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Relationship between the hypertensive vascular degeneration and endogeneous vasoactive peptides.

Research Project

Project/Area Number 01044120
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionYokohama City University

Principal Investigator

SHIONOIRI Hiroshi  Yokohama City University School of Medicine, Associate Professor, 医学部, 講師 (20128599)

Co-Investigator(Kenkyū-buntansha) BRUNNER Hans R.  University of Lausanne School of Medicine, Professor, 医学部(スイス連邦), 教授
SAMBHI Mohinder P.  University of California at Los Angeles, School of Medicine, Professor, ロスアンゼルス校医学部, 教授
CHOBANIAN Ar  ボストン大学, 医学部, 学部長教授
HIMENO Hideo  Yokohama City University Hospital, Clinical Instructor, 医学部病院, 診療医
TAKASAKI Izumi  Yokohama City University Hospital, Clinical Instructor, 医学部病院, 診療医
HIROSE Shigehisa  Tokyo Institute of Technology, Professor, 理学部, 教授 (10134199)
CHOBANIAN Aram V.  Boston University School of Medicine, Dean and Professor
SAMBHI Mohun  カリフォルニア大学, 医学部(米国), 教授
CHOBAMIAN Ar  米国、ボストン大学, 医学部, 教授
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 1991: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsHypertension / Hypertensive vascular complications / Glucose and lipids metabolism / Smoking / Muscle sympathetic nerve activity / Renin-angiotensin-aldosterone system / Primary aldosteronism / Atrial natriuretic peptide receptors / Endothelin receptors / Fibronectin / プロスタグラジン / フィブロネクチン / アンジオテンシン変換酵素 / 高血圧 / 血管障害 / 動脈硬化
Research Abstract

Clinical and basic studies concerning the cardiovascular risk factors and their contribution to hypertensive vascular diseases have been conducted and summarized as follows.
1. Long-term anti-hypertensive treatment and the metabolism of lipid and glucose.
An alpha1-blocker (terazosin), a Ca^<++>-antagonist (felodipin), angiotensin converting enzyme (ACE) inhibitors (captopril, cilazapril, and lisinopril) were administered to hypertensive patients with or without impaired glucose tolerance for more than 6 months. These antihypertensive drugs controlled the blood pressure well without compromising the lipid and glucose metabolism. Chobanian, a coworker of this project, reported that an ACE inhibitor decreased the cellularity of the atherosclerotic subintimal lesion in Watanabe heritable hyperlipidemic rabbits.
2. Smoking and hypertension.
Smoking caused a significantly greater and prolonged increase of blood pressure in normal young males with positive family history of essential hypertensio … More n than in those with negative family history, although the increase in plasma catecholamine was similar in both groups.
3. Sympathetic nervous system and hypertension.
Muscle sympathetic nerve activity in response to cold, mental stress, and vasoactive substances was measured in normotensives, borderline hypertensives, and hypertensives. The results suggested that borderline hypertensives and hypertensives have elevated sympathetic nerve activity, and abnormal baroreceptor reflexes in which endogenous angiotensin II may play a role.
4. Renin-angiotensin-aldosterone system and hypertensive vascular complications.
Hypertensive patients with low plasma renin have been believed to be at low risk for hypertensive vascular complications. Contrary to this belief, our studies revealed relatively high prevalence of hypertensive vascular complications in patients with primary aldosteronism whose plasma active and inactive renin concentration and renin mRNA in both kidneys and adrenals were less than detectable limits.
5. Receptors for vasoactive substances.
We have shown immunohistochemically that the receptor for atrial natriuretic peptide (ANP) was present in human adrenal glomerulosa and medulla. Although ANP suppressed the release of aldosterone from normal adrenal glomerulosa, it could not suppress that from aldosterone-producing adenoma. Hirose, a coworker of this project, isolated and characterized the bovine gene encoding the type C ANP receptor and bovine endothelin ET_B receptor.
6. Fibronectin and hypertensive vasculature.
Fibronectin is one of the major components of extracellular matrix of vasculature which could influence the phenotype of vascular cells. Takasaki and Chobanian, coworkers of this project, have shown that fibronectin gene expression is induced in rat aorta of different hypertensive models including deoxycorticosterone-salt (DOCA/salt), angiotensin II infusion, spontaneously hypertensive rats. More interestingly, EIIIA+ fibronectin, which is known to be fetal form of fibronectin, was found to be selectively induced in aorta of DOCA/salt hypertensive rats. Less

Report

(2 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] Shionoiri H, Hirawa N, Takasaki I, Ishikawa Y, Oda H, Gotoh E, Hosaka M, Shimonaka M, Hirose S: "Lack of atrial natriuretic peptide receptors in human aldosteronoma." Biochem. Biophys. Res. Commun.152. 37-43 (1988)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Takasaki I, Hiroto S, Gotoh E, Ikeda Y, Ito T, Kaneko Y, Kawano M: "Active and inactive plasma renin in hypertensive diabetics with or without nephropathy." Curr. Ther. Res.43. 857-871 (1988)

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      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Gotoh E, Takagi N, Takeda K, Yabana M, Kaneko Y: "Antihypertensive effects and pharmacokinetics of single and consecutive doses of cilazapril in hypertensive patients with normal and impaired renal function." J. Cardiovasc. Pharmacol.11. 242-249 (1988)

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      1991 Final Research Report Summary
  • [Publications] Sesoko S, Iwasawa H, Akema N, Matsukawa T, Sugiyama K, Shionoiri H, Kaneko Y: "Sequential changes in urinary catecholamine in the transition from benign to malignant hypertension in rats." Jpn. Circulation J.52. 197-201 (1988)

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      1991 Final Research Report Summary
  • [Publications] Takasaki I, Shionoiri H, Hiroto S, Yasuda G, Gotoh E, Umemura S, Kaneko Y: "Long-term captopil therapy with no effect on glucose metabolism in patients with essential hypertension." Am. J. Hypertens.1. 217S-220S (1988)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Miyajima E, Yamada Y, Matsukawa T, Uneda S, Shionoii H, Tochikubo O: "Reduced reflex sympathoinhibition in adolescents with hypertensive parents." Jpn. Circulation J.52. 1335-1337 (1988)

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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Miyajima E, Shionoiri H, Tochikubo O, Ishii M: "Angiotensin II inhibits baroreflex control of muscle sympathetic nerve activity and the heart rate in patients with essential hypertension." J. Hypertens.6. S501-S504 (1988)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Yamada Y, Miyajima E, Tochikubo O, Matsukawa T, Shionoiri H, Ishii M: "Impaired baroreflex changes in muscle sympathetic nerve activity in adolescents who have a family history of essential hypertension." J. Hypertens.6(Suppl 4). S525-S528 (1988)

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      1991 Final Research Report Summary
  • [Publications] Hiroshi Shionoiri, Izumi Takasaki, Kohsuke Minamisawa, Yoshihiro Ishikawa, Nobuhito Hirawa, Eiji Gotoh, Masao Ishii: "Evaluation of newly developed direct radioassay for human plasma active renin using antirenin monoclonal antibodies." Circulation. 78(Suppl II). 11-267 (1988)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Gotoh E, Miyakawa T, Takasaki I, Oda H, Ueda S, Kaneko Y: "Pharmacokinetics of single and consecutive doses of cilazapril and its depressor effects in hypertensive patients with renal dysfunction." Am. J. Hypertens.1. 230S-232S (1988)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Gotoh E, Miyakawa T, Takasaki I, Oda H, Ueda S, Kaneko Y: "Pharmacokinetics of single and consecutive doses of cilazapril and its depressor effects in patients with essential hypertension." Am. J. Hypertens.1. 269S-273S (1988)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Sugiyama K, Takasaki I, Minamisawa K, Ueda S, Sugimoto K, Kaneko Y: "Antihypertensive effects of nisoldipine in patients with essential hypertension." Curr. Ther. Res.45. 253-262 (1989)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Miyakawa T, Yasuda G, Sugimoto K, Takasaki I, Minamisawa K, Gotoh E, Kaneko Y: "Antihypertensive effect of delapril during long-term treatment in hypertensive patients." Curr. Ther. Res.45. 813-820 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Hirawa N, Takasaki I, Ishikawa Y, Oda H, Minamisawa K, Sugimoto K, Matsukawa T, Ueda S, Miyajima E, Umemura S, Gotoh E, Ishii M, Ishido M, Shimonaka M, Hirose S: "Functional atrial natriuretic peptide receptor in human adrenal tumor." J. Cardiovasc. Pharmacol.13. S9-S12 (1989)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Gotoh E, Sugimoto K, Takasaki I, Minamisawa K, Ishii M: "Antihypertensive effects and pharmacokinetics of single and consecutive doses of cilazapril in hypertensive patients with normal or impaired renal function." Br. J. Clin. Pharmacol.27. 283S-287S (1989)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Oda H, Shionoiri H, Takagi N, Kobayashi K, Ishii M: "Human atrial natriuretic peptide in aortic and coronary sinus blood during atrial pacing in patients with ischemic heart disease." J. Cardiovasc. Pharmacol.15. 392-397 (1989)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Sugimoto K, Minamisawa K, Ueda S, Ebina T, Matsukawa T, Gotoh E, Ishii M: "Glucose and lipid metabolism during long-term treatment with cilazaprin in hypertensive patients with or without impaired glucose metabolism." J. Cardiovasc. Pharmacol.15. 933-938 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Minamisawa K, ueda S, Abe Y, Ebina T, Sugimoto K, Matsukawa T, Gotoh E, Ishii M: "Pharmacokinetics and antihypertensive effects of lisinoprin in hypertensive patients with normal and impaired renal function." J. Cardiovasc. Pharmacol.16. 594-600 (1990)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Takasaki I, Ishikawa Y, Minamisawa K, Sugimoto K, Hirawa N, Ueda S, Gotoh E: "Measurement of plasma active renin by solid phase radioimmunoassay using monoclonal antibodies." Am. J. Med. Sci.300. 138-143 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I. Takasaki, R. A. Cohen, A. V. Chobanian, P. Brecher: "The effect of endothelial cell denudation on fatty acid metabolism by the rabbit aorta." FASEB J.4. A837 (1990)

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      1991 Final Research Report Summary
  • [Publications] Izumi Takasaki, Richard A. Cohen, Aram V. Chobanian, Peter Brecher: "Effect of endothelial cell denudation on fatty acid metabolism by rabbit aorta." Am. J. Physiol.259(Heart Circ. Physiol. 28). H442-H447 (1990)

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      1991 Final Research Report Summary
  • [Publications] I. Takasaki, Rola Saouaf, R. Sarzani, A. V. Chobanian, P. Brecher: "Hypertension-induced changes in fibronectin expression in the rat aorta." Clinical Research. 38. 242A (1990)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Izumi Takasaki, Aram V. Chobanian, Riccardo Sarzani, Peter Brecher: "Effect of hypertension on fibronectin expression in the rat aorta" Journal of Biological Chemistry. 265. 21935-21939 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] I. Takasaki, A. V. Chobanian, P. Brecher: "Fibronectin biosynthesis in the rabbit aorta." FASEB J.4. A1789 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] R. Saouaf, I. Takasaki, A. V. Chobanian, P. Brecher: "Hypertension increases fibronectin biosynthesis in the rat aorta." Circulation. 82(Suppl III). III-262 (1990)

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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Ueda S, Minamisawa K, Kihara M, Shionoiri H, Tochikubo O, Ishii M: "Effect of atrial natriuretic peptide on angiotensin II-induced activation of sympathetic nerve activity and vasopressin secretion in humans." Therapeutic Res.11. 3835-3839 (1990)

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      「研究成果報告書概要(欧文)」より
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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Ueda S, Gotoh E, Ito T, Ogihara T: "Glucose and lipid metabolism during long-term lisinopril therapy in hypertensive patients." J. Cardiovasc. Pharmacol.16. 905-909 (1990)

    • Description
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      1991 Final Research Report Summary
  • [Publications] Minamisawa K, Shionoiri H, Sugimoto K, Ueda S, Ashino K, Ebina T, Gotoh E, Ishii M: "Depressor effects and pharmacokinetics of single and consecutive doses of delapril in hypertensive patients with normal or impaired renal function." Cardiovasc. Drugs and Therapy. 4. 1417-1424 (1990)

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      1991 Final Research Report Summary
  • [Publications] Miyakawa T, Shionoiri H, Takasaki I, Kobayashi K, Ishii M: "The effect of captopril on pharmacokinetics of digoxin in patients with mild congestive heart failure." J. Cardiovasc. Pharmacol.17. 576-580 (1991)

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      1991 Final Research Report Summary
  • [Publications] Oda H, Satta H, Tanaka S, Takagi N, Tokita Y, Shionoiri H, Ishii M, Ohnishi T: "Annual changes in human atrial natriuretic peptide levels in patients receiving chronic hemodialysis." J. Jpn. Soc. Dial. Ther.4. 1483-1488 (1991)

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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Uneda S, Miyajima E, Shionoiri H, Tochikubo O, Ishii M: "Augmented sympathetic nerve activity in response to stressors in young borderline hypertensive men." Acta Physiol. Scand.141. 157-163 (1991)

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      1991 Final Research Report Summary
  • [Publications] Kihara M, Umemura S, Takagi N, Hirawa N, Minamisawa K, Matsukawa T, Miyajima E, Shionoiri H, Ishii M: "Neurilemoma of the retroperitoneum." Klin. Wochenschrift. 69. 228-231 (1991)

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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Hasegawa O, Shionoiri H, Tochikubo O, Ishii M: "Reduced baroreflex changes in muscle sympathetic nerve activity during blood pressure elevation in essential hypertension." J. Hypertens.9. 537-542 (1991)

    • Description
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      1991 Final Research Report Summary
  • [Publications] Young SC, Shionoiri H, Takasaki I, Kihara M, Gotoh E: "Hypertensive complications in patients with primary aldosteronism ; A retrospective study." Curr. Ther. Res.50. 317-325 (1991)

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      1991 Final Research Report Summary
  • [Publications] Takasaki I, Shionoiri H, Young SC, Yasuda G, Kishi Y, Ishii M: "A case of aldosterone-producing adrenocortical adenoma complicated with intracerebral hemorrhage and chronic renal failure and resected after 16 years of follow-up." Curr. Ther. Res.50. 504-510 (1991)

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      1991 Final Research Report Summary
  • [Publications] Miyajima E, Yamada Y, Yoshida Y, Matsukawa T, Shionoiri H, Tochikubo O, Ishii M: "Muscle sympathetic nerve activity in patients with renovascular hypertension and in these with primary aldosteronism." Hypertension,. 17. 1057-1062 (1991)

    • Description
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      1991 Final Research Report Summary
  • [Publications] Izumi Takasaki, Aram V. Chobanian, Peter Brecher: "Biosynthesis of fibronectin by rabbit aorta." Journal of Biological Chemistry. 266. 17686-17694 (1991)

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      1991 Final Research Report Summary
  • [Publications] Rola Saouaf, Izumi Takasaki, Elizabeth H. Eastman, Aram V. Chobanian, Peter Brecher: "Fibronectin biosynthesis in the rat aorta in vitro : Changes due to experimental hypertension." Journal of Clinical Investigation. 88. 1182-1189 (1991)

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      1991 Final Research Report Summary
  • [Publications] Riccardo Sarzani, Giorgio Arnaldi, Izumi Takasaki, Peter Brecher, Aram V. Chobanian: "Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart." Hypertension. 18(Suppl III). III-93-III-99 (1991)

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      1991 Final Research Report Summary
  • [Publications] Izumi Takasaki, Aram V. Chobanian, Peter Brecher: "Hypertension causes the selective induction of an alternatively spliced form of fibronectin in rat aorta." Hypertension. 18. 402 (1991)

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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Hasegawa O, Miyajima E, Shionoiri H, Tochikubo O, Ishii M: "Reduced arterial baroreflex control of muscle sympathetic nerve activity in young borderline hypertensives." Functional Neurology. 6. 113-120 (1991)

    • Description
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      1991 Final Research Report Summary
  • [Publications] Matsukawa T, Gotoh E, Minamisawa K, Kihara M, Ueda S, Shionoiri H, Ishii M: "Effects of intravenous infusions of angiotensin II on muscle sympathetic nerve activity in humans." Am. J. Physiol.261. R690-R696 (1991)

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      1991 Final Research Report Summary
  • [Publications] Sugimoto K, Shionoiri H, Minamisawa K, Abe Y, Ueda S, Himeno H, Matsukawa T, Gotoh E, Ishii M: "Measurement of plasma total renin by the anti-human renin monoclonal antibodies." Am. J. Med. Sci.302. 342-346 (1991)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Hirawa N, Ueda S, Himeno H, Gotoh E, Noguchi K, Fukamizu A, Seo MS, Murakami K: "Renin gene expression in the adrenal and kidney of patients with primary aldosteronism." J. Clin. Endocrinol. Metab.74. 103-107 (1992)

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      1991 Final Research Report Summary
  • [Publications] Takasaki I, Chobanian AV, Brecher P: "Hypertension causes the selective induction of an alternatively spliced form of fibronectin in rat aorta." Hypertension,. 19. (1992)

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      1991 Final Research Report Summary
  • [Publications] Shionoiri H, Ueda S, Minamisawa K, Minamisawa M, Takasaki I, Sugimoto K, Gotoh E, Ishii M: "Pharmacokinetics and pharmacodynamics of benazepril in hypertensive patients with normal and impaired renal function." J. Cardiovasc. Pharmacol.20. (1992)

    • Description
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      1991 Final Research Report Summary
  • [Publications] Hiroshi Shionoiri,Izumi Takasaki,et al.: "Measurement of plasma active renin by solid phase radioimmunoassay using monoclonal antibodies." American Journal of Medical Sciences. 300. 138-143 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Izumi Takasaki,Aram V.Chobanian,et al.: "Effect of hypertension on fibronectine expression in the rat aorta." Journal of Biological Chemistry. 265. 21935-21939 (1990)

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      1990 Annual Research Report
  • [Publications] Hiroshi Shionoiri,Shinichiro Ueda,et al.: "Glucose and lipid metabolism during longーterm lisinopril therapy in hypertensive patients." Journal of Cardiovascular Pharmacology. 16. 905-909 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Izumi Takasaki,Aram V.Chobanian,et al.: "Effect of endotherial cell denudation on fatty acid metabolism by rabbit aorta." American Journal of Physiology. 259. H442-H447 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hiroshi Shionoiri,Kohsuke Minamisawa,et al.: "Pharmacokinetics and antihypertensive effects of lisinopril in hypertensive patients with noraml and impaired renal function." Journal of Cardiovascular Pharmacology. 16. 564-600 (1990)

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      1990 Annual Research Report
  • [Publications] Takeshi Mizuno,Shigehisa Hirose,et al.: "Radioreceptor assay for atrial natriuretic peptide using purified recptor." Biomedical Research. 11. 29-34 (1990)

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      1990 Annual Research Report
  • [Publications] Hiroshi Shinoiri,Kohichi Sugimoto,et al.: "Clucose and lipid metabolism during longーterm treatment with cilazapril in hypertensive patients with or without impaired glucose metabolism." Journal of Cardiovascular Pharmacology. 15. 933-938 (1990)

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      1990 Annual Research Report
  • [Publications] Mohinder P.Sambhi,et al.: "Selectively enhanced stimulation of DNA synthesis by EGF in vascular smooth muscle cell from SHR." Clinical and Experimental Hypertension. 12 A. 307-316 (1990)

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      1990 Annual Research Report
  • [Publications] Aram V.Chobanian,et al.: "Adaptive and maladaptive responses of the arterial wall to hypertension." Hypertension. 15. 666-674 (1990)

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      1990 Annual Research Report
  • [Publications] Aram V.Chobanian,et al.: "The effect of ACE inthibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis." Clinical Cardiology. 13 Suppl.43-48 (1990)

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      1990 Annual Research Report
  • [Publications] Hans R.Brunner,et al.: "The reninーangiotensin system in hypertension." Hospital Practice. 25. 71-81 (1990)

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      1990 Annual Research Report
  • [Publications] Hans R.Brunner,et al.: "Prevention of renal hypertension in the rat by neuropeptide Y." Journal of Hypertension. 8. 21-25 (1990)

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      1990 Annual Research Report
  • [Publications] Hiromi Hagiwara,Shigehisa Hirose,et al: "Properties of rat uterus endothelin receptor site." Biomedical Research. 11. 93-98 (1990)

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      1990 Annual Research Report
  • [Publications] Kohsuke Minamisawa,Hiroshi Shionoiri,et al.: "Depressor effects and pharmacokinetics of single and consecutive doses of delapril in hypertensive patients with normal or impaired renal function." Cardiovascular Drugs and Therapy. 4. 1417-1424 (1990)

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      1990 Annual Research Report
  • [Publications] Masamichi Kozuka,Shigehisa Hirose,Hiromi Hagiwara,et al.: "Endothelin action on rat uterus is inhibited by an inhibitor of protein Kinase C and by inhibitors of the phospolipase A_2ーarachidonic acdーlipoxygenase pathway." Biomedical Research. 11. 287-289 (1990)

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      1990 Annual Research Report
  • [Publications] Hiromi Hagiwara,Shigehisa Hirose,et al.: "Solubilization of endothelin receptors from bovine lung plasma membranes in a nonーaggregated state and estimation of their minimal function sizes." Biochemical and Biophysical Reserch Communications. 172. 576-581 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Aram V.Chobanian,et al.: "Stressーinduced protein in aortic smooth muscle cells and aorta of hypertensive rats." American Journal of Physiology. 258. H1699-H1705 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hans R.Brunner,et al.: "Treating the individual hypertensive patients:Consideration on dose,sequential monotherapy and drug combination." Journal of Hypertension. 8. 3-11 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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