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Physiological Roles of Cell Growthー or Differentiationーfactors and Their Participations in the Pathologic Changes in the Hereditary Abnormal Models.

Research Project

Project/Area Number 01304025
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

SHIOTA Kunio  Univ. Tokyo, Fac. Agricul., Associ. Prof., 農学部, 助教授 (80196352)

Co-Investigator(Kenkyū-buntansha) ASANO Toshihiko  NIH, Japan, Dep. Vet. Sci., Cheaf Res., 獣疫部, 主任研究員 (60100062)
HAYASHI Yoshihiro  Univ. Tokyo, Fac. Agricul., Prof., 農学部, 教授 (90092303)
TAKAHASHI Michio  Univ. Tokyo, Fac. Agricul., Prof., 農学部, 教授 (30011943)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 1990: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1989: ¥7,800,000 (Direct Cost: ¥7,800,000)
KeywordsSHC rat / anterior pituitary hormones / activin A / transforming growth factorーbeta / cell growth factor / ICGN mice / PC mice / ocd / ocd rat / アクチビン / Fibroblast Growth Factor / マストミス
Research Abstract

1) Spontaneously hypercholesterolemic (SHC) rats were originally selected based on their high plasma cholesterol levels from sprague-dawley rats and established as a model for hypercholesterolemia. We have found that SHC rat exhibits abnormal bone metabolism characterized by higher excretion of hydroxyproline and calcium into urine, a high level of serum calcium, or a decrease in bone weight and calcium content in the ash. In SHC rats, the rats exhibits abnormalities in endocrine function including hypersecretions of thyroid stimulating hormone and growth hormone preceding the occurrence of renal dysfunction. These abnormalities seems to depend on the cellular component of hormone producing cells in the anterior pituitary gland.
2) Hormone producing cells in the anterior pituitary gland are heterogeneous and are thought to be composed of cells in various stages of differentiation. Since some of cells in adult rats are thought to be stem cells, it is possible that activin A may induce di … More fferentiation of proliferation in such stem cells. The mode of action of activin A on the anterior pituitary gland was investigated using primary cultured cells. In the study, folliclestimulating hormone (FSH) secretory activity was stimulated by activin A in a cell density-dependent manner and that the treatment with activin increased the number of FSH cells. Thus, we found that activin A acts on pituitary cells in the same way as a growth- or differentiation promoting factor. We also demonstrated that the capacity of Activin A to release the 2-cell block and stimulate early embryonal development in vitro.
3) Prolactin is known to be a hormone carrying luteotropic action in rats and enhances progesterone secretion. We found that transforming growth factor-beta can suppress luteal 20 alpha-hydroxysteroid dehydrogenase activity and that luteotropic action of PRL is at least in part mediated by TGF-beta.
4) Electron microscopic studies of glomerular lesions in hereditary nephrotic mice (ICGN strain) and of epiphyseal cartilage of congenital osteochondrodysplasia rat (ocd/ocd) have been done. Less

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Tetsuro Katayama: "Effects of activinA on anterior pituitary cells fractionated by centrifugal elution" Mol.Cell.Endocrinol.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Katsuichi Sudo: "Abnormal bone metabolism of spontaneously hyperchoresterolemic (SHC) rats before and after the onset of renal dysfunction" Endocrinol.Jpn.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noboru Murakami: "Longーterm cultured neurons from rat suprachiasmatic nucleus retain the capacity for circadion oscillation of vasopressin release" Brain Res.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shigetoshi Kurosawa: "A histological study on the skin and hairs of PC(poor coat)mice" Exp.Anim.40. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Atsuo Ogura: "Evolution of glomerular lesions in nephrotic ICGN mice:Serial biopsy study with electron microscopy" J.Vet.Med.Sci. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kenji Ogawa: "Histochemical localization of inhibin and activin α,βA and βB subunits in rat gonads" J.Vet.Med.Sci. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tetsuro Katayama: "Effects of activin A on anterior pituitary cells fractionated by centrifugal elusion." Mol. Cell. Endoc.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Katusichi Sudo: "Abnormal bone metabolism of spontaneously hyper-cholesterolemic (SHC) rats before and after the onset of renal dysfunction." Endocrinol. Jpn.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noboru Murakami: "Long-term cultured neurons from rat suparachiasmatic nucleus retain the capacity for circadian oscillation of vasopressin release." Brain Res.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shigetoshi Kurosawa: "A histological study on the skin and hairs of PC (poor coat) mice." Exp. Anim.vol. 40.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Atsuo Ogura: "Evolution of glomerular lesios in nephrotic ICGN mice : Serial biopsy study with electron microscopy." J. Vet. Med. Sci.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kenji Ogawa: "Histochemical localization of inhibin and activin alpha, betaA and betaB subunits in rat gonads." J. Vet. Med. Sci.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tetsuro Katayama: "Effects of activin A on anterior pituitary cells fractionated by centrifugal elution" Mol.Cell.Endocrinol.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Katsuichi Sudo: "Abnormal bone metabolism of spontaneously hyperchores terolemic (SHC) rats before and after the onset of renal dysfunction" Endocrinol.Jpn.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Noboru Murakami: "Longーterm cultured neurons from rat suprachiasmatic nucleus retain the capacity for circadian oscillation of vasopressin release" Brain Res.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Shigetoshi Kurosawa: "A histological study on the skin and hairs of PC (poor coat) mice" Exp.Anim.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Atsuo Ogura: "Evolution of glomerular lesions in nephrotic ICGN mice:Serial biopsy study with electron microscopy" J.Vet.Med.Sci. 40.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kenji Ogawa: "Histochemical localization of inhibin and activin α,βA and βB subunits in rat gonads" J.Vet.Med.Sci.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kunio Shiota: "Calcium Metabolism,Serum Thyroid Stimulating Hormone,Prolactin,and Growth Hormone in Spontaneously Hypercholesterolemic Rats" Proceedings of the Society for Experimental Biology and Medicine. 190. 229-233 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Atsuo Ogura: "Development of Nephrotic ICGN Mice-The Origin,Reproductive Ability,and Incidence of Glomerlonephritis" Experimental Animals. 38. 349-352 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Atsuo Ogura: "Characteristics of Mutant Mice(ICGN)with Spontaneous Renal Lesions:a New Model for Human Nephrotic Syndrome" Laboratory Animals. 23. 169-174 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tetsuro Katayama: "Activin A Increses the Number of FSH Cells in Anterior Pituitary Cultures" Molecular and Cellular Endocrinology. (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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