| Project/Area Number |
01480269
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Institute of Clinical Medicine, University of Tsukuba |
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Principal Investigator |
MATSUMOTO K. (1990-1991) Univ. Tsukuba, Clinical Medicine, lecturer, 臨床医学系, 講師 (30117907)
秋貞 雅祥 (1989) 筑波大学, 臨床医学系, 教授 (90110494)
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| Co-Investigator(Kenkyū-buntansha) |
ANNO I. Univ. Tsukuba, Clinical Medicine, lecturer, 臨床医学系, 講師 (50138707)
KATSUTA S. Univ. Tsukuba, Sports Science, proffesor, 体育科学系, 教授 (70038446)
MITSUMORI F. Nat. Inst, Senior Scientist, 環境健康部, 主任研究員 (90125229)
井上 多門 筑波大学, 物理工学系, 教授 (10168453)
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| Project Period (FY) |
1989 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1989: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | NMR / muscle metabolism / endurance training / aging / Aging / exercise physiology / ^<31>PNMR / muscle energetics / ^<31>P NMR / training / Sports medicine |
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| Research Abstract |
To evaluate changes in muscle energetics following endurance training, we measured phosphorus -31 nuclear magnetic resonance ( ^<31>P NMR) spectra on rat muscle in vivo before and after training in the same animals. The endurance training was performed in the training group for 3 months. ^<31>P NMR spectra were obtained serially at rest, during exercise by electric stimulation, and during recovery. Intramuscular phosphocreatine (PCr), inorganic phosphate (Pi), ATP and pH were determined from the NMR spectra. The ratio of PCr/ (PCr+Pi) at rest showed no difference between the training and control group even after 3 months of training. During exercise, however, this ratio was significantly higher in the training group than in the control group. The ratio also recovered more rapidly after exercise in the training group. The muscular pH slightly decreased - 0.1 pH unit during exercise, but did not show significant difference in both groups. These results indicate that the endurance training of 3 months improves the ATP supply system in the muscle without significant change in the muscular fiber types. It is also demonstrated that ^<31>P NMR is a potent method to evaluate the training effects on the same individuals consecutively.
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