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Development of analyzing methods for protein-protein interactions and protein dynamics by means of ODMR and in-cell NMR

Planned Research

Project AreaNovel measurement techniques for visualizing 'live' protein molecules at work
Project/Area Number 26119004
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionKyoto University

Principal Investigator

Shirakawa Masahiro  京都大学, 工学研究科, 教授 (00202119)

Co-Investigator(Renkei-kenkyūsha) TOCHIO Hidehito  京都大学, 理学研究科, 教授 (70336593)
Project Period (FY) 2014-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥153,270,000 (Direct Cost: ¥117,900,000、Indirect Cost: ¥35,370,000)
Fiscal Year 2018: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2017: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2016: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥66,300,000 (Direct Cost: ¥51,000,000、Indirect Cost: ¥15,300,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
KeywordsODMR / in-cell NMR / 細胞内蛋白質 / 細胞小器官 / Rheo-NMR / in cell NMR
Outline of Final Research Achievements

Methods to create NV centers which are characterized by a crystal lattice vacancy and it adjustments are created. In addition, method targeting the NVC containing ND to biomolecules and technique to measure ODMR of the biomolecule-attached ND have been developed. For protein assemblies (ex. cytoskeltons), by labeling subunit of the assemblies with ND particles, it was possible to characterize the assembly states and mechanism.
We also generated a method to measure NMR spectroscopy of proteins under the presence of rheologic forces --- rheology NMR. The new method is convenient, and applicable to modern NMR machine.

Academic Significance and Societal Importance of the Research Achievements

生細胞・生体内での生体高分子の立体構造、集合状態、ダイナミクス等を直接定量的に計測する方法を得つつある。これにより、将来的には、生物の生きた状態を生体分子がいかに成立させているかを、一分子レベルで、またはアンサンブルレベルで可視化・計測することが可能になる。よって、生きた状態を成り立たせる分子論的な必要条件の端緒が見つかると期待される。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (47 results)

All 2018 2017 2016 2015 2014

All Journal Article (26 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 25 results,  Open Access: 24 results,  Acknowledgement Compliant: 9 results) Presentation (21 results) (of which Int'l Joint Research: 4 results,  Invited: 21 results)

  • [Journal Article] Backbone and side-chain resonance assignments of the methyl-CpG-binding domain of MBD6 from Arabidopsis thaliana2018

    • Author(s)
      Iwakawa Naoto、Mahana Yutaka、Ono Arina、Ohki Izuru、Walinda Erik、Morimoto Daichi、Sugase Kenji、Shirakawa Masahiro
    • Journal Title

      Biomolecular NMR Assignments

      Volume: 13 Issue: 1 Pages: 59-62

    • DOI

      10.1007/s12104-018-9851-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] One-Pot Synthesis of Highly Dispersible Fluorescent Nanodiamonds for Bioconjugation2018

    • Author(s)
      Terada Daiki、Sotoma Shingo、Harada Yoshie、Igarashi Ryuji、Shirakawa Masahiro
    • Journal Title

      Bioconjugate Chemistry

      Volume: 29 Issue: 8 Pages: 2786-2792

    • DOI

      10.1021/acs.bioconjchem.8b00412

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization2018

    • Author(s)
      Fujita Hiroaki、Tokunaga Akira、Shimizu Satoshi、Whiting Amanda L.、Aguilar-Alonso Francisco、Takagi Kenji、Walinda Erik、Sasaki Yoshiteru、Shimokawa Taketo、Mizushima Tsunehiro、Ohki Izuru、Ariyoshi Mariko、Tochio Hidehito、Bernal Federico、Shirakawa Masahiro、Iwai Kazuhiro
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 4 Pages: 1192-1204

    • DOI

      10.1016/j.celrep.2018.03.112

    • NAID

      120006460107

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enrichment of ODMR-active nitrogen-vacancy centres in five-nanometre-sized detonation- synthesized nanodiamonds: Nanoprobes for temperature, angle and position2018

    • Author(s)
      Sotoma S, Terada D, Segawa TF, Igarashi R, Harada Y, Shirakawa M.
    • Journal Title

      Sci.Rep.

      Volume: 8 Issue: 1 Pages: 5463-5463

    • DOI

      10.1038/s41598-018-23635-5

    • NAID

      120006517896

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isolation and characterization of a minimal building block of polyubiquitin fibrils2018

    • Author(s)
      Morimoto Daichi、Walinda Erik、Shinke Mayo、Sugase Kenji、Shirakawa Masahiro
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2711-2711

    • DOI

      10.1038/s41598-018-21144-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-time observation of the interaction between thioflavin T and an amyloid protein by using high-sensitivity Rheo-NMR.2017

    • Author(s)
      Iwakawa N., Morimoto D., Walinda E., Kawata Y., Shirakawa M., Sugase K.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 18 Issue: 11 Pages: 2271-2271

    • DOI

      10.3390/ijms18112271

    • NAID

      120006501319

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure of the Dnmt1 reader module complexed with a unique two-mono-ubiquitin mark on histone H3 reveals the basis for DNA methylation maintenance.2017

    • Author(s)
      Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M
    • Journal Title

      Mol Cell

      Volume: 68 Issue: 2 Pages: 350-360

    • DOI

      10.1016/j.molcel.2017.09.037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches2017

    • Author(s)
      Morimoto Daichi、Walinda Erik、Sugase Kenji、Shirakawa Masahiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 6 Pages: 1145-1145

    • DOI

      10.3390/ijms18061145

    • NAID

      120006318888

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] F1F2-selective NMR spectroscopy2017

    • Author(s)
      Walinda Erik、Morimoto Daichi、Shirakawa Masahiro、Sugase Kenji
    • Journal Title

      Journal of Biomolecular NMR

      Volume: 68 Issue: 1 Pages: 41-52

    • DOI

      10.1007/s10858-017-0113-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical considerations for investigation of protein conformational dynamics by 15N R 1ρ relaxation dispersion.2017

    • Author(s)
      Walinda E, Morimoto D, Shirakawa M, Sugase K.
    • Journal Title

      Biomol NMR.

      Volume: 印刷中 Issue: 3 Pages: 201-209

    • DOI

      10.1007/s10858-017-0097-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Backbone resonance assignments of monomeric SOD1 in dilute and crowded environments.2017

    • Author(s)
      Iwakawa N, Morimoto D, Walinda E, Sugase K,Shirakawa M
    • Journal Title

      Biomol NMR Assign.

      Volume: 11 Issue: 1 Pages: 81-84

    • DOI

      10.1007/s12104-016-9724-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ubiquitylation Directly Induces Fold Destabilization of Proteins.2016

    • Author(s)
      Morimoto D , Walinda E, Fukada H, Sugase K, Shirakawa M
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 39453-39453

    • DOI

      10.1038/srep39453

    • NAID

      120005947214

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Nanodiamond-peptide Bioconjugate for Fluorescence and ODMR Microscopy of a Single Actin Filament2016

    • Author(s)
      Genjo T1, Sotoma S, Tanabe R, *Igarashi R, Shirakawa M.
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 11 Pages: 1165-1170

    • DOI

      10.2116/analsci.32.1165

    • NAID

      130005278003

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-invasive Analysis of Proteins in Living Cells Using NMR Spectroscopy2015

    • Author(s)
      Tochio H, Murayama S, Inomata K, Morimoto D, Ohno A, Shirakawa M.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 135 Issue: 3 Pages: 391-398

    • DOI

      10.1248/yakushi.14-00240-3

    • NAID

      130004756506

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2015-03-01
    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Nucleosome compaction facilitates HP1γ binding to methylated H3K9.2015

    • Author(s)
      Mishima Y, Jayasinghe CD, Lu K, Otani J, Shirakawa M, Kawakami T, Kimura H, Hojo H, Carlton P, Tajima S, Suetake I
    • Journal Title

      Nucleic Acids Res

      Volume: 43 Pages: 10200-10212

    • DOI

      10.1093/nar/gkv841

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling.2015

    • Author(s)
      Yoshinari, Y., Mori, S., Igarashi, R., Sugi, T., Yokota, H., Ikeda, K., Sumiya, H., Mori, I, Tochio, H., *Harada, Y. and Shirakawa, M.
    • Journal Title

      J Nanosci Nanotechnol.

      Volume: 15 Issue: 2 Pages: 1014-1021

    • DOI

      10.1166/jnn.2015.9739

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive and quantitative analysis for controlling the physical/chemical states and particle properties of nanodiamonds for biological applications2015

    • Author(s)
      Sotoma, S., Akagi, K., Hosokawa, S., Igarashi, R., Tochio, H., Harada, Y., and Shirakawa
    • Journal Title

      RSC Advances

      Volume: 5 Issue: 18 Pages: 13818-13827

    • DOI

      10.1039/c4ra16482b

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of Non-Specific Protein-Nanodiamond Adsorption Enabling Specific Targeting of Nanodiamonds to Bio-molecules of Interest2015

    • Author(s)
      Shingo Sotoma, Ryuji Igarashi, Jun Iimura, Yuta Kumiya, Hedehito Tochio, Yoshie Harada and Masahiro Shirakawa,
    • Journal Title

      Chemistry letters

      Volume: 44 Issue: 3 Pages: 354-356

    • DOI

      10.1246/cl.141036

    • NAID

      130004868380

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.2015

    • Author(s)
      Morimoto D,Walinda E, Fukada H, Sou YS, Kageyama S, Hoshino M, Fujii T, Tsuchiya H, Saeki Y, Arita K, Ariyoshi M, Tochio H, Iwai K, Namba K, Komatsu M, Tanaka K, Shirakawa M.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 6116-6116

    • DOI

      10.1038/ncomms7116

    • NAID

      120005528125

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer2015

    • Author(s)
      Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo
    • Journal Title

      Journal of the American Chemical Society

      Volume: 137 Issue: 2 Pages: 799-806

    • DOI

      10.1021/ja510479v

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effective Production of Fluorescent Nanodiamond Containing Negatively-Charged Nitrogen-Vacancy Center by Ion Irradiation2014

    • Author(s)
      Shingo Sotoma, Yosuke Yoshinari, Ryuji Igarashi, Akiyoshi Yamazaki, Shige H. Yoshimura, Hidesato Tochio, Masahiro Shirakawa and Yoshie Harada
    • Journal Title

      Diamond and Related Materials

      Volume: 49 Pages: 33-38

    • DOI

      10.1016/j.diamond.2014.07.011

    • NAID

      120005474529

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The structural basis for receptor recognition of human interleukin-182014

    • Author(s)
      Naotaka Tsutsumi, Takeshi Kimura, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Takahiro Yamamoto, Xiaobing Zuo, Katsumi Maenaka, Enoch Y. Park, Naomi Kondo, Masahiro Shirakawa, Hidehito Tochio and Zenichiro Kato
    • Journal Title

      Nat. Commun.

      Volume: 5 5340 Issue: 1 Pages: 1-13

    • DOI

      10.1038/ncomms6340

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-throughput optical quantification of mechanosensory habituation reveals neurons encoding memory in Caenorhabditis elegans.2014

    • Author(s)
      Sugi T, Ohtani Y, Kumiya Y, Igarashi R, Shirakawa M
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 111 Issue: 48 Pages: 17236-17241

    • DOI

      10.1073/pnas.1414867111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes2014

    • Author(s)
      Takeshi Kimura, Naotaka Tsutsumi, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Naomi Kondo, Masahiro Shirakawa, Zenichiro Kato and Hidehito Tochio
    • Journal Title

      Acta Crystallogr. Sect. F Struct. Biol. Commun.

      Volume: 70 Issue: 10 Pages: 1351-1356

    • DOI

      10.1107/s2053230x14016926

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and its Interaction with Ubiquitin and Polyubiquitin.2014

    • Author(s)
      E. Walinda, D. Morimoto. K. Sugase. T. Konuma. H. Tochio, M. Shirakawa
    • Journal Title

      The Journal of Biological Chemistry

      Volume: (印刷中) Issue: 20 Pages: 13890-13902

    • DOI

      10.1074/jbc.m114.555441

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquitin-proteasome-mediated degradation of S-RNase in a solanaceous cross-compatibility reaction2014

    • Author(s)
      Tetsuyuki Entani, Ken-ichi Kubo, Shin Isogai, Yoichiro Fukao, Masahiro Shirakawa, Akira Isogai, Seiji Takayama
    • Journal Title

      Plant Journal

      Volume: 印刷中 Issue: 6 Pages: 1014-1021

    • DOI

      10.1111/tpj.12528

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ダイヤモンドNV中心を使った量子センシングの分子・細胞生物学への応用2018

    • Author(s)
      白川昌宏
    • Organizer
      量子生命科学研究会第2回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Magnetic resonance spectroscopy of single nanoparticle - a quantum sensor for molecular and cell biology2018

    • Author(s)
      白川昌宏
    • Organizer
      2018 Korean Magnetic Resonance Society Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cell biology using nanogyroscope by optically detected magnetic resonance (ODMR) spectroscopy2018

    • Author(s)
      白川昌宏
    • Organizer
      the 7th Yamada workshop on RI Science Evolution (RISE18)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ダイアモンドNV中心の量子センシングを使った分子・細胞生物学2018

    • Author(s)
      白川昌宏
    • Organizer
      日本学術振興会「先端ナノデバイス・材料テクノロジー」151委員会平成29年度第5回研究会「量子計測・センシングの最前線と今後の展開」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ダイヤモンドNV中心を使った量子センシングの分子・細胞生物学への応用2017

    • Author(s)
      白川昌宏
    • Organizer
      生命科学系学会合同年次大会(ConBIo2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光検出磁気共鳴法による生細胞における1分子運動の計測2017

    • Author(s)
      白川昌宏
    • Organizer
      第56回NMR討論会(2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光検出磁気共鳴法を使った細胞生物学の実験手法2017

    • Author(s)
      白川昌宏
    • Organizer
      化学研究所NMR国際シンポジウム2017:DNP-NMR ワークショップ
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell biology using nanogyroscope by optically detected magnetic resonance (ODMR) spectroscopy2017

    • Author(s)
      白川昌宏
    • Organizer
      the 5th Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications” (5th AWEST 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ダイヤモンドNV中心を使った量子センシングの分子・細胞生物学への応用2017

    • Author(s)
      白川 昌宏
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生細胞または生体における生体分子の量子センシング2017

    • Author(s)
      白川 昌宏
    • Organizer
      ミニシンポジウム 生命科学・量子技術・ナノエレ・研究の融合 Interdisciplinary field : 「Life science」-「Quantum technology」-「Nano electronics」
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体分子間の非共有結合相互作用に関する物理的化学的研究2017

    • Author(s)
      白川 昌宏
    • Organizer
      日本学術会議 薬学委員会 化学・物理系薬学分科会、生物系薬学分科会、日本薬学会シンポジウム『新しい展開を目指す化学・物理系薬学領域の研究』
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cell Biology using nanogyroscope by optically detected magnetic resonance(ODMR) spectroscopy2016

    • Author(s)
      白川 昌宏
    • Organizer
      The 21th International Conference on Magnetic Resonance in Biolgical Systemes(ICMRBS
    • Place of Presentation
      京都
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光検出磁気共鳴法を使った高分解能イメージング2016

    • Author(s)
      白川 昌宏
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ナノダイアモンド標識による蛋白質構造解析2016

    • Author(s)
      白川 昌宏
    • Organizer
      第55回電子スピンサイエンス学会
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Actions of cellular macromolecules observed by magnetic resonance spectroscopy2016

    • Author(s)
      白川 昌宏
    • Organizer
      大阪大学 国際蛋白研究所セミナー”Protein NMR Beyond”
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] High-resolution imaging by using optically-detected magnetic resonance2015

    • Author(s)
      白川昌宏
    • Organizer
      九大生医研国際シンポジウム
    • Place of Presentation
      九州大学馬出病院キャンパス 福岡市
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 光検出磁気共鳴法による細胞・生体の高分解能イメージング2015

    • Author(s)
      白川昌宏
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所, 大阪府吹田市
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ダイアモンド粒子の窒素-空孔中心(NVC)を用いた生体・細胞のナノジャイロセンシング手法の開発2015

    • Author(s)
      白川昌宏、五十嵐龍治、久美屋雄太、 杉拓磨、 外間進悟、 杤尾豪人、 吉成洋祐、 原田慶恵
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      徳島あわぎんホール 徳島市
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] In cells and in vitro studies of ubiquitin, polyubiquitin chains and proteins attached to them.2015

    • Author(s)
      白川昌宏、猪股晃介 , 森本大智 , Walinda Erik , 菅瀬謙治 , 杤尾豪人 , 二木史朗
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場 神戸市
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Magnetic resonance study of structures, functions and dynamics of proteins in living cells2015

    • Author(s)
      白川昌宏
    • Organizer
      the 16th Beijing Conference and Exhibition on Instrumental Analysis
    • Place of Presentation
      China National Convention Center, Beijing, 中華人民共和国
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNAメチル化の構造生物学とin-cell NMRによる細胞内でのタンパク質と薬剤の相互作用の観察2014

    • Author(s)
      白川 昌宏
    • Organizer
      日本薬学会医薬化学部会第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-11-20   Modified: 2020-03-30  

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