| Project/Area Number |
01101013
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| Research Category |
Grant-in-Aid for Special Project Research.
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| Allocation Type | Single-year Grants |
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
EBASHI Setsuro National Institute for Physiological Sciences, Director-General, 生理学研究所, 所長 (10009863)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANO Toshio Department of Biochemistry, Osaka University, emeritus professor, 医, 名誉教授 (40028270)
IRISAWA Hiroshi National Institute for Physiological Sciences, emerits professor, 生理学研究所, 名誉教授 (30033947)
NONOMURA Yoshiaki University of Tokyo, Professor, 医, 教授 (80009993)
NAGAI Yoshitaka University of Tokyo, Professor, 医, 教授 (80072974)
MUROTA Seiitsu Faculty of Dentistry, Tokyo Medical and Dental University, Professor, 歯, 教授 (50072989)
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| Project Period (FY) |
1986 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Keywords | vasoactive peptides / endothel growth factor / culture of vascular system / bioactive lipides / Ca^<2+> in vascular system / intracellular Ca^<2+> concentration / regulatory proteins of smooth muscle |
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| Research Abstract |
The research group has achieved a remarkable success in many respects of the field: 1) An enormous development has been attained in introducing molecular genetic approach to this field. This technique has become a common method for most of the members of this group. 2) A tremendous progress has been made in the studies on the interaction between endothel and smooth muscle. 3) Role of lipoproteins in pathogenesis of arterioscherosis were studied with special reference to macrophage. 4) Notable findings were obtained in the studies on structural proteins which regulate the contractile proteins of smooth Muscle. 5) The method of measuring intracellular Ca^<2+> concentrations in active state was markedly advanced. 6) Reexamination of various peptides affecting vascular system was carried out from the cardiovascular points of view. 7) Studies on the blood flow from the viewpoints of not only theology but also metabolism has provided a new scope as to the spasm and thrombosis in vascular system. 8) Various kinds of experimental models were explored, which will be a very useful tool for cardiovascular research.
As a whole, a new concept "Endothel-smooth muscle coupling" has emerged as the next subject of research in this field.
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