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Co-operative Research on the Clinical Application of Liver Transplantation.

Research Project

Project/Area Number 01304041
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MORI Takesada  Osaka University, Medicine, Professor, 医学部, 教授 (60028496)

Co-Investigator(Kenkyū-buntansha) TANIGAWA Kyuichi  Kurume University, Medicine, Professor, 医学部, 教授 (10080649)
DOHI Yukihiko  Hirosima University, Medicine, Professor, 医学部, 教授 (90034024)
TAKAGI Hiroshi  Nagoya University, Medicine, Professor, 医学部, 教授 (70154755)
OZAWA Kazue  Kyoto University, Medicine, Professor, 医学部, 教授 (00026858)
UCHIDA Hisanori  Tokyo University, Medical Science, Professor, 医科学研究所, 教授 (30050420)
鎌田 武信  大阪大学, 医学部, 教授 (80028399)
杉町 圭蔵  九州大学, 医学部, 教授 (00038762)
森岡 恭彦  東京大学, 医学部, 教授 (10048952)
内野 純一  北海道大学, 医学部, 教授 (40000989)
森 昌造  東北大学, 医学部, 教授 (70004877)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 1991: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1990: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1989: ¥7,300,000 (Direct Cost: ¥7,300,000)
KeywordsLiver transplantation / end-stage liver disease / indication / national network / registration system / perioperative management / rejection / organ preservation / 肝移植ネットワ-ク / 術中術後管理
Research Abstract

In the western countries, liver transplantation has been accepted as a state-of-the-art therapy for end-stage liver diseases. In contrast, no liver transplantations from brain-dead donors have been performed yet in our country. The aim of this multi-center study is to investigate various medical problems related with liver transplantation and to establish a computed registration system of recipients, in order to start successful liver transplantation program in Japan.
The problems investigated include: 1) indications of liver transplantation, based on the characteristics of the liver diseases in our country, 2) fundamental research on immunosuppression, 3) research on the pre-, intra-, and post-operative management of liver recipients, 4) fundamental research on liver preservation and refinement of operative techniques of the donor operation, and 5) development of a national registration system using a computer, as a part of national network system for liver transplantation.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Kawai M: "Differential involvement of CD4^+ cells in mediating skin graft rejection against different amounts of transgenic H-2Kb antigen." J Exp Med. 173(1). 261-264 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohzato H: "Improvement in islet yield from a cold-presepved pancreas by pancreatic ductal collagenase distention at the time of harvesting." Transplantation. 51(3). 566-570 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Seiji Marubayashi: "Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury" SURGERY. 110(3). 537-543 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N.Ohkohchi,M: "Role of Free Radicals and Energy Synthesis on Primary Graft Nonfunction in Liver Transplantation" Transplantation Proceeding. 23(5). 2416-2419 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 織井 崇: "温阻血・再潅流に伴う肝細胞膜の機能傷害に関する検討( ^<31>P-MRSおよび ^<23>Na-MRSを用いて)" 肝臓. 31(12). (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 柿添 三郎: "地域国立基幹病院における肝疾患患者の予後ー肝臓移植の適応を考慮してー" 日本消化器病学会雑誌. 88(9). (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Monden M: "Proceeding of the First Congress of Asian Society of Transplantation." Asian Transplantation Society, (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 王 国新: "Cytoprotection and Biology Vol.8" 蟹書房, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawai M: "Differential involvement of CD4^+ cells in mediating skin graft rejection against different amounts of transgenic H-2Kb antigen." J Exp Med. 173(1). 261-264 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohzato H: "Improvement in islet yield from a cold-presepved pancreas by pancreatic ductal collagenase distention at the time of harvesting." Transplantation. 51(3). 566-570 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Seiji Marubayashi: "Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury" SURGERY. 110(3). 537-543 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] N. Ohkohchi, M: "Role of Free Radicals and Energy Synthesis on Primary Graft Nonfunction in Liver Transplantation" Transplantation Proceedings. 23(5). 2416-2419 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawai M: "Differential involvement of CD4^+ cells in mediating skin graft rejection against different amounts of transgenic Hー2Kb antigen." J Exp Med. 173(1). 261-264 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ohzato H: "Improvement in islet yield from a coldーpresepved pancreas by pancreatic ductal collagenase distention at the time of harvesting." Transplantation. 51(3). 566-570 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Seiji Marubayashi: "Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury" SURGERY. 110(3). 537-543 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] N.Ohkohchi,M: "Role of Free Radicals and Energy Synthesis on Primary Graft Nonfunction in Liver Transplantation" Transplantation Proceedings. 23(5). 2416-2419 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 織井 崇: "温阻血・再潅流に伴う肝細胞膜の機能傷害に関する検討( ^<31>PーMRSおよび ^<23>NaーMRSを用いて)" 肝臓. 31(12). (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 柿添 三郎: "地域国立基幹病院における肝疾患患者の予後ー肝臓移植の適応を考慮してー" 日本消化器病学会雑誌. 88(9). (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Monden M: "Proceeding of the First Congress of Asian Society of Transplantation." Asian Transplantation Society, (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 王 国新: "Cytoprotection and Biology Vol.8" 蟹書房, (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Fukao,H.Iwasaki,K.Yuzawa,M.Otsuka,Y.Yu,K.Terao,J.Yamashita: "Immunosuppressive Effect and Toxicity of 15ーDeoxyー spergualin in Cynomolgus Monkey" Transplantation Proceedings. 23(1). 556-558 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumimoto R and Kamada N: "Specific suppression of allograft rejection by soluble class I antigen and complexes with monoclonal antibody" Transplantation. 50. 678-679 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kurozumi.Y,Sakagami.K,Orita.K: "Ex vivo perfusion of the liver with antiーclass II antibody can prevent acute rejecion in canine liver transplantation" Transplantation Proceedings. 23. 593-596 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Nakano,M.Monden,M.Gotoh,L.A.Valdivia,J.Okamura,T.Mori: "LongーTerm Acceptance of Rat Liver Allografts Induced by Intraportal Administration of Donor Spleen Cells" Transplantation Proceedings. 23(1). 813-814 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Tono,M.Monden,K.Yoshizaki,M.Gotoh,T.Kinoshita,T.Mori: "Interleukin 6 Levels in Bile Following Liver Transplantation" Transplantation Proceedings. 23(1). 630-631 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 谷川 久一: "内科医からみた肝移植ー適応を中心にー" 医学のあゆみ. 154(1). 39-42 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 三村 信英、秋山 暢夫(編): "臓器移植フィジビリティ-スタディ-:現況と将来" 東京医学社, 133 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 王 国新,門田 守人,金井 俊雄,梅下 浩司,諸井 敏定,村田 賢,王 俊生,後藤 満一,森 武貞: "Cytoーprotection & biology" 蟹書房, 448 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hasuike Y.,Monden M.,Mori T.et al.: "Immunological unresponsiveness to hepatic allografts in rats.Immunological reactivity of the recipient to donor antigen." Transplantation. 47(6). 1043-1047 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M Monden,T Mori.et al.: "A Potent Immunosuppressive Effect of FK 506 in Orthotopic Liver Transplantation in Primates." Transplantation Proceedings. 22(1). 66-71 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nobuhiro Ohkochi,Shozo Mori.et al.: "Successfull Kasai Operation in Biliary Atresia;Selection of Recipients for Liver Transplantation." Journal of Pediatric Gastroenterolgy and Nutrition. 9. 416-420 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] S.Marubayashi,K.Dohi,K.Sugino,T.Kawasaki: "The Protective Effect of Admonistered α-Tocopherol against Hepatic Damage Caused by Ischemia-Reperfusion or Endotoxemia." Annals of the New York Academy of Sciences. 570. 208-218 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村純、柿田章、中島保明、田中康夫、大村孝志、槌本真也、長谷泰司、内野純一: "ブタ同所性肝移植 術後胃潰瘍発生に関する検討" 今日の移植. 3(1). 25-30 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 谷川久一: "成人例の肝移植の適応に関する問題点 第1回九州山口臓器移植検討会における講演" 臨床と研究. 66(4). 1224-1228 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] (岡村純)、門田守人、後藤満一、森武貞: "“肝移植"新外科学大12「臨床肝臓病学」P293-326" 中山書店, 426 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] (岡村純)、門田守人、後藤満一、森武貞: "“肝移植"「臨床肝臓病学」P583-594" 朝倉書店, 634 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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