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Inhalation anesthetics and oncogene

Research Project

Project/Area Number 01440063
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionNagoya University

Principal Investigator

SHIMADA Yasuhiro  Nagoya Univ. School of Med. Prof., 医学部, 教授 (50028669)

Co-Investigator(Kenkyū-buntansha) WAKAMIYA N.  Osaka Univ. Ins. of MB. Dis. Assistant Prof., 微生物病研究所, 助手 (20210867)
MIKE N.  Nagoya Univ. School of Med. Assistant Prof., 医学部, 助手 (20192354)
AZUMA K.  Nagoya Univ. School of Med. Assistant Prof., 医学部, 助手 (50202619)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 1991: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1990: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1989: ¥6,500,000 (Direct Cost: ¥6,500,000)
KeywordsOncogene / c-myc / N-myc / Inhalation anesthetics / HLA-DR / ICAM-1 / cーmyc / Nーmyc / HLAーDR / ICAMー1 / Cーmyc / HLAーDR抗原 / がん遺伝子蛋白 / cーmyc遺伝子 / cーmyc蛋白
Research Abstract

Although almost cancer patients are undergone with general anesthesia, a few researchers and anesthesiologists are interest in the interaction between cancer cells and anesthesia. So we have been doing researches of the influence of anesthesia on cancer cells in order to try to establish the best anesthesia for cancer patients. We put on a focus on "oncogene". We guessed that anesthesia agents might influence oncogene.
We studied as follows; (1)halothane and the expression of c-myc protein in human leukemia cells in vitro, (2)halothane and the amplification of N-myc in neuroblastoma in vitro. Results were as follows; (1)the expression of c-myc protein did not change during/after halothane exposure, (2)the amplification of N-myc did not also change during/after halothane exposure.
As far as our results, anesthesia did not influence oncogene. There are many other oncogenes. Some of other oncogene might change during/after anesthesia.
Furthermore, we did other researches. We tried to evaluate the change of antigens in cancer cells during/after anesthesia in vitro. We studied as follows; (1)halothane and the expression of HLA-DR antigen in melanoma cells, (2)halothane/sevoflurane and the expression of intercellular adhesion molecule-1 (ICAM-1) in melanoma cells. The results were as follows; (1)the expression of HLA-DR in melanoma cells increased after halothane exposure, (2)the expression of ICAM-1 in melanoma cells decreased during halothane/sevoflurane exposure.
These results suggested that anesthetic agents influence on antigen expression in cancer cells, and that the change might decrease the recognition of immune surveillance. Anesthetic agents might deteriorate cancer patients.
Anesthesiologists and surgeons should be aware that anesthesia might deteriorate cancer patients, and had better continue to do research on the relation between cancer and anesthesia.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 三毛 紀夫: "ハセロンのがん遺伝子増幅に及ぼす影響について" 麻酔. 40. S349- (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 東 佳世: "ハセロンによるメラノーマ細胞の細胞間接着分子発現変化についての解析" 麻酔. 40. S350- (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 若宮 伸隆: "Expression of Hanganutziu-Deicher antigen in activated human T lymphocytes" Biochem.Biophys.Res.Comm.81. 310-315 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeyama,H.: "Tumor necrosis factor expression by human ovarian carcinoma in vivo" Cancer Research. 51. 4476-4480 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishimura,T.: "T cell receptor-independent cell-mediated cytotoxity by nude mouse LAK cells" Jpn.J.Cancer Res.(Gann). 82. 448-455 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤原 祥裕: "Halothane and proto-oncogene c-myc expression" Anesthesia and Analgesia. 82. S84- (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Mike, N.: "Effects of halothane on oncogene amplification" Masui. 40. 349 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Azuma, K.: "Effects of halothane on ICAM-1 in the melanoma cells in vitro" Masui. 40. 350 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Wakamiya, N.: "Expression of Hanganutziu-Deicher antigen in activated human T lymphocytes" Biochem. Biophys. Res. Comm.81. 310-315 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takeyama, H.: "Tumor necrosis factor expression by human ovarian carcinoma in vivo" Cancer Research. 51. 4476-4480 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishimura, T.: "T cell receptor-independent cell-mediated cytotoxicity by nude mouse lyphokine activated killer cells" Jpn. J. Cancer Res. (Gann). 82. 448-455 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fujiwara, Y.: "Halothane and proto-oncogene c-myc expression" Anesthesia and Analgesia. 82. 84 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 三毛 紀夫: "ハロセンのがん遺伝子増幅に及ぼす影響について" 麻酔. 40. S349 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 東 佳世: "ハロセンによるメラノ-マ細胞の細胞間接着分子 発現変化についての解析" 麻酔. 40. S350 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 若宮 伸隆: "Exprseeion of HanganutziuーDeicher antigen in activated human T lymphocytes" Biochem.Biophys.Res.Comm.81. 310-315 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takeyama,H.: "Tumor necrosis factor expression by human ovarian carcinoma in vivo" Cancer Research. 51. 4476-4480 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nishimura,T.: "T cell receptorーindependent cellーmediated cytotoxity by nude muse LAK cells" Jpn.J.Cancer Res.(Gann). 82. 448-455 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 藤原 祥裕: "Halothane and protoーoncogene cーmyc expression" Anesthesia and Analgesia. 82. S84 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三毛 紀夫: "吸入麻酔薬とがん細胞について" 病態生理. Vol10. 232-235 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 東 佳世: "ハロセンによるメラノ-マ細胞のHLAーDR抗原発現の変化について" フロ-サイトメトリ-. 10. 22-26 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Azuma: "Effects of halothane on HLAーDR antigen expression in the melanoma cells in vitro" Journal of Cancer Research and Clinical Oncology. 116. 293 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤原 祥裕: "ハロセンのCーmyc蛋白質に対する影響" 麻酔. 39. 5626 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.MIKE: "Effect of Halothane on HLA-DR Antigen Expression in the Melanoma Cells-Anesthetics and Anti-Tumor Immunity-" Anesthesiology. 71ー3A. A309 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 東佳世: "ハロセンによるメラノ-マ細胞のHLAーDR抗原発現の変化" Proceedings of the Japanese Cancer Association. 256 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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