| Project/Area Number |
01470100
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Faculty of Science and Technology, Keio University |
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Principal Investigator |
YOSHIKAWA Sadao Faculty of Science and Technology, Keio University, Professor., 理工学部, 教授 (70010759)
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| Co-Investigator(Kenkyū-buntansha) |
OSANAI Shuichi Faculty of Science and Technology, Keio University, Assoc. Professor., 理工学部, 助教授 (70051828)
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| Project Period (FY) |
1989 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Amphiphilic Complexes / Molecular Aggregates / Optical Activities / Quasi-Lecithin / Vesicle / ラメラ / 複鎖型両親媒化合物 |
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| Research Abstract |
There is few papers on the preparation of complexes consisting of metal and complex lipids in spite of they have plenty of opportunities to encounter each other in the vital organism.
An amphilic cobalt (III) complex containing two long acyl groups was prepared by acylation of the corresponding precursory complex, which has two hydroxyl groups in - and - position, as shown in Fig. 1. A schematic preparation sequence was shown below.
In this study, we investigate the preparation methods to obtain the amphiphilic complex more effectively. Following two methods were discussed.
1) Through the reaction between metal and complete ligand, in which two hydroxyl groups on - and - position were previously acylated with higher fatty acid.
2) Through the acylation of the precursory complex by higher acyl group.
In the case 1), the reaction condition at which only hydroxyl group might be acylated regardless of the coexistence of amino and hydroxyl groups, must be developed. The influence of the counter ion of the complex on the solubility were also discussed. Perchlorate anion complex showed most excellent solubility against to the solvent, DMSO.
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