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腫瘍局所に対する至適な化学療法の確立に関する研究

Research Project

Project/Area Number 01010046
Research Category

Grant-in-Aid for Cancer Research

Allocation TypeSingle-year Grants
Research InstitutionKyushu University

Principal Investigator

馬場 恒男  九州大学, 生体防御医学研究所, 教授 (70037323)

Co-Investigator(Kenkyū-buntansha) 永末 直文  島根医科大学, 教授 (40117198)
藤田 浩  鶴見大学, 歯学部, 教授 (50064332)
平林 光司  国立福山病院, 医長
前田 浩  熊本大学, 医学部, 教授 (90004613)
秋吉 毅  九州大学, 生体防御医学研究所, 教授 (70038660)
Project Period (FY) 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 1989: ¥14,200,000 (Direct Cost: ¥14,200,000)
Keywords昇圧2経路化学療法 / シスプラチナ / アンギオテンシン-II / Sodium thiosulfate / 時間差化学療法
Research Abstract

癌性腹膜炎(胃癌、腸癌、卵巣癌、等)に対して、基礎及び臨床的治療研究で昨年に比べて大きく前進した。すなわち、我々の独自の研究によって開発された処のいわゆる昇圧2経路化学療法は、基礎実験的研究が大いに進展し、肝転移癌、子宮体部移植癌に対して局所動脈内DDP+ATーII投与、10分後にSTSを静注する時間差投与化学療法が極めて優秀な制癌性を発揮し、しかも腎毒性を強く抑制出来ることが明かとなった。
更に動物実験が進展して、遂に2経路投与に頼る事なく、同一の静脈より時間差をおいて投与(DDP+ATーII、5〜10分後にSTS)すれば、全身的薬剤投与によっても極めて優れた制癌効果を得ることが証明された。この治療法により臨床的に末期の卵巣癌、胃癌、腸癌等による癌性腹膜炎患者の多数例が治療された。高率に腹水減少、生存期間の延長等が観察され、現在、更に症例を増して検討続行中である。一方、臨床的肝癌、肝転移癌に対して栓塞化学療法が種々の工夫改良されながら症例を増加させている。
シスプラチンの各種誘導体についてその薬理動態、制癌性の優劣が比較検討され、制癌剤の高分子化について腫瘍内血管の透過性との関連から開発が研究された。

Report

(1 results)
  • 1989 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Hiroaki Kobayashi: "Two-route Chemotherapy"Using cis-Diamminedichloroplatinum(II)and Its Antidote,Sodium Thiosulfate,Combinated with Angiotensin II is effective against Peritoneally Disseminated Cancer in Rats." Cancer Chemotherapy & Pharmacology. 24. 141-147 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Keitaro Hasuda: "Efficacy of two-route Chemotherapy Using cis-Diamminedichloro-platinum(II)and Its Antidote,Sodium thiosulfate,in Combination with Angiotensin II for Rat Liver Tumor." International Journal of Cancer. 44. 373-377 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Keitaro Hasuda: "Efficacy of two-route Chemotherapy Using Intraperitoneal Neocarzinostatin and Its Antidote,Intravenous Tiopronin,for Peritoneally Disseminated Tumors in Mice." Japanese Journal of Cancer Research. 80. 283-289 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hiroshi Maeda: "Tumoritropic and Lymphotropic Principles of Macromolecular Drugs" Critical Reviews in Therapeutic Drug Carrier Systems. 6. 193-210 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤田浩: "新プラチン誘導体の実験動物における体内動態について" 癌と化学療法. 16. 1366-1372 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hironobu Nakamura: "Transcatheter Oily Chemoembolization of Hepatocellular Cancinoma" Radiology. 170. 783-786 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 中村仁信: "肝細胞癌に対する油性塞栓化学療法の限界と肝区域性動脈門脈同時塞栓化学療法" 癌と化学療法. 16. 2849-2852 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Naofumi Nagasue: "Adverse effects of preoperative Hepatic Artery Chemoembolization for resectable Hepatocellular Carcinoma:A retrospective Comparison of 138 Liver Resections" Surgery. 106. 81-86 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Naofumi Nagasue: "Liver Resection for Hepatocellular Carcinoma:Results from 150 Consecutive Patients" Cancer Chemotherapy&Pharmacology. 23. S78-S82 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Naofumi Nagasue: "Iron,Copper and Zine Levels in Serum and Cirrhotic Liver of Patients with and without Hepatocellular Carcinoma" Oncology. 46. 293-296 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Naofumi Nagasue: "Androgen and Estrogen Receptors in Hepatocellular Carcinoma and the Surrounding Liver in Women" Cancer. 63. 112-116 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 西満正: "胃癌の集学的治療" 外科治療. 60. 56-62 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 平林光司: "腹腔内投与" 癌と化学療法. 16. 180-186 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nobuaki Kaibara: "Hyperthermic Peritoneal Perfusion Combined with Anticancer Chemotherapy as Prophylactic Treatment of Peritoneal Recurrence of Gastric Cancer" Hepatogastroenterology. 36. 75-78 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Michio Maeta: "The Effect of Angiotensin II on Blood Flow in Tumours during Localized Hyperthermia" International Journal of Hyperthermia. 5. 191-197 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 古賀成昌: "温熱療法" 臨床と研究. 66. 809-813 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ryoji Abe: "Inactivation of cis-Diamminedichloroplatinum(II)in Blood by by Sodium Thiosulfate" Oncology. 47. 65-69 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Toshiharu Kamura: "Efficacy of Second-look Laparotomy for the Patients with Epithelial Ovarian Carcinoma" International Journal of Gynecology&Obstet.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hironobu Nakamura: "Cancer Chemotherapy:Challenges for the Future" Excerpta Medica, 95-103 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Koji Hirabayashi: "Cancer Chemotherapy:Challenges for the Future" Excerpta Medica, 287-292 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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