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Influence of host immune system with parasites

Research Project

Project/Area Number 01480172
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 寄生虫学(含医用動物学)
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

FUJITA K  Tokyo Medical and Dental University, Faculty of Medicine, Professor, 医学部, 教授 (90053107)

Co-Investigator(Kenkyū-buntansha) TSUKIDATE S  Tokyo Medical and Dental University Faculty of Medicine, researcher, 医学部, 助手 (40121256)
YAMAOKA K  Tokyo Medical and Dental University Faculty of Medicine, Lecturer, 医学部, 講師 (50220231)
YAMAMOTO K  Tokyo Medical and Dental Univertisy Medical Research Institute, Professor, 難治疾患研究所, 教授 (40000971)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1989: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordsfilaria / strogyloides / evasive mechanism / ATL-virus / CD^+8 t cell / IL-2 / IL-2 receptor / asialo GM_1^+ NK cell / asialo GM^+NK細胞 / ILー2R / マクロファ-ジ / 好酸球 / ミクロフィラリア / CD^<8+>細胞 / T細胞抑制
Research Abstract

Seroepidemiological studies revealed that filarial as well as strongyloides parasites effected on infestation of adult T-cell leukemia (ATL) virus by our studies of the Goto Island, Nagasaki, Tomigusuku, Okinawa, Kikai Island, Kagoshima and Ashikita, Kumamoto. In this study, we succeeded in making clear the influence of these parasites on T cell, NK cell and/or lymphokines of the host, and also the effects of these parasites on the infestation of ATL virus in cell level.
It was shown in the first report that strongyloides infection elevated the ATL antibody titer of the infected host, but the clevation of the infestation of ATL virus within cell line was not observed in our experiments.
On the other hands, it was reported in our study that the filarial infection suppressed the immune response of the host non-specifically by CD+8 T cells, decreased the number of IL-2 receptor as well as IL-2 itself, and also decreased the function of NK cell.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Horii,Y.,Owhashi,M.,Ishii,A.,Fujita,K.: "Leukocyte accumulation in sparganosis:Further characterizatin of an eosinophil chemotactic factor of the plerocercoid of Spirometra erinacei" J.Helminth.63. 6-12 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakanishi,H.,Horii,Y.,Fujita,K.: "The role of macrophage on the expression of sex difference in the susceptibility to Brugia pahangi in infection in C57BL/6mice" J.Helminth. 63. 213-217 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakanishi,H.,Horii,Y.,Terasima,K,Fujita,k.: "Age-related changes of the suscetibility to infection with Brujia pahangi in male and female BALB/c mice" Paresitol.Res.76. 283-285 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Owhashi,M.,Horii,Y.,Ikeda,T,Tsukidate,S.,Fujita,K.,Nawa,Y.: "Non-specific immune supperssion by CD8^t cells in Brugia papangi-infected rats" Int.J.Parasitol.20. 951-956 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamaoka,K.,Tsukidate,S.Higaki,M.,Miyasaka,N.,Fujita,K.: "Induction of CD23(FcεRII)on human T cells by excretoty and secretory antigen of Dirofilaria immitis" Int.Archs.Allergy appl.Immunol.95. 92-93 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sato,M.,Tsukidate,S.,Fujita,K.,Yamaoka,K.: "Strongyloides influences the elevation of adult T-cell leukemia-associated antigen antibody titer" Int.Archs.Allergy appl.Immunol.96. 95-96 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤田 紘一郎(編者原 耕平): "イラスト感染症内科" 文光堂, 35 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山岡 國士(編者宮坂 信之): "サイトカイン" メジカルビュ-社, 8 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Horii, Y., Owhashi, M., Ishii, A. & Fujita, K.: "Leukocyte accumulation in sparganosis ; Further characterization of an eosinophil chemotactic factor of the plerocrcoid of Spirometra erinacei" J. Helminth.63. 6-12 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakanishi, H., Horii, Y. & Fujita, k.: "The role of macropfage on the expression of sex difference in the susceptibility to Brugia pahangi in infection in C57BL/6 mice" J. Helminth.63. 213-217 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakanishi, H., Horii, Y., Terashima, K. & Fujita, K.: "Age-related changes of the susceptibility to infection with Brugia pahangi in male and female BALB/c mice" Parasitol. Res.76. 283-285 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Owhashi, M., Horii, Y., Ikeda, T., Tsukidate, S., Fujita, K. & Nawa, Y.: "Non-specific immune suppression by CD8^+ cells in Brugia pahangiinfected rats" Int. J. Parasitol.20. 951-956 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamaoka, K., Tsukidate, S., Higaki, M., Miyasaka, N. & Fujita, K.: "Induction of CD23 (FcepsilonRII) on human T cells by excretory and secretory antigen of Dirofilaria immitis" Int. Archs. Allergy appl. Immunol.95. 92-93 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sato, M., Tsukidate, S., Fujita, K. & Yamamoto, K.: "Strongyloides influences the elevation of adult t cell leukemia-associated antigen antibody titer" Int. Archs. Allergy appl. Immunol.96. 95-96 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Horii,Y.,Fujita,K.et.al.: "Eosinophil hyporesponse of jirds induced by microfilariae of Brugia pahangi" Am.J.Trop.Med.Hyg.41. 183-188 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nakanishi,H.,Fujita,K.et.al.: "The role of macrophages on the expression of sex diffrence in the susceptibility to Brugia pahangi infected in C57BL/6 mice" J.Helminth.63. 213-217 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Owhashi,M.,Fujita,K.et.al.: "Nonーspecific immune suppression by CD8+ T cells in Brugia pahangiーinfected rats" Int.J.Parasitol.20. 951-956 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nakanishi,H.,Fujita,K.et.al.: "Ageーrelated changes of the susceptibility to injection with Brugia pahangi in male and female BALB/c mice" Parasitol.Res.76. 283-285 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤田 紘一郎: "免疫学的排除機構からのエスケ-プ:寄生虫" 臨床免疫. 22. 180-187 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamaoka,K.,Fujita,K.et.al.: "Induction of CD23(FC ε RII) on human T cells by excretory and secretory antigen of Dirofilaria immitis" Int.Arch.Allergy Appl.Immnol.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤田 紘一郎(分担): "今日の治療指針(Vol.33)" 医学書院, 1242 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐藤正夫,月舘,説子,山岡國士,藤田絋一郎: "Flow cytometryを用いたBrugia pahangi感染ラットにおける末梢リンパ球surface makerの検討" 寄生虫学雑誌. 39. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山岡國士,月舘,説子,藤田絋一郎: "フィラリア感染におけるIgE抗体産生機構の解析:FcεR2/CD23を介するB細胞活性化機構" 寄生虫学雑誌. 39. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大橋真,名和行文,藤田絋一郎他: "Brugia pahangi感染ラットにおけるCD8^+T細胞による非特異的抑制について" 寄生虫学雑誌. 39. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Owhashi,H.,Ikeda,T.,Fujita,K.et al.: "Nonspecific immune suppression by CD8^+Tcells in Brugia pahangi-infected rats" Int.J.Parasitol.

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakanishi,H.,Horii,Y.,Terashima,K.& Fujita,K.: "Effect of testosterone on the susceptibility of C57BL/6 mice to infection with Brugia pahangi with reference toinflammatry cell response" J.Parasitol.Res. 76. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakanishi,H.,Horii,Y.,Fujita,K.: "The role of macrophages on the expression of sex difference in the susceptibility to Brigia pahangi infected in C57BL/6 mice" J.Helminth.63. 213-217 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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