| Project/Area Number |
01042003
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEBE Hiraku Kyoto University, 医学部, 教授 (10028318)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIGORI Chikako Kyoto University, 保健診療所, 助手 (50198454)
蒋 左庶 第二軍医大学, 生物学科, 教授
朴 相大 ソウル国立大学, 自然科学部, 教授
MOHAMED Zgha チュニス大学病院, 医師
TSUKADA Toshihiko Kyoto University, 医学部, 助手 (10207334)
YAGI Takashi Kyoto University, 医学部, 助教授 (80182301)
ZGHAL Mohamed Hopital Charles Nicolle
PARK Sandai Seoul National University
JINAG Zushou 2nd Military Medical College
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1991: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | xeroderma pigmentosum / skin cancer / sun exposure / ultraviolet light / China / Korea / Tunisia / DNA repair |
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| Research Abstract |
Gene analysis of xeroderma pigmentosum in North-East Asia and Northern Africa
Xeroderma pigmentosum is an autosomal recessively inherited disease with high incidence of skin cancer developing in the sun-exposed area of the patients. Genetic analysis revealed the presence of at least 7 genetic complementation groups and a variant type and the distribution of these groups have been shown to be different in different areas of the world. The chief investigator of this project has been analyzing the gene distribution of xeroderma pigmentosum in Japan, North America and Europe, and this project intends to extend the survey to the above-mentioned areas. Patients in China were found to be very similar to those in Japan, ih clinical manifestations, genetic distribution and DNA repair defects in theocells cultured from the patients. Patients in Korea appeared to be different in genedistribution, with essentially no patients with neurological abnormalities which are the most frequent in Japan. In Tunisia, the frequency of xeroderma pigmentosum patients was found to be approximately 10 times higher that that in Japan, presumably because of the high frequency of consanguineous marriage common in most of Arab countries. Genetic complementation analysis of the Tunisian patients identified groups A and C only, so far, similar to the previous report from Egypt. Although the latitude of Tunisia and South-Western parts of Japan is similar, patients in Tunisia were far more seriously affected, presumably due to the sunny climate and the poor medical care. Genetic analysis supported this possibility, since the genetic complementation groups in South-West Japan are similar to those in Tunisia, with similar levels of DNA repair defects against ultraviolet light induced damages associated with the disease.
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