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Immunogenetical Nature of the Primary Malignant Lymphoma of the Brain : Analyses of Immunoglobulin Gene Rearrangements.

Research Project

Project/Area Number 01440059
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNiigata University

Principal Investigator

KUMANISHI Toshiro  Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (40018601)

Co-Investigator(Kenkyū-buntansha) USUI Hiroshi  Niigata University, Brain Research Institute, Assistant, 脳研究所, 助手 (20192510)
ABE Satoshi  Niigata University, Brain Research Institute, Assistant, 脳研究所, 助手 (90202663)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥17,800,000 (Direct Cost: ¥17,800,000)
Fiscal Year 1990: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1989: ¥14,400,000 (Direct Cost: ¥14,400,000)
KeywordsMalignant Lymphoma / Brain Tumor / Non Hodgkin Lymphoma / Immunoglobulin / Gene Rearrangement
Research Abstract

Using the Southern blot hybridization technique, seven cases of the primary malignant lymphomas of the brain, histologically diffuse large cell lymphoma, were examined for the immunoglobulin gene rearrangements. In these lymphoma cases, control germーline DNAs of peripheral leukocytes or of nonneoplastic tissues from the same patients were available and were examined in parallel. In six lymphomas, the rearrangements were observed in both heavy and light chain genes, providing a strong evidence for a B cell lineage of these tumors. On the other hand, in the remaining lymphoma, the rearrangement was observed only in the heavy chain genes. Despite these, immunohistochemical examination revealed positive stainings for heavy and light chain immunoglobulins in tumor cells, suggesting the occurrence of light chain gene rearrangements at the undetectable level. The patterns of the rearrangements in all the other lymphomas were comparable to the immunohistochemical findings. Thus, B lymphocytic differentiation at the gene level was demonstrated in all of the primary intracerebral malignant lymphomas examined. Since no more than two rearrangements were detected in each immunoglobulin gene, these lymphomas were considered to be monoclonal in nature.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 阿部 聰: "Intravascular malignant lymphomatosis ー いわゆる neoplastic angioendotheliosis ー." 神経内科. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe,Satoshi: "Immunoglobulin λ chain gene polymorphism and primary brain malignant lymphoma" XI Internatl Congress of Neuropath(京都,1990)Abstract. 366 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe,Satoshi: ""Neoplastic angioendotheliosis":demonstration of immunoglobulin gene rearrangements by the Southern blot hybridization technique" Virchows Arch B. 58. 241-244 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumanishi,Toshiro: "Primary malignant lymphoma of the brain:demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique." Acta Neuropathol(Berl.). 79(1). 23-26 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nishiyama,Akiko: "An immunohistochemical analysis of T cells in primary B cell malignant lymphoma." Acta Neuropathol(Berl.). 79(1). 27-29 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 田中 隆一: "頭蓋内原発悪性リンパ腫." 臨床成人病. 19(11). 2005-2008 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe Satoshi et al.: "Intravascular malignant lymphomatosis ー soーcalled neoplastic angioendotheliosis -." Sinkeinaika. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe Satoshi et al.: ""Neoplastic angioendotheliosis" : demonstration of immunoglobulin gene rearrangements by the Southern blot hybridization technique." Virchows Arch B. 58. 241-244 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe Satoshi et al.: "Immunoglobulin lambda chain gene polymorphism and primary brain malignant lymphoma." Xl Internat Congress of Neuropath (Kyoto) Abstract. 366 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumanishi Toshiro et al.: "Primary malignant lymphoma of the brain demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique" Acta Neuropathol (Berl.). 79 : (1). 23-26 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nishiyama Akiko et al.: "An immunohistochemical analysis of T cells in primary B cell malignant lymphoma." Acta Neuropathol(Berl.). 79 : (1). 27-29 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tanaka Ruichi et al.: "Primary intracranial malignant lymphoma." Rinsho Seijinbyo. 19 : (11). 2005-2008 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 阿部 聰: "Intravascular malignant lymphomatosisーいわゆるneoplastic angioendotheliosisー." 神経内科. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Abe,Satoshi: "Immunoglobulin λ chain gene polymorphism and primary brain malignant lymphoma" XI Internatl Congress of Neuropath(京都,1990)Abstract. 366 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Abe,Satoshi: ""Neoplastic angioendotheliosis":demonstration of immunoglobulin gene rearrangements by the Southern blot hybridization technique" Virchows Arch B. 58. 241-244 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 熊西敏郎: "脳原発性悪性リンパ腫の病理と免疫学的特性." 第48回日本脳神経外科学会抄録. pLS-1 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nishiyama,A.: "An immunohistochemical analysis of T cells in primarB cell malignant lymphoma of the brain." Acta neuropathol(Berl).79(1). 27-29 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kumanishi,T.: "Primary malignant lymphoma of the brain:demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique." Acta neuropathol(Berl).79(1). 23-26 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 田中隆一: "頭蓋内原発悪性リンパ腫." 臨床成人病. 19(11). 2005-2008 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Abe,S.: ""Neoplastic angioendotheliosis":Demonstration of immunoglobulin gene rearrangements by the Southern blothybridization technique." Virchows Archiv B,. 58(3). 241-244 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Abe,S.: "Immunoglobulin lambda chain gene polymorphism and primary brain malignant lymphoma" 第11回国際神経病理学会抄録.

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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