| Project/Area Number |
01440092
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
物質生物化学
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
NAKAMURA Toshikazu Kyushu Univ.Faculty of Science,Professor, 理学部, 教授 (00049397)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Kunio Kyushu Univ.,Faculty of Science,Assist., 理学部, 助手 (90201780)
HARANO Tomoyuki Kyushu Univ.,Faculty of Science,Assist., 理学部, 助手 (80037275)
MIZUNO Kensaku Kyushu Univ.,Faculty of Science,Assoc.Prof., 理学部, 助教授 (70128396)
田代 康介 九州大学, 理学部, 助手 (00192170)
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| Project Period (FY) |
1989 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥32,100,000 (Direct Cost: ¥32,100,000)
Fiscal Year 1992: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1991: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1990: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1989: ¥14,400,000 (Direct Cost: ¥14,400,000)
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| Keywords | HGF / Hepatotrophic factor / Renotropic factor / Insurin / Liver Regeneration / Organ regeneration / Platelet-derived factor / TGF-beta masking protein / HGFレセプタ- / 腎再生 / HGFの誘導 / HGF遺伝子 / cell migration / TGFーβ masking protein / ILー1β / HGF cDNA / kringle構造 / EGF-like domain / paracrine system / TGF-β masking protein cDNA |
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| Research Abstract |
Hepatocyte growth factor(HGF)has been discovered,purified,and molecularly cloned as a potent mitogen for mature hepatocytes. HGF is a heterodimeric molecule composed of a 69 kDa alpha-subunit and a 34 kDa beta-subunit and it contains four kringle domains in the alpha-subunit. HGF is produced by mesenchymal cells and predominantly acts on a wide variety of epithelial cells,as a mitogen(stimulation of cell growth),a motogen(stimulation of cell motility),and a morphogen(induction of multicellular tissue-like structure). Since HGF mRNA and HGF protein increase markedly after various hepatic and renal injuries,HGF acts not only as hepatotrophic factor for liver regeneration but also as a renotrophic factor for renal regeneration; intravenous injection of recombinant HGF into mouse remarkably enhances regeneration of the liver and kidney. HGF is now considered to play important roles for construction of normal tissue structure during embryogenesis,organogenesis,and organ regeneration through its uniquely suited ability to act as mitogen,motogen,and morphogen.
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