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Correlative Study on Abnormal Tumor Vascularity and Metabolism

Research Project

Project/Area Number 01480271
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionFukui Medical School

Principal Investigator

ISHII Yasushi  Fukui Medical School, Professor, 医学部, 教授 (00026949)

Co-Investigator(Kenkyū-buntansha) NAKATSUGAWA Shigekazu  Fukui Medical School, Lecturer, 医学部, 講師 (00180315)
HAYASHI Nobushige  Fukui Medical School, Associate Professor, 医学部, 助教授 (20189658)
YAMAMOTO Kazutaka  Fukui Medical School, Associate Professor, 医学部, 助教授 (50158268)
河村 泰孝  福井医科大学, 医学部, 助手 (30214703)
小鳥 輝男  福井医科大学, 医学部, 助教授 (10115818)
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsMR Spectroscopy / Energetic metabolism of tumor / Perfusion of tumor / Hyperthermia therapy / Radiation therapy / 向腫瘍性放射性医薬品 / 腫瘍動態と代謝 / ^<31>PーMRS / ^1HーMRS / MR拡散1微小循環画像(IVIM) / chemical shift imaging(CSI) / 腫瘍代謝 / 腫瘍血流 / 微小循環 / ヌ-ド・マウス移植人癌 / 放射線照射の代謝への影響 / ^<31>PMRS / 高エネルギ-燐酸代謝
Research Abstract

Recent progress of the imaging diagnosis has already established to detect the existence of tumor and its degree of extension. However, in order to select and evaluate the adequate therapeutic regimen, further specified information characterized by physiological state of the tumor such as perfusion and metabolic state should be known. On this line, to understand physiological environment of the tumor as a mass of tumor cells, correlative studies on abnormal vascurality and high enagy metabolism were perfomed at present. A series bf tumor bearing nude mice were subjected to examine using MR contrast enhancement study as well as hydrogen clearance method to evaluate perfusion status, and ^<31>P or ^<>H MR spectroscopy (MRS) to evaluate energetic metabolism. These physiological parameters of the tumor insitu were observed during tumor growth and after therapeutic intervention such as radiation and hyperthermia. During tumor growth, tumor perfusion became insufficient and resulted in anerobic metabolic state oh the whole, and these were improved by irradiation as has been hypothesized by rexygenation process. However, after application of hyperthermia, complete ischemia consequent with metabolic decline were induced. Combined application of these two intervention with opposite effect on the tumor, namely, metabolic activation or decline, revealed additive effect without cancellation, each other. Thus, present result indicated that a growing tumor became heterogenous composing of different perfusion state with different metabolic state, and, therefore, different therapeutic intervention was necessary to induce additive effect on the whole. Futher investigation concerning tumor heterogeneity on the ground of macropathology should be necessary to establish adequate selection of therapeutic intervention. On this line, noninvasive imaging of metabolites such as chemical shift imaging (CSI) using clinical MRI should be completed as a next step.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] H.Kimura: "Metabolic Alterations after combined Therapy of Radiation and Hyperthermia using Implanted Human Tumor by in vivo P31-MRS" Proceeding of 9th Annual Meeting of Society of Magnetic Resonance in Medicine. p835 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 玉川 洋一: "拡散/微小循環画像の基礎的検討" 日本磁気共鳴医学会雑誌. 10. 335-344 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 玉川 洋一: "ダイナミックファントムを用いたRF誘導加温実験" 日本ハイパ-サ-ミア学会誌. 7. 70-77 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石井 靖: "癌の画像診断:治療評価ーMRS" 第23回日本医学総会誌. III. 498 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石井 靖: "画像診断における腫瘍動態とその代謝について" 病態生理. 10. 655-658 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 木村 浩彦: " ^<31>PーMRSによる放射線照射及び温熱療法の治療効果の検討" 日本磁気共鳴医学会雑誌. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Kimura: "Metabolic alterations after combined therapy of radiation and hyperthermia using implanted human tumor by in vivo ^<31>P-MRS." Proceeding of 9th Annual Meeting of Society of Magnetic Resonance in Medicine.835 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Tamagawa: "Basic consideration of diffusion/perfusion imaging." Jpn J. Magnetic Resonance in Medicine.10(5). 335-344 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Tamagawa: "RF capacitive heating using dynamic phantom." Jpn. J. Hyperthermic Oncol.7(1). 70-77 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Ishii: "Imaging diagnosis of cancer : therapeutic evaluation-MRS" Proceedings of the 23rd General Assembly of the Japan Medical Congress. 1991, Kyoto. III. 498 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Ishii: "Imaging of tumor dynamics and its metabolism." Medicine Philosopica.10(8). 655-658 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H. Kimura: " ^<31>P-MRS study for the assessment of tumor response after radiotherapy and/or hyperthermia." Jpn J. Magnetic Resonance in Medicine.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] H.Kimura: "Metabolic Alterations after Combined Therapy of Radiation and Hyperthermia using Implanted Human Tumor by in vivo P31ーMRS" Procedding of 9th Annual Meeting of Society of Magnetic Resonance in Medicine. 835 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 玉川 洋一: "拡散/微小循環画像の基礎的検討" 日本磁気共鳴医学会雑誌. 10. 335-344 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 玉川 洋一: "ダイナミックファントムを用いたRF誘導加温実験" 日本ハイパ-サ-ミア学会誌. 7. 70-77 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 石井 靖: "癌の画像診断:治療評価ーMRS" 第23回日本医学総会誌. III. 498 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 石井 靖: "画像診断における腫瘍動態とその代謝について" 病態生理. 10. 655-658 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 木村 浩彦: " ^<31>PーMRSによる放射線照射及び温熱療法の治療効果の検討" 日本磁気共鳴医学会雑誌. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Tagami: "Intravoxel Inchoherent Motion Imaging of Bone and Soft Tissue Tumors" Proceeding of 9th Annual Meeting of Society of Magnetic Resonance in Medicine. 198 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Kimura: "Metabolic Alterations after Combined Therapy of Radiation and Hyperthermia using Implanted Human Tumor by in vivo 31P MRS" Proceeding of 9th Annual Meeting of Society of Magnetic Resonance in Medicine. 835 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 玉川 洋一: "拡散/微小循環画像の基礎的検討" 日本磁気共鳴医学会雑誌. 10. 335-344 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 玉川 洋一: "ダイナミックファントムを用いたRF誘電加温実験" 日本ハイパ-サ-ミア学会誌. 7. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐久間肇: "2T小ボア怪超伝導実験用MRによるintravoxel incoherent motion(IVIM)imagingの検討。" 日本医学放射線学会雑誌. 49. 941-943 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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