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Basic and Clinical Analysis of Macroscopic and Microscopic Characteristics of Coronary Circulation in Cardiac Hypertrophy

Research Project

Project/Area Number 01480253
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

KAJIYA Fumihiko  Department of Medical Engineering, Kawasaki School, 医学部・医用工学, 教授 (70029114)

Co-Investigator(Kenkyū-buntansha) TADAOKA Shinichiro  Division of Cardiology, Kawasaki Medical School, 医学部・循環器内科, 講師 (30188255)
OGASAWARA Yasuo  Department of Medical Engineering, Kawasaki Medical School, 医学部・医用工学, 講師 (10152365)
TSUJIOKA Katsuhiko  Department of Medical Engineering, Kawasaki Medical School, 医学部・医用工学, 助教授 (30163801)
TAKAORI Masuhiko  Department of Anesthesiology, Kawasaki Medical School, 医学部・麻酔科, 教授 (30068978)
FUJIWARA Takashi  Department of Surgery, Kawasaki Medical School, 医学部・心臓外科, 教授 (90090224)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1990: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1989: ¥4,700,000 (Direct Cost: ¥4,700,000)
Keywordscardiac hypertrophy / coronary artery flow / intramyocardial vessel / ultrasound Doppler catheter / laser Doppler velocimeter / レ-ザドプラ血流計 / 冠静脈血流 / 心筋内微小血管 / 超音波ドプラ血流計 / 圧負荷肥大心 / 肥大心 / 心筋内圧
Research Abstract

It is well known that the heart can adapt itself to pressure overload or volume overload by inducing cardiac hypertrophy and thus reducing myocardial stress. Whereas, it is indicated that coronary reserve is decreased in hypertrophied heart. However, only little finding is reported on why coronary circulation is deteriorated in cardiac hypertrophy.
In this study we measured coronary artery flow in human being with cardiac hypertrophy by 20 MHz ultrasound Doppler velocimeter, and epicardial and intramyocadial artery flow in dogs by laser Doppler velocimeter.
We found that myocardiac contraction impedes coronary inflow and it may affect directly to intramyocardial vessels and the effect of intramyocadial pressure is relatively small. In addition we found that in human cardiac hypertrophy there exists reverse arterial flow in systole and that early diastolic flow is reduced. These findings suggest that myocadial contraction is a major factor determining phasic arterial flow and cardiac hypertrophy has complex effects on coronary circulation.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] M.Goto,K.Tsujioka,Y.Ogasawara,Y.Wada,S.Yadaoka,O.Hiramatsu,M.Yanaka and F.Kajiya: "Effect of blood filling in intramyocardial vessels on coronary arterial inflow." Am.J.Physiol.258. H1042-H1048 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F.Kajiya,K.Tsujioka,Y.Ogasawara,O.Hiramatsu,Y.Wada,M.Goto and M.Yanaka: "Analysis of the Characteristics of the Flow Velocity Waveforms in Left Atrial Small Arteries and Veins in the Dog" Circulation Research. 65ー4. 1172-1181 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F.Kajiya,K.Tsujioka,Y.Ogasawara,K.Mito,O.Hiramatsu,M.Goto,Y.Wada and S.Matsuoka: "Mechanical control of Coronary Artery Inflow and Vein Outflow" Japanese Circulation Journal. 53. 431-439 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F.Kajiya: "Progress and recent topics in blood flow measurements" Frontiers.Med.Biol.Engng.1ー4. 271-285 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] D.Kilpatrick,F.Kajiya and Y.Ogasawara: "FIBRE OPTIC LASER DOPPLER MEASUREMENT OF INTRAVASCULAR VELOCITY" Australasian Physical & Engineering Sciences in Medicine. 11ー1. 5-14 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Fujiwara,A.Nogami,H.Masaki,H.Yamane,S.Matsuoka,H.Yoshida,H.Fukuda,T.Katsumura and F.Kajiya: "Coronary Flow Velocity Waveforms in Aortic Stenosis and the Effects of Valve Replacemnt" Ann.Thorac.Surg.48. 518-522 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F.Kajiya,J.I.E.Hoffman,J.A.E.Spaan and G.Klassen: "Coronary Circulation" Springer Verlag, 300 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F.Kajiya: "Coronary Circulation in Physiological and Pathophysiological States" Springer Verlag, 250 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Goto, K. Tsujioka, Y. Ogasawara, Y. Wada, S. Tadaoka, O. Hiramatsu, M. Yanaka and F. Kajiya: "Effect of blood filling in intranyocardial vessels on coronary arterial inflow." Am. J. Physiol.258. 1042-1048 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F. Kajiya, K. Tsujioka, Y. Ogasawara, O. Hiramatsu, Y. Wada, M. Goto and M. Yanaka: "Analysis of the Characteristics of the Flow Velocity Wave forms in Left Atrial Small Arteries and Veins in the Dog" Circulation Research. 65-4. 1172-1181 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F, Kajiya, K. Tsujioka, Y. Ogasawara, K. Mito, O. Hiramatsu, M. Goto, Y. Wada and S. Matsuoka: "Mechanical Control of Coronary Artery Inflow and Vein Outflow" Japanese Circulation Journal. 53. 431-439 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F. Kajiya: "Progress and recent topics in blood flow measurements" Frontiers. Med. Bio. Eng.1-4. 271-285 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Fujiwara, A. Nogami, H. Masaki, H. Yamane, S. Matsuoka, H. Yoshida, H. Fukuda, T. Katsumura and F. Kajiya: "Coronary Flow Velocity Wave forms in Aortic Stenosis and the Effects of Valve Replacement" Ann. Thorac. Surg.48. 518-522 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] F. Kajiya, J. I. E. Hoffman, J. A. E. Spaan and G. Klassen: "Coronary Circulation" Springer Verlag. 300 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Goto,K.Tsujioka,Y.Ogasawara,Y.Wada,S.Tadaoka,O.Hiramatsu,M.Yanaka,F.Kajiya: "Effect of blood filling in intramyocardial vessels on coronary arterial inflow." Am.J.Physiol.258. H1042-H1048 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] F.Kajiya(分担執筆): "SpringerーVerlag" Coronary Circulation in Physiological and Pathophysiological States., 250 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] F.Kajiya,K.Tsujioka,Y.Ogawasara,O.Hiramatsu,Y.Wada,M.Goto,and M.Yanaka: "Analysis of the Characteristics of the Flow Velocity Waveforms in Left Atrial Small Arteries and Veins in the Dog" Circulation Research. 65ー4. 1172-1181 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] F.Kajiya,K.Tsujioka,Y.Ogawasara,K.Mito,O.Hiramatsu,M.Goto,Y.Wada,and S.Matsuoka: "Mechanical Control of Coronary Artery Inflow and Vein Outflow" Japanese Circulation Journal. 53. 431-439 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] F.Kajiya: "Progress and recent topics in blood flow measurements" Frontiers.Med.Biol.Engng.1ー4. 271-285 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] D.Kilpatrick,F.Kajiya,and Y.Ogasawara: "FIBRE OPTIC LASER DOPPLER MEASUREMENT OF INTRAVASCULAR VELOCITY" Australasian Physical & Engineering Sciences in Medicine. 11ー1. 5-14 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Fujiwara,A.Nogami,H.Masaki,H.Yamane,S.Matsuoka,H.Yoshida,H.Fukuda,T.Katsumura,and F.Kajiya: "Coronary Flow Velocity Waveforms in Aortic Stenosis and the Effects of Valve Replacement" Ann.Thorac.Surg.48. 518-522 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] F.Kajiya,J.I.E.Hoffman,J.A.E.Spaan,and G.Klassen: "Coronary Circulation" Springer Verlag, 300 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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