Mechanism of tau protein aging and neurodegeneration

• Project Area: Prevention of brain protein aging and dementia
• Project/Area Number: 26117004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Gakushuin University (2016-2018); National Center for Geriatrics and Gerontology (2014-2015)
• Principal Investigator: 高島 明彦 学習院大学, 理学部, 教授 (00154774)
• Co-Investigator(Kenkyū-buntansha): 久永 眞市 首都大学東京, 理学研究科, 客員教授 (20181092) ; 石垣 診祐 名古屋大学, 医学系研究科, 特任准教授 (40378170) ; 宮坂 知宏 同志社大学, 生命医科学部, 准教授 (90342857) ; 池川 雅哉 同志社大学, 生命医科学部, 教授 (60381943)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥237,250,000 (Direct Cost: ¥182,500,000、Indirect Cost: ¥54,750,000); Fiscal Year 2018: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2017: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000); Fiscal Year 2016: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2015: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000); Fiscal Year 2014: ¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
• Keywords: タウタンパク質 / Aβ / 老化 / 認知症 / 脳機能 / 凝集 / リン酸化 / 神経細胞死 / 神経科学 / 脳神経疾患 / タウ / 局在 / 過活動 / 樹状突起

Outline of Annual Research Achievements

この計画班ではタウタンパク質の生理機能が加齢に伴い神経変性を引き起こす凝集体形成を行うまでの分子機構を明らかにすることを目的にしている。
タウリン酸化に関して霊長類モデルとして使用されているマーモセットの内在性タウについて調べた。リン酸化に関して生後直後に増大し成体になるとリン酸化タウの減少が観察された。タウの配列、アイソフォームの観察からマーモセットには霊長類特有の配列が欠損し、アイソフォーム変化も齧歯類と同様の変化を示した。
ヒト脳では生体においても4R,3Rタウのアイソフォームが存在している。これらタウアイソフォームの役割を調べたところ4Rタウノックインのホモマウスにおいて、有意に成体神経新生細胞数が減少することを見出した。またタウノックアウトマウスでは新生細胞の移動距離が増加しており、このことはタウが微小管の安定化を促進することより、タウの喪失によって新生神経細胞の移動性が増加することを反映していると推測された。
タウの分布についての検討ではタウは主に無髄線維およびオリゴデンドロサイトに局在し、タウ病変が好発する錐体細胞では相対的なタウの発現量は低かった。タウの発現制御機構について転写因子としてSOX11/12 を同定した。転写によって生成されたタウmRNAはRNA結合タンパク質と複合体を作り細胞体、樹状突起に存在している。神経過活動によりmRNAからの翻訳活性化が起こり、後シナプス領域でタウ発現が起こる。このタウの役割を調べるためグルタミン酸刺激後のAMPA受容体の１分子観察を行った。その結果、グルタミン酸刺激によってAMPA受容体の移動速度は増大するがタウがないと細胞内への取り込みが阻害されシナプス外でのAMPA受容体の移動が阻害されることが明らかになった。このことからシナプスにおけるタウの増大はAMAP受容体を取り込み神経過活動を抑制する補償機構として作用し得ることが示唆された。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus (2019)
  • Author(s): Ano Yasuhisa、Yoshikawa Misato、Takaichi Yuta、Michikawa Makoto、Uchida Kazuyuki、Nakayama Hiroyuki、Takashima Akihiko
  • Journal Title: Frontiers in Pharmacology Volume: 10 Pages: 81-81
  • DOI: 10.3389/fphar.2019.00081
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of Amyloid beta Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry (2019)
  • Author(s): Ikegawa Masaya、Nirasawa Takashi、Kakuda Nobuto、Miyasaka Tomohiro、Kuzuhara Yuki、Murayama Shigeo、Ihara Yasuo
  • Journal Title: Journal of Visualized Experiments Volume: 145
  • DOI: 10.3791/57645
  • Peer Reviewed / Open Access
• [Journal Article] Cytoplasmic control of Rab family small GTPases through BAG6. (2019)
  • Author(s): Takahashi Toshiki、Minami Setsuya、Tsuchiya Yugo、Tajima Kazu、Sakai Natsumi、Suga Kei、Hisanaga Shin‐ichi、Ohbayashi Norihiko、Fukuda Mitsunori、Kawahara Hiroyuki
  • Journal Title: EMBO Rep. Volume: 20
  • DOI: 10.15252/embr.201846794
  • Peer Reviewed / Open Access
• [Journal Article] Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation (2019)
  • Author(s): Takahashi Miyuki、Kobayashi Yuki、Ando Kanae、Saito Yumiko、Hisanaga Shin-ichi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 510 Pages: 370-375
  • DOI: 10.1016/j.bbrc.2019.01.093
  • Peer Reviewed / Open Access
• [Journal Article] Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease (2019)
  • Author(s): Soeda Yoshiyuki、Saito Marino、Maeda Sumihiro、Ishida Kohki、Nakamura Akira、Kojima Shuichi、Takashima Akihiko
  • Journal Title: Journal of Alzheimer's Disease Volume: 68 Pages: 1677-1686
  • DOI: 10.3233/jad-181001
  • Peer Reviewed
• [Journal Article] Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy (2018)
  • Author(s): Ano Yasuhisa、Takaichi Yuta、Uchida Kazuyuki、Kondo Keiji、Nakayama Hiroyuki、Takashima Akihiko
  • Journal Title: Molecules Volume: 23 Pages: 3133-3133
  • DOI: 10.3390/molecules23123133
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology (2018)
  • Author(s): Silva Joana Margarida、Rodrigues Sara、Sampaio-Marques B、Gomes Patr?cia、Neves-Carvalho Andreia、Dioli Chrysoula、Soares-Cunha Carina、Mazuik Brandon F、Takashima Akihiko、Ludovico Paula、Wolozin Benjamin、Sousa Nuno、Sotiropoulos Ioannis
  • Journal Title: Cell Death & Differentiation Volume: -
  • DOI: 10.1038/s41418-018-0217-1
  • Peer Reviewed
• [Journal Article] Distribution of endogenous normal tau in the mouse brain (2018)
  • Author(s): Kubo Atsuko、Misonou Hiroaki、Matsuyama Makoto、Nomori Akane、Wada-Kakuda Satoko、Takashima Akihiko、Kawata Mitsuhiro、Murayama Shigeo、Ihara Yasuo、Miyasaka Tomohiro
  • Journal Title: Journal of Comparative Neurology Volume: 527 Pages: 985-998
  • DOI: 10.1002/cne.24577
  • Peer Reviewed
• [Journal Article] Novel lactopeptides in fermented dairy products improve memory function and cognitive decline (2018)
  • Author(s): Ano Yasuhisa、Ayabe Tatsuhiro、Kutsukake Toshiko、Ohya Rena、Takaichi Yuta、Uchida Shinichi、Yamada Koji、Uchida Kazuyuki、Takashima Akihiko、Nakayama Hiroyuki
  • Journal Title: Neurobiology of Aging Volume: 72 Pages: 23-31
  • DOI: 10.1016/j.neurobiolaging.2018.07.016
  • Peer Reviewed / Open Access
• [Journal Article] Deposition of phosphorylated α-synuclein in the rTg4510 mouse model of tauopathy (2018)
  • Author(s): Takaichi Yuta、Ano Yasuhisa、Chambers James K、Uchida Kazuyuki、Takashima Akihiko、Nakayama Hiroyuki
  • Journal Title: Journal of Neuropathology and Experimental Neurology Volume: 77 Pages: 920-928
  • DOI: 10.1093/jnen/nly070
  • Peer Reviewed
• [Journal Article] Frontotemporal dementia with Parkinsonism linked to chromosome-17 mutations enhance tau oligomer formation (2018)
  • Author(s): Maeda Sumihiro、Sato Yuhei、Takashima Akihiko
  • Journal Title: Neurobiology of Aging Volume: 69 Pages: 26-32
  • DOI: 10.1016/j.neurobiolaging.2018.04.014
  • Peer Reviewed / Open Access
• [Journal Article] Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory (2018)
  • Author(s): Yoshikawa Misato、Soeda Yoshiyuki、Michikawa Makoto、Almeida Osborne F. X.、Takashima Akihiko
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 124-124
  • DOI: 10.3389/fnins.2018.00124
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathogenesis of Frontotemporal Lobar Degeneration: Insights from Loss of Function Theory and Early Involvement of the Caudate Nucleus. (2018)
  • Author(s): Sobue Gen、Ishigaki Shinsuke、Watanabe Hirohisa
  • Journal Title: Front Neurosci Volume: 12 Pages: 473-473
  • DOI: 10.3389/fnins.2018.00473
  • Peer Reviewed / Open Access
• [Journal Article] Importance of Functional Loss of Fus in Ftld/Als (2018)
  • Author(s): Ishigaki Shinsuke、Sobue Gen
  • Journal Title: Front Mol Biosci Volume: 5 Pages: 44-44
  • DOI: 10.3389/fmolb.2018.00044
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A Pet (Thk5351, Pib) and Resting Fmri Study. (2018)
  • Author(s): Yokoi Takamasa、Watanabe Hirohisa、Ishigaki Shinsuke、Katsuno Masahisa、Miyao Shinichi、Kato Katsuhiko、Naganawa Shinji、Harada Ryuichi、Okamura Nobuyuki、Yanai Kazuhiko、Yoshida Mari、Sobue Gen （ほか9名）
  • Journal Title: Front Aging Neurosci Volume: 10 Pages: 304-304
  • DOI: 10.3389/fnagi.2018.00304
  • Peer Reviewed / Open Access
• [Journal Article] Silencing of Fus in the Common Marmoset (Callithrix Jacchus) Brain Via Stereotaxic Injection of an Adeno-Associated Virus Encoding Shrna (2018)
  • Author(s): Endo K, Ishigaki S, Masamizu Y, Fujioka Y, Watakabe A, Yamamori T, Hatanaka N, Nambu A, Okado H, Katsuno M, Watanabe H, Matsuzaki M, Sobue G
  • Journal Title: Neuroscience Research Volume: in press Pages: 56-54
  • DOI: 10.1016/j.neures.2017.08.006
  • Peer Reviewed
• [Journal Article] Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy (2018)
  • Author(s): Miyasaka T, Shinzaki Y, Yoshimura S, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y.
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 415-415
  • DOI: 10.3389/fnins.2018.00415
  • Peer Reviewed / Open Access
• [Journal Article] Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin (2018)
  • Author(s): Mita Yuichiro、Kataoka Yuto、Saito Yoshiro、Kashi Takuma、Hayashi Kojiro、Iwasaki Asa、Imanishi Takanori、Miyasaka Tomohiro、Noguchi Noriko
  • Journal Title: Scientific Reports Volume: 8 Pages: 12056-12056
  • DOI: 10.1038/s41598-018-30561-z
  • Peer Reviewed / Open Access
• [Journal Article] S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy (2018)
  • Author(s): Chiku Tomoki、Hayashishita Motoki、Saito Taro、Oka Mikiko、Shinno Kanako、Ohtake Yosuke、Shimizu Sawako、Asada Akiko、Hisanaga Shin-ichi、Iijima Koichi M.、Ando Kanae
  • Journal Title: Neurobiology of Aging Volume: 71 Pages: 255-264
  • DOI: 10.1016/j.neurobiolaging.2018.07.021
  • Peer Reviewed / Open Access
• [Journal Article] Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods (2018)
  • Author(s): Tarutani A, Arai T, Murayama S, Hisanaga SI, Hasegawa M
  • Journal Title: Acta Neuropathologica Communications Volume: 6 Pages: 1-18
  • DOI: 10.1186/s40478-018-0532-2
  • NAID: 120006469308
  • Peer Reviewed / Open Access
• [Journal Article] Isoform-independent and phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. (2018)
  • Author(s): Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
  • Journal Title: Journal of Biological Chemistry Volume: 293 Pages: 1781-1793
  • DOI: 10.1074/jbc.m117.798918
  • Peer Reviewed / Open Access
• [Journal Article] Phospho-tau bar code: analysis of phosphoisotypes of tau and its application to tauopathy. (2018)
  • Author(s): Kimura T, Sharma G, Ishiguro K, Hisanaga SI.
  • Journal Title: Fron. Mol. Neurosci. Volume: 12 Pages: 44-44
  • DOI: 10.3389/fnins.2018.00044
  • Peer Reviewed / Open Access
• [Journal Article] Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. (2017)
  • Author(s): Maekawa M、Watanabe A、Iwayama Y、Kimura T、Hamazaki K、Balan S、Ohba H、Hisano Y、Nozaki Y、Ohnishi T、Toyoshima M、Shimamoto C、Iwamoto K、Bundo M、Osumi N、Takahashi E、Takashima A、Yoshikawa T
  • Journal Title: Transl Psychiatry Volume: 7
  • DOI: 10.1038/tp.2017.182
  • Peer Reviewed / Open Access
• [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice (2017)
  • Author(s): Umcda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
  • Journal Title: Acta Neuropathol Commun Volume: 5 Pages: 59-59
  • DOI: 10.1186/s40478-017-0461-5
  • NAID: 120006371271
  • Peer Reviewed / Open Access
• [Journal Article] Local somatodendritic translation and hyperphosphorylation of tau protein triggered by AMPA and NMDA receptor stimulation. (2017)
  • Author(s): Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F. X. Almeida, Akihiko Takashima
  • Journal Title: EBio Medicine Volume: 印刷中 Pages: 120-126
  • DOI: 10.1016/j.ebiom.2017.05.012
  • Peer Reviewed / Open Access
• [Journal Article] Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease. (2017)
  • Author(s): Ano Y, Dohata A, Taniguchi Y, Hoshi A, Uchida K, Takashima A, Nakayama H.
  • Journal Title: J Biol Chem. Volume: 292 Pages: 3720-3728
  • DOI: 10.1074/jbc.m116.763813
  • Peer Reviewed
• [Journal Article] Altered tau isoform ratio caused by loss of FUS and SFPQ function leads to FTLD-like phenotypes (2017)
  • Author(s): Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno H, Sobue G.
  • Journal Title: Cell Report Volume: 18 Pages: 1118-1131
  • DOI: 10.1016/j.celrep.2017.01.013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging (2017)
  • Author(s): Yagishita S, Suzuki S, Yoshikawa K, Iida K, Hirata A, Suzuki M, Takashima A, Maruyama K, Hirasawa A, Awaji T.
  • Journal Title: Mol Brain. Volume: 10 Pages: 2-2
  • DOI: 10.1186/s13041-016-0282-7
  • NAID: 120005971848
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pathologic Involvement of Glutamatergic Striatal Inputs From the Cortices in TAR DNA-Binding Protein 43?kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis (2017)
  • Author(s): Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S.
  • Journal Title: J Neuropathol Exp Neurol Volume: 76(9) Pages: 759-768
  • DOI: 10.1093/jnen/nlx055
  • Peer Reviewed
• [Journal Article] 3′UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function (2017)
  • Author(s): Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M.
  • Journal Title: Cell Rep. Volume: 20(13) Pages: 3071-3084
  • DOI: 10.1016/j.celrep.2017.08.100
  • Peer Reviewed / Open Access
• [Journal Article] Altered GluA1 ( Gria1 ) Function and Accumbal Synaptic Plasticity in the Clock Δ19 Model of Bipolar Mania (2017)
  • Author(s): Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, Huang Y, McClung CA.
  • Journal Title: Biol Psychiatry Volume: S0006 Pages: 31721-3
  • DOI: 10.1016/j.biopsych.2017.06.022
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry (2017)
  • Author(s): Kakuda N, Miyasaka T, Iwasaki N, Nirasawa T, Wada-Kakuda S, Takahashi-Fujigasaki J, Murayama S, Ihara Y, Ikegawa M.
  • Journal Title: Acta Neuropathol Commun Volume: 5 Issue: 1 Pages: 73-73
  • DOI: 10.1186/s40478-017-0477-x
  • Peer Reviewed / Open Access
• [Journal Article] Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. (2017)
  • Author(s): Oka Mikiko、Fujisaki Naoki、Maruko-Otake Akiko、Ohtake Yosuke、Shimizu Sawako、Saito Taro、Hisanaga Shin-Ichi、Iijima Koichi M、Ando Kanae
  • Journal Title: J Biochem. Volume: 162 Pages: 335-342
  • DOI: 10.1093/jb/mvx038
  • Peer Reviewed
• [Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains (2017)
  • Author(s): Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
  • Journal Title: Sci Rep. Volume: 7 Pages: 8602-8602
  • DOI: 10.1038/s41598-017-09239-5
  • Peer Reviewed / Open Access
• [Journal Article] Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth. (2017)
  • Author(s): Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga SI.
  • Journal Title: J Neurosci. Volume: 37 Pages: 790-806
  • DOI: 10.1523/jneurosci.2197-16.2016
  • Peer Reviewed / Open Access
• [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production (2017)
  • Author(s): Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga S, Murayama S, Hashimoto Y, Manya H, Endo, T.
  • Journal Title: J Biochem. Volume: 161 Issue: 1 Pages: 99-111
  • DOI: 10.1093/jb/mvw056
  • NAID: 40021091544
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析 (2017)
  • Author(s): 木村妙子、久永眞市
  • Journal Title: 電気泳動 Volume: 61 Pages: 49-52
  • NAID: 130006207357
  • Peer Reviewed
• [Journal Article] Cdk5の多彩な機能-神経細胞から非神経系 (2017)
  • Author(s): 斎藤太郎、久永眞市
  • Journal Title: 生化学 Volume: 89 Pages: 710-718
  • Peer Reviewed
• [Journal Article] Modification of Tau by 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation (2016)
  • Author(s): Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.
  • Journal Title: Journal of Biological Chemistry Volume: 291 Pages: 22714-22720
  • DOI: 10.1074/jbc.m116.734350
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mechanism of neurodegeneration through tau and therapy for Alzheimer disease. (2016)
  • Author(s): Takashima A
  • Journal Title: Journal of Sport and Health Science Volume: 5 Pages: 391-392
  • DOI: 10.1016/j.jshs.2016.08.009
  • Peer Reviewed / Open Access
• [Journal Article] Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated (2016)
  • Author(s): Ando K, Oka M, Ohtake M, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 478 (2) Pages: 929-34
  • DOI: 10.1016/j.bbrc.2016.08.053
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants (2016)
  • Author(s): Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.
  • Journal Title: Scientific Reports Volume: 6 Pages: 33479-33479
  • DOI: 10.1038/srep33479
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons (2016)
  • Author(s): Sharma S, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura T, Hisanaga S.
  • Journal Title: Genes Cells. Volume: 21 Pages: 1080-1094
  • DOI: 10.1111/gtc.12404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation. (2016)
  • Author(s): Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, and Hasegawa M.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 18675-18688
  • DOI: 10.1074/jbc.m116.734707
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly. (2016)
  • Author(s): Oikawa T, Nonaka T, Hisanaga S, Hasegawa M.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 15046-15056
  • DOI: 10.1074/jbc.m116.736355
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. (2016)
  • Author(s): Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M.
  • Journal Title: J Biol Chem. Volume: 291 Pages: 8896-907
  • DOI: 10.1074/jbc.m115.713552
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two degradation pathways of the p35 Cdk5 activation subunit, dependent and independent of ubiquitination. (2016)
  • Author(s): Takasugi et al.,
  • Journal Title: J. Biol. Chem. Volume: 291 Pages: 4649-4657
  • DOI: 10.1074/jbc.m115.692871
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method. (2016)
  • Author(s): Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.
  • Journal Title: Am J Pathol. Volume: 186 Pages: 398-409
  • DOI: 10.1016/j.ajpath.2015.10.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis (2016)
  • Author(s): Noda, T., Iijima, M., Noda, S., Maeshima, S., Nakanishi, H., Kimura, S., Koike, H., Ishigaki, S., Iguchi, Y., Katsuno, M., and Sobue, G.
  • Journal Title: Intern. Med. Volume: 55 Issue: 18 Pages: 2571-2580
  • DOI: 10.2169/internalmedicine.55.6706
  • NAID: 130005414859
  • Peer Reviewed
• [Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. (2016)
  • Author(s): Masuda M, Senda J, Watanabe H, Epifanio B, Tanaka Y, Imai K, Riku Y, Li Y, Nakamura R, Ito M, Ishigaki S, Atsuta N, Koike H, Katsuno M, Hattori N, Naganawa S, and Sobue G.
  • Journal Title: Amyotroph Lateral Scler Frontotemporal Degener Volume: 17 Pages: 571-579
  • Peer Reviewed
• [Journal Article] Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. (2016)
  • Author(s): Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, Ishigaki S, Katsuno M, Sobue G.
  • Journal Title: J Neuropathol Exp Neurol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular (2016)
  • Author(s): Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
  • Journal Title: Sci Rep. Volume: 22 Pages: 28512-28512
  • DOI: 10.1038/srep28512
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low (2016)
  • Author(s): Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry Volume: in press Pages: 851-8
  • DOI: 10.1136/jnnp-2015-311541
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The role of the carboxyl-terminal sequence of tau and MAP2 in the pathogenesis of dementia. (2016)
  • Author(s): Xie C, Miyasaka T.
  • Journal Title: Frontiers in Molecular Neuroscience Volume: 9 Pages: 158-158
  • DOI: 10.3389/fnmol.2016.00158
  • Peer Reviewed / Open Access
• [Journal Article] Drug discovery focused on the pathological mechanisms of tauopathy. (2016)
  • Author(s): Miyasaka T.
  • Journal Title: Proceeding of the Annual Meeting of the Japanese Research Group on Senile Dementia Volume: 21 Pages: 1-5
  • Open Access
• [Journal Article] Imaging Mass Spectrometry for the Research of Alzheimer’s Disease (2016)
  • Author(s): Ikegawa M, Miyasaka T, Kakuda N, Ihara Y
  • Journal Title: J. Mass Spectrom. Soc. Jpn. Volume: 64 Issue: 1 Pages: 17-20
  • DOI: 10.5702/massspec.S16-04
  • NAID: 130005125536
  • Peer Reviewed / Open Access
• [Journal Article] The Advantages of Structural Equation Modeling to Address the Complexity of Spatial Reference Learning. (2016)
  • Author(s): Moreira PS, Sotiropoulos I, Silva J, Takashima A, Sousa N, Leite-Almeida H, Costa PS.
  • Journal Title: Front Behav Neurosci. Volume: 10 Pages: 18-18
  • DOI: 10.3389/fnbeh.2016.00018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway. (2015)
  • Author(s): Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H
  • Journal Title: Hum Mol Genet. Volume: 24(17) Pages: 4879-4900
  • DOI: 10.1093/hmg/ddv212
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. (2015)
  • Author(s): Xie C, Soeda Y, Shinzaki Y, In Y, Tomoo K, Ihara Y, Miyasaka T.
  • Journal Title: J Neurochem Volume: 135 Pages: 19-26
  • DOI: 10.1111/jnc.13228
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glycogen Synthase Kinase-3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2. (2015)
  • Author(s): Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A
  • Journal Title: J Biol Chem Volume: 290 Pages: 29438-48
  • DOI: 10.1074/jbc.m114.619668
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residue with 1,2-dihydroxybenzene groups (2015)
  • Author(s): Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
  • Journal Title: Nature Commun. Volume: 6 Pages: 10216-10216
  • DOI: 10.1038/ncomms10216
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. (2015)
  • Author(s): Udagawa, T., Fujioka, Y., Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki S*., and Sobue, G.
  • Journal Title: Nat Commun. Volume: 6 Pages: 7098-7098
  • DOI: 10.1038/ncomms8098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcriptional and post-transcriptional regulation of transmembrane protein 132A. (2015)
  • Author(s): Oh-Hashi, K., Sone, A., Hikiji, T., Hirata, Y., Vitiello, M., Fedele, M., Ishigaki S., Sobue, G., and Kiuchi, K.
  • Journal Title: Mol Cell Biochem Volume: 405 Pages: 291-299
  • DOI: 10.1007/s11010-015-2419-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length (2015)
  • Author(s): Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
  • Journal Title: Genes Dev Volume: 29(10) Pages: 10451057-10451057
  • DOI: 10.1101/gad.255737.114
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors. (2015)
  • Author(s): Hikiji, T., Norisada, J., Hirata, Y., Okuda, K., Nagasawa, H., Ishigaki S., Sobue, G., Kiuchi, K., and Oh-hashi, K.
  • Journal Title: Biochem Biophys Res Commun Volume: 463 Pages: 881-887
  • DOI: 10.1016/j.bbrc.2015.05.132
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis. (2015)
  • Author(s): Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.
  • Journal Title: Am J Pathol. Volume: 185 Pages: 3053-3065
  • DOI: 10.1016/j.ajpath.2015.07.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of p35 mutations associated with mental retardation on the cellular function of p35-CDK5 (2015)
  • Author(s): Takada S, Mizuno K, Saito T, Asada A, Giese KP, Hisanaga S.
  • Journal Title: PLOSONE Volume: 10
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau (2015)
  • Author(s): Takahashi M, Miyata H, Kametani F, Nonaka T, Akiyama H, Hisanaga SI, Hasegawa M.
  • Journal Title: Acta Neuropathol Volume: 129 Pages: 893-907
  • DOI: 10.1007/s00401-015-1415-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Female Hippocampus Vulnerability to Environmental Stress as Precipitating Factor in Tau Aggregation Pathology. (2015)
  • Author(s): Sotiropoulos I, Silva J, Kimura T, Rodrigues AJ, Costa P, Almeida OF, Sousa N, Takashima A.
  • Journal Title: J Alzheimers Dis. Volume: 43 Pages: 763-774
  • DOI: 10.3233/jad-140693
  • Peer Reviewed
• [Journal Article] Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau. (2015)
  • Author(s): Takahashi, M., Miyata, H., Kametani, F., Nonaka, T., Akiyama, H., Hisanaga, S., Hasegawa, M.
  • Journal Title: Acta Neuropathol. Volume: in press
  • Peer Reviewed
• [Journal Article] How Does the Ca²⁺-paradox Injury Induce Contracture in the Heart?—A Combined Study of the Intracellular Ca²⁺ Dynamics and Cell Structures in Perfused Rat Hearts— (2015)
  • Author(s): Mani H, Tanaka H, Adachi T, Ikegawa M, Dai P, Fujita N, Takamatsu T.
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 48 Issue: 1 Pages: 1-8
  • DOI: 10.1267/ahc.14059
  • NAID: 130004902931
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcriptional and post-transcriptional regulation of transmembrane protein 132A. (2015)
  • Author(s): Oh-Hashi K, Sone A, Hikiji T, Hirata Y, Vitiello M, Fedele M, Ishigaki S, Sobue G, Kiuchi K.
  • Journal Title: Mol Cell Biochem. Volume: in press
  • Peer Reviewed
• [Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length. (2015)
  • Author(s): Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
  • Journal Title: Gen. Dev. Volume: in press
  • Peer Reviewed
• [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. (2015)
  • Author(s): Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S*, Sobue G*.
  • Journal Title: Nat Commun. Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice (2014)
  • Author(s): Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.
  • Journal Title: Acta Neuropathol Volume: 127(5) Pages: 685-698
  • DOI: 10.1007/s00401-014-1259-1
  • Peer Reviewed
• [Journal Article] Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau. (2014)
  • Author(s): Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A.
  • Journal Title: Front Neurol. Volume: 5 Pages: 26-26
  • DOI: 10.3389/fneur.2014.00026
  • Peer Reviewed / Open Access
• [Journal Article] Development of disease modifying drugs for dementia—focusing on anti-tau drugs— (2014)
  • Author(s): 添田義行, 高島明彦
  • Journal Title: Rinsho Shinkeigaku Volume: 54 Issue: 12 Pages: 1178-1180
  • DOI: 10.5692/clinicalneurol.54.1178
  • NAID: 130004921162
• [Journal Article] サイクリン依存性キナーゼ５の活性制御機構と神経細胞死における役割 (2014)
  • Author(s): 斎藤太郎、久永眞市
  • Journal Title: 生体の科学 Volume: 65 Pages: 266-270
• [Journal Article] LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. (2014)
  • Author(s): Takano et al
  • Journal Title: Mol Biol. Cell Volume: 25 Pages: 1755-1768
  • DOI: 10.1091/mbc.e14-01-0675
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Valproic acid downregulates Cdk5 activity via transcription of p35 mRNA. (2014)
  • Author(s): Takahashi, et al.
  • Journal Title: Biochem. Biophysic Res Commun. Volume: 447 Pages: 678-682
  • DOI: 10.1016/j.bbrc.2014.04.072
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state. (2014)
  • Author(s): Furusawa et al.,
  • Journal Title: J. Neurochem. Volume: 130 Pages: 498-506
  • DOI: 10.1111/jnc.12746
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ,Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5 (2014)
  • Author(s): Ito, Y., Asada, A., Kobayashi, H., Takano, T., Sharma, G., Saito, T., Ohta, Y., Amano, M., Kaibuchi, K., and Hisanaga, S.
  • Journal Title: Mol Cell Neurosci. Volume: 61 Pages: 19627-19636
  • DOI: 10.1016/j.mcn.2014.05.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. (2014)
  • Author(s): Kobayashi, H., Saito, T., Sato, K., Furusawa, K., Hosokawa, T., Tsutsumi, K., Asada, A., Kamada, S., Ohshima, T., and Hisanaga, S.
  • Journal Title: J. Biol. Chem. Volume: 289 Pages: 19627-19636
  • DOI: 10.1074/jbc.m113.501148
  • Peer Reviewed
• [Journal Article] Physiological and pathological phosphorylation of tau by Cdk5. (2014)
  • Author(s): Kimura, T., Ishiguro, K., Hisanaga, S.
  • Journal Title: Frontiers Mol. Neurosci. Volume: 7 Pages: 65-65
  • DOI: 10.3389/fnmol.2014.00065
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Filamin acts as a key regulator in epithelial defence against transformed cells (2014)
  • Author(s): Kajita M., Sugimura, K., Ohoka, A., Burden, J., Suganuma, H., Ikegawa, M., Shimada, T., Kitamura, T., Shindoh, M., Ishikawa, S., Yamamoto, S., Saitoh, S., Yako, Y., Takahashi, R., Okajima, T., Kikuta, J., Maijima, Y., Ishii, M., Tada, M., and Fujita, Y.
  • Journal Title: Nat Commun. Volume: 5 Pages: 4428-4428
  • DOI: 10.1038/ncomms5428
  • NAID: 120005537465
  • Peer Reviewed / Open Access
• [Presentation] Development of a single cell analysis tool for neuroscience on 2D planar-patch-clamp plate with positional information (2019)
  • Author(s): Ishigaki S, Uno H, Wang Z-H, Ukita Y, Bhardwaj R, Tue PT, Hashimoto S, Oka T, Kawahara K, Sobue G, Urisu T, Takamura Y
  • Organizer: The 12th International workshop on approaches to single cell analysis
  • Int'l Joint Research
• [Presentation] CD2-associated protein (CD2AP) sorts amyloid precursor protein (APP) to late endosomes from early endosomes. (2019)
  • Author(s): Furusawa, K., Takasugi, T., Fukuda, M., Hisanaga, S.
  • Organizer: AD/PD 2019
  • Int'l Joint Research
• [Presentation] Tau in marmoset brains, its isoform expression and phosphorylation. (2019)
  • Author(s): Sharma, G., Huo, A., Kimura, T., Shiozawa, S., Kobayashi, R., Sahara, N., Ishibashi, M., Ishigaki, S., Saito, T., Ando, K., Murayama, S., Hasegawa, M., Sobue, G., Okano, H., Hisanaga, S.
  • Organizer: AD/PD 2019
  • Int'l Joint Research
• [Presentation] AMPA/NMDA stimulation causes somatodendritic localization of hyperphosphorylated tau protein (2018)
  • Author(s): Takashima A
  • Organizer: EuroTau2018
  • Int'l Joint Research
• [Presentation] 認知症治療に向けたタウ凝集剤の開発 (2018)
  • Author(s): 高島明彦
  • Organizer: 創薬薬理フォーラム第26回シンポジウム
• [Presentation] Methylene blue inhibits formation of tau fibrils but not granular tau oligomers（ポスター） (2018)
  • Author(s): Saito M, Soeda Y, Maeda S, Takashima A
  • Organizer: Society for Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Physiological role of dendritic tau protein on AMPA receptor dynamics (2018)
  • Author(s): Kanatani M, Bannai H, Soeda Y, Maeda S, Takashima A
  • Organizer: Society for Neuroscience 2018
  • Int'l Joint Research
• [Presentation] FUS/TLSに関連するALS/FTLDの分子病態 Functional Significance of FUS/TLS in ALS/FTLD (2018)
  • Author(s): 石垣診祐
  • Organizer: 第59神経学会学術大会
• [Presentation] Functional Loss of FUS in neurodegenerative diseases (2018)
  • Author(s): Ishigaki,S, Sobue,G
  • Organizer: The 41st annual Meeting of the Japan Neuroscience Society
• [Presentation] RNA結合タンパク質FUSの機能と神経変性疾患への関わり Importance of Functional Loss of FUS in in neurodegenerative diseases (2018)
  • Author(s): Ishigaki S, Sobue G
  • Organizer: 第41回日本分子生物学会年会 ワークショップ
• [Presentation] Development of a single cell analysis tool for neurological disorders on 2D planar-patch-clamp plate with positional information (2018)
  • Author(s): Ishigaki S, Uno H, Wang Z-H, Ukita Y, Bhardwaj R, Tue PT, Hashimoto S, Oka T, Kawahara K, Takamura Y, Urisu T, Sobue G
  • Organizer: The 48th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] Aberrant interaction between FUS and SFPQ in the nucleus of neurons in sporadic FTLD/ALS and PSP brains（ポスター） (2018)
  • Author(s): Fujioka Y, Ishigaki S, Riku Y, Ishibashi M, Yokoi S, K. Endo K, Iwade N, Kawai K, Watanabe H, Katsuno M, Yoshida M, Sobue G
  • Organizer: The 48th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] Silencing of FUS in the caudate nucleus of non-human primates induces disruption of its fiber bundles（ポスター） (2018)
  • Author(s): Endo K, Ishiagki S, Hatanaka N, Hata J, Watanabe H, Katsuno M, Nambu A, Okano H, Sobue G
  • Organizer: The 48th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] Tau phosphorylation at AT8 pathological site during brain development（ポスター） (2018)
  • Author(s): Tuerde D, Furusawa K, Takasugi T, Kimura T, Ishigaki S, Ando K, Sobue G, Hisanaga SI.
  • Organizer: The 48th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] ALS/FTLDおよび4R-tau優位のタウオパチーにおけるFUSとSFPQの結合性の低下 Aberrant interaction between FUS and SFPQ in FTLD/ALS and 4R-tau dominant tauopathies (2018)
  • Author(s): Ishigaki S, RIku Y, Fujioka Y, Yokoi S, Endo K, Iwade N, Kawai K, Ishibashi M, Watanabe H, Katsuno M, Yoshida M, Sobue G
  • Organizer: The 41st annual Meeting of the Japan Neuroscience Society 2018
• [Presentation] タウ蛋白は摂食量及び体重を制御する Tau regulates food intake and body weight (2018)
  • Author(s): Fujioka Y, Ishigaki S, Kawai K, Iwade N, Endo K, Ishibashi M, Yokoi S, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 41st annual Meeting of the Japan Neuroscience Society
• [Presentation] マーモセット尾状核でのFUS KDは、グリア炎症を伴い神経線維の短縮を引き起こす Silencing of FUS in common marmoset caudate induces shortening of fiber tracts accompanied with glial inflammation (2018)
  • Author(s): Endo K, Ishigaki S, Watanabe H, Hatanaka N, Hata J, Watakabe A, Nambu A, Okano H, Yamamori T, Katsuno M, Sobue G
  • Organizer: The 41st annual Meeting of the Japan Neuroscience Society 2018/7/26-29 Kobe, Japan
• [Presentation] タウisoformの成体神経新生における役割 (2018)
  • Author(s): 石垣診祐、岩出展行、藤岡祐介、遠藤邦幸、河合香里、石橋みなか、勝野雅央、渡辺宏久、宮坂知宏、祖父江元
  • Organizer: 第13回 臨床ストレス応答学会大会
• [Presentation] Tubulin degeneration causes tau abnormalities (2018)
  • Author(s): 藤原 ひとみ，渡辺 祥司，岩田 実里，上田 翔洋，延原 美香，和田 聡子，御園生 裕明，宮坂 知宏
  • Organizer: 第61回日本神経化学会
• [Presentation] tbcEノックダウンによるチューブリン変性を介したタウ異常性の獲得 (2018)
  • Author(s): 藤原ひとみ、渡辺祥司、岩田実里、上田翔洋、和田聡子、延原美香、御園生裕明、宮坂知宏
  • Organizer: 第37回日本認知症学会学術集会
• [Presentation] Tubulin degeneration induces tau abnormalities (2018)
  • Author(s): Fujiwara H, Watanabe S, Iwata M, Nobuhara M, Wada-Kakuda S, Misonou H, Miyasaka T
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] The study of axonal localization mechanisms of tau in neuron (2018)
  • Author(s): Iwata M, Watanabe S,Miyasaka T, Misonou H
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] In vitro disease modeling of the FTDP-17 TAU R406W mutation using patient-derived iPSCs. (2018)
  • Author(s): Nakamura M, Watanabe H, Shiozawa S, Maeda S, Hisanaga SI, Sahara N, Kimura T, Miyasaka T, Takashima A, Ikeuchi T, Okano H
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Lemur kinase 1 (LMTK1A) regulates dendritic spine formation through the TBC1D9B Rab11 GAP and Rab11 cascade. (2018)
  • Author(s): Nishino, H., Saito, T., Takano, T., Tsutsumi, K., Ando, K., Tomomura, M., Fukuda, M., Hisanaga, S.
  • Organizer: 第69回日本細胞生物学会
• [Presentation] The role of Thr231 phosphorylation of tau on its localization into the nucleus. (2018)
  • Author(s): Zhu, Y., Kimura, T., Kikuchi, C., Wei, R., Ando, K., Hisanaga, S.
  • Organizer: 15th meeting of APSN
  • Int'l Joint Research
• [Presentation] In vivo phosphorylation of tau in brains of Marmoset, a non-human Primate. (2018)
  • Author(s): Hisanaga, S., Shiozawa, S., Kobayashi, R., Murayama, S., Saito, T., Ando, K., Okano, H., Kimura, T., Sharma, G.
  • Organizer: 第61回日本神経化学会大会
• [Presentation] アルツハイマー病危険因子CD2APはAPPの初期エンドソームから後期エンドソームへの輸送を促進する. (2018)
  • Author(s): Furusawa, K., Fukuda, M., Hisanaga, S.
  • Organizer: 第91回日本生化学会大会
• [Presentation] Lemur kinase 1 (LMTK1) regulates dendritic spine formation through Rab11-dependent endosomal trafficking. (2018)
  • Author(s): Nishino, H., Saito, T., Ando, K., Tomomura, M., Fukuda, M., Hisanaga, S.
  • Organizer: アメリカ神経科学会大会 （Neuroscience 2018）
  • Int'l Joint Research
• [Presentation] タウタンパク質老化機構 (2017)
  • Author(s): 高島明彦
  • Organizer: 第30回日本老年学会総会シンポジウム
• [Presentation] Local somatodendrititc translation of tau protein triggered by AMPA and NMDA receptor stimulation (2017)
  • Author(s): 高島明彦
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] タンパク質の生理機能と認知症における役割 (2017)
  • Author(s): 高島明彦
  • Organizer: CnBio(分子生物学会）ワークショップ
• [Presentation] ALS/FTLDにおけるFUSの機能の重要性 (2017)
  • Author(s): 石垣診祐
  • Organizer: 2017年度 生命科学系学会合同年次大会
• [Presentation] 3’UTR length-dependent control of SynGAP isoform α2 mRNA by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function. (ポスター） (2017)
  • Author(s): Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
  • Organizer: WCN 2017
  • Int'l Joint Research
• [Presentation] Silencing of FUS in the brain of non-human primates via stereotaxic injection of an adeno-associated virus encoding shRNA.(ポスター） (2017)
  • Author(s): Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
  • Organizer: WCN 2017
  • Int'l Joint Research
• [Presentation] Aberrant interaction between FUS and SFPQ in 4R-tau dominant tauopathy brains. (ポスター） (2017)
  • Author(s): Ishigaki S, Riku Y, Fujioka Y, Honda D, Yokoi S, Endo K, Kawai K, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 47th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] Silencing of FUS in the non-human primate brain via stereotaxic injection of an adeno-associated virus encoding shRNA. (ポスター） (2017)
  • Author(s): Endo K, Ishigaki S, Fujioka Y, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 47th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] FUS and ELAV-like proteins cooperatively control SynGAP isoform α2 in a 3'UTR length-dependent manner to promote dendritic spine maturation and cognitive function. (2017)
  • Author(s): Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
  • Organizer: The 47th Society for Neuroscience annual meeting
  • Int'l Joint Research
• [Presentation] Development of a single cell analysis tool for neurological disorders on 2D-plate with positional information. （ポスター） (2017)
  • Author(s): Ishigaki S, Uno H, Wang Z-H, Ukita Y, Bhardwaj R, Tue PT, Yurino H, Hashimoto S, Oka T, Kawahara K, Urisu T, Takamura Y, and Sobue G.
  • Organizer: The 40th annual Meeting of the Japan Neuroscience Society
• [Presentation] Cooperative control of SynGAP isoform α2 mRNA stability by FUS and ELAV-like proteins promotes dendritic spine maturation and cognitive function. (ポスター） (2017)
  • Author(s): Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
  • Organizer: The 40th annual Meeting of the Japan Neuroscience Society
• [Presentation] Establishment of adeno-associated virus vector system for silencing FUS in common marmoset brain. (ポスター） (2017)
  • Author(s): Endo K, Ishigaki S, Masamizu Y, Hatanaka N, Fujioka Y, Watakabe A, Yamamori T, Katsuno M, Watanabe H, Matsuzaki M, Nambu A, Sobue G.
  • Organizer: The 40th annual Meeting of the Japan Neuroscience Society
• [Presentation] Ubiquitin-dependent and -independent degradation of p35 activation subunit of neuronal Cdk, Cdk5. (2017)
  • Author(s): Takasugi T, Minegishi S, Asada A, Saito T, Hiroyuki K, Hisanaga S.
  • Organizer: Experimental Biology 2017 (Annual meeting of American Socity of Biochemistry and Molecullar Biology)
  • Int'l Joint Research
• [Presentation] エンドソームのトラッフィキング制御と軸索形成及び維持 (2017)
  • Author(s): 久永眞市
  • Organizer: SAM研究会シンポジウム
• [Presentation] Cdk5 regulation of the GRAB-mediated Rab11-Rab8 cascade in axon outgrowth. (2017)
  • Author(s): Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
  • Organizer: 第60回日本神経化学会
• [Presentation] LMTK1 is a novel membrane bound kinase involved in anxiety and depression. (2017)
  • Author(s): Takahashi M, Sugiyama A, Takahashi R, Fukuda K, Tomomura M, Ando K, Hisanaga S.
  • Organizer: ISN-ESN Meeting 2017
  • Int'l Joint Research
• [Presentation] Dendritic spine formation is regulated by Lemur kinase 1A (LMTK1A) via Rab11A-positive endosome trafficking. (2017)
  • Author(s): Nishino H, Takano T, Tsutsumi K, Asada A, Saito T, Ando K, Hisanaga S.
  • Organizer: ISN-ESN Meeting 2017
  • Int'l Joint Research
• [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. (2017)
  • Author(s): Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
  • Organizer: The International Society of Neurochemistry (ISN) and the European Society for Neurochemistry (ESN)
  • Int'l Joint Research
• [Presentation] Phosphorylation of serotonin 1A receptor (5HT1AR) by Cdk5. (2017)
  • Author(s): Takahashi M, Kobayashi Y, Ando K, Saito Y, Hisanaga S.
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Cyclin-dependent kinase 5, its role in neuronal differentiation, synaptic activity and neurodegeneration. (2017)
  • Author(s): Hisanaga S.
  • Organizer: Royan International Conference
  • Int'l Joint Research
• [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-tag解析 (2017)
  • Author(s): 木村妙子、久永眞市
  • Organizer: 電気泳動学会シンポジウム
• [Presentation] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. (2017)
  • Author(s): Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga S.
  • Organizer: Cell symposium: Big question in Neuroscience
  • Int'l Joint Research
• [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates neuronal migration in the developing cerebral cortex. (2017)
  • Author(s): Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
  • Organizer: ASCB/EMBO 2017 Meeting
  • Int'l Joint Research
• [Presentation] アルツハイマー型認知症関連因子βセクレターゼ（BACE1）の細胞内輸送におけるLemur kinase1A（LMTK1A）の役割 (2017)
  • Author(s): 駒木圭介、池田識人、佐藤裕、淺田明子、斉藤太郎、久永眞市
  • Organizer: 第40回日本分子生物学会
• [Presentation] Phospho-tau bar code－死後脳でのタウリン酸化解析はタウオパチーの診断に役立つか？ (2017)
  • Author(s): 久永眞市
  • Organizer: 新学術領域研究「コホート・生体試料支援プラットフォーム」研究者対象シンポジウム
• [Presentation] 認知症治療最前線 (2017)
  • Author(s): 高島明彦
  • Organizer: 学際生命科学東京コンソーシアム 第11回市民講演会
  • Place of Presentation: 東京医科歯科大学
  • Invited
• [Presentation] Unravelling Alzheimer’s Brain Pathology with MALDI Imaging mass spectrometry (2017)
  • Author(s): 池川雅哉
  • Organizer: 第１回京都生体質量分析研究会シンポジウム
  • Place of Presentation: 京都
  • Invited
• [Presentation] Unraveling amyloid beta-pathology in Alzheimer's Disease with MALDI Imaging Mass Spectrometry (2017)
  • Author(s): 池川雅哉
  • Organizer: 17th Korean Human Proteome Organization
  • Place of Presentation: Seoul
  • Invited
• [Presentation] Cdk5-dependent phosphorylation of GRAB, a guanine nucleotide exchange factor for Rab8, regulates axon outgrowth by directing Rab8A to Rab11A-positive endosomes. (2016)
  • Author(s): Furusawa K, Asada A, Urrutia P, Gonzalez-Billault C, Fukuda M, Hisanaga S.
  • Organizer: American Society for Cell Biology
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2016-12-03
• [Presentation] イメージング質量分析法を用いたアルツハイマー病脳タンパク質の解析 (2016)
  • Author(s): 池川雅哉
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-12-01
• [Presentation] βセクレターゼ（BACE1）の細胞内輸送におけるLemur kinase1（LMTK1）の役割 (2016)
  • Author(s): 駒木圭介、池田識人、高野哲也、友村美根子、淺田明子、斎藤太郎、安藤香奈絵、久永眞市
  • Organizer: 第３９回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30
• [Presentation] DEVELOPMENT OF A MOLECULAR ANALYSIS CHIP FOR SINGLE CELLS ON 2D-PLANE WITH POSITIONAL INFORMATION (2016)
  • Author(s): Takamura Y, Uno H, Wang Z-H, Ishigaki S, Shimura R, Tue PT, Miyuki C, Shimoda T, Ukita Y, Urisu T, Kawahara K
  • Organizer: International conference on single cell research 2016
  • Place of Presentation: Tokyo（ポスター）
  • Year and Date: 2016-11-16
• [Presentation] In vivo regulation of GSK3b activity unveiled by the quantitative measurement of its phospho-isotypes. (2016)
  • Author(s): Krishnankutty K, Kimura T, Saito T, Aoyagi K, Asada A, Ando K, Ohara-Imaizumi M, Ishiguro K, Hisanaga S.
  • Organizer: 46th annual meeting of Society for Neuroscience
  • Place of Presentation: サンディエゴ、アメリカ
  • Year and Date: 2016-11-12
• [Presentation] Accumulation of phosphorylated tau in neurons in FUS-silenced mice (2016)
  • Author(s): Ishigaki S, Fujioka Y, Honda D, Yokoi S, Endo K., Okado H, Watanabe H, Katsuno M, Takashima A., Sobue G.
  • Organizer: The 46th Society for Neuroscience annual meeting
  • Place of Presentation: San Diego, CA
  • Year and Date: 2016-11-12
• [Presentation] Loss of SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes (2016)
  • Author(s): Fujioka Y, Ishigaki S, Yokoi S, Honda D, Okado H, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 46th Society for Neuroscience annual meeting
  • Place of Presentation: San Diego, CA（ポスター）
  • Year and Date: 2016-11-12
• [Presentation] プレーナパッチクランプによる単一細胞解析と外部汚染の検証 (2016)
  • Author(s): 宇野 秀隆, 王 志宏, 石垣 診祐, 浮田 昭, 高村 禅, 宇理須 恒雄
  • Organizer: 第77用物理学会秋季学術講演会
  • Place of Presentation: 新潟（ポスター）
  • Year and Date: 2016-09-13
• [Presentation] Phosphorylation and Isoform Expression of Microtubule-Associated Protein Tau are Regulated Independently during Brain Development. (2016)
  • Author(s): Tuerde D, Kimura T, Miyasaka T, Asada A, Saito1 T, Ando, K, Hisanaga S.
  • Organizer: Asian-Pacific Society for Neurochemistry
  • Place of Presentation: クアラルンプール、マレーシア
  • Year and Date: 2016-08-26
• [Presentation] Loss of PSF/SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes (2016)
  • Author(s): Fujioka Y, Ishigaki S, Yokoi S, Honda D, Okado H, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 39th annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜（ポスター）
  • Year and Date: 2016-07-20
• [Presentation] 樹状突起スパイン形成におけるLemur kinase1A(LMTK1A) の役割 (2016)
  • Author(s): 西野尋紀、堤弘次、浅田明子、斎藤太郎、久永眞市
  • Organizer: 第68回日本細胞生物学会大会
  • Place of Presentation: 京都
  • Year and Date: 2016-06-15
• [Presentation] Loss of FUS causes phosphorylated tau accumulation in aged mice (2016)
  • Author(s): 石垣 診祐、藤岡 祐介、本田 大祐、横井 聡、岡戸 晴生、渡辺 宏久、勝野 雅央、祖父江 元
  • Organizer: 第57回神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] Loss of PSF/SFPQ, an intra-nuclear counterpart of FUS causes FTLD-like phenotypes (2016)
  • Author(s): 藤岡 祐介、石垣 診祐、本田 大祐、横井 聡、岡戸 晴生、渡辺 宏久、勝野 雅央、祖父江 元
  • Organizer: 第57回神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 前頭側頭葉変性症と筋萎縮性側索硬化症の線条体ではstriosomeの障害が特徴である (2016)
  • Author(s): 陸 雄一、渡辺 宏久、吉田 眞里、三室 マヤ、岩崎 靖、石垣 診祐、祖父江 元、勝野 雅央
  • Organizer: 第57回神経学会学術大会
  • Place of Presentation: 神戸（ポスター）
  • Year and Date: 2016-05-18
• [Presentation] A rapid functional decline type of sporadic ALS is linked to low expression of TTN (2016)
  • Author(s): Naoki Atsuta, Hazuki Watanabe, AkihiroHirakawa, Ryoichi Nakamura, Masahiro Nakatochi, Shinsuke Ishigaki, Aritoshi Iida, Shiro Ikegawa, Daichi Yokoi, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Ryuji Kaji, Gen Sobue,
  • Organizer: 第57回神経学会学術大会
  • Place of Presentation: 神戸（ポスター）
  • Year and Date: 2016-05-18
• [Presentation] Mechanism of Neurodegeneration through Tau and Therapy for AD. (2016)
  • Author(s): Takashima A
  • Organizer: The 1st International Gachon Neuroscience Symposium,
  • Place of Presentation: Korea
  • Year and Date: 2016-02-24
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of neurodegeneration and therapy for Alzheimer's disease (2016)
  • Author(s): 高島明彦
  • Organizer: AD International Conference in Hefei
  • Place of Presentation: University of Science and Technology of China
  • Invited
• [Presentation] タウとアルツハイマー病 (2016)
  • Author(s): 高島明彦
  • Organizer: 埼玉医科大学 卒後教育委員会 後援 学術集会
  • Place of Presentation: 埼玉医科大学
  • Invited
• [Presentation] 認知症治療最前線 (2016)
  • Author(s): 高島明彦
  • Organizer: 第88回学習院大学技術交流会
  • Place of Presentation: 学習院大学
  • Invited
• [Presentation] タウのタンパク質老化と毒性機序 (2016)
  • Author(s): 高島明彦
  • Organizer: 次世代脳プロジェクト 冬のシンポジウム
  • Place of Presentation: 一橋大学
  • Invited
• [Presentation] Functional linkage between FUS and tau in ALS/FTLD (2016)
  • Author(s): Ishigaki S, Fujioka Y, Honda D, Yokoi S, Okado H, Watanabe H, Katsuno M, Sobue G.
  • Organizer: The 39th annual Meeting of the Japan Neuroscience Society Symposium
  • Place of Presentation: Yokohama, Japan
• [Presentation] Accumulation of phosphorylated tau in FUS-silenced mice (2016)
  • Author(s): Ishigaki S
  • Organizer: Brain Protein Aging and Dementia Control International Workshop 2016
  • Place of Presentation: Nagoya（ポスター）
• [Presentation] 神経細胞におけるアルツハイマー病原因蛋白質タウの軸索局在の分子機序 (2016)
  • Author(s): 岩田美里、渡邊祥司、宮坂知宏、朴洪宣、御園生裕明
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 東北大学（仙台）
• [Presentation] 脳発生に伴うタウ関連タンパク質の発現変化 (2016)
  • Author(s): 上田翔洋、角田聡子、久保厚子、宮坂知宏
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
• [Presentation] 神経細胞におけるタウ蛋白質の軸索局在化機構の解明 (2016)
  • Author(s): 岩田美里、渡邊祥司、宮坂知宏、朴洪宣、御園生裕明
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
• [Presentation] Strategy of tau related therapy. (2015)
  • Author(s): 高島明彦
  • Organizer: 第55回日本核医学会学術総会 シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] タウイメージングに期待されること (2015)
  • Author(s): 高島明彦
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2015-10-02
  • Invited
• [Presentation] アルツハイマー病治療に向けて：タウ研究からのアプローチ (2015)
  • Author(s): 高島明彦
  • Organizer: 第10回青森神経科学談話会
  • Place of Presentation: 弘前
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] イメージング質量分析を用いたアルツハイマー病脳の解析 (2015)
  • Author(s): 池川雅哉
  • Organizer: 日本質量分析学会 第63回質量分析総合討論会
  • Place of Presentation: つくば市
  • Year and Date: 2015-06-18
• [Presentation] Proteomic Imaging of amyloids in Brains from Amyloid Precursor Protein (APP) Transgenic Mice in comparison with Human Alzheimer Disease. (2015)
  • Author(s): Masaya Ikegawa, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Hiroyuki Sumikura, Shigeo Murayama, Yasuo Ihara.
  • Organizer: 63rd ASMS Conference on Mass Spectrometry and Allied Topics.
  • Place of Presentation: St. Louis, USA
  • Year and Date: 2015-05-31 – 2015-06-04
• [Presentation] Proteomic Mass Imaging of Pancreas from Type 2 Diabetes (T2D) Rat Model (2015)
  • Author(s): Noriyuki Iwasaki, Kei Masuyama, Hiroshi Wakazono, Takashi Nirasawa, Hirofumi Fujigaya, Masumi Higashiyama, Daisuke Hibi, Mayu Shukutani, Yuki Kuzuhara, Hiroyuki Yanagi, Masaya Ikegawa
  • Organizer: 63rd ASMS Conference on Mass Spectrometry and Allied Topics.
  • Place of Presentation: St. Louis, USA
  • Year and Date: 2015-05-31 – 2015-06-04
• [Presentation] Therapy against toxic tau aggregation in AD (2015)
  • Author(s): 高島明彦
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-21
  • Invited
• [Presentation] Distribution of endogenous and exogenous tau in the mouse brain (2015)
  • Author(s): Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akihiko Takashima, Yasuo Ihara, Tomohiro Miyasaka
  • Organizer: The 12th International Conference on Alzheimer's and Parkinson's Diseases
  • Place of Presentation: Nice, France
  • Year and Date: 2015-03-21
• [Presentation] Aging and Tau (2015)
  • Author(s): Takashima A.
  • Organizer: Asian Aging Core for Longevity (AACL) 10 years and Beyond Japan-Korea Joint Seminars
  • Place of Presentation: Osaka, Japan.
  • Year and Date: 2015-03-12
  • Invited
• [Presentation] タウの基礎研究から試みる認知症治療薬開発 (2015)
  • Author(s): 高島明彦
  • Organizer: シンポジウム「アルツハイマー病先制治療薬の創出」
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-01-17
• [Presentation] 脳特異的キナーゼCdk5の活性制御と生理および病理 (2014)
  • Author(s): 久永眞市
  • Organizer: 第４回メトロポリタン脳の老化・認知症ファーラム 特別講演
  • Place of Presentation: 東京
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] tau-Tg マウス脳における内在性および外来性タウの神経細胞内局在 (2014)
  • Author(s): 久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-12-01
• [Presentation] FUS/TLSからみたALS/FTLDのRNA病態 (2014)
  • Author(s): 石垣診祐、祖父江 元
  • Organizer: 第33回 日本認知症学会学術集会 シンポジウム
  • Place of Presentation: 横浜市
  • Year and Date: 2014-12-01
  • Invited
• [Presentation] 正常脳におけるタウの神経細胞内局在 (2014)
  • Author(s): 久保厚子、御園生裕明、松田響子、松山誠、河田光博、初田裕幸、村山繁雄、井原康夫、宮坂知宏
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-30
• [Presentation] FUSとSFPQの複合体はMaptの選択的splicingを制御しALS/FTLDの高次機能障 害に関与する (2014)
  • Author(s): 石垣 診祐、 藤岡 祐介、 宇田川 剛、本田 大祐、横井 聡、渡辺 宏 久、勝野 雅央、祖父江 元
  • Organizer: 第33回 日本認知症学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] FUSはGluA1 mRNA安定性の調節を介してシナプス機能及びFTLD様行動を制御する (2014)
  • Author(s): 渡辺宏久、宇田川剛、藤岡祐介、本田大祐、横井聡、石垣診祐、田中基樹、曽我 部正博、永井拓、山田清文、岡戸晴生、大野欽司、勝野雅央、祖父江元
  • Organizer: 第33回 日本認知症学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] Rab結合タンパク質GRABのCdk5-p35によるリン酸化とその役割 (2014)
  • Author(s): 古澤孝太郎、浅田明子、斎藤太郎、福田光則、久永眞市
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-27
• [Presentation] 新規の神経セリン/スレオニンキナーゼ LMTK1 の新生ニューロンの移動や形態における役割 (2014)
  • Author(s): 漆原智己、高橋路佳、網本紫、高野哲也、土屋幸憲、斎藤太郎、友村美根子、久永眞市.
  • Organizer: 第37回日本分子生物学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-27
• [Presentation] アミロイド前駆体タンパクAPPの細胞内輸送に対するCD2APおよびCIN85の役割 (2014)
  • Author(s): 金子秀一郎、浅田明子、斎藤太郎、久永真市
  • Organizer: 第37回日本分子生物学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-27
• [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathophysiology -FUS knock-down glial cells have a neuro-protective effect. (2014)
  • Author(s): Yusuke Fujioka, Shinsuke Ishigaki, Takashi Shiromizu, Tsuyoshi Udagawa,Satoshi Yokoi, Daiyu Honda, Kensuke Ikenaka, Masahisa Katsuno, Takeshi Tomonaga and Gen Sobue
  • Organizer: The 43rd Society for Neuroscience annual meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] PP1-binding neuronal protein kinase LMTK1 suppresses neurite outgrowth through the regulation of Rab11-dependent endosomal trafficking. (2014)
  • Author(s): Takano, T., Tsutsumi, K., Fukuda, M., Tomomura, M., Hisanaga, S.
  • Organizer: 第11回国際フォスファターゼコンファレンス
  • Place of Presentation: 仙台市
  • Year and Date: 2014-11-13
  • Invited
• [Presentation] 脳神経疾患解析のための時間・空間プロテオミックイメージング (2014)
  • Author(s): 池川雅哉、韮澤 崇、岩崎了教
  • Organizer: 日本質量分析学会関東談話会イメージングマスワークショップ
  • Place of Presentation: 東京都
  • Year and Date: 2014-11-10
  • Invited
• [Presentation] Cdk5活性化因子p35のプロテアソーム分解について (2014)
  • Author(s): 高杉俊之、嶺岸正治、小林弘侑、斎藤太郎、浅田明子、久永眞市.
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2014-10-18
• [Presentation] タウタンパク質老化と毒性機序 (2014)
  • Author(s): 高島明彦
  • Organizer: 脳タンパク質老化と認知症制御キックオフシンポジウム
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2014-10-08
• [Presentation] p39で活性化されるCdk5のRac1依存的ラメリポディアへの選択的集積 (2014)
  • Author(s): 淺田明子、伊藤有紀, 高野哲也, Sharma Govinda, 斉藤太郎, 太田安隆、天野睦紀, 貝淵弘三, 久永眞市.
  • Organizer: 第57回日本神経化学会大会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-30
• [Presentation] 電位依存性カルシウムチャネル活性に対するCdk5の影響 (2014)
  • Author(s): 古澤孝太郎、浅田明子、斎藤太郎、久永眞市
  • Organizer: 第57回日本神経化学会大会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-30
• [Presentation] New insights in tau phosphorylation obtained by Phos-tag SDS-PAGE analysis. (2014)
  • Author(s): Kimura, T., Hatsuta, H., Masuda-Suzukake, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
  • Organizer: 第57回日本神経化学会大会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-29
• [Presentation] 微小管結合タンパク質タウのGSK3βによる生理的および病理的リン酸化のPhos-tag法を用いた再検証 (2014)
  • Author(s): 米澤遼、 網本紫、木村妙子、斎藤太郎、 久永眞市
  • Organizer: 第57回日本神経化学会
  • Place of Presentation: 奈良市
  • Year and Date: 2014-09-29
• [Presentation] Tau /tau interaction through Cys residue form a toxic tau aggregate. (2014)
  • Author(s): Takashima A.
  • Organizer: 7th Asian Aging Core for Longevity (AACL) conference in Jeju
  • Place of Presentation: Jeju, Korea.
  • Year and Date: 2014-09-22
  • Invited
• [Presentation] マウス脳における内在性および外来性 tau の局在 (2014)
  • Author(s): 久保厚子、御園生裕明、松山誠、高島明彦、井原康夫、宮坂知宏
  • Organizer: 第37回日本神経科学大会 Neuroscience 2014
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-12
• [Presentation] Quality loss of FUS and SFPQ in the nucleus causes FTLD-like behavioral abnormalities by modulating Tau isoforms. (2014)
  • Author(s): Shinsuke Ishigaki, Yusuke Fujioka, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Masahisa Katsuno, Haruo Okado, and Gen Sobue
  • Organizer: The 37th annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] The involvement of glial cells in FUS-related ALS/FTLD pathology -FUS knock-down glial cells have a neurotrophic effect.- (2014)
  • Author(s): Yusuke Fujioka, Shinsuke Ishigaki, Takashi Shiromizu, Tsuyoshi Udagawa, Satoshi Yokoi, Daiyu Honda, Kensuke Ikenaka, Masahisa Katsuno, Takeshi Tomonaga, and Gen Sobue
  • Organizer: The 37th annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 神経脱髄疾患の時間・空間的多発性の解析 (2014)
  • Author(s): 池川雅哉
  • Organizer: 第67回日本酸化ストレス学会
  • Place of Presentation: 京都市
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] Characterizing Mouse Thymus using Imaging Mass Microscope. (2014)
  • Author(s): Yudai Tsuji, Hayato Nishitani, Tomoyuki Nakamura, Yumi Matsumoto, Hideshi Fujiwake, Kei Tashiro, Masaya Ikegawa.
  • Organizer: International Mass Spectrometry Conference,
  • Place of Presentation: Geneva, Switzerland.
  • Year and Date: 2014-08-29
• [Presentation] Plasma proteomic biomarker strategy in a porcine hepatectomy model. (2014)
  • Author(s): Kohta Iguchi, Masaya Ikegawa, Etsuro Hatano, Takashi Nirasawa, Noriyuki Iwasaki, Tomohito Sakai, Kenya Yamanaka, Motohiko Sato, Gen Yamamoto, Tatsuya Okamoto, Yosuke Kasai, Kojiro Taura, Kei Tashiro, Shinji Uemoto.
  • Organizer: International Mass Spectrometry Conference,
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2014-08-29
• [Presentation] The effect of Cyclin-dependent kinase 5 on voltage-dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state. (2014)
  • Author(s): Furusawa, K., Asada, A., Saito, T., Hisanaga, S.
  • Organizer: 第12回アジア太平洋神経化学会
  • Place of Presentation: 台湾
  • Year and Date: 2014-08-25
• [Presentation] Phosphorylation of Drebrin by Cyclin-dependent kinase 5 and Its Role in Neuronal Migration. (2014)
  • Author(s): Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima, T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., Hisanaga, S.
  • Organizer: 第12回アジア太平洋神経化学会
  • Place of Presentation: 台湾
  • Year and Date: 2014-08-25
• [Presentation] New aspects of tau phosphorylation obtained by Phos-tag SDS-PAGE. (2014)
  • Author(s): Kimura, T., Hosokawa, T., Tsutsumi, K., Masuda-Suzukake, M., Hosokawa, M., Ishiguro, K., Akiyama, H., Murayama, S., Hasegawa, M., Hisanaga, S.
  • Organizer: 第12回アジア太平洋神経化学会
  • Place of Presentation: 台湾
  • Year and Date: 2014-08-24
• [Presentation] Effect of valproic acid on Cdk5 activity and mouse behavior. (2014)
  • Author(s): Takahashi, M., Ishida, M., Saito, T., Ohshima, T., Hisanaga, S.
  • Organizer: 第12回アジア太平洋神経化学会
  • Place of Presentation: 台湾
  • Year and Date: 2014-08-24
• [Presentation] タウ分子からアプローチするアルツハイマー病 (2014)
  • Author(s): 高島明彦
  • Organizer: 公益財団法人新世代研究所 バイオ単分子研究会
  • Place of Presentation: 静岡県伊東市
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] Granular tau oligomer as toxic tau aggregation form in AD. (2014)
  • Author(s): Takashima A.
  • Organizer: Alzheimer’s Association International Conference 2014
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-07-14
• [Patent(Industrial Property Rights)] タウのスプライシングを制御するアンチセンスオリゴヌクレオチド及びその用途 (2018)
  • Inventor(s): 祖父江、石垣、佐橋、遠藤、閨、藤原、松田
  • Industrial Property Rights Holder: 国立大学法人名古屋大学、神戸天然物化学株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途 (2018)
  • Inventor(s): 祖父江、石垣、佐橋 、永井、前田、武内、閨、藤原、松田
  • Industrial Property Rights Holder: 国立大学法人名古屋大学、国立大学法人大阪大学、神戸天然物化学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途 (2017)
  • Inventor(s): 祖父江、石垣、佐橋、永井、前田、武内、閨、藤原、松田
  • Industrial Property Rights Holder: 国立大学法人 名古屋大学/大阪大学, (株)神戸天然物化学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] 細胞内容物の回収方法および回収装置 (2017)
  • Inventor(s): 宇理須恒夫、石垣診祐、宇野秀隆、高村禅
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] 2,4-ジアミノフェノール誘導体、及び、タウ及び／又はアミロイドβの凝集阻害剤 (2017)
  • Inventor(s): 宮坂知宏、杉本八郎、井上善一 他4名
  • Industrial Property Rights Holder: 同志社大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-03-08
  • Overseas
• [Patent(Industrial Property Rights)] 灌流用注射針 (2016)
  • Inventor(s): 宮坂知宏、久保厚子
  • Industrial Property Rights Holder: 同志社大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-22
  • Overseas
• [Patent(Industrial Property Rights)] イメージング質量分析の前処理方法 (2016)
  • Inventor(s): 池川雅哉、宮坂知宏、角田伸人、韮沢崇
  • Industrial Property Rights Holder: 同志社大学、ブルカー・ダルトニクス株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-231372
  • Filing Date: 2016-11-29