| Project/Area Number |
01480252
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
KATORI Ryo Kinki Univ. School of Med. professor, 医学部, 教授 (40088521)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Hiroyuki Kinki Univ. School of Med. Assistant, 医学部, 助手 (90216606)
INOKI Tatsu Kinki Univ. School of Med. Assistant, 医学部, 助手 (60213188)
MIYAZAKI Toshio Kinki Univ. School of Med. Assist. Prof, 医学部, 講師 (10209893)
SAKAGUCHI Yoshihide Kinki Univ. School of Med. Assist. Prof, 医学部, 講師 (10215626)
清水 稔 近畿大学, 医学部, 講師 (20178990)
森下 昌亮 近畿大学, 医学部, 講師 (00191023)
大野 允 近畿大学, 医学部, 講師 (40194253)
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | myocardial infarction / coronary artery occlusion / myocardial ischemia / collateral circulation / NMR / myocardial blood flow / thrombolysis / left ventricular function / 心エコ-図 / ATP / Stunned myocardium / ウロキナ-ゼ / stunned myocardial |
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| Research Abstract |
1. Experiments of coronary occlusion and reperfusion : We measured regional myocardiall contractility and myocardial blood flow by the colored microsphere method in dogs which underwent a breaf (15 min) occlusion of the left anterior descending branch. In order to examine the stunned myocardium positive inotropic intervention of an atrial premature beat was performed before, during and after the occlusion. The stunned myocardium occured only in the myocardium with less 20 % collateral circulation.
2. NMR determination of ischemic myocardial metabolism under breaf global ischemia in rabbit hearts : The experiment was performed by using the Langendorf method with artificial blood, FC43. Rabbit hearts underwent 15 min global ischemia with suspension of coronary artery supply in a NMR chamber and ATP, CrP, Pi and pH were measured continuously before, during and after ischemia. Adminstration of methylpredonisolone before ischemia significantly improved the post-ischemic derangement of ATP and developed tension of the left ventricle. The effects were not observed by post-ischemic administration. This was considered to be due to membrane stabilizing action of this drug.
3. Clinical studies in myocardial infarction patients : Recanalization of occluded infarct-related- coronary artery with urokinase prevented the expansion and thinning of the infarcted myocardium observed 4 and 5 days later. The patients with thrombolysis also had more cardiac output than the other patients did. In the study of recovery phase, it is concluded that exercise-induced ST-segment elevation is induced by electrophysiological difference between infarction area and non-infarction area which is resulted from stimulation of beta-adrenergic receptors.
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