• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of Pig Family of Congenital Diaphragmatic Hernia, and Studies on its Embryological Basis.

Research Project

Project/Area Number 01480304
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionInstitute of Clinical Medicine, Tsukuda University

Principal Investigator

OHKAWA Haruo  Univ. of Tsukuba, Inst. Clin. Med. Sci., Prof., 臨床医学系, 教授 (30009667)

Co-Investigator(Kenkyū-buntansha) YAGAMI Ken-ichi  Univ. of Tsukuba, Inst. Basic Med. Sci., Associate Prof., 基礎医学系, 助教授 (40166476)
OCHI Gohei  Univ. of Tsukuba, Inst Clin. Med. Sci., Assist. Prof., 臨床医学系, 講師 (20185614)
Project Period (FY) 1989 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1989: ¥3,900,000 (Direct Cost: ¥3,900,000)
KeywordsPig model / Congenital diaphragmatic hernia / Anorectal malformations / Autosomal gene / Double recessive gene / 直腸肛門奇形 / 動物モデル / 先天性横隔膜ヘルニア / 発生学 / 胸腹裂孔ヘルニア / doable recessiuegeve
Research Abstract

Neonatal diaphragmatic hernia is one of the most improtant emergency diseases, with great difficulty of treatment and poor prognosis even in the present stage of pediatric Surgery. This study was performed with a final goal of improvement of the clinical results. Substantially this consists of a part of our research of a pig model with anorectal malformations, which has been established in our Unit.
The main purpose of this study is to establish a pig family of congenital diaphragmatic hernia, from our pig Family with anorectal malformations. So the proper maintenance of our pig Family with anorectal malformations itself will be proven to be a great fruit of the present study.
Unfortunately we did not obtain any new abnormal piglets after the first 13 pigs with congenital diaphragmatic hernia, and the operatively rescued female pig did not give any birth of anomalous piglets in the three normal deliveries. We have not succeeded in the production of Pig Family of congenital diaphragmatic hernia so far.
Detailed anatomical and pathological studies on the 13 anomalous pigs with late onset were performed and were reported precisely in the J. Jpn. Soc. Pediatr. Surg. 1990. The heredity in the pig Family was analyzed by the statistical calculation and the autosomal double recessive genes were proven to exist. This results will be presented in the International Meeting of Pediatric Surgery this year, and will be pressed in the J. Pediatr. Surg.
As without any fetus material with diaphragmatic hernia in this experiment up to the present, we have not been successful in the embryological analysis with anomalous materials so far.

Report

(3 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 大川 昭央: "新性児外科の治療成績" 日本外科学会雑誌. 9(9). 1314-1316 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松本 正智: "ブタ家族性横隔膜ヘルニアの病理学的遺伝学的検討" 日本小児外科孝雑誌. 26. 1118-1124 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 大川 治夫: "直腸肚門奇形〜ブタモデル" 小児外科. 22(6). 499-505 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 大川 治夫: "ブタ鎖肚モデルさ用いた研究" 外科. 53(1). 93-97 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 大川 治夫: "肺の低形成自体が先天性横隔膜ヘルニアの発性原因か" Mebio. 7(2). 9 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H.Ohkawa: "Familialcongenitaldiaphragmaficherniaofp:g;PathologyandGenetics" J.Pediatr.Surg. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 大川 治夫: "産婦人科治療の実際" 永井書店, 5 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Matsumoto, H. Ohkawa, G. Ochi, T. Hori, K. Ueoka and S. Sawaguchi ;: "Pathological and genetical studies on familial congenital diaphragamatic hernia in pig." J. Jpn. Soc. Pediatric Surgeons. 26(6). 1118 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohkawa, M. Kaneko, M. Sakaniwa, G. Ochi, T. Hori, M. Matsumoto ;: "Treatment results of neonatal surgical cases." J. Jpn. Surgical Society. 9(9). 1314 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohkawa and M. Matsumoto ;: "Research on the pig model of anorectal malformations" Surgery (Tokyo). 53(1). 93 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohkawa, M. Matsumoto, K. Ikebukuro and G. Ochi: "Establishment of a pig animal model for anorectal malformations and its application to embryological studies." Jpn. J. Pediatr. Surg.22(6). 499 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohkawa ;: "Is the dysplastic lung itself the embryological csuse for genesis of diaphragamtic hernia." Mebio. 7(2). 9 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Sawaguchi and H. Ohkawa ;: "Review on the new aspect of Clinical Medicine : Pediatric Surgery." Japan Medical Journal. 3435. 43 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohkawa, M. Matsumoto ;: "Familial congenial diaphragmatic hernia of pig ; Pathology and genetics." J. Pediatr. Surg.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松本 正智: "ブタ家族性横隔膜ヘルニアの病理学的遺伝学的検討" 日本小児外科学会雑誌. 26. 1118-1124 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大川 治史: "新生児外科の治療成績" 日本外科学会雑誌. 9(9). 1314-1316 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大川 治史: "ブタ鎖肛モデルを用いた研究" 外科. 53(1). 93-97 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大川 治史: "直腸肛門奇形ーブタモデル" 小児外科. 22(6). 499-505 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大川 治史: "肺の低形成自体が先天性横隔膜ヘルニアの発生原因か" Mebio. 7(2). 9 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 澤口 重徳: "臨床医学の展望〜小児外科学" 日本医事新報. 3435. 43-53 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 大川 治夫: "産婦人科治療の実際" 永井書店, 5 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松本正智: "疾患モデルとしてのブタの家族性横隔膜ヘルニアの検討" 医学のあゆみ. 148. 371-372 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松本正智: "ブタ家族性横隔膜ヘルニアの病理学的遺伝学的検討" 日本小児外科学会雑誌. 26. inpress (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: "ブタ鎖肛における内肛門括約筋の発生学的検討" 日本小児外科学会雑誌. 25. 530 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: "鎖肛ブタモデルの確立とその発生学への応用" 小児外科. 26. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ohkawa,H: "Fauilial congerital diaphragmatic herria in pig,as a disease model" J.Pediatr.Surg.(1991)

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1989-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi