| Project/Area Number |
01044116
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKATSUKI Kiyoshi Kumamoto University Medical School, 医学部, 教授 (80026830)
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| Co-Investigator(Kenkyū-buntansha) |
GONGORA Biac ユカタン大学, 医学部, 講師
DANIEL Catov ロンドン大学, 医学部, 教授
ESTELA Matut ロンドン大学, 医学部, 講師
ANUVAT Roong マヒドール大学, 医学部, 講師
DAVID Naor ヘブリー大学, 医学部, 教授
MIYAZAKI Kohji Kumamoto University Medical School, 医学部附属病院, 講師 (50145322)
KIYOKAWA Tetsuyuki Kumamoto University Medical School, 医学部, 助手 (50195400)
YAMAGUCHI Kazunari Kumamoto University Medical School, 医学部附属病院, 講師 (20128325)
GONGORABIACHI R. Yucaton University
CATOVSKY Daniel London University
MATUTES Estela London University
ROONGPISUTHIPONG Anuvat Mahidol University
NAOR David Hebrew University, Jerusalem
ROONGPISUTHI アナバツト マヒドール大学, 医学部, 講師
NAOR David ヘブリー大学, 医学部, 教授
GREEN Michel ウエスト, インディー大学・医学部, 講師
CATOVSKY Dan ロンドン大学, 医学部, 教授
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 1991: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1990: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1989: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | ATL / HTLV-I / HAM / TSP / Epidemiology / HTLV-II / HTLVーI / HTLVーIキャリア / HTLVーI variant / レトロウイルス / カリブ海 |
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| Research Abstract |
Human T lymphotropic virus type I (HTLV-I) is a retrovirus associated with adult T cel1 leukemia, HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and possibly with other diseases. HTLV-I is transmitted via breast milk, sexual intercourse and through blood transmission. Seroepidemiological studies have been shown distinct geographic clusters of HTLV-I and its associated diseases in southwestern Japan, the Caribbean basin, the southeastern United States and central Africa. The prevalence and distribution of HTLV-I around the world is unknown because the laboratory procedures that have been used in most of the sera&&&& epidemiologic studies cannot distinguish between HTLV-I and-II.
We have investigated the seroprevalence of HTLV-I in Mexico, Cuba, Thailand, United Kingdom, USA, Brazil and Papua New Guinea for 3 years. We got some interested seropidemiological results from each countries.
1) Yucatan, Mexico : a low prevalence of HTLV-I/II intection among eight population groups (14 positive cases of 2.277)
2) Cuba : Very low seroprevalence of HTLV-I/II in blood donors and in hematological and nonhematological patients (one positive and 5 indeterminate cases of 2.429)
3) Thailand : Very low seroprevalence of HTLV-I/II in patients with malignancies (only one case out of 882)
4) Brazil : high seroprevalence of HTLV-I/II in blood donors and hematological disorders (in Recife 0.8% in donors was positive, and we diagnosed 20 cases as adult T cell leukemia in 2 hospitals in Rio de Janeiro)
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