| Project/Area Number |
01041009
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Institution | Faculty of Agriculture, Tohoku University |
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Principal Investigator |
YASUMOTO Takeshi Faculty of Agriculture, Tohoku University, 農学部, 教授 (20011885)
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| Co-Investigator(Kenkyū-buntansha) |
ANNEーMARIE L ルイ, マラルデ医学研究所・薬理・毒性学研究室, 主任研究員
ISHIMARU Takashi Tokyo University of Fisheries, 資源育成学科, 助教授 (90114371)
INOUE Akio Research Center for the South Pacific, Kagoshima University, 南太平洋海域研究センター, 教授 (10034456)
LEGRAND Anne-Marie Institut Territorial de Recherches Medicales Louis Malarde
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| Project Period (FY) |
1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Ciguatera / Ciguatoxin / Gambierdiscus toxicus / Chemical structure / Causative organism |
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| Research Abstract |
In tropical coral reef areas many edible fishes may accumulate toxins through the food chain and thus cause human intoxication when eaten. Ciguatera represents the most prevalent form of such poisoning, affecting nearly 20,000 people annually. The aim of the present survey was set to elucidate the source and structures of implicated toxins.
For the first time in ciguatera research, we determined with only 350 ug material the chemical structure of ciguatoxin, the principal toxin in ciguatera. We also proved the origin of ciguatoxin by isolating a less oxidized analos from this alga. The two toxins are characterized by the presence of 13 contiguously fused ether rings. They differed from each other only at the terminal parts of the molecules. The structural information suggests the possibility of screening individual fish by means of fluorometric HPLC analyses and immunoenzyme assays.
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