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CoーOperative Study for Clinical Application of Lung and Heart-Lung Transplantation

Research Project

Project/Area Number 01304043
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTpkyo Medical College, Faculty of Medicine

Principal Investigator

HAYATA Y  Tokyo Medical College, Professor Emeritus, 医学部, 名誉教授 (30074470)

Co-Investigator(Kenkyū-buntansha) TANABE T  Hokkaido University, Professor, 医学部, 教授 (50000956)
KOYANAGI H  Tokyo Women's Medical College, Professor, 医学部, 教授 (90138884)
FUJIMURA S  Tohoku University, Professor, 抗酸菌病研究所, 教授 (40006078)
FURUSE A  Tokyo University, Professor, 医学部, 教授 (70010163)
TOMITA M  Nagasaki University, Professor, 医学部, 教授 (70039808)
川島 康生  大阪大学, 医学部, 教授
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1990: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1989: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsLung and heart-lung transplantation / Lung transplantation in rats, dogs and monkey / Reperfusion injury / Monitoring of early rejection / BALF / Immunosuppressive agents / Wound healing of bronchial anastomotic site / Lung preservation after cardiac arrest / reimplantation response / 肺胞洗浄液 / Ca拮抗剤 / 拒絶反応の診断 / 抗酸化剤 / 気管支吻合部血流
Research Abstract

In the near future lung or heart-lung transplantation will be performed in Japan.
At that time we should certainly prevent failures due to rejection. We have performed basic studies such as an organ preservation, monitoring of early rejection, observation of wound healing of anastomotic site of the bronchi, immunosuppressive treatment etc.
Organ can be preserved for 5-6 hours using Euro-Collins solution, but the possibility of prolongation for 12-24 hours by the addition of CA^<++>antagonist and/or antioxydizing agents (SOD, CoQ10). In the case of heart-lung preservation, reperfusion injury sometimes develops.
In order to suppress this, the application of compliment-activated agent (FUT-175) and/or perfusion using blood from which leukocytes have been removed seem effective. At present as we cannot obtain donor lung from brain death case, use of lungs after cardiac arrest is considered. According to injection of heparin and predonisolone before cardiac arrest in animals preservation for 24 hours will be possible using lung extracted 2 hours after cardiac arrest. For physiological and immunological study of lung and heart-lung transplantation are being performed in rats. Shortening of operation time and ischemic time and improvement of survival rate were obtained. As monitoring parameters of early rejection there was a relationship between early rejection and total cell number, cell analysis, CD4/CD8 rate of leukocytes in BALF in rat, canine and monkey lung transplantation models.
In relation to this, donor-specific cytotoxic activity derived from T lymphocytes was observed. There was similar effects of new immunosuppressive agents (FK506 and DSG) compared to cyclosporin A, To observe wound healing of the anastomotic site of the bronchi endoscopic observation of the lesion using fluorescence and blood flow measurement by laser Doppler Velocity were used. A mannual of lung and heart-lung transplantation was published as a step towards human application.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (193 results)

All Other

All Publications (193 results)

  • [Publications] 田近 栄四郎: "肺移植術後の移植肺気管支粘膜下血流動態の観察" 気管支学. 12. 42-50 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 中嶋 伸: "犬肺保存実験における血中PGICC2DD及びTXACC2DDの経時的方動に関する実験的研究" 東京医科大学雑誌. 48. 1-9 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 梶谷 道夫: "Autoperfusion法による心肺同時保存に関する研究特に保存時間延長のための検討" 北海道医学雑誌. 65. 311-319 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 浅井 康文: "サルとひひを用いた同所性異種心肺移植の検討" 胸部外科. 41. 1061-1064 (1988)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] H.Taniguchi: "Experimental study on active oxygen species to warm ischemic lung availability of GSH,SOd and alloprinol" Acta Medica Nagasakiensis. 34. 177-187 (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 谷口 英樹: "雑種成犬温阻血肺における各種抗酸化剤の効果に関する実験的検討" Cytoーprotection and biology. 7. 433-441 (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 仲曽根 朝紀: "肺移植における好中球・肺胞マクロファ-ジの活性酵素産生能に関する実験的検討" 長崎医学会雑誌. 65. 3999-408 (1990)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 高橋 孝郎: "肺移植の虚血再〓豆傷害に対する Superoxide dismutaseの効果" Cytoーprotection and Biology. 8. 385-392 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H.Yokomise: "Application of Laser Doppler Velocimetry to Lung Transplantation" Transplantation. 48. 550-554 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 青木 稔: "犬同種肺移植におけるFkー506の免疫抑効果 ー病理組織学的検討を中心にー" 京大胸部研紀要. 22. 65-72 (1989)

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      1990 Final Research Report Summary
  • [Publications] F.Yamzaki: "An Evaluation of the Tolerance of the Autotransplanted Canine Lung againist Warm Ischemia" Jap.J Surg. 19. 326-333 (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 和田 洋巳: "肺移植" 外科治療. 63. 41-45 (1990)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] F.Yamazaki: "The Superiority of an Extracellular Fluid SOlution over EuroーCollins for Pulmonary Preservation" Transplantation. 49. 690-694 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H.Yokomise: "The Effect and Optimal Time of Administration of Verapamil on Lung Transplantation" Transplantation. 49. 1039-1043 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 川内 基裕: "日本猿による心肺同時移植における asynchronous rejection" 移植. 24. 73-79 (1989)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 川内 基裕: "ニホンザルによる同種心肺移植における拒絶反応の病理組織学的検討ーdonor気管と末梢肺の比較検討ー" 移植. 24. 502-509 (1989)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 川内 基裕: "移植心の拒絶反応の診断におけるミオシン軽鎖の意義" 日本外科学会雑誌. 90. 795. (1989)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 川内 基裕: "心臓移植の現況と人工心臓のbridge use" 外科診療. 32. 1282-1288 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Kawauchi: "Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains" Jap.J.Surg.20. 212-216 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 中島 淳: "抗白血球モノクロ-ナル抗体を用いた日本猿肺移植の免疫病理組織学的検討" 日本胸部外科学会雑誌. 38. 332 (1990)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 柳生 邦良: "心エコ-法による移植心の急性拒絶反応の診断" 日本胸部外科学会雑誌. 38. 287 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 中 好文: "Autoperーfusion法による心肺保存の実験的研究" 日本胸部外科学会雑誌. 37. 867-868 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 川島 康生: "心肺同時移植の現況と将生性ー肺高血圧症をめぐって" 医学のあゆみ. 148. 509-593 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Naka: "Prevention of pulmonary edema developing in autoperfusing heartーlung preparation by leukocyte depletion" Europian J Cardiothoracic Surg. 2. 355-358 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Naka: "Prevention of pulmonary edema in autoperfusing heartーlung preparation by FUT175 and leukocyte depletion" Transplantation Proceedings. 21. 1353-1356 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Naka: "Canine heartーlung transplantation after 24ーhours hypo thermic preservation" Europian J.Cardiothoracic Surg.4. 499-503 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] A.Matsumura: "Filtration coefficient in isolated pressred and reperfuad canine lung" J.Surg.Res.accepted.

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] T.Mizuta: "Total non microsuture technique for rat lung transplantation" J.Thorac Cardiovas Surg.accepted.

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 明石 章則: "虚血肺細胞内ATPレベル低下に伴う細胞態害と界面活性物質分泌能の変化一気管支肺胞洗浄法による評価" 大阪大学医学雑誌 発表予定.

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 安田 雄司: "ラット移植肺の末梢肺野にみられる急性拒絶反応に関する形態学的研究" 滋賀医科大学雑誌. 5. 147-166 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 藤野 昇三: "内胸動問における気管支動脉の再辺行ー気管支吻合部血流量にもたらす経時吻効果の検討" 日本胸部外科学会雑誌. 38. 1873 (1990)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] Y.Yasuda: "Ultrastructual Study of the Rat Transplanted Lung During Acute Stage Rejection" Journal Clinical Electron Microscopy. 22. 876-877 (1989)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] L.Zhang: "Morphological Study of the Effect of Immunosuppresants, Cyclosporine A and FK506,on the Rejection of Lung Transplants." Journal Clinical Electron Microscopy. 23. (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] Y.Yasuda: "Change in the Fine Structure of the Lung During the Acute Rejection of Rat Lung Trannsplants." Journal Clinical Electoron Microscopy. 23. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Hirakawa: "New Technique for Intrathracic HeartーLung Transplantation in the Rat." The Journal of Heart Transplantation. 9. 495-501 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] M.Takao: "Significance of Measurement of Bronchial Mucosal Blood Flow for the Monitoring of Acute Rejection of Transplanted Lungs." Transplantation. 50. 345-348 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] M.Takao: "Application of bronchial Mucosal Blood Flow Measuement to Monitoring Acute Rejection of Transplanted Lungs" Mie Medical Journal. 40. 171-184 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 草川 實: "肺移植における拒〓反応のモニタリング" 外科治療. 61. 1050-1051 (1989)

    • Description
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      1990 Final Research Report Summary
  • [Publications] Y.Katayama: "Experimental Lung Transplantation in Rats Antirejection Effects of FK506 and 15ーDeocyspergualin." Mie Medical Journal. 40. 215-228 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 八田 光弘: "心肺同時移植後の癌細胞発育に関する実験的検討" 移植. 25. 69-73 (1990)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 八田 光弘: "肺保存後の虚血ー再〓流態障害の肺胞系変化に関する研究" 日本胸部外科学会誌. 38. 1424-1428 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 八田 光弘: "胸死下臓器移植としての心.心肺移植の問題点と展望" 日本外科学会誌. 91. 1403-1405 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] M.Hachida: "Significant Immuno Suppressive Effect of Ganglioside GM in Organ Transplantation." Transplantation Proceedings. 22. 1663-1665 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 斎藤 幸雄: "イヌ同種肺移植におけるドナ-皮線維芽細胞に対する細胞障害活性に関する検討" 移植. 24. 131-140 (1989)

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      1990 Final Research Report Summary
  • [Publications] Y.Saito: "Morphological rejection phases and Cytotoxic activity in peripheral blood lymphocytes in canine lung allo." Japanese Journal of Surgery. 20. 205-211 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 斎藤 幸雄: "実験的肺移植における肺移植の組織学的変化と末梢リンパ球細胞傷害活性の関連" 今日の移植. 3. 387-391 (1990)

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      1990 Final Research Report Summary
  • [Publications] 藤沢 武彦: "肺移植の拒絶反応" 臨床胸部外科. 11. ). 02%33 (1991)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 卜部 憲和: "保存肺のProstaglandin IG(PGICC2DD)産生能に関する実験的検討" 移植. 26. ). 02%33 (1991)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 藤沢 武彦: "雑種成大同種肺移植における特異的障害Tリンパ球活性の検出" 日本胸部外科学会雑誌. 37. 203-207 (1989)

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      1990 Final Research Report Summary
  • [Publications] 半田 政志: "原発性肺高血圧症における心肺移植の現況" 医学のあゆみ. 152. 429-432 (1990)

    • Description
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      1990 Final Research Report Summary
  • [Publications] R.Saito: "Detection of Peripheral Blood and bronchoalveolar Lavage Fluid Lynphocytesin Rat Lung Transplantation for Early Diagnosis of Rejection." Tohku J.Exp. Med.160. 231-249 (1990)

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      1990 Final Research Report Summary
  • [Publications] 一ノ瀬 高志: "心停止後摘出肺の移植及び保存に関する実験的研究" 抗酸菌病研究所雑誌. 41. 272-282 (1989)

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      1990 Final Research Report Summary
  • [Publications] M.Handa: "A Study of Preservation Solution for 48ーhours Simple Hypothermic Storige of canine Lung Transplants." Tohku J.Exp.Med.159. 215-219 (1959)

    • Description
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      1990 Final Research Report Summary
  • [Publications] 藤村 重文: "肺移植" 外科. 52. 157-160 (1990)

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      1990 Final Research Report Summary
  • [Publications] 日石 裕治: "心肺除神経が抗利尿ホルモン,心房性ナトリウム 利尿ペプチド分泌に及ぼす影響について" 抗酸菌病研究所雑誌. 41. 69-78 (1990)

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      1990 Final Research Report Summary
  • [Publications] 藤村 重文: "同種肺移植" 抗酸菌病研究所雑誌. 41. 195-224 (1990)

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      1990 Final Research Report Summary
  • [Publications] Y.Shiraishi: "Vasopressin and atrial natriuretic peptide release in cardiopulmonary denervoted dog." American Journal Physiology. 258. 704-710 (1990)

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      1990 Final Research Report Summary
  • [Publications] 藤村 重文: "肺移植における拒絶反応の診断" 臨床胸部外科. 9. 13-18 (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 半田 政志: "肺移植と心肺同時移植ー肺外科からー" 臨床胸部外科. 9. 117-122 (1989)

    • Description
      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 藤村 重文: "呼吸不全対策としての肺移植" 日本胸部疾患学会雑誌. 27. 390-395 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 斎藤 亮: "ラット肺移植における気管支肺胞洗浄液リンパ球による拒絶反応早期診断の研究" 移植. 24. 262-269 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 白石 裕治: "心肺除神経後の体液調節に関する実験的研究" 今日の移植. 2. 299-304 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松村 輔二: "日本猿を用いた肺移植の実験的研究一移植手技及び免疫抑制法について" 移植. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 文部省科研費肺及び心肺移植研究班員: "肺・心肺移植マニュアル" 肺及び心肺移植研究班, (51)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] E. Tajika: "Evaluation of the revascularization and hemodynamic condition of transplanted bronchi following experimental transplantation" J. Jap. Soc. Bronchology. 12. 42-50 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Nakajima: "Time-course changes of serum Prograstandin I_2 (PGI_2) and Thromboxan A_2 (TAX_2) levels before and after reimplantation of canine preserved lung" J. Tokyo Med. College. 48. 277-285 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Taniguchi: "Experimental study on active oxygen species to warm ischemic lung-Availability of GSH, SOd and alloprinol" Acta Medica Nagasakiensis. 34. 177-187 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Yokomise: "Application of laser Doppler Velocimetry to lung transplantation" Transplantation. 46. 550-554 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F. Yamazaki: "An evaluation of the tolerance of the autotransplanted canine lung against warm ischemia" Jap. J Surg. 19. 326-333 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F. Yamazaki: "The superiority of an extracellular fluid solution over Euro-Collins for pulmonary preservation" Transplantation. 49. 690-694 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Yokomise: "The effect and optimal time of administration of Verapamil on lung transplantation" Transplantation. 49. 1039-1043 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Kawauchi: "Diagnosis of cardiac allograft rejection by the detection of circulation plasma cardiac myosin light chains." Jap. J. Surg. 20. 212-216 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Naka: "Prevention of pulmonary edema developing in autoperfusing heart-lung preparation by leukocyte depletion" Europ. J. Cardiothoracic Surg. 3. 355-358 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Naka: "Prevention of pulmonary edema in autoperfusing heartーlung preparation by FUT175 and leukocyte depletion" Transplantation Proceeding. 21. 1353-1356 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Naka: "Canine heart-lung transplantation after 24 hours hypothermic preservation" Europ. J. Cardiothoracic. Surg. 4. 499-503 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Matsumura: "Filtration coefficient in isolated preserved and reperfused canine lung" J. Surg. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Mizuta: "Total non-microsuture technique for rat lung transplantation" J. Thorac Cardiovasc. Surg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Yasuda: "Ultrastructural study of the rat transplanted lung during acute stage rejection" J. Clinical Electron Microsc. 22. 876-877 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] L. Zhang: "Morphological study of the effect of immunosuppressants, Cyclosporine A and FK506 on the rejection of lung transplants" J. Clinical Electron Microsc.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Yasuda: "Change in the fine structure of the lung during the acute rejection of rat lung transplants" J. Clinical Electron Microsc.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Hiraiwa: "New technique for intrathoracic heart-lung transplantation in rat" J. Heart Transplantation. 9. 495-501 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Takao: "Significance of measurements of bronchial mucosal blood flow for the monitoring of acute rejection of transplanted lung" Transplantation. 50. 345-348 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Takao: "Application of bronchial mucosal blood flow measurement to monitoring acute rejection of transplanted lung" Mie Med. J.40. 171-184 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Katayama: "Experimental lung transplantation in rats-Antirejection effects of FK506 and 15-Deoxy-spergualin" Mie Med. J.40. 215-228 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Hachida: "Singnificant immunosuppressive effect of Ganglioside GM in organ transplantation" Transplantation Proceeding.22. 1663-1665 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Saitoh: "Morphological rejection phases and cytotoxic activity in peripheral blood lymphocytes in canine lung allotransplantation" Jap. J. Surg.20. 205-211 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R. Saito: "Detection of peripheral blood and bronchoalveolar lavage fluid lymphocytes in rat lung transplantation for early diagnosis of rejection" Tohoku J. Exp. Med. 41. 231-249 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Handa: "A study of preservation solution for 48 hour simple hypothermic storage of canine lung transplants" Tohoku J. Exp. Med. 159. 205-214 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shiraishi: "Vasopression and atrial natriuretic peptide release in cardiopulmonary denervated dogs" Am. J. Physiol. 258. 704-710 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 田近 栄四郎: "肺移植術後の移植肺気管支粘膜下血流動態の観察" 気管支学. 12. 42-50 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 中嶋 伸: "犬肺保存実験における血中PGI_2及びTXA_2の経時的変動に関する実験的研究" 東京医科大学雑誌. 48. 1-9 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 梶谷 道夫: "Autoperfusion法による心肺同時保存に関する研究 特に保存時間延長のための検討" 北海道医学雑誌. 65. 311-319 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 浅井 康文: "サルとヒヒを用いた同所性異種心肺移植の検討" 胸部外科. 41. 1061-1064 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Taniguchi: "Experimental study on active oxygen species to warm ischemic lung availability of GSH,SOd and alloprinol" Acta Medica Nagasakiensis. 34. 177-187 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 谷口 英樹: "雑種成犬温阻血肺における各種抗酸化剤の効果に関する実験的検討" Cytoーprotection and biology. 7. 433-441 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 仲曽根 朝紀: "肺移植における好中球・肺胞マクロファ-ジの活性酸素産生能に関する実験的検討" 長崎医学会雑誌. 65. 3999-408 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 孝郎: "肺移植の虚血再潅流傷害に対するSuperoxide dismutaseの効果" Cytoーprotection and Biology. 8. 385-392 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yokomise: "Application of Laser Doppler Velocimetry to Lung Transplantation" Transplantation. 48. 550-554 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 青木 稔: "犬同種肺移植におけるFKー506の免疫抑制効果ー病理組織学的検討を中心にー" 京大胸部研紀要. 22. 65-72 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] F.Yamazaki: "An Evaluation of the Tolerance of the Autotransplanted Canine Lung against Warm Ischemia" Jap.J Surg. 19. 326-333 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 和田 洋巳: "肺移植" 外科治療. 63. 41-45 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] F.Yamazaki: "The Superiority of an Extracellular Fluid Solution over EuroーCollins for Pulmonary Preservation" Transplantation. 49. 690-694 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yokomise: "The Effect and Optimal Time of Administration of Verapamil on Lung Transplantation" Transplantation. 49. 1039-1043 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川内 基裕: "日本猿による心肺同時移植におけるasynchronous rejection" 移植. 24. 73-79 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川内 基裕: "ニホンザルによる同種心肺移植における拒絶反応の病理組織学的検討ーdonor気管と末梢肺の比較検討ー" 移植. 24. 502-509 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川内 基裕: "移植心の拒絶反応の診絶におけるミオシン軽鎖の意義" 日本外科学会雑誌. 90. 795 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川内 基裕: "心臓移植の現況と人工心臓のbridge use" 外科診療. 32. 1282-1288 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Kawauchi: "Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains" Jap.J.Surg.20. 212-216 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 中島 淳: "抗白血球モノクロ-ナル抗体を用いた日本猿肺移植の免疫病理組織学的検討" 日本胸部外科学会雑誌. 38. 332 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 柳生 邦良: "心エコ-法による移植心の急性拒絶反応の診断" 日本胸部外科学会雑誌. 38. 287 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 中 好文: "Autoperfusion法による心肺保存の実験的研究" 日本胸部外科学会雑誌. 37. 867-868 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川島 康生: "心肺同時移植の現況と将来性ー肺高血圧症をめぐって" 医学のあゆみ. 148. 590-593 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Naka: "Prevention of pulmonary edema developing in autoperfusing heartーlung preparation by leukocyte depletion" Europian J Cardiothoracic Surg. 2. 355-358 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Naka: "Prevention of pulmonary edema in autoperfusing heartーlung preparation by FUT175 and leukocyte depletion" Transplantation Proceedings. 21. 1353-1356 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Naka: "Canine heartーlung transplantation after 24ーhours hypothermic preservation" Europian J.Cardiothoracic Surg.4. 499-503 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] A.Matsumura: "Filtration coefficient in isolated preserved and reperfused canine lung" J.Surg.Res.

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Mizuta: "Total non microsuture technique for rat lung transplantation" J.Thorac Cardiovas Surg.

    • Related Report
      1990 Annual Research Report
  • [Publications] 明石 章則: "虚血肺細胞内ATPレベル低下に伴う細胞障害と界面活性物質分泌能の変化ー気管支肺胞洗浄法による評価" 大阪大学医学雑誌.

    • Related Report
      1990 Annual Research Report
  • [Publications] 安田 雄司: "ラット移植肺の末梢肺野にみられる急性拒絶反応に関する形態学的研究" 滋賀医科大学雑誌. 5. 147-166 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 安田 雄司: "ラット移植肺での急性期拒絶反応に関する超微形態学的研究" 呼吸器外科. 3. 195 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 安田 雄司: "ラット移植における肺胞領域での超微形態学的研究ーANTU肺水腫との対比ー" 日本胸部疾患学会雑誌. 27. 366 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 榎堀 徹: "ラット移植肺の急性拒絶反応におけるhecipient縦隔リンパ節の形態学的変化" 呼吸器外科. 4. 243 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 桂 敦史: "ラット肺移植におけるシクロスポリンAとFK506の拒絶抑制効果と問題点" 呼吸器外科. 4. 243 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 安田 雄司: "ラット移植肺の急性期拒絶反応にみられる超微形態学的変化" 移植. 24. 131 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤野 昇三: "内胸動脉・気管支動脉吻合による気管支血流再建を伴う肺移植手術" 日本胸部外科学会雑誌. 37. 1717 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤野 昇三: "内胸動脉における気管支動脉の再建術ー気管支吻合部血流量にもたらす経時的効果の検討" 日本胸部外部学会雑誌. 38. 1873 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Yasuda: "Ultrastructual Study of the Rat Transplanted Lung During Acute Stage Rejection" Journal Clinical Electron Microscopy. 22. 876-877 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] L.Zhang: "Morphological Study of the Effect of Immunosuppresants,Cyclosporine A and FK506,on the Rejection of Lung Transplants." Journal Clinical Electron Microscopy. 23. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Yasuda: "Change in the Fine Structure of the Lung During the Acute Rejection of Rat Lung Transplants." Journal Clinical Electron Microscopy. 23. (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Hirakawa: "New Technique for Intrathracic HeartーLung Transplantation in the Rat." The Journal of Heart Transplantation. 9. 495-501 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takao: "Significance of Measurement of Bronchial Mucosal Blood Flow for the Monitoring of Acute Rejection of Transplanted Lungs." Transplantation. 50. 345-348 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takao: "Application of bronchial Mucosal Blood Flow Measuement to Monitoring Acute Rejection of Transplanted Lungs." Mie Medical Journal. 40. 171-184 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 草川 實: "肺移植における拒絶反応のモニタリング" 外科治療. 61. 1050-1051 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Katayama: "Experimental Lung Transplantation in Rats Antirejection Effects of FK506 and 15ーDeoxyspergualin." Mie Medical Journal. 40. 215-228 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 八田 光弘: "心肺同時移植後の癌細胞発育に関する実験的検討" 移植. 25. 69-73 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 八田 光弘: "肺保存後の虚血ー再灌流障害の肺胞系変化に関する研究" 日本胸部外科学会誌. 38. 1424-1428 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 八田 光弘: "脳死下臓器移植としての心.心肺移植の問題点と展望" 日本外科学会誌. 91. 1403-1405 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Hachida: "Significant Immuno Suppressive Effect of Ganglioside GM in Organ Transplantation." Transplantation Proceedings. 22. 1663-1665 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 斎藤 幸雄: "イヌ同種肺移植におけるドナ-皮膚線維芽細胞に対する細胞障害活性に関する検討" 移植. 24. 131-140 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Saito: "Morphological rejection phases and Cytotoxic activity in peripheral blood lymphocytes in canine lung allo." Japanese Journal of Surgery. 20. 205-211 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 斎藤 幸雄: "実験的肺移植における肺移植の組織学的変化と末梢血リンパ球細胞傷害活性の関連" 今日の移植. 3. 387-391 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤沢 武彦: "肺移植の拒絶反応" 臨床胸部外科. 11. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 卜部 憲和: "保存肺のProstaglandin IG(PGI_2)産生能に関する実験的検討" 移植. 26. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤沢 武彦: "雑種成犬同種肺移植における特異的障害Tリンパ球活性の検出" 日本胸部外科学会雑誌. 37. 203-207 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 半田 政志: "原発性肺高血圧症における心肺移植の現況" 医学のあゆみ. 152. 429-432 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] R.Saito: "Detection of Peripheral Blood and Bronchoalveolar Lavage Fluid Lynphocytesin Rat Lung Transplantation for Early Diagnosis of Rejection." Tohoku J.Exp.Med.160. 231-249 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 一ノ瀬 高志: "心停止後摘出肺の移植及び保存に関する実験的研究" 抗酸菌病研究所雑誌. 41. 272-282 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Handa: "A Study of Preservation Solution for 48ーhours Simple Hypothermic Storige of canine Lung Transplants." Tohoku J.Exp.Med.159. 205-214 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤村 重文: "肺移植" 外科. 52. 157-160 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 白石 裕治: "心肺除神経が抗利尿ホルモン,心房性ナトリウム利尿ペプチド分泌に及ぼす影響について" 抗酸菌病研究所雑誌. 41. 69-78 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤村 重文: "同種肺移植" 抗酸菌病研究所雑誌. 41. 195-224 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Shiraishi: "Vasopressin and atrial natriuretic peptide release in cardiopulmonary denervoted dog." American Journal Physiology. 258. 704-710 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤村 重文: "肺移植における拒絶反応の診断" 臨床胸部外科. 9. 13-18 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 半田 政志: "肺移植と心肺同時移植ー肺外科からー" 臨床胸部外科. 9. 117-122 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤村 重文: "呼吸不全対策としての肺移植" 日本胸部疾患学会雑誌. 27. 390-395 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 斎藤 亮: "ラット肺移植における気管支肺胞洗浄液リンパ球による拒絶反応早期診断の研究" 移植. 24. 262-269 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 白石 裕治: "心肺除神経後の体液調節に関する実験的研究" 今日の移植. 2. 299-304 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松村 輔二: "日本猿を用いた肺移植の実験的研究ー移植手抜及び免疫抑制法について" 移植. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 内藤淳: "肺移植における保守肺の酵素学的研究" 日本胸部外科学会雑誌. 37. 871 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田近栄四郎: "肺移植術後の移植肺気管支粘膜下血流動態の観察" 気管支学. 12. 42-50 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 浅井康文: "ラットを用いた異所性心肺移植" 胸部外科. 41. 561-565 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] NANAMURA,T.: "Behavior of immunocompetent cells in the spleen and lymphnodes at lung transplantation-Especially alteration of Ia positive cell population among mononuclear cells-" Acta Medica Nagasakiensia. 34. 105-112 (1989)

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      1989 Annual Research Report
  • [Publications] TANIGUTI,H.: "Experimental study on active oxygen species to warm ischemic lung-Availability of GSH,SOD,and Alloprinol-" Acta Medica Nagasakiensia. 34. 177-187 (1989)

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  • [Publications] TSUJI,H.: "Bronchial blood flow at anastomosis of allografts in relation on immunosuppressive drugs" Acta Medica Nagasakiensia. 34. 213-223 (1989)

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  • [Publications] 藤村重文: "肺移植における拒絶反応の診断" 臨床胸部外科. 9. 13-18 (1989)

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  • [Publications] 斉藤亮: "ラット肺移植における気管支肺胞洗浄液リンパ球による拒絶反応早期診断の研究" 移植. 24. 262-269 (1989)

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  • [Publications] 半田政志: "肺移植と心肺同時移植" 臨床胸部外科. 9. 117-122 (1989)

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  • [Publications] 藤村重文: "呼吸不全対策としての肺移植" 日本胸部疾患学会雑誌. 27. 390-395 (1989)

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  • [Publications] 白石裕治: "心肺除神経後の体液調節に関する実験的研究" 今日の移植. 2. 299-304 (1989)

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  • [Publications] 八田光弘: "心肺同時移植後の心筋拒絶反応について組織学的考察(II)" 日本胸部外科学会雑誌. 37. 2256-2261 (1989)

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  • [Publications] 八田光弘: "Lung Function after Prolonged Lung preservation" Journal of Thoracic and Cardio vascular Surgery. 97. 911-919 (1989)

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  • [Publications] 八田光弘: "A New soulution for Lung preservation" Journal of Thoracic and Cardio vascular Surgery. 97. 53-520 (1989)

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  • [Publications] 藤沢武彦: "雑種成犬同種肺移植における特異的障害性Tリンパ球活性の検出" 日本胸部外科学会雑誌. 37. 203-207 (1989)

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  • [Publications] 斉藤幸雄: "イヌ同種肺移植におけるドナ-皮膚線維芽細胞に対する細胞障害活性に関する検討" 移植. 24. 134-140 (1989)

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  • [Publications] SAITOH,Y.: "Morphological rejection phases and cytotoxic activity in peripherol blood lymphocytes in canine lung allo-transplantation" Japanese Journal of Surgery. 20. (1990)

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  • [Publications] 草川實: "肺移植における拒絶反応のモニタリング" 外科治療. 61. 1050-1051 (1989)

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  • [Publications] TANABE,H.: "Early Detection of Lung Rejection by Measurement of Branchial Mucosal Blood Flow Using Laser Doppler Flowmeter" Transplantation Proceeding. 21. 2590-2591 (1989)

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  • [Publications] 田辺一: "気管支粘膜血流量による移植肺の拒絶反応の診断" 三重医学. 33. 87-96 (1989)

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  • [Publications] KATAYAMA,Y.: "Experimental Lung Transplantion in the Rat:Effects of FK506 and 15-Deoxyspergualin in Rat Lung Transplantaion" Mie Medical Journal. (1990)

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  • [Publications] TAKAO,M.: "Application of Bronchial Mucosal Blood Flow Measurement to Monitoring Acute Rejection of Transplanted Lungs" Mie Medical Journal. (1990)

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  • [Publications] 八田光弘: "心肺同時移植後の心筋拒絶反応についての組織学的考察(I)" 日本胸部外科学会雑誌. 37. 2250-2255 (1989)

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  • [Publications] KAWAUCHI,M.: "Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains" The Japanese Journal of Surgery.

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  • [Publications] MIZUTA,T.: "Simplified rat lung transplantation using a cuff technique" J Thorac Cardiovasc Surg. 97. 578-581 (1989)

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  • [Publications] MIZUTA,T.: "Simplified rat lung transplantation using a cuff technique" Transplant Proc. 21(1). 2601-2602 (1989)

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  • [Publications] NAKA,Y.: "Prevention of pulomonary edema in autoperfusing heart-lung preparation by FUT-175 and leukocyte depletion" Transplant Proc. 21(1). 1353-1356 (1989)

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  • [Publications] NAKA,Y.: "Prevention of pulmonary edema developing in autoperfusing heart-lung preparation by leukocyte depletion" Eur J Cardiothorac Surg. 3. 355-358 (1989)

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  • [Publications] 松岡正紀: "Autoperfusionによる心肺保存の研究" 日本胸部外科会誌. 37. 694-701 (1989)

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  • [Publications] OKA,T.: "Experimental study on lung preservation-Function of a 6-hours preserved donor lung" Acta Medica Nagasakiensia. 34. 272-282 (1989)

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  • [Publications] YOKOMISE,H.: "Application of Doppler Velocimetry to Lung Transplantation" Transplantation. 48(4). 550-554 (1989)

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  • [Publications] YAMAZAKI,F.: "An Evaluation of the Tolerance of the Autotransplanted Canine Lung Against Warm Ischemia" Jap.J.Surg.19. (1989)

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  • [Publications] 川内基裕: "日本猿による心肺同時移植におけるasyncronous rejection" 移植. 24. 73-79 (1989)

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  • [Publications] 川内基裕: "実験的心肺同時移植後の胸部X線写真上の変化と病理組織学的所見との比較検討" 日本胸部外科学会雑誌. 37. 455-462 (1989)

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  • [Publications] 川内基裕: "ニホンザルによる同種心肺移植における拒絶反応の病理組織学的検討" 移植. 24. 502-509 (1989)

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Published: 1989-04-01   Modified: 2016-04-21  

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