| Budget Amount *help |
¥125,060,000 (Direct Cost: ¥96,200,000、Indirect Cost: ¥28,860,000)
Fiscal Year 2018: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2017: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
Fiscal Year 2016: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
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| Outline of Final Research Achievements |
Protein secretion in bacteria is an essential mechanism, which is mediated by Sec proteins. However, the detailed molecular mechanism of how Sec proteins are transported still remains unclear. In this study, we performed X-ray crystallographic analysis and observation of Sec proteins using high-speed atomic force microscope to elucidate the mechanism. As the result, the system which could observe the protein secretion reaction by real-time single unit analysis was established, while the structures of Sec proteins in various forms was solved.
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