• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A Study of the Nuclear Magnetic Resonance (NMR) Relaxation Times to Characterize the Pathophysiology of Lung Injuries.

Research Project

Project/Area Number 01480237
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTokai University Shool of Medicine

Principal Investigator

YAMABAYASHI Hajime  Tokai Univ. Sch. of Med. Prof. of Med., 医学部, 教授 (60055697)

Co-Investigator(Kenkyū-buntansha) HAIDA Munetaka  Tokai Univ. Sch. of Med. Assistant of Med., 医学部, 助手 (20208408)
KUTSUZAWA Tomoko  Tokai Univ. Sch. of Med. Assistant of Med., 医学部, 助手 (10183310)
TSUJI Chizuko  Tokai Univ. Sch. of Med. Assist. Prof. of Med., 医学部, 講師 (80130079)
SHIOYA Sumie  Tokai Univ. Sch. of Med. Assist. Prof. of Med., 医学部, 講師 (20102840)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1990: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1989: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsLung Injury / Nuclear magnetic Resonance / Relaxation Time / 核磁気共鳴法(NMR) / 核磁気共鳴
Research Abstract

We previously found that the nuclear magnetic resonance (NMR) relaxation times T_1 and T_2 characterized various lung injuries (1). The present project investigated the pathophysiology of lung injury through the NMR relaxation behavior of water molecules in lung tissue.
1. Two T_2 components (T_2 fast : T_<2f> and T_2 slow : T_<2s>) have been observed for peripheral lung tissue (1-3). We analyzed the origin of water for these components and found that the T_<2f> component related to the water in alveolar walls, mainly the intracellular water of alveolar epithelial cells, and the T_<2s> component related to the interstitium (4).
2. We developed a motion insensitive NMR imaging technique which we call Interleaved Line Scan (ILS) and measured the two components of T_2 for peripheral lung tissue in living spontaneously breathing rats (5). With this technique, we demonstrated the time course of T_2 in endotoxin lung injury using living animals (6). We are now to develop a method to measure the in-vivo relaxation times of lung tissue using a surface coil.
3. The changes in T_1 and T_2 of lung injuries reflect the interactions between water molecules and tissue's macromolecules (1-3). We measured the temperature dependence of T_1 and T_2 for experimental lung injuries to investigate the state of water in the tissue. The results suggest that the changes in activation energy of water molecules is different for the normal and injured lung tissues. With the calculated activation energy of water molecules, it would be possible to understand the damages of tissue macromolecules in various stages and types of lung injury.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report

Research Products

(23 results)

All Other

All Publications (23 results)

  • [Publications] 塩谷 寿美恵: "胸部のMRI(磁気共鳴画像)" 呼吸と循環. 39. 3-8 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sumie Shioya: "A 1ーYear Time Course Study of The Relaxation Times and Histology foy Irradiated Rat Lungs." Magnetic Resonance in Medicine. 14. 358-368 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sumie Shioya: "T_2 of Endotoxin Lung Injury with and without Methylprednisolone Treatment." Magnetic Resonance in Medicine. 15. 201-210 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sumie Shioya: "An Inーvivo Determination of Multiexponential Hahn T_2 of Normal Lung." Magnetic Resonance in Medicine. 16. 49-56 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sumie Shioya: "A Study of the Lung Water Components which Contribute to the Fast and Slow T_2 Components of Peripheral Lung Tissue." Book of Abstracts, Ninth Annual Meeting,Society of Magnetic Resonance in Medicine. 591 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sumie Shioya: "A Time Course Study of the Nuclear Megnetic Resonance (NMR) Spinーspin Relaxation Times for Encotoxin Lung in Living Rats." Amer.Rev.Respir.Dis.141. A544 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "In-vitro T_1 and T_2 to characterize the Pathophysiology of Pulmonary Injuries." Abstracts of International Symposium, on Tissue Characterizationin MR Imaging. 93 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "A 1-Year Time Course Study of the Relaxation Times and Histology for Irradiated Rat Lungs." Mag. Reson Med. 14. 358-368 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "T_2 of Endotoxin Lung Injury with and without methylprednisolone Treatment." Mag. Reson Med. 15. 201-210 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "A Study of the Lung Water Components which Contribute to the Fast and Slow T_2 Components of Peripheral Lung Tissue." Book of Abstracts, Ninth Annual Meeting, Soc of Mag. Reson Med. 591 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "An In-vivo Determination of Multiexponential Hahn T_2 of Normal Lung." Mag. Reson Med. 16. 49-56 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya, et al.: "A Time Course Study of the Nuclear Magnetic Resonance (NMR) Spinspin Relaxation Times for Endotoxin Lung Injury in Living Rats." Amer Rev Respir Dis. 141. A544 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Shioya et al.: "Differentiation of Lung Cancer and Radiation Fibrosis Using Magnetic Resonance Images : A Cace Study." Tokai J Exp Clin Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 塩谷 寿美恵: "胸部のMRI(磁気共鳴画像)" 呼吸と循環. 39. 3-8 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumie Shioya: "A 1ーYear Time Course Study of the Relaxation Times and Histology for Irradiated Rat Lungs." Magnetic Resonance in Medicine. 14. 358-368 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumie Shioya: "T_2 of Endotoxin Lunf Injury with and without Methylprednisolone Treatment." Magnetic Resonance in Medicine. 15. 201-210 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumie Shioya: "An inーvivo Determination of Mutiexponential Hahn T_2 of Normal" Magnetic Resonance in Medicine. 16. 49-56 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumie Shioya: "Differentiation of Lung Cancer and Radiation Fibrosis Using Magnetic Resonance Images:A Case Study" Tokai J Exp Clin Med.

    • Related Report
      1990 Annual Research Report
  • [Publications] Sumie Shioya: "A 1- Year Time Course Study of the Relaxation Times and Histology for Irradiated Rat Lungs" Magnetic Resonance in Medicine.

    • Related Report
      1989 Annual Research Report
  • [Publications] Sumie Shioya: "T_2 of Endotoxin Lung Injury with and without Methylprednisolone Treatment" Magnetic Resonanoe in Medicine.

    • Related Report
      1989 Annual Research Report
  • [Publications] Sumie Shioya: "A Time Course Study of the Nuclear Magnetic Resonance(NMR)Spin-Spin Relaxation Times for Endotoxin Lung Injury in Living Rats" American Review of Respiratory Disease.

    • Related Report
      1989 Annual Research Report
  • [Publications] 塩谷寿美恵: "Interleaves Line Scanを用いた自発呼吸ラット正常肺,inーvivo NMR緩和時間T_2の2成分解析" 胸部疾患学会雑誌.

    • Related Report
      1989 Annual Research Report
  • [Publications] 塩谷寿美恵: "ラットエンドトキシン傷害肺におけるinーvivo NMR緩和時間T_2およびproton densityの時間経過" 胸部疾患学会雑誌.

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi