| Budget Amount *help |
¥140,920,000 (Direct Cost: ¥108,400,000、Indirect Cost: ¥32,520,000)
Fiscal Year 2018: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2017: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2015: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2014: ¥59,150,000 (Direct Cost: ¥45,500,000、Indirect Cost: ¥13,650,000)
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| Outline of Final Research Achievements |
The aim of this study is largely classified into two: (1) Extensively exploring a new research field of “dynamic structural biology” that seeks to film protein molecules in dynamic action with high-speed AFM, not only by conducting the study by myself but also by collaborating with researchers of the project group as well as external researchers, and (2) enabling observation of new molecular phenomena that have been impossible with the current high-speed AFM, by advancing the capability of high-speed AFM. For the aim (1), our instruments were opened to these researchers. Through many collaborations, we succeeded in observing a variety of proteins, providing mechanistic insights into their molecular processes. For the aim (2), we succeeded in developing high-speed AFM combined with optical tweezers and super-resolution fluorescence microscopy based on high-speed AFM. The actual application studies of these new instruments are subjects to be done in the future.
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