフシンポジウム
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] p39で活性化されるCdk5のRac1依存的ラメリポディアへの選択的集積2014

    • Author(s)
      淺田明子、伊藤有紀, 高野哲也, Sharma Govinda, 斉藤太郎, 太田安隆、天野睦紀, 貝淵弘三, 久永眞市.
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電位依存性カルシウムチャネル活性に対するCdk5の影響2014

    • Author(s)
      古澤孝太郎、浅田明子、斎藤太郎、久永眞市
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] New insights in tau phosphorylation obtained by Phos-tag SDS-PAGE analysis.2014

    • Author(s)
      Kimura, T., Hatsuta, H., Masuda-Suzukake, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
    • Organizer
      第57回日本神経化学会大会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 微小管結合タンパク質タウのGSK3βによる生理的および病理的リン酸化のPhos-tag法を用いた再検証2014

    • Author(s)
      米澤遼、 網本紫、木村妙子、斎藤太郎、 久永眞市
    • Organizer
      第57回日本神経化学会
    • Place of Presentation
      奈良市
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tau /tau interaction through Cys residue form a toxic tau aggregate.2014

    • Author(s)
      Takashima A.
    • Organizer
      7th Asian Aging Core for Longevity (AACL) conference in Jeju
    • Place of Presentation
      Jeju, Korea.
    • Year and Date
      2014-09-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] マウス脳における内在性および外来性 tau の局在2014

    • Author(s)
      久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
    • Organizer
      第37回日本神経科学大会 Neuroscience 2014
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quality loss of FUS and SFPQ in the nucleus causes FTLD-like behavioral abnormalities by modulating Tau isoforms.2014

    • Author(s)
      Shinsuke Ishigaki, Yusuke Fujioka, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Masahisa Katsuno, Haruo Okado, and Gen Sobue
    • Organizer
      The 37th annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathology -FUS knock-down glial cells have a neurotrophic effect.-2014

    • Author(s)
      Yusuke Fujioka, Shinsuke Ishigaki, Takashi Shiromizu, Tsuyoshi Udagawa, Satoshi Yokoi, Daiyu Honda, Kensuke Ikenaka, Masahisa Katsuno, Takeshi Tomonaga, and Gen Sobue
    • Organizer
      The 37th annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経脱髄疾患の時間・空間的多発性の解析2014

    • Author(s)
      池川雅哉
    • Organizer
      第67回日本酸化ストレス学会
    • Place of Presentation
      京都市
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Characterizing Mouse Thymus using Imaging Mass Microscope.2014

    • Author(s)
      Yudai Tsuji, Hayato Nishitani, Tomoyuki Nakamura, Yumi Matsumoto, Hideshi Fujiwake, Kei Tashiro, Masaya Ikegawa.
    • Organizer
      International Mass Spectrometry Conference,
    • Place of Presentation
      Geneva, Switzerland.
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Plasma proteomic biomarker strategy in a porcine hepatectomy model.2014

    • Author(s)
      Kohta Iguchi, Masaya Ikegawa, Etsuro Hatano, Takashi Nirasawa, Noriyuki Iwasaki, Tomohito Sakai, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Tatsuya Okamoto, Yosuke Kasai, Kojiro Taura, Kei Tashiro, Shinji Uemoto.
    • Organizer
      International Mass Spectrometry Conference,
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state.2014

    • Author(s)
      Furusawa, K., Asada, A., Saito, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phosphorylation of Drebrin by Cyclin-dependent kinase 5 and Its Role in Neuronal Migration.2014

    • Author(s)
      Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima, T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] New aspects of tau phosphorylation obtained by Phos-tag SDS-PAGE.2014

    • Author(s)
      Kimura, T., Hosokawa, T., Tsutsumi, K., Masuda-Suzukake, M., Hosokawa, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of valproic acid on Cdk5 activity and mouse behavior.2014

    • Author(s)
      Takahashi, M., Ishida, M., Saito, T., Ohshima, T., Hisanaga, S.
    • Organizer
      第12回アジア太平洋神経化学会
    • Place of Presentation
      台湾
    • Year and Date
      2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] タウ分子からアプローチするアルツハイマー病2014

    • Author(s)
      高島明彦
    • Organizer
      公益財団法人新世代研究所 バイオ単分子研究会
    • Place of Presentation
      静岡県伊東市
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Granular tau oligomer as toxic tau aggregation form in AD.2014

    • Author(s)
      Takashima A.
    • Organizer
      Alzheimer’s Association International Conference 2014
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途2017

    • Inventor(s)
      祖父江、石垣、佐橋、永井、前田、武内、閨、藤原、松田
    • Industrial Property Rights Holder
      国立大学法人 名古屋大学/大阪大学, (株)神戸天然物化学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Application Year
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞内容物の回収方法および回収装置2017

    • Inventor(s)
      宇理須恒夫、石垣診祐、宇野秀隆、高村禅
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Application Year
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 2,4-ジアミノフェノール誘導体、及び、タウ及び/又はアミロイドβの凝集阻害剤2017

    • Inventor(s)
      宮坂知宏、杉本八郎、井上善一 他4名
    • Industrial Property Rights Holder
      同志社大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-08
    • Application Year
      2017
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 灌流用注射針2016

    • Inventor(s)
      宮坂知宏、久保厚子
    • Industrial Property Rights Holder
      同志社大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-22
    • Application Year
      2016
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] イメージング質量分析の前処理方法2016

    • Inventor(s)
      池川雅哉、宮坂知宏、角田伸人、韮沢崇
    • Industrial Property Rights Holder
      同志社大学、ブルカー・ダルトニクス株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-231372
    • Filing Date
      2016-11-29
    • Application Year
      2016
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2018-12-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi