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Research on Risk Factors of Adverse Reactions to Iodinated Contrast Media

Research Project

Project/Area Number 01480276
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionJuntendo University School of Medicine

Principal Investigator

KATAYAMA Hitoshi.  Juntendo University. Department of Radiology. Professor, 医学部, 教授 (80053007)

Co-Investigator(Kenkyū-buntansha) KUWATSURU Ryohei  Juntendo University. Department of Radiology. Assistant Professor, 医学部, 助手
SUMI Yukiharu.  Juntendo University. Department of Radiology. Associate Professor, 医学部, 助教授 (40171300)
TOMITA Takashi.  Juntendo University. Department of Radiology. Lecturer, 医学部, 講師 (20188783)
住江 寛俊  順天堂大学, 放射線医学教室, 講師 (30053127)
中田 肇  産業医科大学, 放射線医学教室, 教授
Project Period (FY) 1989 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordscontrast media / adverse reaction / risk factor / ヨ-ザ造影剤 / 造影剤
Research Abstract

Comparative studies of adverse reactions (ADR) to ionic and nonionic iodinated contrast media was performed using a large scale of survey from multi-institutional sources. The studies were restricted to examinations with intravenous application of contrast media A total of 352, 817 cases were collected. The pevalence of all ADRs were 12.66% for ionic and 3.13% for nonionic contrast media examinations. Severe ADRs occurred in 0.22% of ionic and 0.04% of nonionic contrast media examinations. About 70% of ADRs due to either ionic or nonionic contrast media occurred during or within 5 minuts of injection. As far as severe ADRs concerned, prevalence of ADRs were highest- : patients with a history of previous ADRS, history of allergy, especially asthma, and cardiac disease.
In order to clarify the risk factors to intravenous administration of iodinated contrast media, meta-analysis of 337, 647 cases was performed by using logistic regression technique. Logistic regression showed that nonionic low osmolar contrast media was 5.6 times safer than conventional ionic high osmolar contrast media. Major risk factors were : history of ADRs at exposure to contrast media (4-7 times), history of asthma (10 times), and underlying cardiac disease (3 times). The incidence of severe ADRs in patients with above three major risk factors was 120 times higher than in patients without. All ADRs were significantly reduced by using nonionic low osmolar contrast media, including life-threatening ADRS : sudden drop of blood pressure (8・3 times), loss of consciousness (7・5 times), cardiac arrest (7-0 times), and dyspnea (4・5 times). Mechanism of ADRs to iodinated contrast media is still indeterminate, and further investigation should be performed. We are much interested immunological approach.

Report

(4 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 宗近 宏次: "造影CTのための造影剤最適濃度オムニパ-ク300とオムニパ-ク240の比較" 映像情報. 22. 651-655 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama: "Adverse Reactions to Ionic and Nonionic Contrast Media.A Report from the Japanese Committee on the Safety of Contrast Media." Radiology. 175. 621-628 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama: "A New Age for Contrast Media" Asian Medical Journal. 33. 405-408 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 片山 仁: "ヨ-ド造影剤の近況ー明と暗 高浸透圧,低浸透圧造影剤の副作用を中心に" 新医療. 17. 64-68 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama: "The contrast media controversy:Implications of a landmark safety study" Administrative Radiology. IX. 20-22 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 住 幸治: "新しい造影剤" 臨床画像. 6. 8-15 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama, Kouchi Yamaguchi, Takahiro Kozuka, Tsutomu Takashima, Peter Seez, et al: "Adverse Reactions to Ionic and Nonionic Contrast Media. A Report from the Japanese Committee on the Safety of Contrast Media." Radiology. 175. 621-628 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroshi Katayama: "A New Age for Contrast Media" Asian med. J.33. 405-408 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama: "The contrast media controversy : Implication of landmark safety study" Adiministr. Radiol.9. 20-22 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama, Ryohei Kuwatsuru: "How to use contrast media correctly (JPN)" Jpn. J. Clin. Experim. Med.68(1). 167-173 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichi Yamaguchi, Hitoshi Katayama, Tsutomu Takashima, Takahiro Kozuka, Peter Seez, et al: "Prediction of Severe Adverse Reactions to Ionic and Nonionic Contrast Media in Japan : Evaluation of Pretesting" Radiology. 178. 303-367 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama, Ryohei Kuwatsuru, Hirotoshi Sumie, Yukiharu Sumi: "Adverse Reactins to Low Osmolar Contrast Media (1st Report) (Jpn)" Nippon Acta Radiol.51(6). 632-642 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama, Ryohei Kuwatsuru: "New Contrast Agents - their merite and demerits (Jpn) -" J. Med. Imagings. 11(5). 581-590 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hitoshi Katayama, Koichi Yamaguchi, Takahiro Kozuka, Tsutomu Takashima, Keiichi Matsuura, et al: "Full-scale Investigation into Adverse Reactions in Japan - Risk Factor Analysis -" Invest. Radiol.26(s). s33-s36 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ryohei Kuwatsuru, Hitoshi Katayama, Takashi Tomiya, Yutaka Naoi, Akira Hirano, et al: "Adverse Reactions to Low Osmolar Iodine" Nippon Acta Radiol.Contrast Media (2nd Report) (Jpn).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamaguchi,K.: "Prediction of Severe Adverse Reactions to Ionic and Monionic Contrast Media in Japan: Evaluation of Pretesting" Radiology. 178. 363-367 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 片山 仁: "新しい造影剤と功罪" 画像診断. 11(5). 581-590 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 片山 仁: "低浸透圧造影剤の副作用(第1報)" 日本医学放射線学会雑誌. 51(6). 632-642 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katayama,H.: "Fullーscale Investigation into一Adverse Reactions in JapanーRisk Factor Analysisー" Investigative Radiology. 26(s). S33-S36 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 桑鶴 良平: "低浸透圧ヨ-ド造影剤の副作用(第2報)" 日本医学放射線学会雑誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 片山 仁: "造影剤マニュアル" 金原出版 東京, 116 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hitoshi Katayama: "New Dimensions of Contrast (Fullーscale investigation into adverse reactions in Japanーrisk factor analysis)" Excerpta Media AmsterdamーPrincetonーHongKongーTokyoーSydney, 384 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 宗近 宏次: "造影CTのための造影剤最適濃度オムニパ-ク7300とオムニパ-ク240の比較" 映像情報. 22. 651-655 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hitoshi Katayama: "Adverse Reactions to Ionic and Nonionic Contrast Media. A Report from the Japanese Committen on the Safety of Contrast Media." Radiology. 175. 621-628 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hitoshi Katayama: "A New Age for Contrast Media." Asian Medical Journal. 33. 405-408 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 片山 仁: "ヨ-導造影剤の近況ー明と暗 高浸透圧,低浸透圧造影剤の副作用を中心に" 新医療. 17. 64-68 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hitoshi Katayama: "The contrast media controversy:Implications of a landmark safety study." Administrative Radiology. IX. 20-22 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 住 幸治: "新しい造影剤" 臨床画像. 6. 8-15 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 片山 仁: "造影剤の正しい使い方" 臨床と研究. 68. 167-173 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hitoshi Katayama: "Adverse Reactions to Ionic and Nonionic Contrast Media" Radiology. 175. 00-00 (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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