| Project/Area Number |
01044155
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | National Institute of Health |
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Principal Investigator |
KOYAMA Tsutomu Department of Parasitology, National Institute of Health, 寄生虫部, 部長 (70072874)
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| Co-Investigator(Kenkyū-buntansha) |
HOSAKA Yukio Department of Parasitology, National Institute of Health, 寄生虫部, 客員研究員 (60072873)
KAJIHARA Noriaki Yamanashi Prefectural Institute for Public Health, 生物研究部, 研究員
SHO Masanori Yamanashi Medical College, 助手 (90154682)
OHTA Nobuo Okayama University School of Medicine, 医学部, 助教授 (10143611)
KAGEI Noboru Department of Parasitology, National Institute of Health, 寄生虫部, 室長
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| Project Period (FY) |
1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Schistosomiasis japonica / Dong-ting lake / Epidemiology / Immunopathology / Hepatic carcinoma / Hepatitis B / Activating T lymphocyte by idiotypic antibodies / Control of intermediate host snail |
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| Research Abstract |
The newly selected foci were: (A) high prevalent area; (B) low prevalent one; and (C) nearly controlled one. The positive rates of the Schistosoma japonicum egg were 65.4%, 12.2-18.3% and 0% in areas (A), (B) and (C), respectively. In (C), the positive rate of 6.5% was obtained as a result of serological tests (COPT and IHA). Some of the people with the eggs were serologically tested by means of ELISA before and after the treatment with praziquantel. Within six months of the treatment, there occurred a remarkable decrease of the antibody titer against the egg antigen. Three kinds of molluscicides were investigated for their effects in laboratories and fields. Cartap among them showed high activity in field trials. The protozoan parasites of vector snails were also investigated for the purpose of biological control. We investigated heterogeneity of idiotypes of anti-egg antibodies in Chinese patients. The serum samples were tested for activating schistosome-specific T lymphocyte in vitro. The result suggests that there is a regulatory idiotypic antibodies in some patients and that the test seems useful for the analysis of immunopathological mechanisms in schistosomiasis japonica. Pathological features of hepatic carcinoma related to schistosomiasis and hepatitis B were studied on the patients both in China and in Japan.
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