| Project/Area Number |
01440051
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TOGE Tetsuya (1990) Res. Inst. Nucl. Med. Biol. Dept. Surgery, Professor, 原爆放射能医学研究所, 教授 (40034657)
戸井 雅和 (1989) 広島大学, 原爆放射能医学研究所, 助手 (10207516)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Hirofumi Hiroshima University Hospital Senior, Research Assistant, 医学部・附属病院, 医員
KUROI Katsumasa Res. Inst. Nucl. Med. Biol. Dept. Surgery, Research Associate, 原爆放射能医学研究所, 助手
和田 務 広島大学, 医学部附属病院, 医員
中村 隆志 広島大学, 医学部附属病院, 医員
峠 哲哉 広島大学, 原爆放射能医学研究所, 教授 (40034657)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 1990: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1989: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | Thermography / breast cancer / Diagnosis / Heat metabolism / Nonpalpable breast cancer / prognostic factor / Mass screening |
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| Research Abstract |
The usefulness of thermography in the diagnosis of breast cancer patients was investigated. Stress thermography revealed the resistance of tumor vessels against the infusion of cooled saline (4^0C) or angiotensin-II. Furthermore, thermographical findings closely correlated with lymphnode metastasis. Poor prognosis was found in patients with temperature difference of more 1.5^0C between tumor and contralateral region. According to pathological examination, the hyperthermia area reflected the spread of cancer cells.
Although the diagnositic modality of thermography could not compared with that of mammography or ultrasonography, the usefulness of contact thermography (sinotest) in diagnosis of breast cancer was comparable to the tele thermography. Hyperthermic areas with temperature difference of more than 1^0C against contralateral region were found in approximately 40% of nonpalpable breast cancer, while not in benign lesions.
These results indicated that thermographic appearance reflect the metabolic and vascular phenomenon in breast tissue and might be useful for not only a prognositic indicator but the detection of high risk group in mass screening.
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