| Project/Area Number |
01440045
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMADA Kenji (1990) Tohoku Univ., Dept. of Radiol. Nucl. Med., Associate Professor, 抗酸菌病研究所, 助教授 (40134051)
松澤 大樹 (1989) 東北大学, 抗酸菌病研究所, 教授 (10006108)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masatoshi Tohoku Univ., Cyclotron & RI Center, Associate Professor, サイクロトロンRIセンター, 助教授 (00125501)
MATSUZAWA Taiju Tohoku Univ., Emeritus Professor, 名誉教授 (10006108)
ISHII Keizo Tohoku Univ., Cyclotron & RI Center, Associate Professor, サイクロトロンRIセンター, 助教授 (00134065)
WATANABE Tatehiko Tohoku Univ., Med. Dept., Professor, 医学部, 教授 (70028356)
山田 健嗣 東北大学, 抗酸菌病研究所, 助教授 (40134051)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1990: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1989: ¥11,700,000 (Direct Cost: ¥11,700,000)
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| Keywords | Brain atrophy / Cerebral blood flow / Regional cerebral glucose metabolism / Senile dementia of Alzheimer type / Multi-infarct dementia / Positron emission tomography(PET) / Hippocampus / Amygdala / PETとMRI / 扁桃核と海馬 / 大脳辺縁系 / 痴呆の発症 / ADとMID / ブドウ糖摂取率 / 神経伝達物質 |
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| Research Abstract |
In this research, we tried to extract the characters of changes from normal aging through senile dementia. The results obtained were as follows.
(1) Cerebral metabolism and aging changes on MRI.
We investigated the relationship between cerebral blood flow by PET and the periventricular hyperintensity (PVH) which is an aging change on MRI and found decreased cerebral blood flow in cases of severe PVH.
(2) Characters of formal changes in multi-infarct dementia (MID) on X-CT.
Brain atrophy progresses during aging. We revealed the characteristic widening of the inferior horns of the lateral ventricles in cases of MID unlike in normal aging.
(3) Regional cerebral glucose metabolism on PET in senile dementia of Alzheimer type (SDAT) and MID.
We assumed the common basis of functional changes in SDAT and MID which have different pathogenesis but have same clinical symptoms. We studied these functional abnormalities from the aspect of regional cerebral glucose metabolism and found common hypometabolism of glucose in the association corteces of dementia cases.
(4) Correlation between widening of the inferior horns of the lateral ventricles and decrease of regional cerebral glucose metabolism.
We investigated the relationship between the size of ventricular system and regional cerebral glucose metabolism. The results showed that widening of the inferior horns of the lateral ventricles was strongly correlated with decrease of regional cerebral glucose metabolism in cerebral corteces regardless of the type of dementia, MID or SDAT.
These results suggested that dementia was closely related to the changes in hippocampus and amygdala which constitutes the medial aspect of the inferior horns. Therefore we emphasize here the great necessity for studies of the limbic system as a focus in the investigation of dementia.
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