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With Cardiac Disease with Special Emphasis on -ANP Clinical Significant of Atrial Natriuretic Peoptide in Patients

Research Project

Project/Area Number 01480217
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTokyo Medical and Dental university, School of Medicine

Principal Investigator

MARUMO Fumiaki  Tokyo Med&Dent Univ. Professor, 医学部, 教授 (00050443)

Co-Investigator(Kenkyū-buntansha) TAKAMOTO Toshihiko  Tokyo Med&Dent Univ. Assistant, 医学部, 助手 (00134742)
HIRATA Yukio  Tokyo Med&Dent Univ. Assistant Professor, 医学部, 助教授 (50135787)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1990: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordsatrial natriuretic peptide (ANP) / beta-ANP / alpha-ANP / Heart Failure / Renal Failure / Processing / 心房性Na利尿ホルモン / 心疾患 / プロセシング機序 / β-ANP / 脳性Na利尿ホルモン / 心房細胞
Research Abstract

Circulating atrial natriuretic peptide (ANP) consists predominantly of alpha-form in normal subjects. Plasma ANP levels are elevated in patients with heart failure, which increase in relation to its seventy. However, circulating forms of ANP in patients with heart failure remain unknown. To elucidate clinical significance of ANP in heart failure, we have analyzed the molecular forms of plasma ANP in patients with conjestive heart failure by gel filtration and reverse-phase HPLC. As the seventy of heart failure progressed, the proportion of beta-form to the total ANP in plasma increased, and gamma-form also appeared. Circulating beta-form conversely decreased after successful treatment for heart failure. During cardiac surgery with extracorporeal circulation, plasma ANP levels did not significantly decrease after total aortic cross claming (TACC), remarkably increased after the release of TACC, where alpha-form predominated without distinct beta- or gamma-form. In patients with chronic renal failure, the predominant circulating ANP was alpha-form, although beta-form was also present in some cases. After hemodialysis, plasma ANP levels, mostly alpha-form, decreased these rats suggest that 1) the enhanced biosynthetic activity of ANP in the faility heart is associated with the increased processing from gamma- to alpha- and beta-form, 2) the processing of ANP secreted after the release of ATCC due to immediate rise in atrial pressure appears to be essentially similar to that of normal subjects, 3) the appearance of circulating beta-form in some renal failure patients may be due to delayed metabolism, increased body fluid and or metabolic change of myocardium, although its pathophysislogical function remains undetermined. From our results it appears that circulating beta-ANP should be a useful marker as a noninvasive parameter for assessment of heart failure as well as its therapeutic outcome.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Masuda.t.et al.: "Degradation of atrial natriuretic peptide in dogs" Aota Endocrinol.120. 170-174 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kurosawa.T.et al.: "No specific organ removes atrial natriuretic peptide from the human plasma" Jpn.Cir.J.53. 779-785 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura,N.et al.: "Measurement of atrial natriuretic peptide in bovine plasma and urine by radioimmunoassay" Jpn.J.Vet.Sci. 51. 843-845 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Asari,H.etal.: "Extracorporeal circulation inbluence on plasma atrial natriuretic peptide concentration in cardiac surgery patients" Chest. 96. 757-760 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hirata,Y.etal.: "Vasoconstrictorーinduced heterologous downーregulation of vascular atrial natriuretic peptide receptor" Eur.J.Pharmacol. 164. 603-606 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Togashi,K.et al.: "Brain Natriuretic peptideーlike immunoreactivity is present in human plasma" FEBS.Lett. 250. 235-237 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura,N. et al.: "Pharmacokinetics of human αーatrial natriuretic peptide (αーhANP) in cow and dog." Jpn.J.Vet.Sci.52. 165-166 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura,N.et al.: "Bovin atrial natriuretic peptide in heart failure" J.Endocrind.124. 463-467 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Satoh,K.et al.: "Hemodynamic changes by recombinant erythropoietin therapy in hemodialyzed patients" Hypertension. 15. 262-266 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Iida,T.et al.: "Brain Natriuretic Peptide is consecreted with atrial natriuretic peptide from porcine cardiocytes" FEBS.Lett.260. 98-100 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ando.K.et.al.: "Circulating torms of human atrial natriuretic peptide in patieuts with congestive heart failure" J.Clin.Endocrinol.Metab.70. 1603-1607 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Marumo,F.etal.: "Concentration of atrial natriuretic pepticle in plasma and wine of kidney disease patients"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Marumo,F.and Ando,K.: "Atrial Natriuretic Factor" Blackwell Scientific, 259 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masuda, T, et al.: "Degradation of Atrial natriuretic peptide in dogs" Acta Endocrinol.120 ;. 170-174 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kurosawa, T, et al.: "No specific organ removes atrial natriuretic peptide from the human plasma" Jpn. Cir. J.53 ;. 779-785 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura, N, et al.: "Measurement of Atrial natriuretic peptide in bovine plasma and urine by radioimmunoassay" Jpn. J. Vet. Sci. 51 ;. 843-845 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura, N, et al.: "Pharmacokinetics of human alphaーatrial natriuretic peptide (alphaーhANP ) in cow and dog" Jpn. J. Vet. Sci. 52 ;. 165-166 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Asari, H, et al.: "Extracorporeal circulation influence on plasma atrial natriuretic peptide concentration in cardiac surgery patients" Chest. 96 ;. 757-760 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takemura, N, et al.: "Bovine atrial natriuretic peptide in heart failure" J. Endocrind.124. 463-467 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hirata, Y, et al.: "Vasoconstrictor-induced heterologous down-regulation of vascular atrial natriuretic peptide receptor" Eur. J. Pharmacol.164. 603-606 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Togashi, K, et al.: "Brain natriuretic peptide -like immunoreactivity is present in human plasma" FEBS. Lett.250. 235-237 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Satoh, K, et al.: "Hemodynamic changes by recombinant erythropoietin therapy in hemodialyzed patients" Hypertension. 15 ;. 262-266 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Iida, T, et al.: "Brain natriuretic peptide is cosecreted with atrial natriuretic peptide from porcine cardiocytes" FEBS. Lett.260. 98-100 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ando, K, et al.: "Circulating torms of human atrial natriuretic peptide in patients with congestive heart failure" J. Clin. Endocrinol. Metab.70 ;. 1603-1607 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Marumo, F, and Ando, K.: "Molecular forms of atrial natriuretic factor "Atrial Natriuretic Factor"" Blackwell Scientific. 259. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Marumo, M, Sakamoto, H, Ando, K, and Ishigami, T.: "Concentration of atrial natriuretic peptide in plasma and urine of kidney disease patients." Clin. Chem.36 ;. 1650-1653 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ando,K.,et al.: "Circulating forms of human atrial natriuretic peptide in patients with congective heart failure" J.Clin.Endocrinol.Metal.70. 1603-1607 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Satoh,K.,et al.: "Hemodynamic changes by recombinant ergthropoietin therapy in hemodialgzed patients" Hypertension. 15. 262-266 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takemura,N.,et al.: "Bovine atrial natriuretic peptide in heart failure" J.Endocrinol.124. 463-467 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takemura,N.,et al.: "Pharmaco kinetics of human αーatrial natriuretic peptide (αーhANP) in cow and dog." Jpn.J.Vet.Sci. 52. 165-166 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Marumo,F.,et al.: "Concentration of atrial natriuretic peptide in plasma and urine of kidney disease patients" Clin.Chom.36. 1650-1653 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Marumo,F,& Ando,K.: "Atrial Natriuretic Factor" Blackwell Scientific, 259 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Asari,H.Kondo,A.Ishihara,K.Ando,F.Morumo: "Extracorporeal circulation lufluence on plasma atrial natriuretic peptide concertration in cardiac surgery patients" CHEST. 96. 757-760 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Kurosawa,S.Hiramatsu,Y.Katoh,R.Kikawada,F.Marumo: "No specific organ removes atrial natriuretic peptide from the human plasma" Jpn.Circ.J.53(7). 779-785 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Togashi,Y.Hirata,K.Ando,Y.Takei,M.Kawakami,F.Marumo: "Brain natriuretic peptide-like immunoreactivity is present in human plasma" FEBs.Left.250(2). 235-237 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Ilda,Y.Hirata,N.Takemura,K.Togashi,S.Nakagawa,F.Marumo: "Brain natriuretic peptide cosecreted with atrial natriuretic peptide from porcine cardiocytes" FEBs.Left.260(1). 98-100 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Hirata,T.Emori,K.Ohta,M.Shichiri,F.Marumo: "Vasoconstrictor-induced heterologous downregulation of vascularatrialna" Eur.J.Pharmacol. 164. 603-606 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Shichiri,Y.Hirata,K.Kanno,K.Ohta,T.Emori,F.Marumo: "Effect of endothelin-1 on release of argine-vasopressin from perifused rat hypothalamus" BIOCHEM.BIOPHYS.RES.COMMUN.163(3). 1332-1337 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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