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Advanced Scientific Approach to Basic and Actual Problems of "Living"

Research Project

Project/Area Number 01045033
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionMinatogawa Women's College

Principal Investigator

OKAMOTO Syosuke  Minatogawa Women's College, Rector & Professor, 学長 (20030801)

Co-Investigator(Kenkyū-buntansha) WAYAN Redi A  ウダヤナ大学, 畜産学部, 講師
I Gusti Ngur  ウダヤナ大学, 医学部・細菌, 講師
SOETJININGSIH  Udayana University, Faculty of Medicine, Pediatrics, Professor, 医学部・小児科, 小児栄養部長
I.GDE Anggan  ウダヤナ大学, 教育学部, 教授
ADNYANA I.G.  ウダヤナ大学, 学長
FJKUDA Kazuo  Minatogawa Women's College, Faculty of Children's Education, Professor, 児童教育学科・英文学, 教授 (30089073)
KIHARA Seiichiro  Minatogawa Women's College, Faculty of Children's Education, Associate Professor, 児童教育学科・幼児教育, 講師 (20214851)
OMAE Mamoru  Minatogawa Women's College, Faculty of Children's Education, Professor, 児童教育学科・幼児教育, 教授 (40149662)
KUSAKABE Keiko  Minatogawa Women's College, Faculty of Living Sciences, Professor, 家政学科・栄養, 教授 (40158100)
OKAMOTO Susumu  Minatogawa Women's College, Faculty of Living Sciences, Associate Professor, 家政学科・生活文化, 助教授 (70152345)
SAEKI Takamichi  Minatogawa Women's College, Faculty of Living Sciences, Professor, 家政学科・栄養, 教授 (80215574)
NISHIRA Hiroshi  Minatogawa Women's College, Faculty of living Sciences, Professor, 家政学科・栄養, 教授 (80031160)
OMORI Masato  Minatogawa Women's College, Faculty of Living Sciences, Lecturer, 家政学科・生活文化, 講師 (00194308)
KOJIMA Masami  Minatogawa Women's college, Faculty of Living Sciences, Professor, 家政学科・養護, 教授 (90149667)
I. G. N. P. Adnyana  Udayana University, Rector & Professor (Faculty of Medicine)
I. G. A. Suhandana  Udayana University, Department of Education, Professor
I. W. R. Aryanta  Udayana University, Faculty of Animal Science, Senior Lecturer
I. G. N. Suyasa  Udayana University, Faculty of Medicine, Senior Lecturer
I.KETUT Sula  ウダヤナ大学, 蓄産学部, 講師
I.GST.NGR.AG  ウダヤナ大学, 農学部, 講師
MADE Badra A  ウダヤナ大学, 蓄産学部, 講師
SOETJININGSI  ウダヤナ大学, 医学部・小児科, 小児栄養部長
NY.HILDA Sud  ウダヤナ大学, 医学部・心理学, 講師
I.G.N.P.ADNY  ウダヤナ大学, 学長
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1991: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1989: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsEndotoxin / Limulus test / Protenase-inhibitor / Horseshoe crab / Bali-traditional food / Food putrefaction / Comparative pedagogy
Research Abstract

Achievements of the University-to-University Cooperative Research for the past three years are briefly reported.
1. STUDIES FOR LIFE PROTECTION
(1) Variations of Endotoxin concentration of fresh blood, obtained from infectious diseases children in Udayana and Indonesia University Hospitals, were investigated. Noteworthy was that high and middle levels of Endotoxin were observed in patients of Typhoid Fever and Hepatitis ; Unexpectably, extremely low level of Endotoxin in Dengue Haemorrhagic Fever and Purulent Meningitis was observed.
(2) A novel protenase-inhibitor, synthetized as a trypsin-inhibitor, was able to inhibit Limulus Test for Endotoxin, suggesting the involvement of trypsin-like enzyme in Test system.
(3) lndonesia "horseshoe crabs (Tachypleus and Carcinoscorpius rotundicauda)" were found. to be useful for Limulus Test. Geological distributions of the crabs in Indonesia have been keenly under investigations.
2. STUDIES FOR LIFE QUALITY IMPROVEMENT
A. Foods :
(1) Repeated discussio … More n on traditional foods in Bali concluded that the improvement of food-processing and storage conditions is and will be a significant issue for us.
(2) The investigation of putrefaction process of "LAWAR", a typical traditional food in Bali, shows a high correlation between the putrefaction process and quantitative changes of a bacteria population, endotoxin and volatile basic nitrogen. Consequently, endotoxin was proven to be as a marker for food spoilage. Several gram-negative bacteria were isolated form food sample, which showed different reactions to Limulus Test.
B. Educational Aspect :
The research was focused on comparative studies of child education in Japan and Indonesia (Bali). Although there was a big cultural difference between the two countries, common problems were isolated from psychological and educational standpoints. In the third year, the child bearing, rearing, and child education patterns were compared and discussed. Besides this cooperative research, six related forums were held (three forums in Japan and Indonesia respectively). Less

Report

(2 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] S.Okamoto: "Highly selective synthetic inhibitors with regard to plasma kallikrein activities" KININS V,Part B. 247B. 29-34 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y.Tsuda: "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein." Chem.Pharm.Bull.37. 3108-3111 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Wanaka: "Effect of a highly selective plasmaーkallikrein synthetic inhibitor on contact activation relating to kinin generation,coagulation and fibrinolysis." Thromb.Res.57. 889-895 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A.HijikataーOkunomiya: "Effect of a synthetic thrombinーinhibitor MD805 on the reaction between thrombin and plasma antithrombinーIII." Thromb.Res.59. 967-977 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Okamoto: "Proteinaseーinhibitors and my lifeーーThe present and futureーー" Protease inhibitors. 207-218 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shosuke Okamoto: "The Forum:Advanced Biological Approach to Living for the Purpose of“Preventing Loss of Life and Improving Quality of Life,Scienfifically"" 湊川女子短期大学紀要. 第23集. 129-140 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mamoru Omae: "Culture and Personality of BALI." 湊川女子短期大学紀要. 第25集. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "A study on the relationship between food putrefuction and quantitative changes of the bacteria population and nedotoxin concentration in the putrefuction process of a typical traditional food“LAWAR"in Bali,Indonesia." 湊川女子短期大学紀要. 第25集. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "The Forum:Summary of the Lecture Meetings concerning the Cooperative Rescarch Project.(1)Endotoxin and Horseshoe Crab.(2)Recent Japanese family education and Youth." 湊川女子短期大学紀要. 第25集. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I G.N.P.Adnyana: "Value education in Indonesia:An overview of some problems and methods of instruction." 湊川女子短期大学紀要. 第25集. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Wayan Redi Aryanta: "The processing and microbiological aspects of some traditional foods in Bali,Indonesia." 湊川女子短期大学紀要. 第25集. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N.Teno: "Development of active centerーdirected inhibitors against plasmin." Chem.Pharm.Bull.39. 2340-2346 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N.Teno: "Development of selective inhibiotor against plasma kallikrein." Chem.Pharm.Bull.39. 2930-2936 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "Preparation of amoebocyte lysate from horseshoe crab for a Limulusーtest." 湊川女子短期大学紀要. 第24集. 162-164 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I Gusti Ngurah Suyasa: "The problem of health care and the strategy of prevention in the province of Bali,Indonesia." 湊川女子短期大学紀要. 第24集. 165-172 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A.HijikataーOkunomiya: "A strategy for rational approach to design synthetic selective inhibitors." SEMINARS IN THROMBOSIS AND HEMOSTASIS. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Matsuo: "Clinical application of the synthetic thrombin inhibitor,argatroban(MDー805)." SEMINARS IN THROMBOSIS AND HEMOSTASIS. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Okamoto: "Highly selective synthetic inhibitors with regard to plasma kallikrein activities." KININS V, Part B. 29-34 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Tsuda: "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein." Chem. Pharm. Bull.37. 3108-3111 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Wanaka: "Effect of a highly selective plasma-kallikrein synthetic inhibitor on contact activation relating to kinin generation, coagulation and fibrinolysis." Thromb. Res.57. 889-895 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Hijikata-Okunomiya: "Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III." Thromb. Res.59. 967-977 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S. Okamoto: "Proteinase-inhibitors and my life --The present and future --." Protease inhibitors. 207-218 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shosuke Okamoto: "The Forum : Advanced Biological Approach to Living for the Purpose of "Preventing Loss of Life and Improving Quality of Life, Scientifically"." Minatogawa Joshi Tanki Daigaku Kiyo. 23. 129-140 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N. Teno: "Development of active center-directed inhibitors against plasmin." Chem. Pharm. Bull.39. 2340-2346 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N. Teno: "Development of selective inhibitors against plasma kallikrein." Chem. Pharm. Bull.39. 2930-2936 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "Preparation of amoebocyte lysate from horseshoe crab for a Limulus-test." Minatogawa Joshi Tanki Daigaku Kiyo. 24. 162-164 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I Gusti Ngurah Suyasa: "The problem of health care and the strategy of prevention in the province of Bali, Indonesia." Minatogawa Joshi Tanki Daigakiu Kiyo. 24. 165-172 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] A. Hijikata-Okunomiya: "A strategy for rational approach to design synthetic selective inhibitors." SEMINARS IN THROMBOSIS AND HEMOSTASIS. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Matsuo: "Clinical application of the synthetic thrombin inhibitor, argatroban (MD-805)." SEMINARS IN THROMBOSIS AND HEMOSTASIS. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mamoru Omae: "Culture and Personality of BALI." Minatogawa Joshi Tanki Daigaku Kiyo. 25. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "A study on the relationship between food putrefuction and quantitative changes of the bacteria population and nedotoxin concentration in the putrefuction process of a typical traditional food "LAWAR" in Bali, Indonesia." Minatogawa Joshi Tanki Daigaku Kiyo. 25. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Masami Kojima: "Minatogawa Joshi Tanki Daigaku Kiyo" The Forum : Summary of the Lecture Meetings concerning the Cooperative Research Project. (1) Endotoxin and Horseshoe Crab. (2) Recent Japanese family education and Youth.25. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I G. N. P. Adnyana: "Value education in Indonesia : An overview of some problems and methods of instruction." Minatogawa Joshi Tanki Daigaku Kiyo. 25. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Wayan Redi Aryanta: "The processing and microbiological aspects of some traditional foods in Bali, Indonesia." Minatogawa Joshi Tanki Daigaku Kiyo. 25. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shosuke Okamoto: "Synthesis of tripeptide chloromethyl Ketones and examination of their inhibitory effects on plasmin and plasma Kallikrein." Chem.Pharm.Bull.37(11). 3108-3111 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shosuke Okamoto: "Effect of a Synthetic thrombinーinhibitor MD805 on the reaction between thrombin and plasuma antithrombin III" Thromb.Res.59(6). 967-977 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shosuke Okamoto: "Effect of a highly selective plasmaーkallikrein synthetic inhibitor on contact activiation relating to kinin generation,Coagulation and fibrinolysis." Thromb.Res.57(6). 889-895 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shosuke Okamoto: "The forum:Advanced diological approach of living for the purpose of “preventing loss of life and improving guality of life,scientifically."" 湊川女子短期大学紀要. 第23集. 129-140 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shosuke Okamoto: "KININ V Part B (Eds.k.Abe et al.)" Plenum Publishing Cooperation, 29-34 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shosuke Okamoto: "Protease Inhibitors (Eds.K.Abe et al.)" Elsevier Science Publishers BV, 207-218 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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