| Co-Investigator(Kenkyū-buntansha) |
SOUZA Jose Maria Sao Paulo University, School of Public Health, 疫学教室, 教授
GOTLIEB Sabina Sao Paulo University, school of Public Health, 疫学教室, 教授
LAURENTI Ruy Sao Paulo University, 副学長
TAKASHIMA Yutaka Kitasato University, School of Medicine, 公衆衛生学教室, 講師 (20163199)
NANRI Seiichiro Keio University Health Administration Center, 保健管理センター, 講師
KABUTO Michinori National Institute of Environmental Health Science, 環境保健部, 室長 (00113481)
津金 昌一郎 国立がんセンター研究所, 疫学部, 室長 (40179982)
TSUGANE Shoichiro National Cancer Center Research Institute
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| Budget Amount *help |
¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 1990: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1989: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Research Abstract |
This project is a series of collaborative surveys conducted by the Epidemiology Division of the National Cancer Center Research Institute and the Department of Epidemiology of the Sao Paulo University Public Health School. Prior to this project, the same group described the mortality and main causes of death among Japanese immigrants living in Sao Paulo city.
Cancer incidence rates among first-generation Japanese immigrants in the city of Sao Paulo, Brazil were estimated from the data of the Sao Paulo Cancer Registry during the years 1969 to 1978. From all registered cases, 2,179 cancer cases of Japan-born residents (males : 1,288, females : 891) were selected and age-specific and age-adjusted (to the world population) incidence rates (AAIR) were calculated for selected sites of cancer. The AAIR for all sites but non-melanoma skin cancer was 195.2 per 100,000 population (95% confidence interval : 176.4-214.1) in males and 147.3 (134.6-160.0) in females. Stomach cancer has the highest in
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cidence rate in both sexes (males : 69.3, females : 32.0), which was followed by cancer of the lung (22.5), esophagus (10.2), colon (8.3) and prostate (7.1) in males, and by breast (24.0), cervix (18.0), colon (8.4) and lung (7.2) in females. When these rates were compared with those among Japanese in Japan, cancer of the stomach and rectum revealed significantly lower rates, while non-melanoma skin cancer, and prostate and breast cancer showed higher rates. No significant increase of colo-rectal cancer was recognised among Japanese immigrants in Sao Paulo, contrary to the remarkably high rates of colo-rectal cancer being observed among Japanese immigrants in the U. S. A.
Another study is a cross-sectional survey for 273 Japanese households, with 147 Japanese immigrants (males 72, females 75) and 264 Brazil-born Japanese descendants (males 133, females 131) in the 40-69 year age range (born between July 1st. 1919 and June 30th. 1949), selected by geographical random sampling method. The purpose is to collect data on prevalence of lifestyle characteristics, certain biological markers and anthropometric measures among representative sample of Japanese immigrants in Sao Paulo city, and to correlate these data with known cancer mortality/incidence rates. Sampling of biological specimens such as urine and blood, questionnaires and health check-ups were conducted. 251 subjects (61%) responded to this survey. Some serum nutrients, ie. total protein, total cholesterol, triglyceride and uric acid, showed higher levels than those of Japanese living in Japan. The levels for second-generation Japanese were higher than those for first-generation Japanese. Some changes in dietary habits were recognized among Japanese residents in Sao Paulo and are possibly related to changes in the mortality and incidence rates of certain cancer.
We also performed the above mentioned cross-sectional study for the subjects whom we recruited from Japanese association according to original prefecture in Japan. The analysis is on-going. Less
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