| Project/Area Number |
01440046
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Niigata University |
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Principal Investigator |
SAKAI Kunio Niigata Univ. School of Med. Prof., 医学部, 教授 (20018378)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Takeshi Niigata Univ. Hospital Assistant, 医学部附属病院, 助手
OHKUBO Masaki Niigata Univ. Coll. of Biomed. Tech. Assistant, 医療短期大学, 助手 (10203738)
HINATA Hiroshi Niigata Univ. School of Med. Assistant, 医学部, 助手 (00018350)
KIMURA Motomasa Niigata Univ. Hospital Lecturer, 医学部附属病院, 講師 (30161582)
FUJITA Shozo Niigata Univ. Coll. of Biomed. Tech. Ass. Prof., 医療短期大学, 助教授 (90080100)
樋口 健史 新潟大学, 医学部附属病院, 助手
杉田 公 新潟大学, 医学部附属病院, 助手
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥12,600,000 (Direct Cost: ¥12,600,000)
Fiscal Year 1991: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | ^<31>P-MRS / Malignant Tumors / Radiotherapy / Predictive Assay / Dna Histogram / Transplanted Tumor / Superficial Tumor |
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| Research Abstract |
(1) IN VIVO ^<31>P-MR SPECTROSCOPY OF EXPERIMENTAL TUMORS
In vivo ^<31>P-MR spectroscopy of various sizes of experimental tumors revealed progressive increase of Pi/beta -NTP, PME/beta -NTP and Pi/PME ratios in proportion with the tumors increasing in size. On the other hand, PCr/Pi, PDE/PME, PDE/Pi ratios and pHi decreased with the tumor size. Spectral changes after irradiation of tumors of the same size were as follows. (1) Transient marked decrease of NTP levels found immediately after irradiation had no direct relation to the later tumor growth. (2) Sequential changes of Pi/PME roughly correlated with the radiation dose. (3) Relative sequential changes of pHi, Pi/beta -NTP and PME/ beta -NTP observed from the 1st to the 2nd day were related to the later tumor growth. (4) These spectral changes correlated with the grade of G2+M accumulation in DNA histograms and the grade of necrosis or degeneration in histological examinations which were performed on the 5th day after irradiation.
(2) ^<31>P-MR SPECTROSCOPY IN HUMAN SUPERFICIAL MALIGNANT TUMORS
^<31>P-MR spectra obtained from human superficial malignant tumors were characterized by the presence of PME and PDE peaks and by alkaline shift of PHi.
Although there are many variations in the spectral changes after treatments, decrease of PME and PDE peaks seems to be an early indicator of tumor response.
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