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Development of "Hybrid Type" Artificial Articular Cartilage

Research Project

Project/Area Number 01440061
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKytot University

Principal Investigator

OKA Masanori  Kyoto University Res Cer Biomed Engr, Artificial Locomotive Systems, Professor, 生体医療工学研究センター, 教授 (20088537)

Co-Investigator(Kenkyū-buntansha) NAGATA Kazuhiro  Kyoto Univ Res Institute for chest diseases, Molecular Biology, Professor, 胸部疾患研究所, 教授 (50127114)
KOTOURA Yoshihiko  School Medicine, Orthopaedic Surgery, Ass Prof, 医学部・整形外科, 助教授 (50127081)
IKADA Yoshito  Kyoto Univ Res Cer Biomed Engr, Biomaterials, Professor, 生体医療工学研究センター, 教授 (00025909)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 1990: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1989: ¥10,000,000 (Direct Cost: ¥10,000,000)
KeywordsRepair of Articular Cartilage / Differentiation of chondrocytes / Fibronectin / Fibronectin receptor / Culture embedded in Collagen gel / フィブロンネクチン / フィブロンネクチンリセプタ-
Research Abstract

1) We implanted the cultured articular chondrocytes embedded in collagen gel into the osteochondral defects in rat knee joints. 4, 12, 24 weeks postoperatively, the rats were sacrificed, and their knee joints were histologically examined.
2) In order to make clear immunological problems in the-above-mentioned experiments, we compared the results between isografts group and allograft group. As a result, there were not so much difference between two groups until 4 weeks postoperatively. At 12 weeks after operation, Isograft group showed much better repair, particularly better reorganization of subchondral bones, than allograft group.
3) We examined the influence of Fibronectin on the differentiation of cultured chick embryo chondrocytes. As a result, chondrocytes changed their shape by adding Fibronectin into the medium, from spherical to spindle form. That is, dedifferentiation of chondrocyte.
4) We examined immunochemically whether the chick chondrocytes have fibronectin receptor on their cell surfaces or not. As a result, we could verify that they recognized RGDS sequence of Fibronectin and had receptors.
5) We will make more clear influences of various culture conditions on differentiation and phenotype-maintenance of chondrocytes, for the purpose of repairing the damaged joint surface.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 岡 正典: "人工関節の材料特性" 関節外科. 9. 575-586 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機能 (第2報)" 整形外科バイオメカニクス. 11. 69-73 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構 (第2報)" 整形外科バイオメカニクス. 11. 65-68 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 岡 正典: "人工関節軟骨の開発" 病態生理. 10. 52-58 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Noguchi,M.Oka: "Development of an artificial articular cartilage:Evaluation of Biocompatibility" Advances in Biomaterials. 9. 373-378 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤野 まどか, 岡 正典: "培養軟骨細胞のフィブロネクチンリセプタ-" 第4回日本整形外科学会基礎学術集会抄録集. 63. S 1191 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 岡 正典 編集: "図説整形外科診断治療講座15巻 人工関節・バイオマテリアル" メジカルビュ-社, 259 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 永田 和弘: "細胞接着と細胞外マトリックス 分子生物科学 第5巻『難報の伝達と物質の動き1』" 岩波書店, 25 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oka, M: "Material Properties of artificial joints" J of Joint Surgery. 9. 575-586 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oka, M: "Lubrication of natural and artificial joints (2nd Report)" Orthopedic Biomechanics. 11. 69-73 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oka, M: "Load-bearing-mechanisms of natural and artificial joints (2nd Report)" Orthopedic Biomechanics. 11. 65-68 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Oka, M: "Development of an artificial articular Cartilage" Patho-Physiology. 10. 52-58 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Noguchi, T: "Development of an artificial articular cartilage : Evaluation of Biocompatibility" Advances in Biomaterials. 9. 373-378 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujino, M: "Fibronectin receptor of cultured chondrocytes" J. Jpn. Orthop. Ass.63. S1191 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 岡 正典: "人工関節の材料特性" 関節外科. 9. 575-586 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機能(第2報)" 整形外科バイオメカニクス. 11. 69-73 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第2報)" 整形外科バイオメカニクス. 11. 65-68 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡 正典: "人工関節軟骨の開発" 病態生理. 10. 52-58 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Noguchi,M.Oka: "Development of an artificial articular cartilage:Evaluation of Biocompatibility" Advances in Biomaterials. 9. 373-378 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤野 まどか,岡 正典: "培養軟骨細胞のフィブロネクチンリセプタ-" 第4回日本整形外科学会基礎学術集会抄録集. 63. S-1191 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岡 正典編集: "図説整形外科診断治療講座15巻 人工関節・バイオマテリアル" メジカルビュ-社, 259 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 永田 和弘: "細胞接着と細胞外マトリックス 分子生物科学第5巻『情報の伝達と物質の動き1』" 岩波書店, 25 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤野まどか,岡正典,永田和宏,琴浦良彦: "培養軟骨細胞のフィブロネクチンリセプタ-" 日整会誌. 63. S1191 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Fujino,M.Oka,K.Nagata,Y.Kotoura: "Fibronectin receptons of chondrocytes" 日本細胞生物学会抄録.

    • Related Report
      1989 Annual Research Report
  • [Publications] 野口隆,岡正典,他6名: "人工関節軟骨の開発BーI:PVAHの生体適合性" 日整会誌. 62. S570 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤野まどか,岡正典,他3名: "ハイブリッド型人工関節軟骨の開発" 日整会誌. 62. S571 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤野まどか,岡正典,永田和宏,琴浦良彦: "培養軟骨細胞のFibronectin receptor(FNR)" 第3回軟骨代謝研究会抄録集. 11-12 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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