| Budget Amount *help |
¥113,360,000 (Direct Cost: ¥87,200,000、Indirect Cost: ¥26,160,000)
Fiscal Year 2018: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2017: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2016: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2015: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2014: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
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| Outline of Final Research Achievements |
Proteins that cause dementia are "transformed into pathogenic proteins and accumulated" in "selected nervous systems" with aging. This process is accompanied by "quantitative and qualitative alterations in proteins." The amount of protein is controlled by production and degradation, production is controlled by mRNA, and degradation is controlled by intracellular degradation systems and extracellular efflux mechanisms. We found that the RNA metabolism mechanism of TDP-43 causing age-related neurodegenerative diseases is disturbed. Furthermore, by disrupting RNA metabolism in vivo, we succeeded in causing fragmentation of TDP-43 and inducing apoptosis.
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