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Biomechanics on the Growth and Deformation of Living Tissues and its Applications to Engineering

Research Project

Project/Area Number 01044009
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionHokkaido Univ.

Principal Investigator

HAYASHI Kozaburo  Research Institute of Applied Electricity, Hokkaido University, 応用電気研究所, 教授 (90026196)

Co-Investigator(Kenkyū-buntansha) WOO Savio L-Y  Dept. Orthopaedic Surgery, Univ. of California, San Diego, サンディエゴ校・整形外科, 教授
FUNG YuanーCh  カリフォルニア大学, サンディエゴ校・応用力学・物理工学科, 教授
TANAKA Masao  School of Engineering Sciences, Osaka Univ., 基礎工学部, 助手 (40163571)
SEGUCHI Yasuyuki  School of Engineering Sciences, Osaka Univ., 基礎工学部, 教授 (20031073)
MATSUMOTO Takeo  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 助手 (30209639)
YAMAMOTO Noritaka  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 助手 (40210546)
TADANO Shigeru  School of Engineering, Hokkaido Univ., 工学部, 講師 (50175444)
NAKAMURA Takao  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 講師 (00142654)
ISHIKAWA Hiromasa  School of Engineering, Hokkaido Univ., 工学部, 教授 (80001212)
FUNG Yuan-chen B  Dept. Appl. Mech. Eng. Sci., Univ. of California, San Diego
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1990: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1989: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsBiomechanics / Living tissues and organs / Bio-control / Bio-function / Functional adaptation / Optimal design / Model and simulation / Computation
Research Abstract

The purposes of this project were : 1) to study the functional adaptation of living tissues and organs to various mechanical environment, 2) to apply the optimal adaptation mechanisms to the development of new engineering methodologies, and 3) to establish a new organization for international cooperative research activities. The main results obtained are :
1. Arterial wall thickness increased promptly with the increase in blood pressure, Keeping the wall stress within a physiological range, followed by the change in such material properties as elastic modulus.
2. Release of tension in the patellar tendon decreased the tensile strength (fracture load divided by initial cross sectional area) rapidly and remarkably, while the strength was not changed by over-stressing. In response to these variation of mechanical environment, the cross sectional area of ligament increased compensatively to keep the structural strength at a normal level.
3. Air way-lung system was modelled considering the gas … More transportation in the air way, deformation behavior and surface tension of the lung, gas exchange between the alveolus and blood, and so on, which was successfully applied to simulate the respiratory mechanics.
4. An in-plane stress-based 3-D finite element model was proposed for the stress/strain analyses in the human whole lumbar spine, and successfully applied to analyze the stress distribution in each component of the normal and diseased spines exposed to various load condition.
5. The functional adaptation observed with living systems has possibilities of being applied to engineering field, for example, like the growth strain method for structural design. The technique developed to analyze the solid-fluid-gas interaction in biological systems would be very useful for the design and analysis of similar complex engineering systems.
6. By the action of the investigators for this project, the World Committee for Biomechanics has been established for the efficient exchange of information and international cooperative studies. Less

Report

(1 results)
  • 1990 Final Research Report Summary
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] K.Hayashi: "Biomechanical approach to the design of vascular prostheses" Tissue Engineering ー 1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.Yamamoto: "Effects of stress Shielding on the mechanical properties ofpatellar tendon" Tissue Engineering ー 1989. 103-106 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Nakamura: "Effect of longーterm pumping of cardiac assist device on the left ventricular mechanics (In the case of normal heart)" Artificial Organs.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.Yamamoto: "Mechanical properties of the rabbit patellar tendon" ASME,Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N.Yamamoto: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" ASME,Journal of Mechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Ohno: "Effects of stress shielding on the mechanical properties of normal and in situ frozen patellar tendon" Proc.37th Ann.Meet.Orth.Res.Soc.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Tadano: "A finite element model on whole Iumber spine in flexion" Tissue Engineering ー 1989. 71-74 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 但野 茂: "全腰つい(椎)の前方屈曲シミュレ-ション" 日本機械学会論文集. 56. 1885-1892 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 但野 茂: "生体内椎間板矢状面に生じるひずみ分布" 日本機械学会論文集.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Seguchi: "Preliminar study on adaptation by remodeling" Tissue Engineering ー 1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Tanaka: "A note on the ACL deformation under tensile loading along ligament and/or tibia direction" Tissue Engineering ー 1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Wada: "Simulation of breathing and ventilation combined with body circulation" 1990 Advances in Engineering. 67-70 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Wada: "Breathingーventilation model,and simulation of highーfrequency ventilation" JSME International Journal. 34. 98-105 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.C.Fung: "The future of biomechanics" 第2回バイオメカニクスカンファレンス講演論文集. 3 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.LーY.Woo: "Biomechanical evaluation of human anterior cruciate ligament" 第2回バイオメカニクスカンファレンス講演論文集. 1-2 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Hayashi: "Biomechanical approach to the design of vascular prostheses" Tissue Engineering - 1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N. Yamamoto, K. Ohno, H. Kuriyama, K. Yasuda, K. Hayashi and K. Kaneda: "Effects of stress shielding on the mechanical properties of patellar tendon" Tissue Engineering - 1989. 103-106 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Nakamura, K. hayashi, J. Seki, S. Fukuda, H. Noda, T. Nakatani, H. Takano and T. Akutsu: "Effects of long-term pumping of cardiac assist device on the left ventricular mechanics (In the case of normal heart)" Artificial Organs.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N. Yamamoto, K. Ohno, K. Hayashi, H. Kuriyama, K. Yasuda and K. Kaneda: "Mechanical properties of the rabbit patellar tendon" ASME, Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] N. Yamamoto, K. Ohno, K. Hayashi, H. Kuriyama, K. Yasuda and K. Kaneda: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" ASME, Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Ohno, K. Yasuda, N. Yamamoto and K. Hayashi: "Effects of stress shielding on the mechanical properties of normal and in situ frozen patellar tendon" Proc. 37th Ann. Meet. Ortopaedic Research Society. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Tadanao, H. Ishikawa, I. Yamamoto and K. Kaneda: "A finite element model on whole lumbar spine in flexion" Tissue Engineering - 1989. 71-74 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Tadano, H. Ishikawa, I. Yamamoto and K. Kaneda: "Computational simulation of the whole lumbar spine under flexion" Trans. Jap. Soc. Mech. Eng.56. 1885-1892 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Tadano, H. Ishikawa, M. Itoh and K. Kaneda: "Strain distribution on the sagittal plane of an intervertebral disc" Trans. Jap. Soc. Mech. Eng.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Seguchi: "Preliminary study on adaptation by remodeling" Tissue Engineering - 1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Tanaka, Y. Seguchi, T. Mizutani and M. Inoue: "A note on the ACL deformation under tensile loading along ligament and/or tibia direction" Tissue Engineering - 1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Wada, Y. Seguchi and M. Tanaka: "Simulation of breathing and ventilation combined with body circulation" 1990 Advances in Bioengineering. 67-70 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Wada, Y. Seguchi and M. Tanaka: "Breathing-ventilation model, and simulation of high-frequency ventilation" JSME International Journal. 34. 98-105 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. C. Fung: "The future of biomechanics" Proc. 2nd JSME Conference on Biomechanics. 3 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. L-Y. Woo: "Biomechanical evaluation of human anterior cruciate ligament" Proc. 2nd JSME Conference on Biomechanics. 1-2 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary

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Published: 1989-04-01   Modified: 2016-04-21  

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