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Chemical Studies on the Biologically Active Principles of Tropical Plants and Animals in Indonesia

Research Project

Project/Area Number 01044123
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionFaculty of Science, Osaka City University

Principal Investigator

HAYASHI Yuji  Faculty of Science, Osaka City University, 理学部, 教授 (40046917)

Co-Investigator(Kenkyū-buntansha) YAMADA Hidetoshi  Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 薬学部, 助手 (90200732)
NISHIZAWA Mugio  Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 薬学部, 教授 (40137188)
ソフニ カイルー  インドネシア国立原子力研究センター, 研究員
カイルー  インドネシア科学院, 生物学研究センター, 主任研究員
MATSUMOTO Takeshi  Research Institute, DAICEL Chemical Industries, Co., 総合研究所, 主任研究員
TOKUYAMA Takashi  Faculty of Science, Osaka City University, 理学部, 教授 (70046944)
CHAIRUL  National Centre for Research in Biology, Indonesian Institute of Science (LIPI)
CHAIRUL Sofni M  Centre for the Application of Isotopes and Radiation, Indonesian Atomic Energy A
カイルー ソフニ  インドネシア国立原子力研究センター, 研究員
カイルー  インドネシア科学院, 生物学研究センター, 主任研究員
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 1991: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥4,500,000 (Direct Cost: ¥4,500,000)
KeywordsIndonesian poisonous plants / Anti-tumor promoter activity / Polyporaceous Mushroom component / Applanoxidic acids / Skin components of Indonesian toad / Indonesian Institute of Science : LIPI / National Research Centre for Biology (LIPI). / インドネシア国立生物学研究センタ- / インドネシア産熱帯動植物成分 / サルノコシカケ科きのこ類 / Ganoderma applanatum / インドネシア産ヒキ蛙 / Bufo melanosticutus / 新規強心ステロイド / 大環状ステロイドアルカロイド / インドネシア産動植物成分 / サルノコシカケ科きのこ / ヒキ蛙 / 腫瘍プロモ-タ-抑制活性 / ラノスタジェンーケトカルボン酸 / ラノスタトリエンーケトカルボン酸 / 新型強心ステロイド
Research Abstract

This project concerns our cooperative program with the Research Centre for Biology, Indonesian Institute of Science (LIPI), since 1982 titled "Chemical Studies on Biologically Active Principles of Tropical Plants and Animals in Indonesia".
In the first year (1989), we have a research activity in Central Sulawesi, looking for poisonous and medicinal plants and animals in wilder area, according to the informations of Dr. B. Soeroto of Sam Ratulangi Univ., Manado. At Watusongu village of a primitive Tah tribe, about 300 km northeast of Poso, Central Sulawesi, we have collected ca. 50 species of poisonous and medicinal plants, which included three practically used strong poisons, one arrow-poison (local name : "Impoh", latex), two fish-poisons ("Luli", seeds and "Tuwa", fresh roots). Together with these, ca. 20 species of Polyporaceous mushrooms and some quantity of skin of an Indonesian toad, Bufo sulawesiensis. Arrow-poison frogs, so called "green poison frog", were also tried to collect, … More but this was not successful in this year. A remarkable anti-tumor promoter activity was found from nine of the ca. 50 plant species collected and the results was preliminarily presented at 50th Annual Meeting of Japan Cancer Association (1991, Tokyo). The most expected three plants described above, Impoh, Luli and Tuwa, were identified at Bogor Herbarium as Antiaris toxocaria (Urticaceae), Croton tiglium (Euphorbiaceae), and Derris elliptica (Leguminosae), respectively, and their active principles have already been investigated, regrettably, by German chemists before 1970s. Mushroom components have been analyzed chemically and biologically, and applanoxidic acids A -D, isolated from Ganoderma applanatum (Polyporaceae), were reported as anti-tumor promoter components on "Phytochemistry (1991)" and at the Symposium on Medicinal Resources of Tropical Rain Forest (1991, Kuala Lumpur, Malaysia).
In the second year activity (1990), we have visited Watusongu village again, and looked for the "green poison frog" for a week by tight cooperation with local people. However, this time was also unsuccessful, unfortunately. Thorough search by longer stay should be essential for such movable animals in the future activity. At the same time, some additional quantity of the promising plants and mushrooms in the last year activity were also collected.
The last year (1991) of this project was mainly alloted for processing the remaining materials collected, presentation of the results, and discussion on the future program with LIPI. Other than these, a field activity was also carried out at Lake Toba, for collection of Bufo toads in North Sumatra for comparison of the skin components with those in other areas. The results on the toad components in Jawa and Sulawesi were presented at 61st Annual Meeting of Japan Chemical Society (1991, Yokohama) and 33rd Symposium on the Chemistry of Natural Products (1991, Osaka). The joint program with LIPI was decided to be renewed for additional two years, from April, 1992, to March, 1994, by the agreement with the Director of the Research Centre for Biology, LIPI, in Bogor. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Yo.Hayashi,Y.Kim,T.Terada,S.Hazama,Yuji Hayashi: "Synthesis of Aphanamol I,Novel Perhudroazulene Type Sesquiterpene from an Indonesian Meliaceous Plant,Aphanamixis grandifolia." Tetrahedron Lett.31. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Tokuyama,Chairul,T.Nakayama,Yuji Hayashi: "Melanobufotoxins,Novel Steroidal Alkaloids from Indonesian Toad,Bufo melanosticutus." J.of Natural Products. 54. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chairul,T.Tokuyama,Yo.Hayashi,M.Nishizawa,H.Tokuda,S.M.Chairul,Yuji Hayashi: "Applanoxidic Acids A,B,C and D,Biologically Active Tetracyclic Triterpenes from Ganoderma applanatum." Phytochemistry. 30. 4105-4109 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nishizawa,H.Yamada,Chairul,H.Tokuda,Yuji Hayashi: "Structure of Syzygiol,A Skinーtumor Promotion Inhibitor." Tetrahadron Lett.32. 211-212 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chairul,T.Tokuyama,M.Nishizawa,H.Tokuda,Yuji Hayashi: "Malonate Halfーesters of Homolanostanoid,An Antiーtumor Promoter from an Asian Ganoderma Fungus." Phytochemistry. 29. 923-928 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nishizawa,Chairul,H.Tokuda,Yuji Hayashi: "Isolation of a New Cycloartanoid Triterpene from Leaves of Lansium domesticum,Novel Skinーtumor Promotion Inhibitor." Tetrahedron Lett.30. 5615-5618 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yo. Hayashi, Y. Kim. T. Terada, S. Hazama, Yuji Hayashi: "Synthesis of Aphanamol I, A Novel Perhydroazulene-type Sesquiterpene from an Indonesian Meliaceous Plant, Aphanamixis grandifolia." Tetrahedron Lett., in preparation. 31. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chairul, T. Tokuyama, Yo. Hayashi, M. Nishizawa, H. Tokuda, S. M. Chairul, Yuji Hayashi: "Applanoxidic Acids A, B, C and D, Biologically Active Tetracyclic Triterpenes from Ganoderma applanatum." Phytochemistry. 30. 4105-4109 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nishizawa, H. Yamada, Chairul, H. Tokuda, Yuji Hayashi: "Structure of Syzygiol, A Skin-tumor Promotion Inhibitor." Tetrahedron Lett.32. 211-212 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Chairul, T. Tokuyama, M. Nishizawa, H. Tokuda, Yuji Hayashi: "Malonate Half-esters of Homolanostanoid, An Anti-tumor Promotor from an Asian Ganoderma Fungus." Phytochemistry. 29. 923-928 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nishizawa, Chairul, H. Tokuda, Yuji Hayashi: "Isolation of a New Cycloartanoid Triterpene from Leaves of Lansium domesticum, Novel Skin-tumor Promotion Inhibitor." Tetrahedron Lett.30. 5615-5618 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yo.Hayashi,Y.Kim,T.Terada,S.Hazama,Yuji Hayashi: "Synthesis of Aphanamol I,A Novel Perhydro-azulene-type Sesquiterpene from an Indonsian Meliaceous Plant,Aphanamixis grandifolia" Tetrahedron Lett.,in preparation. 31. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Tokuyama,Chairul,T.Nakayama,Yuji Hayashi: "Melanobufotoxin,Novel Steroidal Alkaloids from Indonesian Toad,Bufo melanosticutus." J.of Natural Products,in preparation. 54. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chairul,T.Tokuyama,Yo.Hayashi,M.Nishizawa,H.Tokuda,S.M.Chairul,Yuji Hayashi: "Applanoxidic Acids A,B,C and D,Biologically Active Tetracyclic Triterpenes from Ganoderma applanatum." Phytochemistry. 30. 4105-4109 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Nishizawa,H.Yamada,Chairul,H.Tokuda Yuji Hayashi: "Structure of Syzygiol,A Skin-tumor Promotion Inhibitor." Tetrahedron Lett.32. 211-212 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chairul,T.Tokuyama,M.Nishizawa,H.Tokuda,Yuji Hayashi: "Malonate Half-esters of Homolanostanoid,An Anti-tumor Promoter from an Asian Ganoderma Fungus." Phytochemistry. 29. 923-928 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Nishizawa,Chairul,H.Tokuda,Yuji Hayashi: "Isolation of a New Cycloartanoid Triterpene from Leaves of Lansium domesticum,Novel Skin-tumor Promotion Inhibitor." Tetrahedron Lett.30. 5615-5618 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chairul,T.Tokuyama,Y.Hayashi,M.Nishizawa,H.Tokuda,S.M.Chairul: "Applanoxidic Acids A,B,C,and D,Biologically Active Components from Ganoderma applanatum." Phytochemistry,under Preparation. 30. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Tokuyama,Cairul,T.Nakayama,Y.Hayashi: "Melanobufotoxin,Novel Steroidal Alkaloids from Indonesian Toad,Bufo melanostictus." J.of Natural Products, under preparation. 54. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Chairui,T.Tokuyama M.Nishizawa,H.Tokuda Y.Hayashi: "Malonate Halfーesters of Homolanostanoid an AntiーTumor Promoyer,from an Asian Ganoderma Fungus." Phytochemistry. 29. 923-928 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Chairul,Y.Hayashi: "New Congeners of Norditerpenoid Dilactones from Podocarpus nagi." Phytochemistry,in press. 30. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Uemura,Y.Hayashi,et,al.: "Synthsis of (【.+ー.】)ーDihydroxyserrlatic Acid via(Arene) chromium Complexes." Tetrahedron Letters. 31. 2319-2322 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Chairui,Y Hayashi et,al.: "Isolation of a New Cycloartanoid Triterpene from Leave of Lansium domesticum." Tetrahedron Letters. 30. 5615-5618 (1989)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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